| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Monocyte p 22 , a NADH / NADPH system subunit , transforming growth factor beta ( TGF beta ) , heme oxygenase 1 ( HO 1 ) , and endothelial NOS gene expression were measured in 16 patients . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the effects of Salvia miltiorrhiza ( SM ) extracts on the expression of heme oxygenase 1 ( HO 1 ) and nitric oxide synthase ( NOS ) in small pulmonary arteries ( SPAs ) of rats with chronic hypoxia . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenase 1 ( HO 1 ) , HSP 72 , hepatic steroid hydroxylase / CYPIIA2 , and Cd inducible gene 1 ( cdig 1 , a new gene , Accession Nos . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| The mRNA for type 1 or neuronal nitric oxide synthase ( nNOS ) , and type 2 or inducible ( iNOS ) , and heme oxygenase 1 ( ' inducible ' ) and heme oxygenase 2 ( ' constitutive ' ) , were reverse transcribed to cDNA , amplified by the polymerase chain reaction , and then quantified using a co amplified internal standard , beta actin . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Inhibition of nitrite accumulation was associated with a fall in inducible NOS protein and an induction of heme oxygenase 1 , correlating both dose dependently and temporally . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : a ) To evaluate in vivo , in rat liver , heme oxygenase 1 ( HO 1 ) messenger RNA ( mRNA ) expression level and the regulation of 3 ' , 5 ' cyclic guanosine monophosphate ( cGMP ) production during hepatic regeneration , localized inflammation , and systemic inflammation ; and b ) to investigate the effect of the induction of cytochrome P 450 and nitric oxide synthase ( NOS ) inhibition on HO 1 mRNA level and cGMP production in the liver . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| CGMP increases in satellite cells of nitric oxide synthase containing sensory ganglia . cGMP and the enzymes , nitric oxide synthase ( NOS ) and heme oxygenase 1 ( HO 1 ) , the products of which stimulate soluble guanylyl cyclase activity , were investigated in cultured dorsal root ganglia ( DRG ) , and nodose ganglia of adult rats . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| We observed a correlation between Dpl expression and the induction of both heme oxygenase 1 ( HO 1 ) and nitric oxide synthase systems ( nNOS and iNOS ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Plasma and liver samples were taken 6 h following an injection of LPS for alanine aminotransferase ( ALT ) assays and RT PCR analysis of mRNA levels for genes of interest : endothelin ( ET 1 ) , its receptors ET ( A ) and ET ( B ) , endothelial nitric oxide synthase ( eNOS ) , inducible NOS ( iNOS ) , and heme oxygenase 1 ( HO 1 ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| HIF 1 increases the transcription of several genes for proteins that promote blood flow and inflammation , including vascular endothelial growth factor ( VEGF ) , heme oxygenase 1 , endothelial and inducible nitric oxide synthase ( NOS ) and cyclooxygenase 2 ( COX 2 ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| It is known that both nitric oxide synthase ( NOS ) and heme oxygenase 1 ( HO 1 ) play a role in the maintenance of microvascular integrity . ^^^ |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Currently , it is known that NO produced by nitric oxide synthase ( NOS ) induces heme oxygenase 1 ( HO 1 ) expression and CO produced by the HO 1 inhibits inducible NOS expression . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| The three quinazolidine derivatives specifically inhibit gene expression of NOS 2 , HO 1 and COX 2 only in macrophage cells , indicating that they are selective inhibitors of inducible gene expression in macrophages . . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| In the human prostate , the distribution of heme oxygenase ( HO 1 and HO 2 ) , nitric oxide synthase ( NOS ) , and tyrosine hydroxylase ( TH ) immunoreactive ( IR ) , acetylcholine esterase ( AChE ) positive , and some peptidergic nerve structures was investigated . ^^^ Cell bodies and nerve fibers within coarse nerve trunks expressed HO 1 , HO 2 , NOS , TH , and vasoactive intestinal polypeptide ( VIP ) immunoreactivities , and were AChE positive , but , as revealed by confocal microscopy . ^^^ Along strains of smooth muscle , intraglandular septa , and around acini , HO 1 , NOS , and VIP IR nerves , and AChE positive fibers were observed . ^^^ Some TH IR terminals had profiles that were similar , but not identical , to those of NOS , HO 1 , or VIP IR terminals . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| The specific genes studied were iNOS , nNOS , HO 1 , HO 2 and IL 1beta . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Although NOS inhibitors such as NG nitro L arginine ( NNA ) and NG methyl L arginine did not change LPS induced iNOS expression , these inhibitors suppressed both NO 2 accumulation and the enhancement of HO 1 . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Although a NOS inhibitor , such as N ( G ) nitro L arginine ( NNA ) , did not change LPS induced iNOS expression , the inhibitor suppressed both NO 2 accumulation and the enhancement of HO 1 . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| The objectives of this study were to elucidate the localization of HO 1 and HO 2 isoforms relative to NOS 3 protein , and to determine the enzymatic activity of HO in the placenta of the guinea pig during gestation . ^^^ Immunohistochemical localization of HO 1 , HO 2 and NOS 3 protein was conducted using selective polyclonal antibodies . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of the HO 1 gene was evaluated at the mRNA ( Northern blot analysis ) and protein ( Western blot analysis ) levels in mesangial cells treated with two NO donors , sodium nitroprusside ( SNP ) and S nitroso N acetyl DL penicillamine ( SNAP ) , or was stimulated by the combination of lipopolysaccharide ( LPS ) and interferon gamma ( IFN gamma ) to induce iNOS in the presence and absence of NOS inhibitor NG Monomethyl L arginine ( L NMMA ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Targeted disruption of ICAM 1 or eNOS gene , but not the neuronal NOS gene , attenuated the TD induced neurodegeneration and HO 1 induction . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To characterize the distribution of cholinergic nerves in the human corpus cavernosum ( CC ) and spongiosum ( CS ) using antibodies to the vesicular acetylcholine transporter ( VAChT ) , and to compare this distribution to those of other transmitters / mediators or transmitter / mediator generating enzymes ( heme oxygenases : HO 1 and HO 2 ; neuronal and endothelial NO synthases : nNOS and eNOS ; vasoactive intestinal polypeptide : VIP ; and tyrosine hydroxylase : TH ) , and to investigate NO and carbon monoxide ( CO ) mediated effects . ^^^ RESULTS : Along strands of smooth muscle in the CC and CS , rich numbers of VAChT , nNOS , VIP , TH , and very few HO 1 immunoreactive ( IR ) nerve fibers were observed . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Using a rat model of prehepatic portal hypertension with preserved hepatic function , we examined pulmonary elaboration of endothelial nitric oxide synthase ( NOS ) , inducible NOS , heme oxygenase 1 ( HO 1 ) , heme oxygenase 2 ( HO 2 ) , endothelin 1 mRNA , and protein . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NOS inhibition by L N ( G ) nitroarginine methyl ester ( L NAME ) or 1400 W abolished nitrite production and strongly reduced HO 1 expression . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Macrophage inducible NOS generates NO to kill other cells , whereas HO 1 generates bilirubin to exert antioxidant cytoprotective effects and also provides cytoprotection by facilitating iron extrusion from cells . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Then appeared incubated for 4 h increased expression of mRNAs for haemoxygenase ( HO 1 ) , cyclooxygenase 2 ( COX 2 ) , prostaglandin E synthase ( PGE S ) , but hardly for nitric oxide synthase 2 ( NOS 2 ) . ^^^ Activation of HO 1 may lead to a deficiency in intracellular heme required as a cofactor for both COX and NOS . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Rats treated with the NOS inhibitor N ( G ) nitro L arginine methyl ester for the entire 2 or 5 wk duration had normalized HO 1 expression and HPR . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| These enzymes display isoforms that are both constitutively expressed [ HO 2 , endothelial NOS ( eNOS ) , neuronal NOS ( nNOS ) ] and inducible [ HO 1 , inducible NOS ( iNOS ) ] following different types of stimulation . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| CVF was unrelated to the intensity of NOS 2 , NOS 3 , HO 1 , or TNF alpha gene expression or of NOS 2 protein expression . ^^^ In DCM , myocardial fibrosis is unrelated to the intensity of myocardial gene expression of NOS , antioxidative enzymes ( HO 1 ) , or cytokines ( TNF alpha ) and blunts NOS 2 related recruitment of LV preload reserve . . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| HO 1 mRNA expression in the solid tumour in vivo decreased significantly after treatment with low doses of NOS inhibitors such as L NAME and SMT ( 6 20 mg kg ( 1 ) ) . ^^^ However , the level of HO 1 mRNA in the solid tumour treated with higher doses of NOS inhibitor was similar to that of the solid tumour without NOS inhibitor treatment . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Interestingly , administration of the NOS inhibitor aminoguanidine ( AG ) or N ( G ) nitro L arginine methyl ester inhibited HO 1 expression . ^^^ Zinc protoporphyrin 9 ( ZnPP ) , an HO inhibitor , blocked HO 1 expression in hepatocytes from BDL cirrhotic rats , but enhanced the activity of inducible NOS ( iNOS ) in BDL hepatocytes . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Inhibition of NO production and / or NOS expression by incubating macrophages with different drugs inhibiting NOS activity or modulating the redox state of the cell , such as N acetylcysteine ( NAC ) resulted in inhibition of HO 1 expression , suggesting that NO is an endogenous mediator of this stress response . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Western blot analyses showed that HO 1 expression in AH136B cells was strongly upregulated by NO donors , for example , S nitroso N acetyl penicillamine and propylamine NONOate in vitro ; conversely , it was remarkably reduced in vivo by pharmacological blockade of NOS . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Inhibition of nitric oxide synthase ( NOS ) activity by Nomega nitro l arginine methyl ester ( l NAME ) at the resumption of reperfusion of rat kidney subjected to bilateral ischemia ( 30 min ) was as effective as the most potent HO 1 inducer , the spin trap agent n tert butyl alpha phenyl nitrone ( PBN ) , in causing sustained suprainduction of HO 1 mRNA . ^^^ Inhibition of NOS is potentially useful for sustained induction of HO 1 in organs that will be subjected to oxidative stress insult . . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Differential expression of inducible iNOS , HO 1 and COX 2 and enzyme activities of NOS , HO and COX were found in the gastric ulcer base . ^^^ CONCLUSION : The expression and activities of inducible NOS , HO 1 and COX 2 are found to be correlated to different stages of gastric ulceration . ^^^ Inducible NOS may contribute to ulcer formation while HO 1 and COX 2 may promote ulcer healing . . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| On a rat model of recurrent FS , the ultrastructure of hippocampal neurons was observed under electron microscopy , and expression of neuronal NOS ( nNOS ) in hippocampus and NO formation in plasma were examined after treatment with ZnPP 9 , an HO 1 inhibitor . ^^^ The gene and protein expression of nNOS and HO 1 increased markedly in hippocampus in FS rats , while CO formation in plasma increased markedly and the concentration of NO in plasma increased slightly . ^^^ In the ultrastructure of hippocampal neurons , the expression of HO 1 in hippocampus and CO formation in plasma were examined after treatment with L NAME , a NOS inhibitor . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| COX 2 deficient ( / ) mice display a blunted and delayed induction of the cytokine inducible genes NOS 2 and HO 1 after administration of Escherichia coli lipopolysaccharide ( LPS or endotoxin ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| This study investigated the time course of HO 1 and inducible nitric oxide synthase ( iNOS ) expression in the aortas of ovariectomized rats , and the regulatory relationship between the NO / NOS and the carbon monoxide / HO systems . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| The present study was to explore the influence on expression of HO 1 mRNA and protein and content of CO after recurrent FS by NOS inhibitor N ( omega ) nitro L arginine Methyl ester ( L NAME ) , in order to demonstrate a regulating role in HO / CO system by NO . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : We explored whether inducible nitric oxide synthase ( iNOS ) driven nitric oxide ( NO ) production regulates expression of iNOS , endothelial NOS ( eNOS ) , Cyclooxygenase 2 ( COX 2 ) , and Hemeoxygenase 1 ( HO 1 ) proteins in a rat model of glomerulonephritis induced by antibody raised in rabbits against rat glomerular basement membrane ( anti GBM ) . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Western blot and immunohistochemistry were used to test the presence and localization of HO ( for CO synthesis ) types 1 ( HO 1 ) and 2 ( HO 2 ) , neuronal NO synthase ( nNOS , for NO synthesis ) , and VIP . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| Although NO importantly modulated the effect of shear stress on EC transcription , HMOX 1 was consistently induced by shear stress , but not dependent on NOS or GC . ^^^ The role of HMOX 1 as a potential backup for NOS and the downstream role of SOXes should be explored . . ^^^ |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P29475 |
Pubmed |
SVM Score :0.0 |
| NA |
|