| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Protein kinase Akt / PKB phosphorylates heme oxygenase 1 in vitro and in vivo . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenase 1 gene activation by the NAD ( P ) H oxidase inhibitor 4 ( 2 aminoethyl ) benzenesulfonyl fluoride via a protein kinase B , p 38 dependent signaling pathway in monocytes . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol 3 kinase / Akt pathway mediates heme oxygenase 1 regulation by lipopolysaccharide . ^^^ Since activation of heme oxygenase 1 and PI3K / Akt both protect the cellular environment , we postulated that PI3K / Akt can regulate the induction of heme oxygenase 1 by proinflammatory stress . ^^^ The treatment of primary murine macrophage cells ( RAW 264 . 7 ) with lipopolysaccharide induced heme oxygenase 1 protein and mRNA expression , and increased the phosphorylation of Akt and p 38 mitogen activated protein kinase ( p 38 MAPK ) . ^^^ Transfection of macrophages with dominant negative mutants of PI3K , Akt and Nrf 2 , as well as wortmannin treatment , significantly reduced the transcriptional activity of a minimal heme oxygenase 1 promoter luciferase construct ( D33HO 1luc ) . ^^^ We demonstrate , to our knowledge for the first time , that upon proinflammatory stimulation heme oxygenase 1 gene expression in macrophages depends on PI3K / Akt and p 38 MAPK acting upstream of Nrf 2 dependent promoter activation . . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Upregulation of heme oxygenase 1 by Epigallocatechin 3 gallate via the phosphatidylinositol 3 kinase / Akt and ERK pathways . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Using heme oxygenase 1 ( HO 1 ) as a model phase 2 gene , we found that both PI3K and Akt increased mRNA and protein levels of this enzyme . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenase 1 inhibits apoptosis in Caco 2 cells via activation of Akt pathway . ^^^ Heme oxygenase 1 induction by treatment with cobalt protoporphyrin 9 resulted in resistance to apoptosis , activation of Akt , reduction in p 21 ( Cip / WAF1 ) levels and modification of bcl2 / bax ratio towards survival . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Insulin induces heme oxygenase 1 through the phosphatidylinositol 3 kinase / Akt pathway and the Nrf 2 transcription factor in renal cells . ^^^ Overexpressing a dominant negative form of Akt abrogated the heme oxygenase 1 inducing effects of insulin , whereas cells transfected with a constitutively active Akt construct demonstrated an increase in heme oxygenase 1 promoter activity and protein expression . ^^^ Thus , insulin induces heme oxygenase 1 mRNA and protein expression in renal cells in a phosphatidylinositol 3 kinase / Akt and NF E 2 related factor 2 dependent manner . . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| The results show that transient arsenite pre treatment induces Hsp 72 , HO 1 and , to a lesser extent , Hsp 27 ; it reduces H2O2 induced astrocyte death ; and it causes selective activation of Akt following H2O2 . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| By contrast , cells transfected with a membrane targeted active version of Akt 1 exhibited increased HO 1 expression , even in the absence of NGF , and displayed a greatly attenuated production of ROS and apoptosis in response to 6 OHDA . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Simvastatin activated p 38 and Akt in VSMCs , and the respective inhibitors of p 38 and phosphoinositide 3 kinase ( PI3K ) greatly reduced the level of simvastatin induced HO 1 , which suggests the involvement of p 38 and the PI3K Akt pathway in HO 1 induction . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Thus , the induction of HO 1 expression and the activation of Akt / PKB by 15d PGJ ( 2 ) and PGA ( 2 ) are likely to confer cytoprotective or antiapoptotic effects exerted by these cyPGs . . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| LY 294002 and U 0126 , pharmacological inhibitors of phosphatidylinositol 3 kinase and MEK1 / 2 which are upstream of Akt and ERK1 / 2 , respectively , attenuated resveratrol induced HO 1 expression and exhibited antioxidant effects . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| HO 1 is an inducible enzyme with potent antioxidant and antiapoptotic activities which are regulated by Akt signaling . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| The increase in HO 1 by CoPP administration was associated with a significant increase in the phosphorylation of AKT and levels of BcL XL proteins . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Our results identify endothelial nitric oxide synthase as a downstream target of Lnk mediated activation of the PI3K / Akt pathway and HO 1 as a new substrate of Akt . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Adenoviral overexpression of HO 1 was accompanied by a significant increase in Ang 2 induced phosphorylation of Akt , however , Ang 2 mediated p 38 mitogen activated protein kinase ( MAPK ) phosphorylation was attenuated . ^^^ Inhibition of phosphotidylinositol 3 kinase enhanced myocyte apoptosis elicited by Ang 2 , however , p38MAPK inhibition had no effect , suggesting that overexpression of HO 1 protects myocytes via augmented Akt activation and not through modulation of p38MAPK activation . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Protection of human vascular smooth muscle cells from H2O2 induced apoptosis through functional codependence between HO 1 and AKT . ^^^ Recent evidence suggests that PKB / Akt may modulate HO 1 activity . ^^^ This study examined the role of Akt in mediating the cytoprotective effects of HO 1 in OS induced apoptosis of human aortic smooth muscle cells ( HASMCs ) . ^^^ METHODS AND RESULTS : HASMCs were transduced with retroviral vectors expressing HO 1 , Akt , or GFP and exposed to H2O2 . ^^^ Akt knockdown removed the protective effect of HO 1 on delta psi ( m ) during exposure to H2O2 . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| Eight groups of rats were studied during 7 days : ( 1 ) control rats ; ( 2 ) rats receiving resveratrol ( gavage , 2 . 5 mg / kg ) ; ( 3 ) rats injected tin protoporphyrin ( SnPP ) , a HO 1 inhibitor , i . p . on days 1 , 3 and 6 ; ( 4 ) rats injected 202190 ( SB ) , a p38MAPK inhibitor , i . p . for 7 days ; ( 5 ) rats injected 294002 ( LY ) , a Akt inhibitor , i . p . for 7days ; ( 6 ) rats receiving resveratrol and SnPP ; ( 7 ) rats receiving resveratrol and SB ; and ( 8 ) rats receiving resveratrol and LY . ^^^ These results indicate that resveratrol generates cardioprotection by preconditioning the heart by HO 1 mediated mechanisms , which are regulated by p38MAP kinase and Akt survival signaling , but non dependent on NFkappaB activation . . ^^^ |
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| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P31749 |
Pubmed |
SVM Score :0.0 |
| NA |
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