| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.80522799 |
| We show that recombinant FGF BP 1 specifically binds FGF 2 and that this binding is inhibited by FGF 1 , heparan sulfate , and heparinoids . 0.80522799^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| The FGF binding proteins ( FGF BP , HBp 17 ) is a secreted protein which is able to mobilize and activate FGF 2 from the extracellular matrix . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Androgen stimulation induces AR+ PC 3 clones to secrete FGF BP , likely responsible for activation and mobilization from the extracellular matrix of the high amounts of FGF 2 produced by the same cells . ^^^ CONCLUSION : In the presence of an active AR , the combined production of FGF 2 and FGF BP may play an important role in the progression of prostate cancer through the selection of AR clones expressing high levels of Bcl 2 . . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have characterized an intracellular binding protein ( FGFBP ) for FGF 2 that undergoes a juxtanuclear localization coincident with the nuclear translocation of the growth factor . ^^^ Ligand blot analysis using 125I labeled FGF 2 showed that a FGFBP of 46 48 kDa ( represented by a double band ) was present on the nuclear membrane at mid to late G 1 , and Western blot showed this to be immunologically related to a part of the extracellular domain of the high affinity FGF receptor 1 ( FGFR 1 ) . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Recently , we have shown that a novel human FGF binding protein ( FGF BP ) mediates the release of immobilized FGF 2 from the EM . ^^^ Finally , mouse FGF BP binds to FGF 2 and can function as a modulator of FGF in FGF responsive cells . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| We found that the reduction of FGF BP reduced the release of biologically active basic FGF ( bFGF ) from cells in culture . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor binding protein ( FGF BP ) is a secreted protein that binds and activates fibroblast growth factors ( FGF 1 and FGF 2 ) and induces angiogenesis in some human cancers . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Accordingly , ligand blotting experiments revealed that bovine FGF BP bound FGF 2 . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor binding protein ( FGF BP ) is a secreted protein that binds FGF 1 and FGF 2 and is involved in mobilization and activation of FGFs from the extracellular matrix . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| We showed previously that a secreted FGF binding protein ( FGF BP ) can mobilize and activate FGF 2 from the extracellular matrix . ^^^ In this immunohistochemical study in mice , we show FGF BP protein expression in a broad spectrum of tissues at various stages between day 8 and day 16 of embryonal development , and compare FGF BP and FGF 2 immunolocalization . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| The fibroblast growth factor binding protein ( FGF BP ) binds and activates FGF 1 and FGF 2 , thereby contributing to tumor angiogenesis . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| Here we have mapped the interaction domain between human FGF BP 1 and FGF 2 . ^^^ For this , we generated T 7 phage display libraries of N terminally and C terminally truncated FGF BP 1 fragments that were then panned against immobilized FGF 2 . ^^^ Phage display of a C214A mutation of FGF BP 1 reduced binding to FGF 2 , indicating the functional significance of this disulfide bond . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| By immunohistochemical and in situ hybridization studies , we observed FGF BP protein and mRNA upregulation in regenerating renal tubular epithelial cells from kidneys of HIV Tg 26 mice with late stage renal disease , that is , associated with the development of microcystic tubular dilatation and accumulation of FGF 2 . ^^^ Moreover , FGF BP increased the FGF 2 dependent growth and survival of cultured primary human renal glomerular endothelial cells and enhanced FGF 2 induced MAPK / ERK2 activation , as well as the proliferation of immortalized GM 7373 endothelial cells . ^^^ Furthermore , the upregulation of FGF BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF 2 in renal capillaries can be modulated in children with HIV HUS and other renal disease . . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have purified three acidic ( FGF 1 ) and basic ( FGF 2 ) fibroblast growth factor binding proteins ( FGF BP 1 , FGF BP 2 , and FGF BP 3 ) from human plasma and calf serum and demonstrate the presence of these circulating FGF BPs in blood . ^^^ FGF BP 1 and FGF BP 2 have estimated molecular masses of 70 85 kDa and 55 60 kDa , respectively , and are detected by using 125I labeled FGF 2 ligand blotting . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| This protein , designated HBp 17 , was found to bind the heparin binding peptide growth factors HBGF 1 and HBGF 2 in a noncovalent , reversible manner . ^^^ In addition HBp 17 was found to inhibit the biological activities of both HBGF 1 and HBGF 2 . ^^^ Both the binding and inactivation of HBGF 1 and HBGF 2 by HBp 17 were abolished by heparin . ^^^ |
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| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14512 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
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