| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.6014222 |
| Acidic and basic fibroblast growth factor bind with differing affinity to the same heparan sulfate proteoglycan on BALB / c 3T3 cells : implications for potentiation of growth factor action by heparin . 0.6014222^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.54266745 |
| Heparan sulfate proteoglycan ( HSPG ) , for example , associates with several matrix components such as fibronectin , laminin , and basic fibroblast growth factor . 0.54266745^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.57002719 |
| The data derived from the five assay systems demonstrated that heparin derived hexa and octasaccharides inhibited the interaction between cell surface heparan sulfate proteoglycan and bFGF ( assays 1 and 2 ) and bFGF induced proliferation of ACE cells ( assay 3 ) but were unable to enhance the binding of bFGF to its high affinity receptor in vitro ( assay 5 ) or to support bFGF induced mitogenesis in ACE cells ( assay 4 ) . 0.57002719^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Heparin is required for the binding of basic fibroblast growth factor ( bFGF ) to high affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Heparan sulfate proteoglycan ( HSPG ) is a major component of the muscle extracellular matrix and our previous study has shown that basic fibroblast growth factor ( bFGF ) , a member of the heparin binding growth factor ( HBGF ) family , and its receptor are present in Xenopus myotomal muscle during the period of synaptogenesis . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan : a mechanism for cooperactivity . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the ability of TGF beta 1 to stimulate binding of bFGF to ECM , increase ECM heparan sulfate proteoglycan , and potentiate the mitogenic activity of bFGF are linked . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| A simple procedure using human basic fibroblast growth factor ( FGF ) was utilized for the selection of COS cell mutants with defects in the biosynthesis or expression of heparan sulfate proteoglycan ( HSPG ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol anchored heparan sulfate proteoglycan . ^^^ We report here that primary human bone marrow cultures contain bFGF and express heparin like bFGF binding sites on the cell surface and in the extracellular matrix ( ECM ) . bFGF bound predominantly to a 200 kD cell surface heparan sulfate proteoglycan ( HSPG ) , which was also found in conditioned medium . bFGF was released from bone marrow cultures by incubation with phosphatidylinositol specific phospholipase C ( PI PLC ) and , less efficiently , by plasmin . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that bFGF binds to the heparan sulfate proteoglycan of basement membranes . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Acidic and basic fibroblast growth factor levels in spinal cord cultures are not regulated by alterations in heparan sulfate proteoglycan expression . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We found that basic fibroblast growth factor ( bFGF ) binds to heparinase sensitive sites in NFTs . bFGF binding is due to a heparan sulfate proteoglycan ( HSPG ) immunocytochemically identified in NFTs . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Basic fibroblast growth factor ( b FGF ) binds to heparan sulfate proteoglycan in Bowman ' s layer of the cornea . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Ligand affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor . ^^^ Expression cloning of cDNAs encoding a basic fibroblast growth factor ( FGF ) binding protein confirms previous hypotheses that this molecule is a cell surface heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Cell extracts prepared from BCE cells also contained a bFGF binding heparan sulfate proteoglycan , which could be released from the intact cells by a short proteinase treatment . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Specific binding of basic fibroblast growth factor to basement membrane like structures and to purified heparan sulfate proteoglycan of the EHS tumor . ^^^ The binding of iodinated basic fibroblast growth factor ( bFGF ) to low density heparan sulfate proteoglycan purified from the Engelbreth Holm Swarm ( EHS ) sarcoma was investigated using different techniques . ^^^ Iodinated bFGF bound to purified heparan sulfate proteoglycan but not to laminin or collagen type 4 , three components isolated from the same tumor . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 also down regulated the expression of syndecan 1 , a heparan sulfate proteoglycan that binds FGF with low affinity . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Since heparan sulfate proteoglycan is a major component of the extracellular matrix of skeletal muscle , factors that are bound to this proteoglycan , such as basic fibroblast growth factor ( bFGF ) , are in a strategic position for neuronal signaling . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The production of heparan sulfate proteoglycan and inhibition of basic fibroblast growth factor binding and activity by engrafted cells were indistinguishable from endothelial cells grown in culture . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Developmental regulation of neural response to FGF 1 and FGF 2 by heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Chlorate treated Swiss 3T3 fibroblasts , with impaired synthesis of heparan sulfate proteoglycan , were used as target cells in assessing the ability of exogenous heparin derived saccharides to promote the mitogenic activity of basic fibroblast growth factor 2 ( FGF 2 ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The mitogenic activity of bFGF requires interactions with both a high affinity receptor and a cell surface heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| First , heparan sulfate proteoglycan is a necessary cofactor for the environmental regulation by FGF 2 of nontransformed oligodendrocyte progenitors , including both the mitogenic response and the inhibition of terminal differentiation at a specific stage of the lineage . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| An endogenous glycosylphosphatidylinositol specific phospholipase D releases basic fibroblast growth factor heparan sulfate proteoglycan complexes from human bone marrow cultures . ^^^ In this study , we show the presence of an endogenous GPI specific phospholipase D ( GPI PLD ) that releases the bFGF binding heparan sulfate proteoglycan and the variant surface glycoprotein ( a model GPI anchored protein ) from BM cultures . ^^^ Therefore , we conclude that an endogenous GPI PLD releases bFGF heparan sulfate proteoglycan complexes from human BM cultures . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Cell surface expression of the basement membrane form of heparan sulfate proteoglycan ( HSPG ) , perlecan , basic fibroblast growth factor ( bFGF ) binding forms of heparan sulfate , and laminin has been examined by immunofluorescence during the attachment and outgrowth phases of mouse embryo development in vitro and in utero . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| A heparan sulfate proteoglycan ( HSPG ) from bovine cardiac plasma membrane was purified to homogeneity using either isoelectric focusing or anion exchange chromatography , followed by affinity chromatography on immobilized basic fibroblast growth factor ( bFGF ) . ^^^ We conclude that adult bovine myocardium contains a membrane associated bFGF binding heparan sulfate proteoglycan containing little or no chondroitin sulfate and that this HSPG may be distinct from those of the syndecan family of heparan sulfate proteoglycans . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factor 1 ( FGF 1 ) and 2 ( FGF 2 ) bind to two classes of receptors : the high affinity receptors , a family of four known transmembrane tyrosine kinases ( FGF R 1 R4 ) , and the low affinity receptors , cell surface and basement membrane heparan sulfate proteoglycan ( HSPG ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| High affinity binding of basic fibroblast growth factor ( bFGF ) to the tyrosine kinase receptor requires cell surface heparan sulfate proteoglycan or exogenous addition of heparin . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Codistribution of basic fibroblast growth factor and heparan sulfate proteoglycan in the growth zones of the human placenta . ^^^ In order to obtain an insight into morphogenetic processes such as angiogenesis , cell proliferation , and tissue remodeling we have studied the localization of basic fibroblast growth factor ( bFGF ) and heparan sulfate proteoglycan ( HSPG ) in the human placenta by immunohistochemistry . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 activates multiple signaling pathways by a cell surface signaling complex assembled with FGF , its receptor tyrosine kinase , and heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Using specific antibodies , we compared the immunolocalization of the vascular heparan sulfate proteoglycan ( HSPG ) binding protein vitronectin ( VN ) , HSPG , basic fibroblast growth factor , and collagen type 1 in retinae prepared from 11 month old diabetic and nondiabetic Wistar rats . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| These purified ECM components , as well as heparan sulfate proteoglycan , did not promote oligodendroglial process extension by themselves , although laminin and fibronectin potentiated the effects of bFGF . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| A positive reaction for bFGF was also found in some endothelial cells and in myxoedematous stroma that was rich in heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Perlecan , a ubiquitous heparan sulfate proteoglycan , possesses angiogenic and growth promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor ( FGF 2 ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| In vivo involvement of heparan sulfate proteoglycan in the bioavailability , internalization , and catabolism of exogenous basic fibroblast growth factor . ^^^ Incubation of organ sections with 2 M NaCl or heparin eluted all the radioactivity , indicating that labeling was due to FGF 2 heparan sulfate proteoglycan ( HSPG ) interactions . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| These data suggest a mechanism by which cell density regulates heparan sulfate proteoglycan expression and modulates the cellular response to bFGF . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Isolated heparan sulfate proteoglycan ( HSPG ) from liver cells in cell free complexes with FGFR 4 restored the specificity for FGF 1 and supported the binding of both FGF 1 and FGF 2 when complexed with FGFR 1 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Low affinity heparan sulfate proteoglycan interactions , however , are not a prerequisite , in marked contrast to their obligatory role in FGF 2 mitogenic signaling . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Ligand binding studies indicated that elastase treatment decreased total binding of ( 125 ) 1 bFGF to the cell surface and affected both fibroblast growth factor receptor and heparan sulfate proteoglycan ( HSPG ) binding sites . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The assay has been demonstrated using a model heparan sulfate proteoglycan preparation ( perlecan from cultured bovine endothelial cells ) and FGF 2 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression of a select panel of growth factors and their receptors , including fibroblast growth factor 1 ( FGF 1 ) , fibroblast growth factor 2 ( FGF 2 ) , platelet derived growth factor ( PDGF ) , FGF receptor 1 ( FGF R 1 ) , FGF receptor 3 ( FGF R 3 ) , FGF receptor 4 ( FGF R 4 ) , PDGF receptor alpha ( PDGF Ralpha ) , PDGF receptor beta ( PDGF Rbeta ) , and heparan sulfate proteoglycan ( HSPG ) , in muscle biopsy specimens from nine facioscapulohumeral muscular dystrophy ( FSHD ) patients using immunohistochemistry . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Glypican 4 is an FGF 2 binding heparan sulfate proteoglycan expressed in neural precursor cells . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Membrane heparan sulfate proteoglycan supported FGF 2 FGFR1 signaling : evidence in support of the `` cooperative end structures ' ' model . ^^^ Here , we evaluated the effects of different heparan sulfate proteoglycan ( HSPG ) expressing cell lines and HSPGs derived from these cells on FGF 2 induced FGFR 1 phosphorylation in heparan sulfate negative BaF 3 cells . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Equilibrium ligand binding studies indicated that 125I FGF 2 binding at both cell surface receptor and heparan sulfate proteoglycan sites was reduced to different extents based on the method of proteoglycan depletion . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| However , it fully retains the FGF 2 binding ability of the original heparin , as shown by its capacity to protect FGF 2 from trypsin cleavage and to prevent the formation of heparan sulfate proteoglycan ( HSPG ) / FGF2 / FGFR1 ternary complexes . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We find that secreted FGF 2 fusion proteins accumulate in large heparan sulfate proteoglycan ( HSPG ) containing protein clusters on the extracellular surface of the plasma membrane . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Consistently with this , we have previously shown that oligodendrocyte progenitors are unable to proliferate in response to fibroblast growth factor 2 ( FGF 2 ) in the absence of sulfated heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Internalization of basic fibroblast growth factor at the mouse blood brain barrier involves perlecan , a heparan sulfate proteoglycan . ^^^ Moreover , the heparin resistant binding of [ 125I ] bFGF in TM BBB 4 cells was significantly reduced by 50 % following treatment with sodium chlorate , suggesting the loss of perlecan ( a core protein of heparan sulfate proteoglycan , HSPG ) from the extracellular matrix of the cells . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| To detect changes in the function of the BMZ , we measured immunoreactivity of the heparan sulfate proteoglycan , perlecan , and FGF 2 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| This report describes differences in heparan sulfate proteoglycan expression between myofibroblasts and normal fibroblasts , associated with impaired responses to fibroblast growth factor 2 ( FGF 2 ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We report here that heparan sulfate proteoglycan ( HSPG ) was found in bovine aqueous humor and that it directly inhibits binding of basic fibroblast growth factor and vascular endothelial growth factor to cell surface heparan sulfate . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The heparan sulfate proteoglycan agrin modulates neurite outgrowth mediated by FGF 2 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Moreover , using heparan sulfate proteoglycan ( HSPG ) deficient myeloid cells and porcine aortic endothelial cells ( PAECs ) expressing chimeric FGFR 1 , we show that antagonism of FGFR 1 mediated DNA synthesis and MAPK activation by SPARC does not require the presence of cell surface , low affinity FGF 2 receptors , but can be mediated by an intracellular mechanism that is independent of an interaction with the extracellular ligand binding domain of FGFR 1 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Although the mechanisms of action of endostatin are yet to be fully elucidated , there is evidence that bFGF and endostatin may bind competitively to heparan sulfate proteoglycan receptors on endothelial cells , or endostatin may otherwise downregulate bFGF or VEGF and its receptors , putatively inhibiting cell proliferation . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| On the other hand , lead does not exhibit cytotoxicity but inhibits the repair of endothelial monolayers after wounding by a lower response to endogenous basic fibroblast growth factor mediated by suppression of the synthesis of perlecan , a large heparan sulfate proteoglycan . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The covalently bound heparin provided a crosslinkable analog of a heparan sulfate proteoglycan , thus providing a multivalent biomaterial capable of controlled release of basic fibroblast growth factor ( bFGF ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Syndecan 1 is a multifunctional transmembrane heparan sulfate proteoglycan present on a variety of cell types that mediates basic fibroblast growth factor ( bFGF ) and other growth factor binding . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The heparan sulfate proteoglycan , glypican 1 , is a low affinity receptor for fibroblast growth factor 2 ( FGF 2 ) . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Binding studies with three HS binding growth factors , basic fibroblast growth factor ( b FGF ) , heparin binding epidermal growth factor ( HB EGF ) , and amphiregulin , showed that the HS modified CD 44 isoforms are able to bind to b FGF and HB EGF , but not AR . b FGF and HB EGF binding to HS modified CD 44 was eliminated by pretreating the protein with heparitinase or by blocking with free heparin . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have tested the effects of transforming growth factor beta 1 ( TGF beta 1 ) , basic fibroblast growth factor ( bFGF ) and TGF beta 1 + bFGF on the expression of the cell surface proteoglycans ( CD 44 , syndecans and glypican ) in cultures of human lung fibroblasts ( HLF ) . ^^^ Stimulation of the cells with TGF beta 1 increased the length of the chondroitin sulphate ( CS ) chains on CD 44 ( approximately 1 . 6 fold ) . bFGF , administered solely , also increased the length of the CS chains on CD 44 ( approximately 1 . 4 fold ) , whereas the combination of TGF beta 1 + bFGF nearly doubled both the length and the number of the CS chains on CD 44 . ^^^ This enhanced glycanation of CD 44 after the TGF beta 1 , bFGF and combined treatments correlated with a 2 fold increase in the affinity of the proteoglycan for fibronectin but had no influence on the binding to type 1 collagen . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| In contrast , cytokines such as IFN gamma , TNF alpha , or growth factors such as bFGF , SCF and TGF beta were ineffective in modulating CD 44 expression . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| DSEK cells expressed CD 44 , CD 58 , and HLA DR antigens and spontaneously produced interleukin 10 basic fibroblast growth factor and transforming growth factor beta 1 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We found that basic fibroblast growth factor ( bFGF ) and vascular endothelial growth factor were able to efficiently upregulate CD 44 expression on cultured human EC . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| CD 44 , bFGF and hyaluronan in human pancreatic cancer cell lines . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Colocalization of basic fibroblast growth factor and CD 44 isoforms containing the variably spliced exon v 3 ( CD44v3 ) in normal skin and in epidermal skin cancers . ^^^ Previous in vitro studies have shown CD 44 isoforms containing the alternatively spliced exon v 3 ( CD44v3 ) to be modified with heparan sulphate ( HS ) and to bind HS binding basic fibroblast growth factor ( bFGF ) . ^^^ In aggregate , our results suggest that a function of HS modified CD 44 isoforms such as CD44v3 in skin is to present the HS binding growth factor bFGF , thereby stimulating the proliferation of normal or transformed keratinocytes . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Last , we confirm by immunofluorescent antibody staining that inflamed synovial membrane macrophages express CD 44 HSPGs and that expression is greatest in cells containing high FGF 2 levels . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Culture of melanoma cells in the presence of hyaluronic acid resulted in a dose dependent , CD 44 mediated increase of melanoma cell proliferation and enhanced release of basic fibroblast growth factor and transforming growth factor beta 1 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| A number of angiogenic factors ( e . g . , VEGF and FGF 2 ) and matrix degrading enzymes ( MMPs ) are tightly complexed with CD 44 isoforms , suggesting that they are involved in the onset of oncogenic signals required for breast tumor cell invasion and migration . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Interestingly , blocking of hyaluronan binding to CD 44 receptors by the monoclonal antibody KM 114 inhibited the effect of hyaluronidase , but not of bFGF , on endothelial cell tube formation . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| However , strong expression of both basic fibroblast growth factor and CD 44 was detected in surrounding tissue , and expression of CD 44 was noted within the matrix of the cavernous malformation . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| These genes include EGFR , VEGF , transcription factor AP 2 , insulin growth factor binding proteins 3 and 5 , matrix metalloproteinases , tissue inhibitors of matrix metalloproteinases , CD 44 , basic fibroblast growth factor , and cathepsin H . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to establish the roles of fibrogenic autocrine cytokines ( fibroblast growth factor 2 [ FGF 2 ] and transforming growth factor beta [ TGFbeta ] ) and of different isoforms of CD 44 in this FN production . ^^^ Moreover FN , but not FGF 2 , secretion was blocked by down regulation of the v 3 isoform of CD 44 and by addition of heparitinase . ^^^ As regards CD 44 isoforms , the present work demonstrates that CD44v3 is essential for providing the heparan sulfate necessary for HC stimulation by FGF 2 , whereas the signal for production of the cytokine was provided by HA binding to CD44H , the standard hematopoietic form of the molecule . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| CD 44 negative Namalwa cells transfected with CD44vRA cDNA or with CD44v3 v 10 ( CD44vRA wild type ) cDNA bound FGF 2 to an equal extent via their associated heparan sulfate chains . ^^^ Hence , FGF 2 attached to the heparan sulfate moiety expressed by the novel CD 44 variant of RA synovium cells exhibits an augmented ability to stimulate FGFR 1 mediated activities . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Using bone marrow conditioned medium combined with basic fibroblast growth factor , we cultured a relatively homogeneous population of MPCs from murine bone marrow , which uniformly expressed stem cell antigen 1 , CD 29 , CD 44 , c kit , and CD 105 , while being negative for expression of CD 45 , CD 31 , and CD 34 . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We conclude that markers such as E cadherin , Sialosyl LeX , laminin , collagen 4 , TSP 1 and MVD are useful prognostic markers , alpha , beta , and gamma catenin , MMP 2 and 9 , uPAR , PD ECGF and Bfgf can be considered potentially useful , while research on CD 44 , MMP 1 and 3 , uPA , cathepsin D and VEGF has proved inconclusive . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| METHODS : Paraffin embedded sections from four IVL cases and 10 uterine leiomyoma cases were immunohistochemically stained for CD 34 , CD 44 , basic fibroblast growth factor ( bFGF ) , vascular endothelial growth factor , and platelet derived growth factor and assayed for microvessel densities . ^^^ Hyaluronan and its receptor CD 44 were prominently expressed in IVL when compared to leiomyomas and associated with an elevation in bFGF expression . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| The re epithelialization markers integrin alpha 3 and skin derived antileucoproteinase were remarkably increased with the presence of bFGF in a dose dependent manner , while the mesenchymal cell surface markers CD 29 and CD 44 were downregulated in a time dependent manner . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF 2 binding to the heparan sulfate side chains of CD 44 variant 3 , thus decreasing FGF 2 bioactivity . . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| Chemotaxis of CD 44 ( / ) myoblasts toward hepatocyte growth factor ( HGF ) and basic fibroblast growth factor ( bFGF ) was totally abrogated , although expression of their respective receptors did not appear to differ from wild type . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| In sheep , cows and pigs , numerous growth factor , growth factor receptor and gonadotrophin receptor mRNAs and peptides ( for example c kit , stem cell factor , GDF 9 , beta B and beta A activin / inhibin subunit , alpha inhibin subunit , follistatin , FGF 2 , EGF , EGF R , TGF beta 1 , 2 and 3 FSH R and LH R ) are expressed in a phase of growth ( for example types 1 5 ) specific and cell specific manner . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| FGF 2 signals dominated in maternal vascular endothelia ( VE ) , immature TGC , and MTC , whereas staining in other cell types was clearly weaker . ^^^ |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16070 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|