| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.72053226 |
| In vitro , FGF 2 has a strong affinity for histone H 1 and it activates the protein kinase CKII . 0.72053226^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :1.0346311 |
| Using purified proteins , FGF 2 is shown to directly interact with CK 2 and to stimulate CK 2 activity toward nucleolin . 1.0346311^^^ Here , we show that FGF 2 added to nuclear extract binds to protein kinase CK 2 and nucleolin , a CK 2 natural substrate . 0.98573043^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.0 |
| It was found , in vitro , that ( 1 ) p 37 had a higher binding affinity with bFGF than bLF ; ( 2 ) p 37 functioned as a phosphate acceptor for at least three protein kinases ( PKA , CK 1 and CK 2 ) ; ( 3 ) bLF stimulated about 3 fold the PKA mediated phosphorylation of p 37 , but suppressed its phosphorylation by CK 1 ; and ( 4 ) galloyl pedunculagin was an effective inhibitor for the phosphorylation of p 37 by PKA and CK 1 . ^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.0 |
| Activation of rDNA transcription by FGF 2 : key role of protein kinase CKII . ^^^ Using purified kinase CKII and nucleolin in an in vitro phosphorylation assay , we have shown that FGF 2 activates the protein kinase activity . ^^^ These results suggest that FGF 2 could act as an activator of rDNA transcription through interactions with the protein kinase CKII . . ^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.0 |
| We have previously shown that , in vitro , FGF 2 directly stimulates the activity of the casein kinase 2 ( CK 2 ) , a ubiquitous serine / threonine kinase involved in the control of cell proliferation . ^^^ We report that , in vivo , FGF 2 ( WT ) transiently interacts with CK 2 and stimulates its activity in the nucleus during G 1 S transition in NIH3T3 cells . ^^^ In contrast , the FGF 2 ( S117A ) mutant fails to interact with CK 2 . ^^^ Thus , our results show that FGF 2 mitogenic and differentiation activities can be dissociated by a single point mutation and that CK 2 may be a new nuclear effector involved in FGF 2 mitogenic activity . ^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.0 |
| In vitro , FGF 1 and FGF 2 are phosphorylated by CK 2 , and the presence of FGF 1 or FGF 2 was found to enhance the autophosphorylation of CK 2 beta . ^^^ |
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| Interacting proteins: P09038 and P68400 |
Pubmed |
SVM Score :0.0 |
| NA |
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