| Interacting proteins: O43566 and P09471 |
Pubmed |
SVM Score :0.0 |
| RGS 14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao . ^^^ |
|
| Interacting proteins: O43566 and P09471 |
Pubmed |
SVM Score :0.0 |
| RGS 14 exerts GDI activity on Galphai 1 , but not Galphao . ^^^ |
|
| Interacting proteins: O43566 and P09471 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43566 and P09471 |
Pubmed |
SVM Score :0.0 |
| In reconstitution studies , we found that RGS 14 is a non selective GAP for Galphai 1 and Galphao and that full length RGS 14 is an approximately 10 fold more potent stimulator of Galpha GTPase activity than the RGS domain alone . ^^^ RGS 14 is also a highly selective guanine nucleotide dissociation inhibitor ( GDI ) for Galphai but not Galphao , and this activity is restricted to the C terminus containing the GoLoco domain . ^^^ |
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