| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.75101324 |
| Galectin 1 , a beta galactoside binding protein that can occur as both a monomer and a homodimer , binds to leucocyte membrane antigens such as CD 7 , CD 43 , and CD 45 , and has immune regulatory functions in several animal models of autoimmune disease . 0.75101324^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| We have determined that galectin 1 binds to a restricted set of T cell surface glycoproteins , and that only CD 45 , CD 43 , and CD 7 appear to directly participate in galectin 1 induced apoptosis . ^^^ To determine whether these specific glycoproteins interact cooperatively or independently to deliver the galectin 1 death signal , we examined the cell surface localization of CD 45 , CD 43 , CD 7 , and CD 3 after galectin 1 binding to human T cell lines and human thymocytes . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| CD 7 delivers a pro apoptotic signal during galectin 1 induced T cell death . ^^^ Galectin 1 binds to several glycoproteins on the T cell surface , including CD 7 . ^^^ We show that CD 7 is required for galectin 1 mediated death . ^^^ This demonstrates a novel function for CD 7 as a death trigger and identifies galectin 1 / CD7 as a new biologic death signaling pair . . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| Galectin 1 binds to T cell surface glycoproteins CD 45 , CD 43 , and CD 7 , although the precise roles of each receptor in cell death are unknown . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| Several galectin 1 receptors are discussed such as CD 45 , CD 7 , CD 43 , CD 2 , CD 3 , CD 4 , CD 107 , CEA , actin , extracellular matrix proteins such as laminin and fibronectin , glycosaminoglycans , integrins , a beta lactosamine glycolipid , GM 1 ganglioside , polypeptide HBGp 82 , glycoprotein 90 K / MAC 2BP , CA 125 cancer antigen , and pre B cell receptor . . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| Among the differentially regulated proteins were galectin 1 ( gal 1 ) and CD 7 , and their down regulation was further corroborated with Western blotting and flow cytometry , respectively . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| In addition , CD 7 that is required for galectin 1 induced death is not required for death triggered by galectin 3 . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| Galectin 1 mediated apoptosis in mycosis fungoides : the roles of CD 7 and cell surface glycosylation . ^^^ For T cells to be susceptible to galectin 1 induced apoptosis , the T cells must express specific glycoprotein receptors , such as CD 7 , that bear the specific oligosaccharides recognized by galectin 1 . ^^^ Because Sezary cells are characteristically CD 7 ( ) , lack of CD 7 expression has been proposed to render Sezary cells resistant to galectin 1 induced death . ^^^ To determine specific characteristics of Sezary cells that contribute to galectin 1 resistance , we assessed CD 7 expression and cell surface glycosylation of Sezary cells in mycosis fungoides lesions and of four Sezary T cell lines . ^^^ Expression of CD 7 was necessary but not sufficient for galectin 1 induced death of Sezary cell lines . ^^^ |
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| Interacting proteins: P09564 and P09382 |
Pubmed |
SVM Score :0.0 |
| In contrast to galectin 1 , the glycoproteins CD 3 and CD 7 are not ligands , while the shared affinity to beta 1 integrin ( or a closely associated glycoprotein ) accounts for a substantial extent of cell surface binding . ^^^ |
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