| MMP 7 promotes prostate cancer induced osteolysis via the solubilization of RANKL . ^^^ MMP 7 , which was produced by osteoclasts at the tumor bone interface , was capable of processing RANKL to a soluble form that promoted osteoclast activation . ^^^ MMP 7 deficient mice demonstrated reduced prostate tumor induced osteolysis and RANKL processing . ^^^ |