| Interacting proteins: P09488 and Q99683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09488 and Q99683 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09488 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Glutathione S transferases ( GSTs ; EC 2 . 5 . 1 . 18 ) , a family of phase 2 detoxification enzymes , catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents , and are involved in cell protection against apoptotic signals by inhibiting the stress signaling cascade mediated by ASK 1 ( Apoptosis signal regulating kinase ) JNK ( c Jun N terminal kinase ) . ^^^ |
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| Interacting proteins: P09488 and Q99683 |
Pubmed |
SVM Score :0.0 |
| Instead , heat shock caused the dissociation of glutathione S transferase Mu 1 1 ( GSTM 1 1 ) from Ask 1 and overexpression of GSTM 1 1 inhibited induction of p 38 by heat shock . ^^^ We concluded that because of an alternative regulation by the two distinct repressors thioredoxin and GSTM 1 1 , Ask 1 constitutes the converging point of the heat shock and oxidative stress sensing pathways that lead to p 38 activation . . ^^^ |
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