| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.6013862 |
| We found that HO 1 associated with CPR more tightly in the presence of NADP ( + ) ( K ( D ) = 0 . 5 microm ) than in its absence ( K ( D ) = 2 . 4 microm ) . 0.6013862^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Fluorescence resonance energy transfer ( FRET ) studies indicated that HO 1 ( S188D ) bound to cytochrome P 450 reductase ( CPR ) and biliverdin reductase ( BVR ) with a slightly lower Kd than wild type HO 1 . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenases ( HO 1 and HO 2 ) catalyze the NADPH cytochrome P ( 450 ) reductase ( CPR ) dependent degradation of heme into iron , carbon monoxide , and biliverdin , which is reduced into bilirubin . ^^^ Considering that CPR can be a limiting factor for optimal HO activity , we tested stable HO 1 and HO 2 cell lines that derived from the CPR cells . ^^^ Performing subcellular fractionations revealed that HO 2 and CPR are found together in the microsomal fractions , whereas HO 1 is partially present in the microsome and also found in other fractions , such as the cytosol . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Phenanthraquinone in diesel exhaust particles downregulates Cu , Zn SOD and HO 1 in human pulmonary epithelial cells : intracellular iron scavenger 1 , 10 phenanthroline affords protection against apoptosis . 9 , 10 Phenanthraquinone ( PQ ) , a major quinone contained in diesel exhaust particles and atmospheric PM ( 2 . 5 ) , undergoes one electron reduction by flavin enzymes such as NADPH cytochrome P 450 reductase , leading to production of reactive oxygen species in vitro . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| The dependency of the heme oxygenase reaction catalyzed by the soluble enzyme on the NADPH cytochrome P 450 reductase concentrations and the effect of catalase on the reaction were examined to compare with the purified membrane bound form of heme oxygenase 1 ( Yoshida and Kikuchi , 1978b ) . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenase 1 and NADPH cytochrome P 450 reductase expression in experimental allergic encephalomyelitis : an expanded view of the stress response . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Heme oxygenase 1 ( HO 1 ) catalyzes oxidation of the heme molecule in concert with NADPH cytochrome P 450 reductase following the specific cleavage of heme into carbon monoxide , iron , and biliverdin , which is rapidly metabolized to bilirubin . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| The ability of the human heme oxygenase 1 ( hHO 1 ) R183E mutant to oxidize heme in reactions supported by either NADPH cytochrome P 450 reductase or ascorbic acid has been compared . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| To define further the reaction mechanism , the oxidations of the four isomers of meso methylmesoheme by human truncated HO 1 supported by NADPH cytochrome P 450 reductase , H2O2 , or ascorbate have been examined . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| This feature is suited to the selective binding of ferredoxin , the physiological redox partner of Syn HO 1 ; the molecular size of ferredoxin is approximately 10 kDa whereas the size of NADPH cytochrome P 450 reductase , a reducing partner of mammalian HO 1 , is approximately 77 kDa . ^^^ |
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| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| Genes involved in the synthesis and modification of proteins ( various tRNA synthetases ) , protein degradation ( e . g . , ubiquitin , Herpud 1 , Sqstm 1 ) , and oxidative stress ( Hmox 1 , Por ) could be subgrouped into distinct kinetic profiles as well . ^^^ |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09601 and P16435 |
Pubmed |
SVM Score :0.0 |
| NA |
|