| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.73176547 |
| These results are the first to demonstrate an association between CD 63 and two other TM4SF members , CD 9 and CD 81 in 2 human melanoma cell lines . 0.73176547^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| To date there are 13 members including ME 491 ( CD 63 , Pltgp 40 ) , CD 9 ( p 23 ) , TAPA 1 , CD 37 , CD 53 , MRC OX 44 , CO 029 , MRP 1 , L 6 , the gene product of TI 1 , the target of mAb AD 1 , SM 23 , and SJ 23 ( the Schistosoma japonicum homologue ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The deduced amino acid sequence from the bovine CD 9 cDNA clone shows 83 . 5 % identity with the human counterpart isolated from megakaryocytes , and a lower degree of identity with a group of related antigens ( TAPA 1 , C 0 029 , CD 53 , MRC OX 44 , ME 491 , CD 63 , CD 37 , and Sm 23 ) involved in growth regulation . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Numerous non melanoma associated proteins ( Sm 23 , CO 029 , R 2 , TAPA 1 , CD 9 , CD 37 , CD 53 , and CD 63 ) have recently been shown to have significant homology to this sequence . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The C 33 gene was found to belong to a newly defined family of genes for membrane proteins , such as CD 9 , CD 37 , CD 53 , CD 63 , and TAPA 1 , and was identical to R 2 , a cDNA recently isolated because of its strong up regulation after T cell activation . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Several of the recently described leucocyte surface ( glyco ) proteins with significant amino acid sequence similarity ( human CD 9 , CD 37 , CD 53 , CD 63 , TAPA 1 , CO 029 and R 2 and several homologues of other species ) are distinguished by the polypeptide chain apparently four times crossing the membrane . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The IA 4 protein belongs to the tetra span transmembrane ( TST ) new family of surface molecules , which also includes CD 9 , CD 37 , CD 53 , CD 63 , and TAPA 1 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Mapping of the genes for four members of the transmembrane 4 superfamily : mouse Cd 9 , Cd 63 , Cd 81 , and Cd 82 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The CD 82 Ag , which belongs to the new tetra span transmembrane family ( CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ( TAPA 1 ) ) , has been identified originally in our laboratory for its enhanced expression on three LAK susceptible cell lines , and has been characterized as an activation / differentiation marker of mononuclear cells . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| This protein belongs to the new family of TST proteins ( tetra spans transmembrane ) , which includes CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ( TAPA 1 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The genomic organization of CD 82 is quite similar to that of three other TM4SF members whose genomic structures were described , i . e . , Tapa 1 ( CD 81 ) , CD 53 , and CD 63 . ^^^ Northern blot analysis was also carried out for CD 81 , CD 53 , and CD 63 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 81 ( TAPA 1 ) and CD 82 ( R 2 ) are new members of the tetra spans family of transmembrane proteins , which include CD 9 , CD 37 , CD 53 and CD 63 . ^^^ CD 81 ( TAPA 1 ) and CD 82 ( R 2 ) are new members of the tetra spans family of transmembrane proteins , which include CD 9 , CD 37 , CD 53 and CD 63 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 9 antigen belongs to a new cell surface protein family which includes TAPA 1 and the platelet activation antigen CD 63 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The exon intron organization of the CD 53 gene is strikingly similar to the CD 63 and TAPA 1 genes , which suggests a close evolutionary relationship between these genes . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| First , the gene structure of CD 53 was strikingly similar to two other members of the TM4SF , CD 63 and TAPA 1 ; second , Cd 37 mapped to the same chromosome as Tapa 1 ; and , third , Cd 37 mapped to a segment of chromosome 7 that contains a number of genes that are structurally or functionally related to genes closely linked to Cd 53 on chromosome 3 . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Immunohistological methods were used to examine the relation between the metastatic potential of melanoma and expression of the neuroglandular antigen ( CD 63 ) and other members of this family of molecules , CD 53 , CD 37 , CD 9 and the target of an anti proliferative antibody ( TAPA 1 ) , as well as MHC class 1 and 2 antigens . ^^^ CD 63 and TAPA 1 were expressed on nevi but not on SCC and BCC . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The organization of its gene closely resembles the organization of the genes for two other members of this protein family , TAPA 1 and CD 63 , which share with CD 9 respectively 45 and 25 % identity at the amino acid level . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Staining of human tissues yielded additional results consistent with co localization of alpha 3 beta 1 and CD 9 , CD 63 , and CD 81 proteins . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Transmembrane 4 superfamily proteins CD 81 ( TAPA 1 ) , CD 82 , CD 63 , and CD 53 specifically associated with integrin alpha 4 beta 1 ( CD49d / CD29 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 9 , CD 63 , CD 81 , and CD 82 are components of a surface tetraspan network connected to HLA DR and VLA integrins . ^^^ CD 9 , CD 63 , CD 81 , and CD 82 are glycoproteins of unknown function which belong to the tetraspan superfamily . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| A novel link between integrins , transmembrane 4 superfamily proteins ( CD 63 and CD 81 ) , and phosphatidylinositol 4 kinase . ^^^ Enzymatic and immunochemical assays show a phosphatidylinositol 4 kinase in novel and specific complexes with proteins ( CD 63 and CD 81 ) of the transmembrane 4 superfamily ( TM4SF ) and an integrin ( alpha3beta1 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| A brief overview indicates that some tetraspanins are found in virtually all tissues ( CD 81 , CD 82 , CD 9 , CD 63 ) , whereas others are highly restricted , such as CD 37 ( B cells ) or CD 53 ( lymphoid and myeloid cells ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The specificity of this interaction is demonstrated by the fact that other tetraspans , CD 63 , CD 81 , and CD 82 , do not associate with pre beta 1 , and CD 9 does not associate with immature human histocompatibility leukocyte antigen class 1 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 9 , CD 53 , CD 63 , CD 81 , and CD 82 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Expression of tetra spans transmembrane family ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 and CD 82 ) in normal and neoplastic human keratinocytes : an association of CD 9 with alpha 3 beta 1 integrin . ^^^ Tetra spans transmembrane family ( TSTF ) members ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 and CD 82 ) have potent effects on cell growth , motility and adhesion in various cells . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The tetraspanin superfamily ( or TM4SF ) includes CD 81 , CD 9 , CD 37 , CD 53 , CD 63 , CD 82 , CD 151 , and an increasing number of additional proteins . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| C4 . 8 is a new member of the transmembrane 4 ( TM 4 ) protein family which includes tumor associated antigens such as CD 63 and TAPA 1 , whereas C21 . 7 shows no significant homologies to any known genes or proteins . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that exosomes are enriched in the co stimulatory molecule CD 86 and in several tetraspan proteins , including CD 37 , CD 53 , CD 63 , CD 81 , and CD 82 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| There are five antigens which are detected in 90 % of cell lines at high levels , CD 53 , CD 81 , CD 63 , SAS and CD 82 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Foreskin MC were also recognized by MoAb to CD 47 , CD 48 , CD49d , CD 53 , CD 60 , CD 63 , CD 81 , CD 82 , CD 84 , CD 87 , CD 92 , CD 97 , CD 98 , and CD 99 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 81 , a molecule with 4 transmembrane domains , member of the tetraspan superfamily , is engaged , together with other tetraspans such as CD 9 , CD 53 , CD 63 , and CD 82 , in multimolecular complexes containing beta 1 integrins and major histocompatibility complex antigens . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 151 also associated with other tetraspans in an apparently cell type specific fashion , as defined by its co precipitation with CD 9 , CD 63 and CD 81 from M07e cells , but not from K 562 cells , which express similar levels of these proteins . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| A truncated soluble form of the hepatitis C virus E 2 glycoprotein , E 2661 , binds specifically to the surface of cells expressing human CD 81 ( hCD 81 ) but not other members of the tetraspanin family ( CD 9 , CD 63 , and CD 151 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The authors characterized immunohistologically the localization of six members of TSTF ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 , and CD 82 ) in the normal epithelium from esophagus to colon . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Double immunofluorescence staining showed that various TM4SF proteins , including CD 9 , CD 63 , CD 81 , CD 82 , and CD 151 are colocalized within dot like structures that are particularly abundant at the cell periphery . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Freshly isolated eosinophils expressed CD 9 , CD 37 , CD 53 , CD 63 and CD 81 . ^^^ Incubation with anti CD 9 mAb but not with anti CD 37 , CD 53 , CD 63 or CD 81 mAb induced significant eosinophil homotypic aggregation . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| GST fusion proteins containing the second extracellular domain of different tetraspanins ( CD 9 , CD 63 , CD 53 , CD 81 , A 15 or CO 029 ) were produced separately . ^^^ Several clones binding the fusion protein were identified for each construct tested : four anti CD 9 hybridoma clones , four anti CD 63 , two anti CD 53 , two anti CD 81 , three anti A 15 and one anti CO 029 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments revealed that not only CD 9 but also other TM 4 proteins including CD 63 , CD 81 , and CD 82 associate with proHB EGF on the cell surface . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here we show that TM4SF proteins CD 151 , CD 81 , and CD 63 co distribute with alpha3beta1 integrin on neurites and growth cones of human NT2N cells . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 37 is a membrane protein of the tetraspanin superfamily , which includes CD 9 , CD 53 , CD 63 , CD 81 , and CD 82 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that at least five different TM4SF proteins ( CD 9 , CD 63 , CD 81 , CD 151 and A15 / TALLA1 ) can associate with a similar or identical 55 kDa type 2 PI 4 kinase . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here we show that prototype complexes of CD 9 or CD 81 ( TM4SF proteins ) with alpha ( 3 ) beta ( 1 ) ( an integrin ) and complexes of CD 63 ( a TM4SF protein ) with phosphatidylinositol 4 kinase ( PtdIns 4 K ) may indeed localize within lipid raft like microdomains , as seen by three different criteria . ^^^ However , CD 9 alpha3beta1 , CD 81 alpha3beta1 , and CD 63 PtdIns 4 K complex formation itself was not dependent on localization into raftlike lipid microdomains . ^^^ In summary , prototype TM4SF protein complexes ( CD 9 alpha3beta1 , CD 81 alpha3beta1 , and CD 63 PtdIns 4 K ) can be solubilized as discrete units , independent of lipid microdomains , although they do associate with microdomains resembling lipid rafts . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| CD 9 , CD 81 , CD 63 , and wild type CD 151 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| PSG 17 did not bind to cells transfected with CD 53 , CD 63 , CD 81 , CD 82 , or CD 151 , suggesting that PSG 17 CD9 binding is a specific interaction . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| All tetraspanins studied , CD 9 , CD 37 , CD 53 , CD 63 , CD 81 , CD 82 and CD 151 , were found to incorporate [ 3H ] palmitate . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| We report that TM4SF molecules CD 9 , CD 63 , and CD 81 are physically associated with c kit receptor tyrosine kinase in the human factor dependent myeloid cell line , MO7e . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The association of the palmitoylation deficient mutant of CD 151 ( CD151Cys8 ) with CD 81 and CD 63 was markedly decreased , but the interaction of the alpha ( 3 ) beta ( 1 ) CD151Cys8 complex with phosphatidylinositol 4 kinase was not affected . ^^^ Ectopic expression of CD151Cys8 in Rat 1 cells impaired the interactions of the endogenous CD 63 and CD 81 with the alpha ( 3 ) beta ( 1 ) integrin . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| We evaluated the expression and function of four TM4SF , namely CD 9 , CD 81 , CD 63 and CD 151 , and their involvement in HSC migration , adhesion , and proliferation . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| These particles contain antigen presenting molecules ( MHC class 1 , MHC class 2 , and CD 1 ) , tetraspan molecules ( CD 9 , CD 63 , CD 81 ) , adhesion molecules ( CD11b and CD 54 ) , and costimulatory molecules ( CD 86 ) ; hence , providing them the necessary machinery required for generating a potent immune response [ J . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| To this end , MHC molecules become incorporated into two types of membrane microdomains : ( 1 ) cholesterol and glycosphingolipid enriched domains , denoted lipid rafts , that preconcentrate MHC class 2 molecules ; and ( 2 ) microdomains made up of tetraspan proteins , such as CD 9 , CD 63 , CD 81 or CD 82 , that mediate enrichment of MHC class 2 molecules loaded with a select set of peptides . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here we screened 30 lung cancer cell lines for expression of tetraspanins , CD 9 , CD 63 , CD 81 , CD 82 , CD 151 , and NAG 2 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Pretreatment of primary macrophages with anti CD 63 MAb , but not MAbs to other macrophage cell surface tetraspanins ( CD 9 , CD 81 , and CD 82 ) , was shown to inhibit infection by several R 5 and dualtropic strains , but not by X 4 isolates . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| We show that CD 63 , CD 9 , CD 81 , CD 82 , and CD 151 are present in immature DCs . ^^^ Whereas CD 9 and CD 81 are mostly expressed at the cell surface , CD 63 and CD 82 are also located in intracellular organelles . ^^^ Mabs against CD 9 , CD 63 , CD 81 , and CD 82 enhanced by 50 % the migration induced by the chemokines macrophage inflammatory protein 5 ( MIP 5 ) and MIP 1alpha . ^^^ These results suggest that CD 9 , CD 63 , CD 81 , and CD 82 could play a role in modulating the interactions between immature DCs and their environment , slowing their migratory ability . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| They expressed high levels of CD 29 , CD 63 , CD 81 , CD 122 , CD 164 , hepatocyte growth factor receptor ( cMet ) , bone morphogenetic protein receptor 1B ( BMPR1B ) , and neurotrophic tyrosine kinase receptor 3 ( NTRK 3 ) and were negative for CD 34 , CD 36 , CD 45 , CD 117 ( cKit ) and HLADR . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Membranal and cytoplasmic expression of CD 9 , CD 53 , CD 63 , CD 81 , CD 82 and CD 151 in polymorphonuclears ( PMN ) , monocytes , B and T lymphocytes was assessed using flow cytometry . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Our results show that HACs express surface molecules belonging to different categories : integrins and other adhesion molecules ( CD49a , CD49b , CD49c , CD49e , CD49f , CD51 / 61 , CD 54 , CD 106 , CD 166 , CD 58 , CD 44 ) , tetraspanins ( CD 9 , CD 63 , CD 81 , CD 82 , CD 151 ) , receptors ( CD 105 , CD 119 , CD 130 , CD140a , CD 221 , CD 95 , CD120a , CD 71 , CD 14 ) , ectoenzymes ( CD 10 , CD 26 ) , and other surface molecules ( CD 90 , CD 99 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here , we show that palmitoylated integrins ( alpha 3 , alpha 6 , and beta 4 subunits ) and tetraspanins ( CD 9 , CD 81 , and CD 63 ) coexist in substantially overlapping complexes . ^^^ Also in palmitoylation deficient beta 4 , secondary associations with tetraspanins ( CD 9 , CD 81 , and CD 63 ) were diminished and cell surface CD 9 clustering was decreased , whereas core alpha6beta4 CD 151 complex formation was unaltered . ^^^ Instead , palmitoylation of beta 4 ( and of the closely associated tetraspanin CD 151 ) promotes CD 151 alpha6beta4 incorporation into a network of secondary tetraspanin interactions ( with CD 9 , CD 81 , CD 63 , etc . ) , which provides a novel framework for functional regulation . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The majority of pancreatic and colorectal tumors expressed the alpha 2 , alpha 3 , alpha 6 , beta 1 , and beta 4 integrins and the tetraspanins CD 9 , CD 63 , CD 81 , CD 151 , and CO 029 . ^^^ CD 63 , CD 81 , and beta 1 expression was observed at comparably high levels in healthy pancreatic tissue . alpha3beta1 frequently colocalized and coimmunoprecipitated with CD 9 , CD 81 , and CD 151 , whereas alpha6beta4 colocalized and coimmunoprecipitated mostly with CD 151 and CO 029 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence microscopy indicates that the virus containing compartment in mature DCs ( mDCs ) co labels for the tetraspanins CD 81 , CD 82 , and CD 9 but contains little CD 63 or LAMP 1 . ^^^ Using electron microscopy , we confirm that HIV 1 accumulates in intracellular vacuoles that contain CD 81 positive internal membranes but overlaps only partially with CD 63 . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| We observed that these plasma derived vesicles contain tetraspanin molecules such as CD 63 , CD 9 , CD 81 as well as class 1 and class 2 MHC molecules and Lamp 2 ( i . e . proteins that are known to be enriched in exosomes ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The surface expression of several tetraspanin antigens ( CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ) , and their interacting proteins ( CD 19 , CD 21 , and HLA DR ) were analyzed during normal B cell maturation and compared to a group of 67 B cell neoplasias . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Sorting of subpopulations indicated that the MHC 2 containing exosomes were enriched in Bodipy PC , whereas tetraspanin ( CD 63 or CD 81 ) containing exosomes are essentially labeled with Bodipy Cer and Bodipy PC . ^^^ CD 63 , MHC 2 , and CD 81 containing exosomes accounted for 47 % , 32 % , and 21 % , respectively , of total exosomes . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here , we reveal the presence of tetraspanin enriched microdomains ( TEMs ) containing the tetraspanins CD 9 , CD 63 , CD 81 , and CD 82 at the plasma membrane . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Here , we show that recombinant soluble forms of the large extracellular domain ( EC 2 ) of human tetraspanins CD 9 , CD 63 , CD 81 , and CD 151 produced as fusion proteins with glutathione S transferase ( GST ) can all potently and completely inhibit R 5 HIV 1 infection of macrophages with 50 % inhibitory concentration values of 0 . 11 to 1 . 2 nM . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| The encoded protein belongs to a family of surface molecules , the tetra spans transmembrane protein superfamily , all displaying the four transmembrane domains , expressed on various cell types including lymphocytes ( CD 9 , CD 37 , CD 53 , TAPA 1 ) , melanoma cells ( ME 491 ) , and intestinal cells ( CO 029 ) . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| TAPA 1 showed strong homology with the CD 37 leukocyte antigen and with the ME 491 melanoma associated antigen , both of which have been implicated in the regulation of cell growth . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis revealed that MRP 1 had strong similarity with a B cell surface antigen ( CD 37 ) , a melanoma associated antigen ( ME 491 ) , the target of an antiproliferative antibody ( TAPA 1 ) , a human tumor associated antigen ( CO 029 ) , and the Sm 23 antigen of the trematode parasite Schistosoma mansoni . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Sequence comparisons revealed that pRcT7a / MRC OX 44 is a member of a family of genes which includes the melanoma specific antigen ME 491 ; the human leukocyte antigen CD 37 ; the protein TAPA 1 , which is expressed on the surface of human T cells and appears to be involved in growth regulation ; the human gastrointestinal tumor antigen CO 029 ; and the Schistosoma mansoni associated antigen Sm23 . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| Comparison of SAS organization to human ME 491 , CD 9 , and CD 53 and murine CD 53 and TAPA 1 confirms that SAS is a member of this family of genes and is consistent with the theory that these genes arose through duplication and divergent evolution . . ^^^ |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08962 and P60033 |
Pubmed |
SVM Score :0.0 |
| NA |
|