| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.74690324 |
| These structures demonstrate that both mutations introduce additional interactions between FGFR 2 and FGF 2 , thereby augmenting FGFR 2 FGF2 affinity . 0.74690324^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.66310039 |
| FGF 7 recognizes one FGFR isoform known as the FGFR 2 IIIb isoform or keratinocyte growth factor receptor ( KGFR ) , whereas FGF 2 binds well to FGFR 1 , FGFR 2 , and FGFR 4 but interacts poorly with KGFR . 0.66310039^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We recently identified a bipartite element in the rat osteocalcin ( OC ) promoter that confers synergistic induction by fibroblast growth factor receptor 2 ( FGF 2 ) and cAMP . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of bFGF , fibroblast growth factor receptor 1 ( FGFR 1 ) and fibroblast growth factor receptor 2 ( FGFR 2 ) was analyzed by immunohistochemistry and Western blot . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Previous studies showed that prostaglandin F2alpha ( PGF2alpha ) stimulated fibroblast growth factor 2 ( FGF 2 ) and fibroblast growth factor receptor 2 ( FGFR 2 ) cytosolic and nuclear accumulation , however , the endocytic pathway has not been elucidated . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Tissue was assessed histologically after harvesting and quantitative immunohistochemistry was performed using antibodies against vascular endothelial growth factor ( VEGF ) , vascular endothelial growth factor receptor 2 ( VEGF R 2 ) , fibroblast growth factor basic ( bFGF ) and fibroblast growth factor receptor 2 ( FGF R 2 ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Expression of basic fibroblast growth factor , FGFR 1 and FGFR 2 in normal and malignant human breast , and comparison with other normal tissues . ^^^ The expression of basic fibroblast growth factor ( bFGF ) and two of its receptors , FGFR 1 and FGFR 2 , was detected using the polymerase chain reaction , and quantified by comparison to the relative amount of product obtained following co amplification of the ubiquitous glyceraldehyde phosphate dehydrogenase transcript . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Basic fibroblast growth factor ( bFGF ) and two of its receptors , FGFR 1 and FGFR 2 : gene expression in the rat brain during postnatal development as determined by quantitative RT PCR . ^^^ Regional and temporal patterns of the expression of basic fibroblast growth factor ( bFGF ) , and two of its high affinity receptors ( FGFR 1 and FGFR 2 ) , were examined in the male rat brain during early postnatal development ; the reverse transcription polymerase chain reaction ( RT PCR ) was used to obtain mRNA measurements which were expressed relative to mRNA for GAPDH as a constant . ^^^ Basic fibroblast growth factor ( bFGF ) and two of its receptors , FGFR 1 and FGFR 2 : gene expression in the rat brain during postnatal development as determined by quantitative RT PCR . ^^^ In the rat cerebrum , the mRNAs for bFGF and for FGFR 2 were relatively low in amount within the first postnatal week , but by 28 days , they were as high as in the 1 year old rat cerebrum . ^^^ Quantitation of mRNA from microdissected regions of 28 day old rat brain revealed that the expression of bFGF and of FGFR 2 showed a marked variation between regions but the expression of FGFR 1 appeared less variable between the regions that were analyzed . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Testosterone and FGF 2 increased the expression of FGFR 1 messenger RNA ( mRNA ) and , to a lesser extent , FGFR 3 mRNA , but down regulated FGFR 2 mRNA in S 115 cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We also examined the expression of mRNAs for aFGF , bFGF , KGF , FGF receptor 1 ( FGFR 1 ) and FGFR 2 in epithelial and stromal cells using Reverse Transcriptase Polymerase Chain Reaction ( RT PCR ) analysis . ^^^ Furthermore , RT PCR analysis demonstrated the expression of mRNAs for bFGF , KGF and FGFR 1 in stromal cells and that of FGFR 2 in epithelial cells . ^^^ These findings suggest that bFGF produced by stromal cells acts on stromal cells through FGFR 1 by an autocrine mechanism , KGF produced by stromal cells acts on epithelial cells through FGFR 2 by a paracrine manner in human BPH . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| A mutant FGFR 2 , in which the D E beta hairpin ( T319TDKEI ) is replaced with the KGFR D E beta hairpin ( S319SNA ) , has 9 fold reduced affinity for bFGF . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Thus , FGF 2LA bound , with the same affinity as FGF 1 and FGF 2 , to FGFR 1 and FGFR 2 , whereas only FGF 1 and the FGF 1 loop containing mutant , FGF 2LA , bound to the keratinocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 ( flg ) and FGFR 2 ( bek ) were expressed more by fibroblasts and bFGF was expressed more by corneal than limbal epithelial cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| When FGFR 1 or FGFR 2 were expressed in mutant CHO cells deficient in heparan sulfate synthesis , the cells also bound 125I bFGF in the absence of heparin , and the addition of heparin increased the affinity of bFGF for its receptors 2 3 fold . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In 30 PHT rats and 30 sham operated controls 2 weeks after operation , specimens of lower esophagus were obtained for ( 1 ) quantitative histologic assessment including thickness of epithelium and muscularis mucosae ; ( 2 ) immunostaining with specific antibodies against bFGF and its receptors 1 and 2 ( intensity of bFGF , FGFR 1 and FGFR 2 immunostaining in esophageal structures was measured with a video image system ) ; and ( 3 ) expression of bFGF and FGFR 1 and 2 mRNAs was assessed with reverse transcription polymerase chain reaction . ^^^ The immunostaining intensity of bFGF and FGFR 2 was significantly reduced in PHT rats ( 42 . 1 + / 2 . 3 and 71 . 3 + / 6 . 5 units , respectively ) versus controls ( 49 . 5 + / 5 . 6 and 78 . 6 + / 5 . 7 units , respectively , p < 0 . 05 ) . ^^^ Expressions of bFGF and FGFR 2 mRNAs in PHT esophageal mucosa were significantly reduced versus controls by 30 . 8 % and 30 . 3 % , respectively ( p < 0 . 01 , p 0 . 05 ) . ^^^ CONCLUSIONS : ( 1 ) Esophageal mucosa of PHT rats has thinner muscularis mucosae and reduced bFGF and FGFR 2 mRNAs and proteins . ( 2 ) Because bFGF stimulates smooth muscle cell proliferation and their growth , our findings can explain thinning of esophageal muscularis mucosae in PHT rats , thus indicating a possible mechanism for rupture of varices in the esophagus . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| On six human hepatocellular carcinoma ( HCC ) cell lines ( KIM 1 , KYN 1 , KYN 2 , KYN 3 , HAK 1A , and HAK 1B ) , we examined expressions and functions of the proteins and messenger RNAs ( mRNAs ) of basic fibroblast growth factor ( bFGF ) and its receptor , i . e . , fibroblast growth factor receptor 1 ( FGFR 1 ) , as well as mRNA expressions of FGFR 2 approximately 4 . ^^^ All six cell lines expressed the proteins and mRNAs of bFGF and FGFR 1 , and at least one of FGFR 2 approximately 4 mRNAs . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have screened normal oral mucosa and oral squamous cell carcinoma ( SCC ) for expression of bFGF by immunohistology and northern analysis and used RT PCR to look for transcripts for KGF and the high affinity FGF receptors FGFR 1 and FGFR 2 . ^^^ The predominant FGF receptor detected in the epidermis and oral mucosa was FGFR 2 which binds KGF with greater affinity than bFGF . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The presence of mRNA for aFGF , bFGF , and three isoforms of VEGF , as well as their receptors , FGFR 1 , FGFR 2 , Flt 1 , and KDR , in vessel outgrowths and the parent vessel , as identified by RT PCR , strongly implicated aFGF , bFGF , and VEGF as having an important role in this neovascularization response . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this report , the levels of FGF 1 , FGF 2 , FGF 7 mRNA and their receptors FGFR 1 and FGFR 2 , were investigated during epidermal carcinogenesis in transgenic mice expressing the early region of the ' high risk ' papillomavirus type 16 ( HPV 16 ) under control of the human keratin 14 enhancer / promoter ( K 14 HPV16 transgenic mice ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We found that FGF 2 and FGFR 2 mRNA expression was elevated 8 . 2 and 5 . 6 fold , respectively , in adult aorta . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Prostatic epithelial cells express primarily the FGFR 3 IIIc isoform , which preferentially binds FGF 1 over FGF 2 , with smaller amounts of the FGFR 2 IIIb ( FGF 7 binding ) isoform . ^^^ Prostatic stromal cells express primarily the FGFR 3 IIIc isoform and smaller amounts of FGFR 1 IIIc and FGFR 2 IIIc isoforms , which bind both FGF 1 and FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction analysis of human keratinocyte mRNA for fibroblast growth factor receptors ( FGFRs ) revealed expression of only FGFR 2 IIIb , the KGF specific receptor , which also binds bFGF with low affinity , and FGFR 3 IIIb , which does not bind bFGF or KGF . ^^^ Our results suggest that bFGF and KGF inhibit collagenase 1 expression through the KGF cell surface receptor ( FGFR 2 IIIb ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this study , we performed an immunohistochemical analysis of FGF receptors 1 , 2 and 3 ( FGFR 1 , FGFR 2 and FGFR 3 , respectively ) in NCN and MM and compared their expression and localization with those of bFGF . ^^^ None of the 10 NCN that showed strong , homogeneous staining for bFGF expressed FGFR 1 or FGFR 3 proteins ; six weakly expressed FGFR 2 protein . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Fgfr 2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF 2 . ^^^ Fibroblast growth factor type 2 ( FGF 2 ) protein , which has a high affinity for the FGFR 2 splice variant associated with craniosynostosis , is locally abundant ; immunohistochemical detection showed it to be present at low levels in Fgfr 2 expression domains and at high levels in differentiated areas . ^^^ Implantation of FGF 2 soaked beads onto the fetal coronal suture by ex utero surgery resulted in ectopic osteopontin expression , encircled by Fgfr 2 expression , after 48 hours . ^^^ We suggest that increased FGF / FGFR signalling in the developing skull , whether due to FGFR 2 mutation or to ectopic FGF 2 , shifts the cell proliferation / differentiation balance towards differentiation by enhancing the normal paracrine down regulation of Fgfr2 . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In contrast to the FGFR 2 kinase fused to the ectodomain of FGFR 1 , the FGFR 1 kinase failed initially to support a mitogenic response to FGF 2 in type 1 tumor cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In the present study , the RT PCR method was used to determine the gene expression of basic fibroblast growth factor ( bFGF ) , keratinocyte growth factor ( KGF ) , FGF receptor 1 ( FGFR 1 ) , FGF receptor 2 ( FGFR 2 ) , and KGF receptor ( KGFR ) in mouse embryos and in the stromal and epithelial cells of the uterine endometrium . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Since FGF 1 and FGF 3 can both activate one FGF receptor isoform ( FGFR 2 IIIb ) that is not activated by FGF 2 , these results suggest that activation of FGFR 2 IIIb is sufficient to induce fiber cell differentiation throughout the lens epithelium in vivo . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We describe here a reversible switch from IIIb to IIIc for FGFR 2 and FGFR 3 under the influence of exogenous and endogenous FGF 1 or FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Exogenously added acidic FGF ( aFGF ) , which generated a rapid tyrosine phosphorylation of FGFR 1 and FGFR 2 on KS cells , reversed the inhibitory effects of anti bFGF Ab . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 induces tyrosine phosphorylation of FGFR 1 and FGFR 2 and many cellular substrates including MAP kinases and stimulates proliferation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| PTH also increased FGF 2 mRNA , and FGFR 1 and FGFR 2 mRNA levels within 30 minutes in neonatal mouse calvarial organ cultures . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Expression of basic fibroblast growth factor and its receptors FGFR 1 and FGFR 2 in human benign prostatic hyperplasia treated with finasteride . ^^^ FGFR 1 and FGFR 2 receptors , that exhibit affinity for bFGF , have been identified in normal and hyperplastic prostate . ^^^ This study was designed to assess the effects of finasteride on the expression levels of bFGF , FGFR 1 , and FGFR 2 in patients with BPH . ^^^ METHODS : The expression levels of bFGF , FGFR 1 , and FGFR 2 in 9 patients with prostatic hyperplasia treated with finasteride were assessed by immunohistochemistry and reverse transcription polymerase chain reaction ( RT PCR ) analysis of mRNA expression and were compared with those of 9 control patients with untreated BPH . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Subcutaneous insertion of FGF 2 soaked beads onto the coronal suture on E 15 resulted in up regulation of osteopontin and Fgfr 1 in the sutural mesenchyme , down regulation of Fgfr 2 , and inhibition of cell proliferation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Although no significant differences in the expression of adhesion molecules ( NCAM ) , selected morphogens ( TGFbeta 2 , HGF / SF , FGF 2 , KGF ) , or their receptors ( TGFbetaR 2 , m met , FGFR 1 ) were seen between DP of p75NTR knockout and wild type mice , p75NTR mutants showed a prominent upregulation of FGFR 2 , a high affinity receptor for KGF , in both follicular DP and epithelium . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| It also prevented the increase in protein tyrosine phosphorylation induced by bFGF , including phosphorylation of FGFR 1 , FGFR 2 , phospholipase C gamma ( PLC gamma ) , and Shc as well as the recruitment of the Grb2 / Sos signaling complex . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this study the mRNAs encoding epidermal growth factor receptor ( EGFR ) , basic fibroblast growth factor receptor ( FGFR 2 ) and insulin like growth factor receptor ( IGFR 1 ) genes of the human normal lenses at ages varying from 0 . 5 to 72 years , were identified by semiquantitative reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression of MUC 1 protein and its relationship to the microvessel density and the expression of thymidine phosphorylase , vascular endothelial growth factor ( VEGF ) , VEGF receptor KDR , basic fibroblast growth factor ( bFGF ) , and bFGF receptor ( FGFR 2 ) in non small cell lung cancer . ^^^ Although MUC 1 expression was found equally in poorly and highly vascularized tumors , a significant coexpression with multiple angiogenic factors and their receptors was noted ( P = 0 . 0002 , 0 . 03 , 0 . 19 , 0 . 10 , and 0 . 01 for thymidine phosphorylase , VEGF , KDR , bFGF , and FGFR 2 , respectively ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| To elucidate the structural determinants governing specificity in fibroblast growth factor ( FGF ) signaling , we have determined the crystal structures of FGF 1 and FGF 2 complexed with the ligand binding domains ( immunoglobulin like domains 2 [ D 2 ] and 3 [ D 3 ] ) of FGF receptor 1 ( FGFR 1 ) and FGFR 2 , respectively . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Cross linking demonstrated that FGF 2 / HSGAGB primarily activated FGFR 1 , which in turn up regulated the activity of mitogen activated protein kinase ; in contrast , FGF 1 / HSGAGA led to the phosphorylation of equal proportions of both FGFR 1 and FGFR 2 , which in turn led to the up regulation of Src and p 125 ( FAK ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The effects of FGF 9 and FGF 2 on FGFR and myelin protein levels were comparable ; both up regulated FGFR 1 , and down regulated FGFR 2 , CNP , PLP and MBP . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Vessels were demonstrated by immunocytochemical labelling for CD 34 and expressed as raw counts and volume weighted counts . bFGF protein and its receptors FGFR 1 ( flg ) and FGFR 2 ( bek ) , were demonstrated using immunocytochemical labelling . ^^^ The expression of bFGF receptors was variable , with FGFR 2 being particularly high in areas of keratinisation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this study , we compare the transcription patterns of six developmentally important genes , Oct 4 , IL 6 , FGF 2 , FGF 4 , FGFr 2 , and gp 130 in single in vitro fertilized ( IVF ) and nuclear transfer embryos reconstructed using granulosa cells for the donor nuclei . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We show that the S252W mutation allows the mesenchymal splice form of FGFR 2 ( FGFR2c ) to bind and to be activated by the mesenchymally expressed ligands FGF 7 or FGF 10 and the epithelial splice form of FGFR 2 ( FGFR2b ) to be activated by FGF 2 , FGF 6 , and FGF 9 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) and its receptors VEGFR 1 and VEGFR 2 , fibroblast growth factor 2 ( FGF 2 ) and its receptors FGFR 1 and FGFR 2 , as well as epidermal growth factor ( EGF ) and its receptor EGFR are believed to be important in the control of angiogenesis in the human endometrium . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Histiocytes displayed intense TGF beta 1 , bFGF , and FGFR 2 expression . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The following antibodies were used as the first antibody ; FGF 2 and FGF 7 for FGFs , FGFR 1 and FGFR 2 for FGFRs , NCAM , L1CAM , and N cadherin for CAMs . ^^^ FGF 2 , FGF 7 , and FGFR 2 were expressed in neuronal tissue of NG segments as well as in hypertrophic nerves of AG segments . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of fibroblast growth factors FGF 1 and FGF 2 , and receptors FGFR 2 and FGFR 3 in the epithelium of human odontogenic cysts and tumors . ^^^ With some exceptions , FGF 2 and the receptor FGFR 2 , were found in the cytoplasm and occasionally in the nuclei of cells of odontogenic epithelium , while FGF 1 and the receptor FGFR 3 , were absent or only focally or weakly detected , using standard immunohistochemical techniques . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunogold labeling of MG 63 cells treated with TGF beta showed increased labeling for FGF 2 and FGFR 2 in the nuclei . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to determine whether FGF 1 , FGF 2 , and high affinity receptors FGFR 2 and FGFR 3 are present in the pathogenesis of oral epithelial dysplasias and oral squamous cell carcinoma . ^^^ STUDY DESIGN : Sections from formalin fixed , paraffin embedded samples of oral normal mucosa ( n = 14 ) , epithelial dysplasia ( n = 20 ) , carcinoma in situ ( n = 10 ) , and squamous cell carcinoma ( n = 12 ) were tested for cytoplasmic staining by standard in situ immunohistochemistry with antibodies for FGF 1 , FGF 2 , FGFR 2 , and FGFR 3 . ^^^ Changes in the localization of FGF 2 and FGFR 2 into upper epithelial layers with increasing dysplasia suggest increased mitotic potential of high level cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : To quantify the expression of fibroblast growth factor receptor isoforms FGFR 2 ( IIIb ) , FGFR 2 ( IIIc ) , FGFR 1 ( IIIc ) , and fibroblast growth factors FGF 2 and FGF 7 in normal and tumoral human prostate tissues , and human prostatic epithelial cell lines , we used quantitative real time polymerase chain reaction . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Chondrogenesis was consistently induced when mutant FGFR 1 K656E or FGFR 2 C278F were electroporated in ovo into stage 8 quail premigratory neural crest , followed by in vitro culture without FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Basic fibroblast growth factor : effects on matrix remodeling , receptor expression , and transduction pathway in human periosteal fibroblasts with FGFR 2 gene mutation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Regulation of human cranial osteoblast phenotype by FGF 2 , FGFR 2 and BMP 2 signaling . ^^^ We showed that Fibroblast Growth Factor 2 ( FGF 2 ) , FGF receptor 2 ( FGFR 2 ) and Bone Morphogenetic Protein 2 ( BMP 2 ) , three essential factors involved in skeletal development , regulate the proliferation , differentiation and apoptosis in human calvaria osteoblasts . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Crouzon ' s syndrome : differential in vitro secretion of bFGF , TGFbeta 1 isoforms and extracellular matrix macromolecules in patients with FGFR 2 gene mutation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical studies demonstrated that in vivo hair cells express FGF 2 and the receptors FGFR 1 and FGFR 2 while supporting cells do not express either molecule . ^^^ Following dissociation , HCs continue to express FGF 2 and its two receptors , while supporting cells upregulate the expression of FGF 2 and its receptor FGFR 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunoreactivity for receptors ( R ) for IGF 1 and FGF 2 ( IGF 1R , FGFR 1 , and FGFR 3 ) was most pronounced in chondroblasts and hypertrophic chondrocytes , while FGFR 2 immunoreactivity was strongest in the articular and prechondroblastic zones . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In complementary in vitro assays , bFGF did not directly stimulate avian OC development from bone marrow mononuclear cell precursors , consistent with their low mRNA expression of the four avian signaling FGF receptors ( FGFR ) 1 , FGFR 2 , FGFR 3 , and FGFR like embryonic kinase ( FREK ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In order to investigate which receptor ( s ) may mediate FGF 2 signaling and their role in regeneration , we have studied expression of the four fibroblast growth factor receptors , FGFR 1 , FGFR 2 , FGFR 3 and FGFR 4 , and of the spliced variants , sFGFR and KGFR , in the regenerating spinal cord of the adult urodele , Pleurodeles waltl , following tail amputation . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Treatment with FGF 2 or FGF 4 , or transfection with a vector expressing a mutant FGFR 2 that is constitutively activated in the absence of ligand , strongly stimulates Runx 2 expression . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis revealed that HSPG mRNA and FGFR 1 and FGFR 2 ( tyrosine kinase receptors for bFGF ) mRNA are expressed in TM BBB 4 cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RESULTS : De novo AR expression by PC 3 cells restores FGFR 2 IIIb isoform expression and sensitivity to FGF 7 and FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The biological significance of VEGF , EGF , and bFGF is mediated by their receptors , which belong to the family of tyrosine kinase receptors : Flt 1 ( VEGFR 1 ) , KDR ( VEGFR 2 ) , EGFR , FGFR 1 , FGFR 2 , FGFR 3 , and FGFR 4 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RESULTS : RT PCR revealed that GE cells express FGFR 1 , FGFR 2 , FGFR 3 , and FGFR 4 mRNA ; however , not that of FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Using semiquantitative reverse transcription polymerase chain reaction , we examined the expression of insulin like growth factor 1 ( Igf 1 ) , fibroblast growth factor 2 ( Fgf 2 ) , and their receptors ( Igf 1r , Fgfr 1 , Fgfr 2 , and Fgfr 3 ) in the MCC of 28 day old rats at 3 , 7 , and 14 days after placing intraoral appliances designed to produce a lateral functional shift of the mandible . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Multiple studies have shown that migration , proliferation , and differentiation of oligodendrocyte ( OL ) lineage cells are influenced by fibroblast growth factor 2 ( FGF 2 ) signaling through its receptors ( FGFR ) FGFR 1 , FGFR 2 , and FGFR 3 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RT PCR showed mRNA expression of bFGF receptor 2 ( FGFR 2 ) IIIb , which does not bind bFGF efficiently , by 4T1 cells and B 16 cells express FGFR 1 but not FGFR 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In MC3T3E1 osteoblasts ( with endogenous Runx 2 and FGFR 2 ) , MINT augments transcription driven by the OCFRE that is further enhanced by FGF 2 treatment . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Unregulated fibroblast growth factor 2 ( FGF 2 ) signaling caused by mutations in the fibroblast growth factor receptor ( FGFR 2 ) leads to human craniosynostosis such as the Apert syndrome . ^^^ In an in vitro control model of calvarial osteoblasts from Apert patients carrying the FGFR 2 P253R mutation , we studied the changes in cellular phenotype and evaluated the effects of FGF 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We focused on FGFR 2 because it is expressed in radial glia in the GEs where ActN 1 increases FGF 2 neurosphere frequency , but not in the septum where it does not . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| To determine the minimum size and sulfation content of active dermatan sulfate oligosaccharides , dermatan sulfate was first digested and then separated by size exclusion high pressure liquid chromatography , and the activity to facilitate FGF 2 and FGF 7 was assayed by the cellular proliferation of cell lines expressing FGFR 1 or FGFR 2 IIIb . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have used confocal and electron microscopy to show that , under PGF ( 2alpha ) stimulation , FGF 2 and FGFR 2 proteins accumulate near the nuclear envelope and colocalize in the nucleus of Py1a cells . ^^^ Treatment with SU 5402 does not block prostaglandin mediated nuclear internalization of FGF 2 or FGFR 2 . ^^^ In particular , pre treatment with phorbol 12 myristate 13 acetate ( PMA ) prevents the nuclear accumulation of FGF 2 and FGFR 2 in response to PGF ( 2alpha ) . ^^^ We conclude that PGF ( 2alpha ) stimulates nuclear translocation of FGF 2 and FGFR 2 by a PKC dependent pathway ; we also suggest an involvement of MAPK / ERK2 in this process . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Under these conditions , the enhanced proliferative response of these HUVECs was not associated with an increased synthesis / release of bFGF , but involved rapid ( within 30 min from the onset of exposure to pressure ) tyrosine phosphorylation of the bFGF receptor , FGFR 2 . ^^^ Furthermore , monoclonal antibodies to either bFGF or FGFR 2 attenuated the increased proliferation of HUVECs exposed to 60 / 20 mm Hg cyclic pressure . ^^^ HUVECs proliferation under 60 / 20 mm Hg at 1 Hz cyclic pressure is , therefore , dependent upon bFGF and involves FGFR 2 activation . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RNA was extracted from posterior frontal ( PF ) and sagittal ( SAG ) sutures , and reverse transcription polymerase chain reaction ( RT PCR ) was performed for cranial suture candidate cytokines BMP 2 , BMP 3 , BMP 4 , FGF 2 , FGFR 1 , FGFR 2 , FGFR 4 , TGF betaRI , TGF betaRII , and TGF betaRIII . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| To examine the effects and potential implications for the expression of the two basic fibroblast growth factor ( bFGF ) receptors , FGFR 1 and FGFR 2 , in retinal pigment epithelial ( RPE ) cells , bFGF dependent changes in gene expression and RPE cell function were studied . bFGF increased L type Ca2+ channel activity of RPE cells , which in turn resulted in an increase of vascular endothelial growth factor A ( VEGF A ) secretion from RPE cells . ^^^ Our findings support the hypothesis that there are two different FGFR 1 and FGFR 2 dependent pathways that modulate the role of bFGF in induction of neovascularisation in AMD . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| RESULT ( S ) : The proteins for bFGF , FGFR 2 , FGFR 3 , and FGFR 4 were identified in oocytes of all follicular classes . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In liver samples , the expression of FGF 1 and FGF 2 and of FGF receptors ( FGFRs ; FGFR 1 , FGFR 2 ) was significantly elevated with time after bone marrow transplantation ( BMT ) compared with other factors , and co expression of GFP and FGFs or FGFRs could be detected . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of FGF 2 and its receptors FGFR 2 and FGFR 3 was assessed by immunohistochemistry at different stages of the carcinogenesis protocol . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 receptor ( FGFR 2 ) was also significantly increased within 1 h . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Thus , FGF 2 biological effects on astrocytes appear to be mediated through FGFR 2 dependent mechanisms , and this may provide an indirect route by which FGF 2 acts on neuronal populations . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 inhibition of OPC differentiation was effectively blocked by siRNA targeted to FGFR 1 , but not FGFR 2 or FGFR 3 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Direct binding experiments with radiolabeled acidic FGF ( aFGF ) or basic FGF ( bFGF ) , inhibition of binding with native growth factors , and Scatchard analysis of the binding data indicated that bek and flg bind either aFGF or bFGF with dissociation constants of ( 2 15 ) 10 10 ( 11 ) M . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the latter bek form in NIH3T3 cells has been used to demonstrate that the N terminal Ig like domain and acidic region are not required for binding or activation of bek by aFGF or bFGF . . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The amino acid sequence of the TK 14 protein is closely related to the available partial sequence of the mouse protein bek , and more distantly related to the sequences of a chicken basic fibroblast growth factor receptor ( 73 % sequence homology ) and the apparent human equivalent of this receptor , the FLG protein ( encoded by the fms like tyrosine kinase gene ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The K sam gene had significant homologies with bek , FLG , and chicken basic fibroblast growth factor receptor gene . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analyses using antibodies against VEGF , bFGF , their receptors ( KDR , flt 1 , bek , and flg ) , factor 8 , and proliferating cell nuclear antigen were carried out on archival specimens of 52 human colon carcinomas and 10 adenomas . ^^^ Expression of VEGF and KDR was higher in metastatic than in nonmetastatic neoplasms and directly correlated with the extent of neovascularization and the degree of proliferation , whereas expression of bFGF , flt 1 , bek , and flg did not differ among tumor types . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this study , in order to clarify the targets of such raised endogenous bFGF levels , the messenger RNA ( mRNA ) expression of its receptors ( flg and bek ) in the hippocampus following transient forebrain ischemia induced by four vessel occlusion for 20 min was investigated using an in situ hybridization technique . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Iodinated HSAB FGF 2 maintained the properties of natural FGF 2 such as affinity for heparin , binding to Bek and Fig receptors , interaction with high and low affinity binding sites , and reinitiating of DNA synthesis in CCL 39 cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical analyses were conducted using antibodies against factor 8 ( endothelial cells ) , vascular endothelial growth factor ( VEGF ) and its receptors ( KDR andflt 1 ) , and basic fibroblast growth factor ( bFGF ) and its receptors ( bek andflg ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Archival specimens of 51 intestinal type and 38 diffuse type human gastric carcinomas were examined for tumor vessel counts , angiogenic factor expression , and the presence or absence of angiogenic factor receptors on tumor endothelium using antibodies against vascular endothelial growth factor ( VEGF ) and its receptors ( KDR and flt 1 ) , basic fibroblast growth factor ( bFGF ) and its receptors ( bek and flg ) , and factor 8 ( endothelial cells ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| In another tumor subline , a 3 fold decrease in bFGF high affinity receptor sites , which concurred with a 4 fold decrease in ability to internalize the bFGF ligand , was consistent with a decrease in total cellular expression of the FGF 2 receptor ( Bek ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Indirect immunohistochemistry was performed using the Strept ABC method with four antibodies : bFGF , KGF , FGF receptor ( flg ) , and KGF receptor ( bek ) . ^^^ There was absent or weak bFGF , KGF , flg , and bek immunoreactivity in normal kidneys . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| We performed quantitative immunohistochemistry for bFGF , mast cell tryptase , smooth muscle actin for smooth muscle cell / myofibroblast like cells , and fibroblast growth factor receptors ( Flg , Bek ) and measured collagen and elastic fiber in lung sections from IPF ( n = 14 ) , LAM ( n = 9 ) , and control lung ( n = 10 ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| There was no evidence from immunohistochemistry for up regulation of receptors flg and bek for FGF 2 . ^^^ The presence of FGF 2 , flg and bek in arterioles may indicate a possible role for FGF 2 in the regulation of blood flow since we have previously shown it to be a dilator of small arterioles . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Basic fibroblast growth factor ( bFGF ) and its receptor expression ( bek and flg ) In bone marrow stroma of murine AIDS . ^^^ Basic fibroblast growth factor ( bFGF ) and its receptor expression ( bek and flg ) In bone marrow stroma of murine AIDS . ^^^ RT PCR analysis showed a 40 % reduction in the expression of bFGF transcript expression from viral infected stromal cells , however , the levels of bek and flg bFGF receptors remained unchanged indicating virus infection only inhibited bFGF gene expression in stromal cells . ^^^ We report MuLV infection reduces bFGF transcript expression but not its surface receptors ( bek and flg ) in infected stromal cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Cek 2 and Cek 3 are structurally related to Cek 1 , a chicken basic fibroblast growth factor receptor , and presumably represent receptors for basic fibroblast growth factor related molecules . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The FGF R 2 ( IIIb ) isoform displays high affinity for stromal cell derived FGF 7 , whereas the FGF R 2 ( IIIc ) isoform does not recognize FGF 7 but has high affinity for the FGF 2 member of the FGF ligand family . ^^^ The switch from expression of exclusively exon IIIb to exclusively exon IIIc in the resident FGF R 2 gene was followed by activation of the FGF 2 ligand gene , the normally stromal cell FGF R 1 gene , and embryonic FGF 3 and FGF 5 ligand genes in malignant epithelial cells . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Five micrometer sections were stained with polyclonal antibodies against bFGF , FGF R 1 , and FGF R 2 , and patterns of immunohistochemical staining were assessed by independent reviewers . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : The mRNA expression of FGF 1 , FGF 2 , FGF 7 , FGF R 1 , FGF R 2 ( IIIb ) , and FGF R 2 ( IIIc ) was investigated by RT PCR in androgen sensitive cells ( LNCaP ) , androgen independent cells ( PC 3 ) and primary cultured stromal ( PS ) and epithelial cells ( PE ) from benign prostatic hyperplasia ( BPH ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Gene expression of basic fibroblast growth factor ( bFGF ) and its high affinity receptors [ fibroblast growth factor receptor subtypes 1 3 ( FGF R 1 , FGF R 2 , FGF R 3 ) ] , as well as brain derived growth factor ( BDNF ) and neurotrophin 3 ( NT 3 ) was analysed at 4 h after the hormone injection in CA 1 CA4 ( cornus of Ammon areas of the hippocampus ) and dentate gyrus of the dorsal hippocampus and in neocortex by means of in situ hybridization . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| The genes studied were growth factors [ FGF 2 , transforming growth factor ( TGF ) beta 1 , TGF beta 2 , and TGF beta 3 ] , growth factor receptors ( FGF R 1 , FGF R 2 , TGF beta RI , and TGF beta RII ) , and a marker of osteoblast differentiation ( Co 1 1 alpha 1 ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| A stable Chinese hamster ovary transfectant overexpressing the newt KGFR was capable of binding both 125I fibroblast growth factor 1 ( FGF 1 ) and 125I FGF 7 but not 125I FGF 2 , indistinguishable from the human KGFR . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Since KGF and aFGF ( but not bFGF ) are ligands for the KGF receptor ( KGFR ) , we explored the possibility that the TGF alpha / EGFR pathway is an intermediary in signaling through the KGFR . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Binding studies as well as chemical crosslinking of radiolabeled ligands revealed that the recombinant FGFR1 / KGFR chimera has retained the binding affinity to acidic FGF and FGF 4 ( hst / kfgf ) but lost the capacity to bind basic FGF ( bFGF ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Its receptor ( KGFR ) is a membrane spanning tyrosine kinase , which also binds acidic FGF ( aFGF ) with equally high affinity , and basic FGF ( bFGF ) with much lower affinity . ^^^ The KGFR is encoded by the bek / FGFR 2 gene , whose alternative transcript specifies a receptor with high affinity for aFGF and bFGF , but no detectable binding of KGF . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| BK 1 displayed a slightly better affinity for KGFR than BK 2 and induced a higher level of DNA synthesis in keratinocytes compared with bFGF and BK 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| To investigate the physiologic action of KGF in the healing of TM ( TM ) perforations , we examined KGF and KGF receptor ( KGFR ) mRNA transcript levels as well as those of bFGF and transforming growth factor alpha ( TGFalpha ) in normal and wounded rat TM at varying intervals , using a semiquantitative reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : RT PCR was used to examine the expression of mRNA for eight growth factors ( EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 , beta 3 ) and two growth factor receptors ( KGFR and HGFR ) in human AM preserved at 80 degrees C for one month . ^^^ RESULTS : RT PCR revealed that human AM expresses mRNA for EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 , beta 3 , KGFR and HGFR , while ELISAs showed that it contains EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| All of 13 human esophageal cancer cell lines contained mRNAs for both basic fibroblast growth factor ( bFGF ) and its receptor , FGFR1 / N sam protein , while they did not have mRNAs for keratinocyte growth factor ( KGF ) despite the presence of mRNAs for the KGF receptor gene , K sam . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| Recent study has revealed that this difference signifies a differential ligand affinity ; the receptor encoded by the K sam 1 cDNA has a high affinity for basic fibroblast growth factor ( bFGF ) , while the K sam 2 cDNA corresponds to a receptor with the high affinity for keratinocyte growth factor ( KGF ) . ^^^ |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21802 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|