Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Rat matrilysin produces maximum activation of latent human interstitial collagenase 1 ( pro matrix metalloproteinase 1 ) when added in the presence of 4 aminophenylmercuric acetate ( APMA ) by cleaving the Gln 80 decreases Phe 81 bond . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In five human glioma cell lines , gelatinase A , TIMP 1 , and TIMP 2 genes were constitutively expressed in alll cell lines : the matrilysin gene in three cell lines ; the stromelysin gene in two cell lines ; and the interstitial collagenase gene in one cell line . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In the control brain tissues , mRNA expression was high for TIMP 2 , low for gelatinase A and TIMP 1 , and undetectable for gelatinase B , interstitial collagenase , stromelysin and matrilysin . ^^^ Matrilysin was induced variably in more than half of the primary glioblastomas , and interstitial collagenase was slightly induced in some primary and recurrent glioblastomas . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Antibodies were raised against seven major matrix metalloproteinases : stromelysin 1 ( MMP 3 ) , stromelysin 2 ( MMP 10 ) , stromelysin 3 ( MMP 11 ) , interstitial collagenase ( MMP 1 ) , M ( r ) 72 , 000 type 4 collagenase ( 72 kDa type 4 collagenase , MMP 2 ) , M ( r ) 92 , 000 type 4 collagenase ( 92 kDa type 4 collagenase , MMP 9 ) and matrilysin ( PUMP , MMP 7 ) as well as against prolyl 4 hydroxylase , to study the expression of these collagenolytic enzymes in normal liver in relation to the activity of collagen synthesis . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We now report that the 32 kD product resists any further attack by several matrix metalloproteinases including interstitial collagenase , 92 kD gelatinase , and matrilysin . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We have studied the capacity of various matrix metalloproteinases ( interstitial collagenase , stromelysin , matrilysin , and 92 kDa gelatinase ) to degrade the COL 1 domain of collagen 14 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1 antitrypsin . alpha 1 antitrypsin , the primary physiologic inhibitor of human leukocyte elastase , is proteolytically inactivated by several matrix metalloproteinases including interstitial collagenase , stromelysin and 92 kDa gelatinase . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
This specificity of the collagenases for aggrecan G 1 G2 was identical with that of the truncated metalloproteinase matrilysin ( MMP 7 ) , but different from those of stromelysin ( MMP 3 ) and the gelatinases ( MMP 2 or gelatinase A ; MMP 9 or gelatinase B ) which cleave at the Asn Phe site , but not the Asp Leu site . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We have investigated the expression and regulation of MMP 1 ( interstitial collagenase ) , MMP 2 ( gelatinase A ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin ) , MMP 9 ( gelatinase B ) and their inhibitors TIMP 1 and TIMP 2 in human umbilical vein , femoral vein and microvascular endothelial cells , and compared these data with those obtained with human synovial fibroblasts . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We have studied the capacity of three matrix metalloproteinases ( interstitial collagenase , 92 kDa gelatinase , and matrilysin ) to degrade entactin . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The coding sequences for five of the human MMPs , viz . interstitial collagenase , 72 kDa gelatinase , stromelysin 1 , matrilysin and 92 kDa gelatinase , were cloned and expressed in Chinese hamster ovary cells , and the proteins purified . ^^^ The most active on this substrate was 72 kDa gelatinase , followed by stromelysin 1 ; interstitial collagenase , matrilysin and 92 kDa gelatinase were of comparable but lesser activity . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In this investigation , we used in situ hybridization and immunohistochemistry to identify the sites and cell source of collagenase 1 ( MMP 1 ) , stromelysin 1 ( MMP 3 ) , matrilysin ( MMP 7 ) , and 92 kDa gelatinase ( MMP 9 ) , a subgroup of MMPs with the combined ability to degrade essentially all matrix proteins . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In this study , we describe the activity of CT 1746 , an orally active synthetic MMP inhibitor that has a greater specificity for gelatinase A , gelatinase B and stromelysin than for interstitial collagenase and matrilysin , in a nude mouse model that better mimics the clinical development of human colon cancer . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The overall organization of the collagenase 3 gene is similar to that of other MMP genes clustered at chromosome 11q22 , including fibroblast collagenase ( MMP 1 ) , matrilysin ( MMP 7 ) , and macrophage metalloelastase ( MMP 12 ) , but is more distantly related to genes coding for stromelysin 3 ( MMP 11 ) , gelatinase A ( MMP 2 ) , and gelatinase B ( MMP 9 ) , which map outside of this gene cluster . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We have examined the susceptibility of DCN to five different matrix metalloproteinases ( MMPs ) : MMP 1 ( tissue collagenase ) , MMP 2 ( gelatinase A ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin ) and MMP 9 ( gelatinase B ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Relative amounts of collagenase ( MMP 1 ) and stromelysin ( MMP 3 ) mRNAs were measured by Northern blot analysis , and amounts of stromelysin 3 ( MMP 11 ) and matrilysin ( MMP 7 ) mRNA from each sample were determined by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) and normalized to beta actin mRNA . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Levels of mRNAs for interstitial collagenase , gelatinase A , matrilysin , TIMP 1 and TIMP 2 increased ( p < 0 . 05 ) within 12 h of hCG , while gelatinase B mRNA increased later , by 36 h after hCG . ^^^ Administration of a 3beta hydroxysteroid dehydrogenase inhibitor ( Trilostane [ TRL ] ) during hCG treatment decreased ( p < 0 . 05 ) mRNA levels for interstitial collagenase , gelatinase B , matrilysin , TIMP 1 , and TIMP 2 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
This unusual constitutive expression pattern of MMPs and uPA by KS cells in vitro is characterized by elevated levels of gelatinase A , gelatinase B , interstitial collagenase , stromelysin and a high molecular weight form of uPA , and the lack of expression of matrilysin . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Overexpression of CIZ upregulates the transcriptions from MMP 1 , MMP 3 ( stromelysin ) , and MMP 7 ( matrilysin ) promoters , and this transactivation was enhanced in the presence of Cas . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Neither secreted collagenases ( MMP 1 and MMP 13 ) , gelatinases ( gelatinase A or B ) , stromelysins ( MMP 3 and MMP 11 ) , or matrilysin ( MMP 7 ) affected SF / HGF induced responses . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The aim of this study was to characterize the temporal changes in mRNA profiles for rat collagenase [ matrix metalloproteinase 1 ( MMP 1 ) ] , gelatinase A ( MMP 2 ) , matrilysin ( MMP 7 ) , gelatinase B ( MMP 9 ) , and membrane type 1 MMP ( MT 1 MMP ) , as well as tissue inhibitor of metalloproteinases 1 ( TIMP 1 ) , TIMP 2 , and TIMP 3 during the inflammatory , granulation , and early remodeling phases of excisional skin repair . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
A thiol inhibitor MAG 283 had IC ( 50 ) values of 480 , 3 , 280 , 14 , 1 . 1 , and 2 . 3 nM against human interstitial collagenase ( MMP 1 ) , gelatinase A ( MMP 2 ) , stromelysin ( MMP 3 ) , matrilysin ( MMP 7 ) , neutrophil collagenase ( MMP 8 ) , and gelatinase B ( MMP 9 ) , respectively . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
No binding to matrilysin ( MMP 7 ) and collagenase 1 ( MMP 1 ) was detected at inhibitor concentrations up to 60 microm . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The objectives of these experiments were to determine whether 1 ) PGF ( 2 alpha ) affects expression of mRNA encoding fibrillar collagenases ( MMP 1 and 13 ) , gelatinases A and B ( MMP 2 and 9 ) , membrane type ( mt ) 1 MMP ( MMP 14 ) , stromelysin ( MMP 3 ) , and matrilysin ( MMP 7 ) , and 2 ) PGF ( 2 alpha ) increases MMP activity during PGF ( 2 alpha ) induced luteolysis in sheep . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
We identified and quantified proteases in the culture media of explants : MMP 1 ( collagenase 1 ) , MMP 2 and MMP 9 ( gelatinases A and B ) , MMP 3 ( stromelysin 1 ) , MMP 7 ( matrilysin 1 ) , and tissue inhibitors of metalloproteinases , TIMP 1 and TIMP 2 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The S 1 ' specificity site in MMP 9 is perhaps best described as a tunnel leading toward solvent , as in MMP 2 and MMP 13 , as opposed to the smaller pocket found in fibroblast collagenase and matrilysin . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Additionally , the MMP substrate Dnp PChaGC ( Me ) HK ( NMA ) NH ( 2 ) was not cleaved at all by TACE , while collagenase ( MMP 1 ) , gelatinase ( MMP 9 ) , stromelysin 1 ( MMP 3 ) , and matrilysin ( MMP 7 ) all processed this substrate efficiently . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS : The expression of MMPs , including MMP 1 , 2 , 3 , 7 ( matrilysin ) , and 9 , and that of their inhibitors ( tissue inhibitor of metalloproteinases [ TIMP ] 1 and 2 ) were analyzed immunohistochemically by using 52 formalin fixed and paraffin embedded specimens from patients with ulcerative colitis who had undergone a biopsy or surgery . ^^^ RESULTS : It was observed that MMP 1 , 2 , and 9 , and the TIMPs were expressed in stromal cells , MMP 3 was expressed in both the epithelial cells and stromal components , and matrilysin was expressed only in the epithelial cells on the edge of ulcers . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Association of ets related transcriptional factor E1AF expression with tumour progression and overexpression of MMP 1 and matrilysin in human colorectal cancer . ^^^ Among the MMPs analysed , expression of MMP 1 and matrilysin correlated significantly with E1AF expression . ^^^ Immunohistochemical expression of E1AF was predominantly observed at the invasive front , where the expression of MMP 1 and matrilysin and nuclear beta catenin expression were often co localized . ^^^ Antisense E1AF transfected HT 29 colon cancer cells expressed reduced levels of MMP 1 and matrilysin and were less invasive in vitro than neo transfected HT 29 cells . ^^^ The results of this study suggest that E1AF , the expression of which is closely correlated with the expression of MMP 1 and matrilysin , plays a key role in the progression of colorectal cancer . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Purified TIMP 2 inhibited the activities of transin , matrin ( pump 1 ) , Mr 72k gelatinase , and interstitial collagenase with 1 : 1 stoichiometry . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
To establish the role of these enzymes on colony formation , inhibitory antibodies directed against urokinase plasminogen activator , matrix metalloproteinase 1 and matrix metalloproteinase 7 were added into primary prostatic epithelial cells and bone marrow stroma co cultures . ^^^ All prostatic epithelial cell cultures stained positively for matrix metalloproteinase 1 , matrix metalloproteinase 7 and urokinase plasminogen activator . ^^^ Inhibition studies demonstrated that blocking matrix metalloproteinase 1 , matrix metalloproteinase 7 and urokinase plasminogen activator function reduced the median epithelial colony area significantly in bone marrow stroma co cultures in vitro . ^^^ Using a human ex vivo model we have shown that matrix metalloproteinase 1 , matrix metalloproteinase 7 and urokinase plasminogen activator play an important role in the establishment of prostatic epithelial cells within bone marrow . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 7 showed the highest activity to the substrate among these MMPs , digesting 8 , 30 and 44 fold more preferentially than MMP 2 , 3 , and 9 , respectively . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
These results suggest that in vivo MMP 7 may play a role in degradation of extracellular matrix macromolecules in concert with MMP 1 , 3 , and 9 under pathological conditions . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The MMPs studied included : 72 kDa and 92 kDa gelatinases ( type 4 collagenases ) , interstitial collagenase , PUMP 1 ( MMP 7 ) , and stromelysins 1 and 3 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The matrix metalloproteinases ( MMPs ) gene family includes MMP 1 ( interstitial collagenase ) , MMP 2 ( 72 kD type 4 collagenase / gelatinase ) , MMP 3 ( stromelysin / transin ) , MMP 7 ( putative MMP ; pump 1 ) , MMP 8 ( granulocyte collagenase ) and MMP 9 ( 92 kD type 4 collagenase / gelatinase ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
His 400 may act as a zinc binding ligand similar to the His 197 in interstitial collagenase ( MMP 7 ) and Asp 432 and Asp 433 residues are probably involved in stabilization of the active site of the enzyme . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The response of the assay to equal molar quantities of active MMPs decreases in the order MMP 2 > MMP 9 > MMP 1 > MMP 3 > MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Enzymatic kinetic studies revealed IC 50 values ( concentration at 50 % inhibition ) of 19 , 3 , 45 , 8 , and 83 nM for MMP 1 , MMP 2 , MMP 3 , MMP 7 , and MMP 9 , respectively . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Antibodies used in this study were monoclonal antibodies to MMP 1 , MMP 2 , MMP 7 , MMP 8 , MMP 9 , TIMP 1 , TIMP 2 and polyclonal antibody to MMP 3 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Oligonucleotide primers for thirteen MMPs ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 10 , MMP 11 , MMP 12 , MMP 13 , MMP 14 , MMP 15 , MMP 16 ) were optimized for use in RT PCR . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In the present study , we investigated the expression of several matrix metalloproteinases ( MMPs ) and tissue inhibitors of matrix metalloproteinases ( TIMPs ) , including MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MT 1 MMP , TIMP 1 and TIMP 2 , in these tumors . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Finally , the cleavage efficiency of the Dns substrates by three representative matrixins , namely , MMP 14 ( 215 = Leu ) , MMP 1 ( 215 = Arg ) , and MMP 7 ( 215 = Tyr ) , was determined . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
To establish whether MMPs specific for these collagens participate in early human liver development , we localized immunohistochemically MMP 1 and MMP 13 ( for collagens 1 and 3 ) and MMP 2 and MMP 7 ( for collagen 4 ) in the early human liver anlage [ 6th 10th gestational week ( GW ) ] . ^^^ This study has shown that production of MMP 1 , MMP 2 , MMP 7 , and MMP 13 during human liver development already occurs from the 6th GW . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RESULT ( s ) : Strong staining for MMP 1 and MMP 3 was observed in stroma and for MMP 7 in epithelium . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Expression levels of matrix metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , MT 1 MMP ) and tissue inhibitors of MMP ( TIMP 1 , TIMP 2 ) were evaluated by semiquantitative RT PCR , substrate zymography and western blot . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS : Levels of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 13 , TIMP 1 , and TIMP 2 in SF aspirated from knee joints of 97 patients with RA and 103 patients with OA were measured by the corresponding one step sandwich enzyme immunoassays . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RESULTS : ONO 4817 showed a broad inhibitory activity against MMPs except MMP 1 and MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Proteolytic cleavage by MMP 1 , MMP 7 , MMP 9 , and MMP 12 resulted in considerable loss of TFPI activity . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The structures of the catalytic domain of MMP 1 , MMP 3 , MMP 7 and MMP 8 are known , but structures of enzymes belonging to this family still remain to be determined . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Based on local expression pattern of MMPs at the mRNA level , aseptic loose artificial hip joint was characterized by elevated expression of MMP 1 , MMP 9 , MMP 10 , MMP 12 , and MMP 13 ; moderate expression of MMP 2 , MMP 7 , MMP 8 , MMP 11 , membrane type ( MT ) 1 MMP ( MMP 14 ) , MT 2 MMP ( MMP 15 ) , MT 3 MMP ( MMP 16 ) , MT 4 MMP ( MMP 17 ) , and MMP 19 ; lower expression of MMP 3 ; and little significance of MMP 20 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RESULTS : Significantly higher levels of MMP 1 , 3 , and 9 were found in SF from RA patients compared to OA patients , but MMP 7 was not detectable in either group . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Among other invasion genes , we identified the matrix metallo proteinases MMP 7 and MMP 1 activated by beta catenin in the tumor cells . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Cultured astrocytes constitutively expressed MMP 2 , MT 1 MMP , TIMP 1 , and TIMP 2 , whereas MMP 3 , MMP 7 , MMP 9 , and MMP 12 were not detectable in tissues or in cultured astrocytes . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Expression of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , MMP 14 , TIMP 1 , and TIMP 2 was simultaneously analyzed in tissue homogenates using semiquantitative reverse transcription polymerase chain reaction assay . ^^^ RESULTS : Significantly higher MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 , MMP 11 , MMP 13 , and TIMP 1 levels were found in tumors vs specimens of matched normal mucosa . ^^^ Enhanced expression of MMP 9 was strongly correlated ( P < . 001 ) and levels of MMP 2 , MMP 7 , and MMP 11 were weakly correlated ( P = . 03 . 05 ) with lymph node involvement . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Detailed SAR for the series is reported for five enzymes within the MMP family , and a number of inhibitors such as compound 18 display low nanomolar potency for MMP 2 and MMP 13 , while selectively sparing MMP 1 and MMP 7 . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Individual chondrosarcomas also exhibited elevated levels of MMP 1 , MMP 7 and MMP 9 mRNAs . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Seven metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , and MMP 13 ) were tested against two substrates : gelatin and alpha casein . ^^^ RESULTS : All MMPs except MMP 1 were active against gelatin , whereas MMP 7 was the only enzyme active against alpha casein . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 7 ( but not MMP 1 , 2 , 3 , and 9 ) cleaved corneal epithelium derived collagen 18 to generate a 28 kDa endostatin spanning fragment in a time and concentration dependent fashion . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In RT PCR studies , SUIT 2 , S 2 CP8 and S 2 VP10 cell lines constitutively expressed many matrix metalloproteinases ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 10 and MMP 14 ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Levels of monocytes expressing MMP 1 , MMP 7 and TIMP 1 mRNA were elevated in the acute phase of stroke patients compared to convalescence and healthy controls , as were levels of MMP 1 , 2 , 7 , 9 and TIMP 1 mRNA expressing blood MNC . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In vitro , BMS 275291 is a potent inhibitor ( nM ) of the activities of MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 . ^^^ Pharmacokinetic studies demonstrated that the plasma concentrations of parent BMS 275291 in mice exceeds the in vitro IC ( 50 ) values for MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 for at least 4 h after the administration of a therapeutic dose of BMS 275291 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
HIV infection enhanced MMP 1 ( 46 fold ) and MMP 2 ( 48 fold ) and active MMP 7 ( 33 fold ) and MMP 9 ( 50 fold ) by PBMCs . ^^^ Coculture of HIV infected PBMCs with HMVEC C increased MMP 1 ( 110 fold ) and MMP 2 ( 307 fold ) but not active MMP 7 and 9 . ^^^ The combination of NE , HIV infection , and coculture increased MMP 1 ( 126 fold ) and MMP 2 ( 467 fold ) , and active MMP 7 ( 65 fold ) and MMP 9 ( 75 fold ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The anterior stroma was positive for MMP 1 and MMP 2 , and some MMP 7 was seen in the epithelium . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 7 also upregulated MMP 1 , 2 secretion , but did not stimulate vascular endothelial growth factor ( VEGF ) secretion . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 1 , 2 and 9 were detected strongly in both stromal and epithelial cells and MMP 7 in the epithelial cells in the menstrual period . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 2 and MMP 7 mRNAs were not detected in either cell line . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In this study , structures of 10 enzymes ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 12 , MMP 13 , MMP 14 , and MMP 20 ) were examined with the intention of highlighting regions that could be potential sites for obtaining selectivity . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Immunohistochemical and confocal microscopic studies were conducted to evaluate the reactivity of lung tissue from six patients with pulmonary hypertension for alpha smooth muscle actin ( alpha SMA ) , desmin , vimentin , factor 8 , endothelin 1 , various types of MMPs ( MMP 1 , MMP 2 , MMP 3 , MMP 7 and MMP 9 ) , membrane type MMPs ( MT MMPs ) , tissue inhibitors of MMPs ( TIMPs ) , and type 4 collagen . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Immunohistochemical studies ( peroxidase and dual labeling for confocal microscopy ) of reactivity for MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , and the 4 membrane type MMPs were made on tissues from patients with cardiac ( n = 4 ) and pulmonary ( n = 5 ) sarcoidosis . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
To investigate the roles of MMPs in the progression of nasopharyngeal carcinoma ( NPC ) , the expression of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 12 , MMP 13 , MMP 14 , and MMP 19 was explored by microarray assay . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Neither MMP 3 nor MMP 12 were expressed in odontoblasts or pulp tissue , and MMP 7 , 8 , 24 and 25 were expressed only in the odontoblasts ; MMP 2 , 10 , 11 , 14 and 20 were expressed more abundantly by odontoblasts , whereas pulp tissue expressed more MMP 13 and MMP 17 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
BACKGROUND : The purpose of this study was to quantify the amount of matrix metalloproteinases such as MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , and MMP 13 and tissue inhibitors of metalloproteinases TIMP 1 and TIMP 2 expressed by human gingival explants in culture media and the area fraction ( AA % ) of gingival collagen fibers according to the degree of inflammation , to investigate a possible correlation between these enzymes and collagen loss . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 1 , MMP 2 , MMP 3 , MMP 7 , and MMP 13 , were not so uniform , but suggested that in almost all the cases the substituents at the amide nitrogen may be conducive to the activity , though the whole amide group may be sterically unfavourable . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RNA was isolated from the remaining wounds and skin , and a reduced cycle , primer specific , reverse transcriptase polymerase chain reaction was performed to semiquantitatively determine relative gene expression of MMP 1 , MMP 2 , MMP 7 , MMP 9 , and MMP 14 and of TIMP 1 , TIMP 2 , and TIMP 3 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Furthermore , MMPs were expressed in 30 % ( MMP 1 , 2 ) to 60 % ( MMP 7 ) of primary samples , whereas most blood samples were negative for the expression of MMPs . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Relatively strong associations were found among the three TIMPs while only a significant correlation between MMPs was observed between MMP 2 and MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RESULTS : We detected MMP 7 , urokinase plasminogen activator ( uPA ) and PAI 1 in both Matrigels , TIMP 2 was detected only in regular Matrigel and no MMP 1 or TIMP 1 was detected in either matrix . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Quantitative reverse transcription PCR was used to determine the expression levels of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 11 , MMP 12 , MMP 13 , MMP 14 and the inhibitors TIMP 1 , TIMP 2 and TIMP 3 . ^^^ Besides overexpression of MMP 7 , a known TCF dependent target gene , a striking upregulation of the expression levels of MMP 1 , MMP 3 , MMP 11 , MMP 12 and MMP 13 in desmoid tumours , compared to unaffected fibroblasts from the same patients , was found . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The aim of this study was to evaluate MMP 7 gene expression in comparison with MMP 1 , MMP 3 , and MMP 13 in patients with resectable rectal and colon cancer by a semi quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ CONCLUSION : Taking into account our earlier studies , we conclude that most cases of colorectal carcinogenesis are characterized by enhanced expression of MMP 7 , 13 , 3 and the gelatinases , whereas MMP 1 expression is very inconsistent and not overexpressed in many cases . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
These changes were reflected by enhanced cleavage of the MT 1 LCD bound collagen by the collagenases MMP 1 and MMP 8 but not by trypsin or MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Overexpression of MMP 1 was observed in 72 . 9 % ( n=344 ) of 472 patients , that of MMP 2 was 77 . 9 % ( n=352 ) , MMP 7 63 . 3 % ( n=299 ) and that of MMP 10 was 27 . 1 % ( n=128 ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In addition to MMP 1 , high glucose also augments lipopolysaccharide stimulated MMP 7 , 8 , and 9 mRNA expression . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RXP 03 potently inhibits MMP 11 , MMP 8 and MMP 13 , but not MMP 1 and MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Collagenase 1 ( MMP 1 ) , matrilysin 1 ( MMP 7 ) , and stromelysin 2 ( MMP 10 ) are expressed by migrating enterocytes during intestinal wound healing . ^^^ The aim of this study was to clarify the role of collagenase 1 ( MMP 1 ) , matrilysin 1 ( MMP 7 ) , and stromelysin 2 ( MMP 10 ) in intestinal wound repair and to determine the effect of cytokines on the expression of these MMPs in intestinal epithelial cell lines . ^^^ RESULTS : MMP 7 , MMP 10 , and MMP 1 were expressed by migrating enterocytes bordering intestinal ulcers in 5 / 5 , 3 / 5 , and 3 / 5 samples , respectively . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS : Immunohistochemical expression of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , TIMP 1 , and TIMP 2 was investigated in 33 human RMSs , 12 alveolar , and 21 embryonal histologic subtypes ( 12 high risk and 9 low / standard risk ) . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS : Thirty two patients with supraglottic SCC underwent supraglottic horizontal partial laryngectomy and neck dissection , and the samples of primary cancer and the corresponding adjacent non neoplastic tissues were evaluated for both mRNA and protein expression of MMP 1 , MMP 2 , MMP 7 , MMP 8 , MMP 9 , and MMP 10 using reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry . ^^^ RESULTS : Among the six kinds of MMPs , both mRNA and protein expression of MMP 2 , MMP 7 , and MMP 9 were found up regulated in more than 63 % of the tumor tissues as compared with the adjacent non neoplastic tissues , and this was significantly correlated with lymph node metastasis ( all P < . 05 ) . ^^^ Using RT PCR and immunohistochemical data of MMP 2 , MMP 7 , and MMP 9 , two mathematic models were tested , and their diagnostic efficiencies for lymph node metastasis were 84 % and 88 % , respectively . ^^^ CONCLUSION : Expressions of MMP 2 , MMP 7 , and MMP 9 are up regulated in supraglottic carcinoma tissues , suggesting that MMPs may be useful in the detection of occult lymph node metastasis but that more research is needed . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : In this study all of the major members of the matrix metalloproteinase ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 13 , MT 1 MMP and MT 2 MMP ) / tissue inhibitor of matrix metalloproteinase ( TIMP 1 , TIMP 2 , and TIMP 3 ) system have been investigated by immunohistochemistry in a series ( n = 90 ) of stage 3 ( Dukes ' C ) colorectal cancers . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
CCL 25 differentially modulated the expression of collagenase 1 or matrix metalloproteinase ( MMP ) 1 , collagenase 3 ( MMP 13 ) , stromalysin 2 ( MMP 10 ) , stromalysin 3 ( MMP 11 ) , and gelatinase A ( MMP 2 ) , but not MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 12 , or MMP 14 in prostate cancer cells . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
MMP 1 , 3 , 10 , and 12 were expressed predominantly in perimenstrual period , MMP 7 and 11 had highest levels in proliferative phase , MMP 13 , 14 and 16 were expressed throughout the cycle and MMP 26 was found to be maximal in periovulatory period . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
E1AF expression was correlated significantly with the expression of MMP 1 and MMP 7 . ^^^ The results suggest that E1AF , in conjunction with the expression of MMP 1 , MMP 7 , COX 2 and iNOS , plays an important role in the early stage of colorectal carcinogenesis . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In situ hybridization was performed for MMP 1 , MMP 3 , MMP 7 , MMP 12 and MMP 13 . ^^^ CONCLUSIONS : Our results suggest that epithelial expression of MMP 7 , MMP 12 and MMP 13 , but not that of MMP 1 , MMP 3 , MMP 8 , MMP 9 and MMP 10 , in chronic wounds provides a diagnostic clue for distinguishing SCCs from nonmalignant wounds . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
CCm Tf on the films was degraded selectively by MMP 7 , but showed little or no susceptibility to MMP 1 , 2 , 3 , 9 , or 13 ; MT 1 MMP ; MT 3 MMP ; or ADAMTS 4 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
OBJECTIVE AND DESIGN : To clarify the role of ovarian steroids in the differential regulation of MMP 1 , MMP 3 , MMP 7 , MMP 8 , MMP 10 , TIMP 1 , TIMP 2 , and TIMP 3 mRNAs , we compared their variations in the cycling endometrium in vivo with their response to hormone addition or withdrawal in corresponding explants . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS : We evaluated MMP 1 , MMP 7 , MMP 9 , and MMP 13 expression in tissues from 208 patients with ESCC using immunohistochemistry ( IHC ) , and correlated MMP expression to clinicopathologic characteristics and disease free survival time . ^^^ RESULTS : IHC analysis showed that 63 . 0 % , 41 . 8 % , 49 . 0 % , and 32 . 2 % of 208 ESCC samples were positive for MMP 1 , MMP 7 , MMP 9 , and MMP 13 , respectively . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The organ culture media were analyzed using Western blottings ( MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 9 , MMP 13 , TIMP 1 , and TIMP 2 ) and gelatine zymography . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Functional polymorphisms in the MMP 1 , MMP 2 , MMP 7 , MMP 9 , MMP 12 , and MMP 13 genes have also been related to coronary artery disease , arterial stiffness , and / or abdominal aortic aneurysm . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
In fibroblasts , osteopontin up regulated tissue inhibitor of metalloprotease 1 and type 1 collagen , and down regulated matrix metalloprotease 1 ( MMP 1 ) expression , while in A 549 cells it caused up regulation of MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
RESULTS : MMP 1 and MMP 7 gene expression and secretion are potently upregulated by M . tuberculosis , and no increase in tissue inhibitor of metalloproteinase expression occurs to oppose their activity . ^^^ Dexamethasone completely suppresses MMP 1 but not MMP 7 gene expression and secretion . ^^^ In patients with active tuberculosis , macrophages express MMP 1 and MMP 7 adjacent to areas of tissue destruction . ^^^ MMP 1 but not MMP 7 expression and secretion are relatively M . tuberculosis specific , are not upregulated by tuberculosis associated cytokines , and are prostaglandin dependent . ^^^ In contrast , the vaccine M . bovis bacillus Calmette Gurin ( BCG ) does not stimulate MMP 1 secretion from human macrophages , although M . tuberculosis and BCG do upregulate MMP 7 equally . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
The structure based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP 13 inhibitors with selectivity over MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 14 , Aggrecanase 1 , and TACE are described . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Blood and bronchoalveolar gammadelta T lymphocytes were cultured in the absence and presence of isopentenyl pyrophosphate ( IPP ) or TGF beta1 / IL 15 for 24 h , and assessed for the expression and synthesis of MMP 1 , MMP 7 , and MMP 9 . ^^^ Resting human gammadelta T lymphocytes constitutively expressed MMP 9 mRNA , a marginal or no MMP 7 and MMP 1 mRNA . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
CONCLUSIONS : The study suggested that a possible association between the MMP 7 A / G polymorphism with susceptibility to epithelium ovarian cancer , but there is no support for an association of the selected MMP 1 1G / 2G , MMP 3 5A / 6A , and MMP 9 C / T polymorphisms with the risk for ovarian cancer . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Six widely invasive follicular carcinomas ( WIFCs ) , 15 minimally invasive follicular carcinomas ( MIFCs ) , 19 follicular adenomas ( FAs ) and 10 adenomatous goitres ( AGs ) were analysed immunohistochemically for MMP 1 , MMP 2 , MMP 7 , MMP 9 , membrane type 1 MMP ( MT 1 MMP ) and tissue inhibitor of matrix metalloproteinase 2 ( TIMP 2 ) . ^^^ MMP 2 and MMP 7 were positive in more than 80 % of WIFC and MIFC cases , whereas they were negative in all FA and AG cases except one MMP 2+ FA ( P < 0 . 001 ) . ^^^ In situ hybridization of MMP 2 and MMP 7 mRNA in selected cases demonstrated the expression of these enzymes in the tumour cells as well as in some stromal cells . ^^^ CONCLUSIONS : Our results confirm MMP expression mainly in malignant FTLs and suggest that MMP 2 and MMP 7 may be useful markers to distinguish MIFC from FA . . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
IL 1 alpha increased the mRNA expression of MMP 1 and MMP 3 , as well as induced MMP 7 . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Using computerized image analysis , the differential expression of interstitial collagenase ( MMP 1 ) , gelatinase B ( MMP 9 ) , matrilysin 1 ( MMP 7 ) and the membrane type 1 MMP ( MT 1 MMP ) in the epithelium and stroma of human prostate neoplastic tissues were investigated . ^^^ In most prostatectomy specimens examined , detectable amounts of MMP 1 , MT 1 MMP , MMP 7 and MMP 9 proteins and MT 1 MMP and MMP 9 mRNA were found in the epithelial and stromal components of CaP , PIN and NAP . ^^^ In the epithelium of normal and preneoplastic prostate tissue , MMP 1 , MMP 9 and MT 1 MMP were preferentially expressed in secretory luminal cells ; conversely , MMP 7 was concentrated in basal cells . ^^^ Whereas MMP 1 was overexpressed in NAP epithelial glands and progressively decreased from PIN to CaP , MMP 7 , MMP 9 and MT 1 MMP were more strongly expressed in CaP than in PIN and NAP tissue . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
PC / TP cells , prostate cancer cells that overexpress TP , also had a higher expression of MMP 1 and MMP 7 than PC / CV cells that express no detectable TP . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
Northern hybridization analyses revealed that ConA elevated the steady state mRNA levels for MMPs ; collagenase mRNA increased approximately 16 fold , MMP 2 increased 2 fold , and Pump 1 , a recently described MMP gene , was induced . ^^^ Increased transcription of the mmp genes was confirmed by nuclear run on analyses ; mmp 1 transcription was increased by greater than 25 fold , mmp 2 by approximately 3 fold , and Pump 1 by approximately 7 fold . ^^^
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
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Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA
Interacting proteins: P09237 and P03956	Pubmed	SVM Score :0.0
NA