| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The concomitant overexpression of gelatinase A , gelatinase B , and occasional matrilysin genes was associated with the malignancy of gliomas and accompanied by overexpression of the TIMP 1 gene . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In the control brain tissues , mRNA expression was high for TIMP 2 , low for gelatinase A and TIMP 1 , and undetectable for gelatinase B , interstitial collagenase , stromelysin and matrilysin . ^^^ These results suggest that the concomitant increased expression of gelatinase A , gelatinase B and occasional matrilysin genes is associated with the malignancy of gliomas and accompanied by the increased expression of TIMP 1 gene . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Antibodies were raised against seven major matrix metalloproteinases : stromelysin 1 ( MMP 3 ) , stromelysin 2 ( MMP 10 ) , stromelysin 3 ( MMP 11 ) , interstitial collagenase ( MMP 1 ) , M ( r ) 72 , 000 type 4 collagenase ( 72 kDa type 4 collagenase , MMP 2 ) , M ( r ) 92 , 000 type 4 collagenase ( 92 kDa type 4 collagenase , MMP 9 ) and matrilysin ( PUMP , MMP 7 ) as well as against prolyl 4 hydroxylase , to study the expression of these collagenolytic enzymes in normal liver in relation to the activity of collagen synthesis . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| No expression of the 92 kDa gelatinase mRNA or matrilysin protein was found in the vicinity of neutrophilic accumulations or the damaged basement membrane . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The monocyte derived macrophages synthesized elastinolytic matrix metalloproteinases ( i . e . , gelatinase B and matrilysin ) as well as cysteine proteinases ( i . e . , cathepsins B , L , and S ) , but only the cathepsins were detected in the extracellular milieu as fully processed , mature enzymes by either vital fluorescence or active site labeling . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemistry and northern analysis we observed three metalloproteinases in prostate carcinoma matrilysin , gelatinase A , and gelatinase B . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have studied the capacity of various matrix metalloproteinases ( interstitial collagenase , stromelysin , matrilysin , and 92 kDa gelatinase ) to degrade the COL 1 domain of collagen 14 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1 antitrypsin . alpha 1 antitrypsin , the primary physiologic inhibitor of human leukocyte elastase , is proteolytically inactivated by several matrix metalloproteinases including interstitial collagenase , stromelysin and 92 kDa gelatinase . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Coculture of the human squamous cell carcinoma cell line II 4 with primary human foreskin fibroblasts was observed to induce mRNA expression of urokinase type plasminogen activator ( uPa ) , matrilysin , 92 kDa type 4 collagenase , and c ets , a transcriptional activator of several genes within the serine and matrix metalloprotease families . uPA and c ets induction were localized to the fibroblast cell population . uPa induction was found to be dependent upon cell cell contact with the tumor cell population , whereas c ets induction was due to a combination of cell cell contact and a tumor cell derived soluble factor . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| This repeat sequence is also sensitive to the tissue metalloproteinases , gelatinase B and matrilysin , but , unlike the bacterial collagenase , the mammalian enzymes also cause extensive degradation of the carbohydrate binding carboxyl domain . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Gelatin zymography and sandwich enzyme immunoassays demonstrated marked production of MMP 9 [ 92 kDa gelatinase / type 4 collagenase ( gelatinase B ) ] but not MMP 2 [ 72 kDa gelatinase / type 4 collagenase ( gelatinase A ) ] , MMP 3 ( stromelysin 1 ) or MMP 7 ( matrilysin ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| This specificity of the collagenases for aggrecan G 1 G2 was identical with that of the truncated metalloproteinase matrilysin ( MMP 7 ) , but different from those of stromelysin ( MMP 3 ) and the gelatinases ( MMP 2 or gelatinase A ; MMP 9 or gelatinase B ) which cleave at the Asn Phe site , but not the Asp Leu site . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression and regulation of MMP 1 ( interstitial collagenase ) , MMP 2 ( gelatinase A ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin ) , MMP 9 ( gelatinase B ) and their inhibitors TIMP 1 and TIMP 2 in human umbilical vein , femoral vein and microvascular endothelial cells , and compared these data with those obtained with human synovial fibroblasts . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have studied the capacity of three matrix metalloproteinases ( interstitial collagenase , 92 kDa gelatinase , and matrilysin ) to degrade entactin . ^^^ While all three metalloenzymes cleaved entactin , matrilysin was approximately 100 fold as effective as collagenase and 600 fold as effective as 92 kDa gelatinase . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The coding sequences for five of the human MMPs , viz . interstitial collagenase , 72 kDa gelatinase , stromelysin 1 , matrilysin and 92 kDa gelatinase , were cloned and expressed in Chinese hamster ovary cells , and the proteins purified . ^^^ The most active on this substrate was 72 kDa gelatinase , followed by stromelysin 1 ; interstitial collagenase , matrilysin and 92 kDa gelatinase were of comparable but lesser activity . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The data show that gelatinase A , matrilysin and gelatinase B do interact with alpha 2HS glycoprotein and that gelatinase B associates most tightly with the serum glycoprotein . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In this investigation , we used in situ hybridization and immunohistochemistry to identify the sites and cell source of collagenase 1 ( MMP 1 ) , stromelysin 1 ( MMP 3 ) , matrilysin ( MMP 7 ) , and 92 kDa gelatinase ( MMP 9 ) , a subgroup of MMPs with the combined ability to degrade essentially all matrix proteins . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have evaluated and compared the activity of stromelysin 1 ( MMP 3 ) , matrilysin ( MMP 7 ) , 72 kDa gelatinase A ( MMP 2 ) and 92 kDa gelatinase B ( MMP 9 ) by zymogram analysis and fluorescent substrate degradation assays . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In this study , we describe the activity of CT 1746 , an orally active synthetic MMP inhibitor that has a greater specificity for gelatinase A , gelatinase B and stromelysin than for interstitial collagenase and matrilysin , in a nude mouse model that better mimics the clinical development of human colon cancer . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The overall organization of the collagenase 3 gene is similar to that of other MMP genes clustered at chromosome 11q22 , including fibroblast collagenase ( MMP 1 ) , matrilysin ( MMP 7 ) , and macrophage metalloelastase ( MMP 12 ) , but is more distantly related to genes coding for stromelysin 3 ( MMP 11 ) , gelatinase A ( MMP 2 ) , and gelatinase B ( MMP 9 ) , which map outside of this gene cluster . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have examined the susceptibility of DCN to five different matrix metalloproteinases ( MMPs ) : MMP 1 ( tissue collagenase ) , MMP 2 ( gelatinase A ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin ) and MMP 9 ( gelatinase B ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In the present report , the comparative distribution of five members ( gelatinase A , gelatinase B , matrilysin , stromelysin 1 , and stromelysin 3 ) of the matrix metalloproteinase family and of one inhibitor ( TIMP 1 ) has been morphologically analyzed in human liver and skin with the aid of new monospecific antibodies . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Angiostatin converting enzyme activities of human matrilysin ( MMP 7 ) and gelatinase B / type 4 collagenase ( MMP 9 ) . ^^^ Here we demonstrate that two members of the human matrix metalloproteinase ( MMP ) family , matrilysin ( MMP 7 ) and gelatinase B / type 4 collagenase ( MMP 9 ) , hydrolyze human plasminogen to generate angiostatin fragments . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| MS or cerebral infarct tissue was examined for the presence of gelatinase A , gelatinase B , matrilysin and stromelysin 1 . ^^^ Gelatinase B was strongly expressed by neutrophils in tissue from patients up to 1 week after an infarct , whereas gelatinase A and matrilysin staining was much less marked . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Some or all of these mechanisms might involve proteinases , and here we have studied the cellular localisation and distribution of two matrix metalloproteinases ( MMPs ) , MMP 7 ( matrilysin ) and MMP 9 ( 92 kDa gelatinase ) , in the normal human CNS and active demyelinating MS lesions . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Our findings indicate that 92 kDa gelatinase and matrilysin are selectively upregulated during AT EAE and thus may contribute to the pathogenesis of inflammatory diseases of the CNS . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrilysin , gelatinase A and gelatinase B are matrix metalloproteinases ( MMPs ) implicated in normal and pathological processes that require remodelling of the extracellular matrix . ^^^ TIMP free gelatinase B was also activated by matrilysin . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| A new paradigm is emerging that matrilysin ( MMP 7 ) , MMP 9 , and metalloelastase ( MMP 12 ) may block angiogenesis by converting plasminogen to angiostatin , which is one of the most potent angiogenesis antagonists . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We therefore investigated the expression of the matrix metalloproteinases ( MMPs ) stromelysin 1 ( MMP 3 ) , 72 kDa collagenase ( MMP 2 ) , 92 kDa collagenase ( MMP 9 ) , matrilysin ( MMP 7 ) and the human macrophage metalloelastase ( MMP 12 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : Messenger RNA expression of gelatinase A , gelatinase B , matrilysin and tissue inhibitor of metalloproteinases ( TIMP ) 1 and TIMP 2 were analyzed in 30 patients with hepatocellular carcinoma by semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ RESULTS : Enhanced mRNA expression of gelatinase A , gelatinase B and matrilysin in tumor was observed in 20 , 22 and 19 of 30 patients , respectively . ^^^ Enhanced mRNA expression of gelatinase A or gelatinase B and of matrilysin showed trends toward presence of capsular invasion ( P = 0 . 078 ) and intrahepatic metastasis ( P = 0 . 064 ) , respectively . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Spatiotemporal protein and mRNA expression of gelatinase B ( MMP 9 ) and matrilysin ( MMP 7 ) have been documented respectively in MS lesions and in the central nervous system ( CNS ) of animals developing experimental autoimmune encephalomyelitis ( EAE ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Levels of mRNAs for interstitial collagenase , gelatinase A , matrilysin , TIMP 1 and TIMP 2 increased ( p < 0 . 05 ) within 12 h of hCG , while gelatinase B mRNA increased later , by 36 h after hCG . ^^^ Administration of a 3beta hydroxysteroid dehydrogenase inhibitor ( Trilostane [ TRL ] ) during hCG treatment decreased ( p < 0 . 05 ) mRNA levels for interstitial collagenase , gelatinase B , matrilysin , TIMP 1 , and TIMP 2 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| This unusual constitutive expression pattern of MMPs and uPA by KS cells in vitro is characterized by elevated levels of gelatinase A , gelatinase B , interstitial collagenase , stromelysin and a high molecular weight form of uPA , and the lack of expression of matrilysin . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| A total of 56 samples ( 8 adjoining regions of 6 glioblastoma tumors ) were immunohistochemically examined for the expression and regional distribution of gelatinase A ( MMP 2 ) , gelatinase B ( MMP 9 ) , matrilysin ( MMP 7 ) and stromelysin 1 ( MMP 3 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| All three ligands up regulated multiple MMPs including collagenases , stromelysins , matrilysin and gelatinase B ( MMP 9 ) but had minimal or no effects on gelatinase A ( MMP 2 ) , MT 1 MMP and tissue inhibitors of MMPs ( TIMPs ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to characterize the temporal changes in mRNA profiles for rat collagenase [ matrix metalloproteinase 1 ( MMP 1 ) ] , gelatinase A ( MMP 2 ) , matrilysin ( MMP 7 ) , gelatinase B ( MMP 9 ) , and membrane type 1 MMP ( MT 1 MMP ) , as well as tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) , TIMP 2 , and TIMP 3 during the inflammatory , granulation , and early remodeling phases of excisional skin repair . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| A thiol inhibitor MAG 283 had IC ( 50 ) values of 480 , 3 , 280 , 14 , 1 . 1 , and 2 . 3 nM against human interstitial collagenase ( MMP 1 ) , gelatinase A ( MMP 2 ) , stromelysin ( MMP 3 ) , matrilysin ( MMP 7 ) , neutrophil collagenase ( MMP 8 ) , and gelatinase B ( MMP 9 ) , respectively . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The effect of MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin ) , MMP 9 ( gelatinase B ) or MMP 12 ( metalloelastase ) on cellular fibrinolytic activity was studied with the use of smooth muscle cells ( SMC ) and fibroblasts derived from mice with specific inactivation of these genes . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The expression of MMP 2 , matrilysin ( MMP 7 ) , MMP 9 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The nine expressed proteases were MMPs 1 3 , 7 , 9 , 11 , 14 , and 17 ( collagenase 1 , gelatinase A , stromelysin 1 , matrilysin , gelatinase B , stromelysin 3 , and membrane types 1 and 4 , respectively ) , and MMP 18 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Differential expression of c jun and c fos mRNAs in squamous cell carcinoma of the head and neck : associations with uPA , gelatinase B , and matrilysin mRNAs . ^^^ The invasiveness of these tumors requires proteases , some of which as urokinase type plasminogen activator ( uPA ) , gelatinase B and matrilysin are regulated through AP 1 dependent transcriptional mechanisms . ^^^ The aim of this study was to : first , evaluate the expression levels of matrix metalloproteases ( matrilysin and gelatinase B ) and uPA mRNAs ; second , examine whether these genes might be associated with c jun and c fos expression ; third , examine the relationship between the expression of these genes and HNSCC clinico pathological features . ^^^ METHODS : We have analyzed 38 HNSCC primary tumors and matched mucosa tissues for uPA , gelatinase B , matrilysin , c fos , and c jun by Northern blot analysis . ^^^ RESULTS : uPA , gelatinase B , matrilysin , and c jun mean levels were statistically higher in the tumors than in the normal adjacent mucosa , whereas no difference was found when c fos mRNA values were compared , c jun mRNA expression correlated directly with gelatinase B and matrilysin mRNA levels , but no association with uPA mRNA was observed , c fos mRNA levels were not associated with the tested proteases , but low levels were determined in tumors from older patients who subsequently developed a 2 ( nd ) tumor . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We identified and quantified proteases in the culture media of explants : MMP 1 ( collagenase 1 ) , MMP 2 and MMP 9 ( gelatinases A and B ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin 1 ) , and tissue inhibitors of metalloproteinases , TIMP 1 and TIMP 2 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The S 1 ' specificity site in MMP 9 is perhaps best described as a tunnel leading toward solvent , as in MMP 2 and MMP 13 , as opposed to the smaller pocket found in fibroblast collagenase and matrilysin . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Additionally , the MMP substrate Dnp PChaGC ( Me ) HK ( NMA ) NH ( 2 ) was not cleaved at all by TACE , while collagenase ( MMP 1 ) , gelatinase ( MMP 9 ) , stromelysin 1 ( MMP 3 ) , and matrilysin ( MMP 7 ) all processed this substrate efficiently . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Specificity was shown by absence of cleavage by matrilysin ( MMP 7 ) and the leukocytic MMPs neutrophil collagenase ( MMP 8 ) and gelatinase B ( MMP 9 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Two MMPs capable of generating angiostatin in vivo , matrilysin ( MMP 7 ) and gelatinase B ( MMP 9 ) , were also examined in these tumours . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The decapeptide had poor inhibitory activity toward gelatinase B , matrilysin , and stromelysin ( IC ( 50 ) > 10 microm ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrilysin deficient human macrophages fail to mediate an elastolytic response despite the continued expression of gelatinase B and metalloelastase . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Studies on MMPs and their tissue inhibitors in malignancies of the female genital tract have shown the following : 1 ) In ovarian carcinoma and cervical carcinoma , over expression of MMP 2 and MMP 9 is associated with invasiveness , metastatic spread and poor prognosis ; 2 ) In endometrial carcinoma , MMP 7 ( matrilysin ) is the main MMP associated with invasiveness , metastatic spread and poor prognosis ; 3 ) In cervical intra epithelial neoplasia ( CIN ) , measuring MMP 2 can assist in identifying high risk for progression CIN 1 and CIN 2 ; 4 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase 7 and matrix metalloproteinase 9 are associated with unfavourable prognosis in superficial oesophageal cancer . ^^^ Matrix metalloproteinase 7 ( MMP 7 ) and matrix metalloproteinase 9 ( MMP 9 ) have been reported to have close associations with tumour invasion and metastasis . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The action of three matrix metalloproteinases ( MMPs ) , 72 and 95 kDa gelatinases ( MMP 2 and MMP 9 ) and PUMP ( MMP 7 ) , and a cysteine proteinase , cathepsin B , were investigated on aggrecan the major proteoglycan of cartilage . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The matrix metalloproteinases ( MMPs ) gene family includes MMP 1 ( interstitial collagenase ) , MMP 2 ( 72 kD type 4 collagenase / gelatinase ) , MMP 3 ( stromelysin / transin ) , MMP 7 ( putative MMP ; pump 1 ) , MMP 8 ( granulocyte collagenase ) and MMP 9 ( 92 kD type 4 collagenase / gelatinase ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RT PCR permitted us to confirm the observation that MMP 9 is activated following transformation and also to observe the previously unreported activation of MMP 7 in SV 40 transformed cells . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The response of the assay to equal molar quantities of active MMPs decreases in the order MMP 2 > MMP 9 > MMP 1 > MMP 3 > MMP 7 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Enzymatic kinetic studies revealed IC 50 values ( concentration at 50 % inhibition ) of 19 , 3 , 45 , 8 , and 83 nM for MMP 1 , MMP 2 , MMP 3 , MMP 7 , and MMP 9 , respectively . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Antibodies used in this study were monoclonal antibodies to MMP 1 , MMP 2 , MMP 7 , MMP 8 , MMP 9 , TIMP 1 , TIMP 2 and polyclonal antibody to MMP 3 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinases MMP 9 and MMP 7 are expressed in experimental autoimmune neuritis and the Guillain Barr syndrome . ^^^ By using immunohistochemistry , positive immunoreactivity against MMP 9 and MMP 7 was noted and corroborated by demonstrating augmented mRNA expression in comparison with noninflammatory neuropathies . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Oligonucleotide primers for thirteen MMPs ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 10 , MMP 11 , MMP 12 , MMP 13 , MMP 14 , MMP 15 , MMP 16 ) were optimized for use in RT PCR . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| To determine whether the upregulated MMPs could invoke destructive events in the CNS , highly purified activated MMP 7 , MMP 8 , and MMP 9 were stereotaxically injected into the brain parenchyma . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We analyzed the expression of all known MMPs with established elastolytic activity and TIMPs in human AAA and control tissue . mRNA coding for MMP 9 , MMP 2 , human macrophage metalloelastase , MMP 7 , TIMP 1 , and TIMP 2 were amplified by reverse transcriptase PCR in control and AAA tissue . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the expression of several matrix metalloproteinases ( MMPs ) and tissue inhibitors of matrix metalloproteinases ( TIMPs ) , including MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MT 1 MMP , TIMP 1 and TIMP 2 , in these tumors . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Our results demonstrate the temporal activity of MMP 2 , MMP 3 , MMP 7 , and MMP 9 during the course of normal dermal repair . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expressions of MMP 3 and / or trypsin in the fluids were frequently associated with activation of MMP 7 and MMP 9 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of MMP 2 , MMP 3 , MMP 7 , and MMP 9 in T cells , macrophages , and stromal cells in CIDP , NSVN , and noninflammatory neuropathies ( NIN ) was quantitated by immunohistochemistry . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Sandwich enzyme immunoassays showed enhanced production of MMP 7 , MMP 8 and MMP 9 as well as TIMP 1 in the carcinoma tissues compared with non carcinoma endometrial tissues . ^^^ MMP 7 was immunolocalized predominantly to the carcinoma cells in 73 % of the cases , while MMP 8 and MMP 9 were immunostained in the inflammatory cells infiltrated in the carcinoma tissues . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinases MMP 2 , MMP 7 and MMP 9 in denervated human muscle . ^^^ In normal muscle MMP 2 , MMP 7 , and MMP 9 IR was localized at neuromuscular junctions , in vessels and nerve branches . ^^^ ALS affected biopsies revealed MMP 9 IR , and to lesser extent MMP 2 and MMP 7 IR at normal sized and atrophied myofibers . ^^^ Biopsies of SMA showed MMP 9 and MMP 7 IR at normal sized and atrophic myofibers , while MMP 2 IR was undetectable . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We know that human MMP 12 is associated with these diseases , but as opposed to the mouse , other MMPs may also be of importance ( MMP 9 , and perhaps MMP 7 , in particular ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : We examined the expression of MMPs with single and double immunocytochemistry using antibodies against MMP 2 , MMP 3 , MMP 7 , MMP 9 , major histocompatibility complex ( MHC ) class 1 , CD8+ cells , macrophage , and beta amyloid precursor protein ( beta APP ) on serial muscle biopsy sections from patients with s IBM , polymyositis ( PM ) , dermatomyositis ( DM ) , and disease control specimens . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The present study was performed to evaluate the role of matrix metalloproteinases ( MMP ) in the pathogenesis of the inflammatory reaction and the development of neuronal injury in a rat model of bacterial meningitis . mRNA encoding specific MMPs ( MMP 3 , MMP 7 , MMP 8 , and MMP 9 ) and the inflammatory cytokine tumor necrosis factor alpha ( TNF alpha ) were significantly ( P < 0 . 04 ) upregulated , compared to the beta actin housekeeping gene , in cortical homogenates at 20 h after infection . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| We have observed that in integrin alpha 1 null mice synthesis of MMP 7 and MMP 9 was markedly increased compared with that of their wild type counterparts . ^^^ As MMP 7 and MMP 9 have been shown to generate angiostatin from circulating plasminogen , and angiostatin acts as a potent inhibitor of endothelial cell proliferation , we determined whether tumor vascularization was altered in the alpha 1 null mice . ^^^ Tumors implanted into alpha 1 null mice showed markedly decreased vascularization , with a reduction in capillary number and size , which was accompanied by an increase in plasma levels of angiostatin due to the action of MMP 7 and MMP 9 on circulating plasminogen . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed the presence of MMP 7 and MMP 9 in menstrual serum . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expression levels of matrix metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , MT 1 MMP ) and tissue inhibitors of MMP ( TIMP 1 , TIMP 2 ) were evaluated by semiquantitative RT PCR , substrate zymography and western blot . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : Levels of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 13 , TIMP 1 , and TIMP 2 in SF aspirated from knee joints of 97 patients with RA and 103 patients with OA were measured by the corresponding one step sandwich enzyme immunoassays . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| However , rates of cleavage were most rapid for MMP 7 and MMP 9 . ^^^ MMP 7 and MMP 9 cleaved TFPI at Lys ( 20 ) Leu ( 21 ) with additional COOH terminal processing . ^^^ Proteolytic cleavage by MMP 1 , MMP 7 , MMP 9 , and MMP 12 resulted in considerable loss of TFPI activity . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expressions of trypsin , MMP 7 , and MMP 9 were generally higher in carcinoma and borderline fluids than in adenoma fluids . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP 1 , MMP 9 , MMP 10 , MMP 12 , and MMP 13 ; moderate expression of MMP 2 , MMP 7 , MMP 8 , MMP 11 , membrane type ( MT ) 1 MMP ( MMP 14 ) , MT 2 MMP ( MMP 15 ) , MT 3 MMP ( MMP 16 ) , MT 4 MMP ( MMP 17 ) , and MMP 19 ; lower expression of MMP 3 ; and little significance of MMP 20 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis from cDNA of rat A NK cells revealed mRNA for MMP 2 , MMP 9 , MMP 7 , MMP 10 , MMP 11 , MMP 13 , MT 1 MMP , MT 2 MMP , TIMP 1 , and TIMP 2 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Cultured astrocytes constitutively expressed MMP 2 , MT 1 MMP , TIMP 1 , and TIMP 2 , whereas MMP 3 , MMP 7 , MMP 9 , and MMP 12 were not detectable in tissues or in cultured astrocytes . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expression of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , MMP 14 , TIMP 1 , and TIMP 2 was simultaneously analyzed in tissue homogenates using semiquantitative reverse transcription polymerase chain reaction assay . ^^^ RESULTS : Significantly higher MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , and TIMP 1 levels were found in tumors vs specimens of matched normal mucosa . ^^^ Enhanced expression of MMP 9 was strongly correlated ( P < . 001 ) and levels of MMP 2 , MMP 7 , and MMP 11 were weakly correlated ( P = . 03 . 05 ) with lymph node involvement . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Individual chondrosarcomas also exhibited elevated levels of MMP 1 , MMP 7 and MMP 9 mRNAs . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These observations indicate that matriolytic enzymes such as MMP 2 , MMP 7 and MMP 9 are secreted into cyst fluid from serous adenocarcinoma tissues . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Seven metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , and MMP 13 ) were tested against two substrates : gelatin and alpha casein . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction assessment demonstrated elevated levels of MT 1 MMP and MMP 7 mRNA levels in both groups of patients , and no significant differences in MMP 9 levels , compared with healthy controls . ^^^ Interferon beta treatment was associated with significant suppression of MMP 9 and MMP 7 mRNA in relapsing remitting patients , though no significant changes were observed in the secondary progressive group . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In RT PCR studies , SUIT 2 , S 2 CP8 and S 2 VP10 cell lines constitutively expressed many matrix metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 and MMP 14 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In vitro , BMS 275291 is a potent inhibitor ( nM ) of the activities of MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 . ^^^ Pharmacokinetic studies demonstrated that the plasma concentrations of parent BMS 275291 in mice exceeds the in vitro IC ( 50 ) values for MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 for at least 4 h after the administration of a therapeutic dose of BMS 275291 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| EGFR and c erbB 2 levels were strongly correlated ( P=0 . 0004 0 . 029 ) with the expression of MMP 2 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , VEGF A and VEGF C whereas the levels of c erbB 3 and B 4 showed a weaker correlation ( P=0 . 049 0 . 01 ) with some MMPs and VEGF C . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| HIV infection enhanced MMP 1 ( 46 fold ) and MMP 2 ( 48 fold ) and active MMP 7 ( 33 fold ) and MMP 9 ( 50 fold ) by PBMCs . ^^^ The combination of NE , HIV infection , and coculture increased MMP 1 ( 126 fold ) and MMP 2 ( 467 fold ) , and active MMP 7 ( 65 fold ) and MMP 9 ( 75 fold ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| MATERIAL AND METHODS : We studied the expression of MMP 2 , MMP 7 , and MMP 9 in 19 cases of inflammatory myopathies and controls using immunocytochemistry . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| A series of reverse transcription polymerase chain reactions ( RT PCR ) were performed using MMP ( MMP 2 , MMP 7 , MMP 9 ) primers and TIMP ( TIMP 1 , TIMP 2 ) primers . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In this study , structures of 10 enzymes ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 12 , MMP 13 , MMP 14 , and MMP 20 ) were examined with the intention of highlighting regions that could be potential sites for obtaining selectivity . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Within 3 days after axotomy in the peripheral nervous system , MMP 9 , MMP 7 and MMP 12 are elevated . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical and confocal microscopic studies were conducted to evaluate the reactivity of lung tissue from six patients with pulmonary hypertension for alpha smooth muscle actin ( alpha SMA ) , desmin , vimentin , factor 8 , endothelin 1 , various types of MMPs ( MMP 1 , MMP 2 , MMP 3 , MMP 7 and MMP 9 ) , membrane type MMPs ( MT MMPs ) , tissue inhibitors of MMPs ( TIMPs ) , and type 4 collagen . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RESULTS : MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 13 , MT 1 MMP and TIMP 2 mRNA was detected in the tibial articular chondrocytes of STR / ort mice at all ages ( 12 , 18 , 24 , 30 and 35 weeks ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Comparison of gelatinase activity , MMP expression , and MMP activity in children without pulmonary disease with children who required mechanical ventilation for respiratory failure show : 1 ) gelatinase activity was approximately five to sixfold higher in respiratory failure ; 2 ) MMP 7 , MMP 8 , and MMP 9 concentrations and MMP 8 and MMP 9 activities were markedly elevated in respiratory failure ; and 3 ) MMP 7 , MMP 8 , and MMP 9 levels were significantly correlated in children with lung disease . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies ( peroxidase and dual labeling for confocal microscopy ) of reactivity for MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , and the 4 membrane type MMPs were made on tissues from patients with cardiac ( n = 4 ) and pulmonary ( n = 5 ) sarcoidosis . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The activated MMP 9 products generated by MMP 26 appeared more stable than those cleaved by MMP 7 under the conditions tested . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The purpose of this study was to quantify the amount of matrix metalloproteinases such as MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , and MMP 13 and tissue inhibitors of metalloproteinases TIMP 1 and TIMP 2 expressed by human gingival explants in culture media and the area fraction ( AA % ) of gingival collagen fibers according to the degree of inflammation , to investigate a possible correlation between these enzymes and collagen loss . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Each gene studied [ MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 12 , MMP 13 , membrane type 1 ( MT 1 ) MMP , TIMP 1 , TIMP 2 , GAPDH , cyclophilin and beta actin ] increased in late pregnancy ( day 21 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RNA was isolated from the remaining wounds and skin , and a reduced cycle , primer specific , reverse transcriptase polymerase chain reaction was performed to semiquantitatively determine relative gene expression of MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 and of TIMP 1 , TIMP 2 , and TIMP 3 . ^^^ Levels of MMP 7 and MMP 9 were unchanged in developing skin . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : To test the hypothesis that increased matrix metalloproteinase ( MMP ) and tissue inhibitor of metalloproteinase ( TIMP ) contribute to the pathomechanisms of hypertensive nephropathy , the cortex and medulla of male SHR at 2 and 6 weeks were analyzed for MMP 2 , MMP 7 , and MMP 9 by gelatin and elastin gel zymography . ^^^ In the medulla , MMP 9 and MMP 7 were increased , but there was no change in MMP 2 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In conclusion , it was found that three main networks of MMPs are predominantly involved in the case of HCC , that is , MMP 2 and MT 1 MMP in the carcinogenesis and progression , MMP 7 and MMP 9 in the capsular infiltration and portal vein invasion , as well as MMP 3 and MMP 7 in the progression of HCC . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| For example , it has recently been shown that MMP 3 , MMP 7 , MMP 9 and MMP 12 can generate angiostatin from plasminogen , indicating that their expression in peritumoral area may in fact serve to limit angiogenesis and thereby inhibit tumor growth and invasion . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expression of MMP 2 , MMP 7 , MMP 9 , MMP 10 and MMP 11 in human astrocytic and oligodendroglial gliomas . ^^^ To determine the pattern of MMP expression in astrocytic and oligodendroglial tumors , sections of astrocytic and oligodendroglial differentiated glioblastomas ( WHO grade 4 ) , as well as of anaplastic oligodendrogliomas ( WHO grade 3 ) and anaplastic gemistocytic astrocytomas ( WHO grade 3 ) were immunostained for MMP 2 , MMP 7 , MMP 9 , MMP 10 and MMP 11 . ^^^ These data indicated that MMP 7 , MMP 10 and MMP 11 contribute to the worse prognosis of astrocytic tumors when compared to oligodendrogliomas , while MMP 2 and MMP 9 might play an important role in neo angiogenesis and tumor vascularization . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinases MMP 7 , MMP 9 and their tissue inhibitor TIMP 1 : expression in chronic sinusitis vs nasal polyposis . ^^^ OBJECTIVE : The aim of this study was to investigate MMP 7 , MMP 9 and TIMP 1 proteins in NP and CS in comparison with normal mucosa . ^^^ RESULTS : In NP , compared with controls , staining for MMP 9 and MMP 7 appeared in blood vessels . ^^^ Concentrations of MMP 9 protein was found significantly increased in both CS and NP compared with controls , while MMP 7 was significantly increased in NP compared with controls and CS . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Differential expression of matrilysin 1 ( MMP 7 ) , 92 kD gelatinase ( MMP 9 ) , and metalloelastase ( MMP 12 ) in oral verrucous and squamous cell cancer . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The potencies of these compounds were evaluated against a set of seven MMPs ( MMP 2 , MMP 7 , MMP 8 , MMP 9 , MMP 11 , MMP 13 , and MMP 14 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| To evaluate the clinical applicability of the marker set , the expression of nine genes ( 6Ckine , IL 8 , MMP 9 , MMP 3 , MMP 7 , urokinase R , CXCR 5 , integrin beta 4 , and pleiotrophin ) was tested in tubulointerstitial samples from routine renal biopsies . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Finally , no difference of metalloprotease ( MMP 2 , MMP 3 , MMP 7 , MMP 9 ) activity was observed between cells plated on FN and on FN plus TN , except for B MM which showed an increased MMP 7 activity when TN was added to FN . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : MMP 9 , MMP 2 , MMP 7 , TIMP 2 , TIMP 3 are over expressed in ovarian malignant tissues . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunohistochemical expression of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , TIMP 1 , and TIMP 2 was investigated in 33 human RMSs , 12 alveolar , and 21 embryonal histologic subtypes ( 12 high risk and 9 low / standard risk ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : Thirty two patients with supraglottic SCC underwent supraglottic horizontal partial laryngectomy and neck dissection , and the samples of primary cancer and the corresponding adjacent non neoplastic tissues were evaluated for both mRNA and protein expression of MMP 1 , MMP 2 , MMP 7 , MMP 8 , MMP 9 , and MMP 10 using reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry . ^^^ RESULTS : Among the six kinds of MMPs , both mRNA and protein expression of MMP 2 , MMP 7 , and MMP 9 were found up regulated in more than 63 % of the tumor tissues as compared with the adjacent non neoplastic tissues , and this was significantly correlated with lymph node metastasis ( all P < . 05 ) . ^^^ Using RT PCR and immunohistochemical data of MMP 2 , MMP 7 , and MMP 9 , two mathematic models were tested , and their diagnostic efficiencies for lymph node metastasis were 84 % and 88 % , respectively . ^^^ CONCLUSION : Expressions of MMP 2 , MMP 7 , and MMP 9 are up regulated in supraglottic carcinoma tissues , suggesting that MMPs may be useful in the detection of occult lymph node metastasis but that more research is needed . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Genetic suppression studies using matrix metalloproteinase ( MMP ) deficient mice showed that MMP 9 , MMP 3 , and MMP 7 but not MMP 2 or MMP 12 are needed for resistance . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : In this study all of the major members of the matrix metalloproteinase ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 13 , MT 1 MMP and MT 2 MMP ) / tissue inhibitor of matrix metalloproteinase ( TIMP 1 , TIMP 2 , and TIMP 3 ) system have been investigated by immunohistochemistry in a series ( n = 90 ) of stage 3 ( Dukes ' C ) colorectal cancers . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| CCL 25 differentially modulated the expression of collagenase 1 or matrix metalloproteinase ( MMP ) 1 , collagenase 3 ( MMP 13 ) , stromalysin 2 ( MMP 10 ) , stromalysin 3 ( MMP 11 ) , and gelatinase A ( MMP 2 ) , but not MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 12 , or MMP 14 in prostate cancer cells . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RT PCR confirmed an increased levels of MMP 2 , MMP 9 , MMP 7 , MMP 14 , MMP 16 , and TIMP 1 , TIMP 2 in the spleen of HTS group compared to sham groups , whereas in lungs transcriptional levels of only TIMP 3 and TIMP 1 were significantly changed . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Delta beta catenin expression markedly increased expression of MMP 2 , MMP 3 , MMP 7 , MMP 9 , MT 3 MMP , and ADAMTS 5 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined necropsy samples of renal cortex from normal and XLAS dogs for MMP 3 and MMP 7 as they have the potential to activate MMP 2 and MMP 9 . ^^^ The induction of these MMPs likely contributes to tissue destruction associated with the fibrogenic process , while augmenting the activation of MMP 2 and MMP 9 by MMP 3 and MMP 7 in XLAS . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Full thickness eyelid biopsy specimens from study and control patients were examined by light and transmission electron microscopy , semiquantitative morphometry , and immunohistochemistry using antibodies against matrix metalloproteinase ( MMP ) 2 , MMP 7 , MMP 9 , and MMP 12 and neutrophil elastase . ^^^ Immunohistochemistry demonstrated an increased immunoreactivity for elastolytic proteases , particularly MMP 7 and MMP 9 , in areas of elastin depletion in FES specimens as compared with controls . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The role of matrix metalloproteinase ( MMP ) 2 , MMP 9 , MMP 3 , MMP 7 , and tissue inhibitor of matrix metalloproteinase ( TIMP ) 1 and TIMP 2 are investigated here . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| On the other hand , we conducted investigations on metalloproteinases ( MMP 2 , MMP 9 , MMP 7 ) and their specific tissue inhibitors TIMP 1 and TIMP 2 to verify their possible involvement in the etiopathogeny of SVAS and WBS . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : Samples from nine patients with SCCs that had arisen in chronic wounds and 31 with venous leg ulcers were studied using immunohistochemistry for MMP 7 , MMP 8 , MMP 9 , MMP 13 , MMP 19 and the tumour suppressor p 16 . ^^^ CONCLUSIONS : Our results suggest that epithelial expression of MMP 7 , MMP 12 and MMP 13 , but not that of MMP 1 , MMP 3 , MMP 8 , MMP 9 and MMP 10 , in chronic wounds provides a diagnostic clue for distinguishing SCCs from nonmalignant wounds . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Expression of MMPs ( MMP 2 , MMP 7 , MMP 9 , MT 1 MMP , MT 2 MMP , MT 3 MMP ) and tissue inhibitors of metalloproteinase ( TIMP : TIMP 1 , TIMP 2 ) was investigated on cultured hepatocellular carcinoma ( HCC ) cells and surgically resected HCC tissues . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive MMP 9 and MMP 7 colocalized with leukocyte subsets , particularly neutrophils , whereas MMP 13 staining was always extracellular . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS : We evaluated MMP 1 , MMP 7 , MMP 9 , and MMP 13 expression in tissues from 208 patients with ESCC using immunohistochemistry ( IHC ) , and correlated MMP expression to clinicopathologic characteristics and disease free survival time . ^^^ RESULTS : IHC analysis showed that 63 . 0 % , 41 . 8 % , 49 . 0 % , and 32 . 2 % of 208 ESCC samples were positive for MMP 1 , MMP 7 , MMP 9 , and MMP 13 , respectively . ^^^ Co expression of MMP 7 , MMP 9 , and MMP 13 in relatively early stage ESCC samples identified patients with a poor prognosis ( 13 months median survival time ) compared to those lacking MMP 7 , MMP 9 , and MMP 13 expression ( 58 months median survival time , p < 0 . 001 ) . ^^^ MMP 7 , MMP 9 , and MMP 13 may function in early stage ESCC , and their co expression predicts poor outcome for relatively early stage ESCC patients . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : The aim of our study was to investigate immunoexpression of matrix metalloproteinases MMP 2 , MMP 7 and MMP 9 in muscle specimens from patients with focal myositis ( FM ) vs polymyositis ( PM ) and dermatomyositis . ^^^ RESULTS : MMP 2 immunoreactivity was present in PM and dermatomyositis , MMP 7 only in PM , and MMP 9 in PM , dermatomyositis and FM . ^^^ CONCLUSIONS : Our results confirm that increased MMP 9 immunoreactivity in muscle fibres is a common feature of all inflammatory myopathies and suggest that MMP 2 and MMP 7 can not be implicated in the inflammatory events of FM . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The organ culture media were analyzed using Western blottings ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 13 , TIMP 1 , and TIMP 2 ) and gelatine zymography . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Functional polymorphisms in the MMP 1 , MMP 2 , MMP 7 , MMP 9 , MMP 12 , and MMP 13 genes have also been related to coronary artery disease , arterial stiffness , and / or abdominal aortic aneurysm . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The structure based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP 13 inhibitors with selectivity over MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 14 , Aggrecanase 1 , and TACE are described . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Animals were ventilated for 4 h , then euthanized for in vitro surfactant function analysis , lung histomorphometry , and analysis of MMP 2 , MMP 7 , and MMP 9 and TIMPs 1 and 2 in the lung . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Using the mouse brachiocephalic artery model of plaque instability , we compared apolipoprotein E ( apoE ) / MMP 3 , apoE / MMP 7 , apoE / MMP 9 , and apoE / MMP 12 double knockouts with their age , strain , and sex matched apoE single knockout controls . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinases ( MMP ) are expressed in several cell types of the mammary gland including stromal fibroblasts ( e . g . , MMP 3 , MMP 2 ) , epithelial cells ( e . g . , MMP 7 or MMP 9 ) , adipocytes ( e . g . , MMP 2 ) and lymphoid cells ( e . g . , MMP 9 ) ( Crawford et al . 1996 ; Lund et al . 1996 ; Wiseman et al . 2003 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Blood and bronchoalveolar gammadelta T lymphocytes were cultured in the absence and presence of isopentenyl pyrophosphate ( IPP ) or TGF beta1 / IL 15 for 24 h , and assessed for the expression and synthesis of MMP 1 , MMP 7 , and MMP 9 . ^^^ Resting human gammadelta T lymphocytes constitutively expressed MMP 9 mRNA , a marginal or no MMP 7 and MMP 1 mRNA . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : The study suggested that a possible association between the MMP 7 A / G polymorphism with susceptibility to epithelium ovarian cancer , but there is no support for an association of the selected MMP 1 1G / 2G , MMP 3 5A / 6A , and MMP 9 C / T polymorphisms with the risk for ovarian cancer . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RECK expression in the context of gastric cancer was also compared with various clinicopathologic parameters and compared to the expression of activated MMP 7 , MMP 2 , and MMP 9 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The 22 genes that were up regulated in the 21 F 2 samples relative to the 18 F 1 samples mainly encoded genes involved in cytoskeleton ( KRT 19 and SCG 10 ) , growth factors / cytokines ( CXCL 6 , interleukin 8 [ IL 8 ] , IL1A , IL 2 , and CXCL 10 ) , or growth factor receptors ( CCR 2 , CXCR 3 , and CXCR 4 ) , or were involved in extracellular matrix production ( COL1A1 , CHI3L , and SPP 1 ) , in extracellular matrix remodeling ( TIMP 1 , MMP 7 , and MMP 9 ) , and in cell junction ( ITGA 2 and CLDN 4 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| MMP 7 , MMP 8 , MMP 9 and tissue inhibitor of metalloproteinase ( TIMP ) 1 levels in the culture supernatants were assayed by ELISA . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The role of specific stromal derived matrix metalloproteinases ( MMPs ) was analyzed in experimental metastasis assays in wild type and either MMP 9 , MMP 7 , or MMP 2 null mice . ^^^ MMP 9 null mice showed an 81 % reduction in Lewis lung carcinoma tumor number , whereas MMP 7 null mice showed a 42 % increase in tumor number , and there was no difference in tumor number in MMP 2 null mice compared with wild type controls . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The present study was undertaken to analyze the expression and prognostic value of MMP 7 and MMP 9 in non small cell lung cancer ( NSCLC ) . ^^^ Tumour samples were stained immunohistochemically , and the expression of MMP 7 and MMP 9 was evaluated in both tumour cells and peritumoural stromal tissue . ^^^ A high staining of MMP 7 and MMP 9 in tumour cells was noted in 62 ( 30 % ) and 113 ( 57 % ) cases , respectively . ^^^ MMP 7 or MMP 9 signals were not related to patient ' s outcome . ^^^ The results show that high MMP 9 expression indicates aggressive , and high MMP 7 less aggressive tumour behaviour in NSCLC . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Six widely invasive follicular carcinomas ( WIFCs ) , 15 minimally invasive follicular carcinomas ( MIFCs ) , 19 follicular adenomas ( FAs ) and 10 adenomatous goitres ( AGs ) were analysed immunohistochemically for MMP 1 , MMP 2 , MMP 7 , MMP 9 , membrane type 1 MMP ( MT 1 MMP ) and tissue inhibitor of matrix metalloproteinase 2 ( TIMP 2 ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| To corroborate these observations , we now assessed MMP 2 and MMP 9 with new techniques in an expanded group of gastric cancer patients ( n = 81 ) and included for comparison MMP 7 , MMP 8 and the tissue inhibitors of MMPs , TIMP 1 and 2 . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Infection enhanced mRNA and surface expression of EMMPRIN and Membrane type 1 Matrix Metalloproteinase ( MT 1 MMP ) , plus the secretion of MMP 7 , MMP 9 and the urokinase receptor ( uPAR ) . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| No increases in RNA levels of MMP 2 , MMP 9 , or MMP 8 were found , but levels of MMP 7 , MMP 12 , and MMP 13 RNA did increase at 14 d . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| PATIENTS AND METHODS : We measured plasma levels of MMP 7 and MMP 9 using an enzyme linked immunoassay method in 140 evaluable patients with MBC enrolled on a multicenter clinical trial that compared the MMPI marimastat with placebo . ^^^ RESULTS : Baseline plasma MMP 7 and MMP 9 levels did not correlate with each other or with progression free or overall survival . ^^^ In addition , serial evaluation of plasma MMP 7 and MMP 9 levels revealed no significant changes over time in the marimastat or placebo groups or any correlation with trough plasma marimastat level . ^^^ CONCLUSION : We conclude that measurement of plasma MMP 7 or MMP 9 levels , as performed in our trial , was not a useful prognostic or predictive factor in patients with MBC or in patients treated with an MMPI . . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Using computerized image analysis , the differential expression of interstitial collagenase ( MMP 1 ) , gelatinase B ( MMP 9 ) , matrilysin 1 ( MMP 7 ) and the membrane type 1 MMP ( MT 1 MMP ) in the epithelium and stroma of human prostate neoplastic tissues were investigated . ^^^ In most prostatectomy specimens examined , detectable amounts of MMP 1 , MT 1 MMP , MMP 7 and MMP 9 proteins and MT 1 MMP and MMP 9 mRNA were found in the epithelial and stromal components of CaP , PIN and NAP . ^^^ In the epithelium of normal and preneoplastic prostate tissue , MMP 1 , MMP 9 and MT 1 MMP were preferentially expressed in secretory luminal cells ; conversely , MMP 7 was concentrated in basal cells . ^^^ Whereas MMP 1 was overexpressed in NAP epithelial glands and progressively decreased from PIN to CaP , MMP 7 , MMP 9 and MT 1 MMP were more strongly expressed in CaP than in PIN and NAP tissue . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Curcumin also inhibited MMP 2 levels and promoted MMP 9 levels , but did not affect MMP 7 levels , based on Western blotting assays . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| KK47 / TP cells , bladder cancer cells that overexpress TP , had a higher expression of MMP 7 and MMP 9 than KK / CV cells that express lower level of TP in hypoxic condition . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| MMP 2 , MMP 7 , and MMP 9 are co expressed together with trypsin and seem to be of particular importance in proliferation , progression , and invasion . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| MMP 9 and MMP 7 , as well as osteopontin , were up regulated in fibroblastic foci ( p = 0 . 01 , p = 0 . 08 , p = 0 . 08 ) , the adjacent epithelium ( p = 0 . 001 , p = 0 . 001 , p = 0 . 03 ) , and the hyperplastic type 2 pneumocytes ( p = 0 . 02 , p = 0 . 001 , p = 0 . 08 ) , respectively , compared with control alveoli . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| After purification by gel filtration HPLC and / or column switch HPLC system consisting of an affinity column , which was immobilized with a synthetic BS 10 peptide ( MQKPRCGVPD ) originating from propeptide domain of MMP 7 and a reversed phase column , the N terminal amino acid sequence of the 38 kDa metalloproteinase was identified as FNTFPGDLK which shared a high homology to Xenopus MMP 9 . ^^^ |
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| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| In this study , we determined the expression of EMMPRIN and its association with MMP 2 , MMP 7 , and MMP 9 in interstitial pneumonias ( IPs ) . ^^^ Matrix metalloproteinases were expressed in cells expressing EMMPRIN , although the profile of MMPs varied among the different abnormal epithelial cell types with MMP 2 and MMP 7 in hyperplastic type 2 cells and MMP 7 and MMP 9 in cells showing squamous metaplasia and cells comprising bronchiolization . ^^^ |
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| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to determine MMP 2 , MMP 7 , and MMP 9 and tissue inhibitors of metalloproteinases ( TIMP ) 1 and TIMP 2 expression in endometrial malignancies and their relation to clinical and histologic parameters . ^^^ |
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| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| The 92 kDa type 4 collagenase consists of five domains ; the amino terminal and zinc binding domains shared by all members of the secreted metalloprotease gene family , the collagen binding fibronectin like domain also present in the 72 kDa type 4 collagenase , a carboxyl terminal hemopexin like domain shared by all known enzymes of this family with the exception of PUMP 1 , and a unique 54 amino acid long proline rich domain homologous to the alpha 2 chain of type 5 collagen . . ^^^ |
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| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| Among the MMPs , 92 kDa gelatinase was expressed most consistently ( 35 cases ) , whereas mRNA transcripts of 72 kDa gelatinase , interstitial collagenase , and PUMP 1 were detected in only a few cases . ^^^ |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09237 and P14780 |
Pubmed |
SVM Score :0.0 |
| NA |
|