| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.50245121 |
| Soluble bFGF effectively competed with immobilized bFGF for binding to N syndecan , indicating that these two proteins also interact in solution . 0.50245121^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.75048566 |
| Purified N syndecan binds in vitro with high affinity to several extracellular regulatory ligands , including basic fibroblast growth factor , the secreted adhesive protein heparin binding growth associated molecule , and a novel collagen like protein secreted by Schwann cells . 0.75048566^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| In this study we asked whether chondrocytes produce syndecan 3 , a cell surface receptor for growth factors such as fibroblast growth factor 2 ( FGF 2 ) , and whether syndecan 3 may play a role in proliferation during chondrocyte maturation . ^^^ Treatment with FGF 2 for 24 h stimulated both syndecan 3 gene expression and chondrocyte proliferation ; this growth stimulation was counteracted by cotreatment with heparinase 1 or 3 . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| We have also found that exogenous FGF 2 maintains a domain of high level syndecan 3 expression in the outgrowing mesodermal cells of explants of the posterior mesoderm of normal limb buds cultured in the absence of the AER and in the outgrowing subapical mesoderm of explants of limbless mutant limb buds which lack a functional AER . ^^^ Finally , we report that polyclonal antibodies against a syndecan 3 fusion protein inhibit the ability of FGF 2 to promote the proliferation and outgrowth of the posterior subridge mesoderm of limb buds cultured in the absence of the AER . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| To clarify the mechanism of the IL 1 induced bFGF release , we investigated the production and gene expression of bFGF , matrix metalloproteinases ( MMPs ) , syndecan 3 , and inducible NO synthase ( iNOS ) by IL 1 treated rabbit articular chondrocytes . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| Syndecan 3 is a member of a family of transmembrane proteoglycans that posses highly homologous cytoplasmic and transmembrane domains and function as extracellular matrix receptors and low affinity receptors for signaling molecules such as basic fibroblasts growth factor ( FGF 2 ) . ^^^ In this study we investigated the expression of syndecan 3 and its role on FGF 2 dependent inhibition of myogenesis . ^^^ Reduced expression of syndecan 3 resulted in a 13 fold decrease in sensitivity to FGF 2 dependent inhibition of myogenin expression . ^^^ These results demonstrate that syndecan 3 expression is down regulated during differentiation and the level of expression of membrane bound heparan sulfate on myoblast surface is critical for fine modulation of responsiveness to FGF 2 . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| Proliferation was stimulated by as much as 8 10 fold within 24 h ; strikingly , this stimulation was significantly prevented when the cells were treated with both fibroblast growth factor 2 ( FGF 2 ) and antibodies against syndecan 3 core protein . ^^^ The syndecan 3 antibodies interfered only with FGF 2 mitogenic action , but not that of insulin like growth factor 1 or parathyroid hormone . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| Here we show that members of three families of heparan sulfate proteoglycans , syndecan , perlecan , and glypican , are developmentally and posttranscriptionally regulated during oligodendrocyte lineage progression : Syndecan 3 is synthesized by oligodendrocyte progenitors ( but not terminally differentiated oligodendrocytes ) and is up regulated by FGF 2 ; perlecan synthesis increases as oligodendrocytes undergo terminal differentiation ; glypican 1 is expressed by both progenitors and differentiated oligodendrocytes . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| The spatiotemporal expression of syndecan 3 during feather development suggests that this cell surface HSPG may be involved in the response of competent embryonic skin dermis to FGF 2 . . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| Double staining techniques showed that heparan sulfate was found predominantly at the basal aspect of the endothelium and suggested that syndecan 3 might function as one of the proteoglycans involved in FGF 2 signaling in the endothelium . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| In a solid phase binding assay , N syndecan was found to bind to HB GAM in a similar manner as to basic fibroblast growth factor ( KD = 0 . 6 nM ) . ^^^ |
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| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75056 and P09038 |
Pubmed |
SVM Score :0.0 |
| NA |
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