Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.65913453 |
CD 63 associates with the alphaIIb beta 3 integrin CD 9 complex on the surface of activated platelets . 0.65913453^^^ The association of CD 63 with CD 9 and alphaIIbbeta 3 , was not inhibited by preincubation of platelets with RGDS or EGTA . 0.55497773^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.53677057 |
Sequence and structural comparisons showed extensive similarity of the CD 9 antigen with a 237 amino acid molecule described previously as the human melanoma associated antigen ME 491 and a Schistosoma mansoni membrane protein of 218 amino acids . 0.53677057^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
To date there are 13 members including ME 491 ( CD 63 , Pltgp 40 ) , CD 9 ( p 23 ) , TAPA 1 , CD 37 , CD 53 , MRC OX 44 , CO 029 , MRP 1 , L 6 , the gene product of TI 1 , the target of mAb AD 1 , SM 23 , and SJ 23 ( the Schistosoma japonicum homologue ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The deduced amino acid sequence from the bovine CD 9 cDNA clone shows 83 . 5 % identity with the human counterpart isolated from megakaryocytes , and a lower degree of identity with a group of related antigens ( TAPA 1 , C 0 029 , CD 53 , MRC OX 44 , ME 491 , CD 63 , CD 37 , and Sm 23 ) involved in growth regulation . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Numerous non melanoma associated proteins ( Sm 23 , CO 029 , R 2 , TAPA 1 , CD 9 , CD 37 , CD 53 , and CD 63 ) have recently been shown to have significant homology to this sequence . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
C 33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1 induced syncytium formation is a member of a new family of transmembrane proteins including CD 9 , CD 37 , CD 53 , and CD 63 . ^^^ The C 33 gene was found to belong to a newly defined family of genes for membrane proteins , such as CD 9 , CD 37 , CD 53 , CD 63 , and TAPA 1 , and was identical to R 2 , a cDNA recently isolated because of its strong up regulation after T cell activation . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Novel structurally distinct family of leucocyte surface glycoproteins including CD 9 , CD 37 , CD 53 and CD 63 . ^^^ Several of the recently described leucocyte surface ( glyco ) proteins with significant amino acid sequence similarity ( human CD 9 , CD 37 , CD 53 , CD 63 , TAPA 1 , CO 029 and R 2 and several homologues of other species ) are distinguished by the polypeptide chain apparently four times crossing the membrane . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The IA 4 protein belongs to the tetra span transmembrane ( TST ) new family of surface molecules , which also includes CD 9 , CD 37 , CD 53 , CD 63 , and TAPA 1 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Of the progenitor myeloid markers examined ( CD 9 , CD 13 , CD 33 , CD 34 , and CD 63 ) , only the percent expression of CD 9 was significantly increased on HTLV 1 and 2 infected cell lines as compared with that on virus negative cell lines . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Mapping of the genes for four members of the transmembrane 4 superfamily : mouse Cd 9 , Cd 63 , Cd 81 , and Cd 82 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The CD 82 Ag , which belongs to the new tetra span transmembrane family ( CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ( TAPA 1 ) ) , has been identified originally in our laboratory for its enhanced expression on three LAK susceptible cell lines , and has been characterized as an activation / differentiation marker of mononuclear cells . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
According to previous findings , basophils express CD 9 ( p 24 ) , CD11a ( LFA 1 alpha chain ) , CD11b ( C3biR ) , CD11c ( CR 4 ) , CD 13 ( aminopeptidase N ) , CDw 17 ( lactosylceramide ) , CD 18 ( beta chain of beta 2 ) , CD 25 ( IL 2R alpha chain ) , CD 26 ( dipeptidylpeptidase ) , CD 31 ( PECAM ) , CD 35 ( CR 1 ) , CD 38 ( T 10 ) , CD 43 ( leukosialin ) , CD 44 ( Pgp 1 ) , CD 45 ( pan leukocyte Ag ) , and CD 63 ( basophil activation Ag ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
This protein belongs to the new family of TST proteins ( tetra spans transmembrane ) , which includes CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ( TAPA 1 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Intimal MPs expressed a wide range of macrophage associated antigens , including receptors for Fc ( CD 16 , CD 32 , CD 64 ) and complement ( CD 35 , CD11b , CD11c ) as well as several integrin and non integrin cell adhesion molecules ( CD29 / CD49b , CD49d , CD49f , CD51 / CD61 , CD11a , CD 31 , CD 54 , CD 44 , CD 9 , CD 63 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 81 ( TAPA 1 ) and CD 82 ( R 2 ) are new members of the tetra spans family of transmembrane proteins , which include CD 9 , CD 37 , CD 53 and CD 63 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The sequences of UPIa and UPIb ( the latter is almost identical to a hypothetical , TGF beta inducible , TI 1 protein of mink lung epithelial cells ) are homologous to members of a recently described family all possessing four transmembrane domains ( the `` 4TM family ' ' ) ; members of this family include many important leukocyte differentiation markers such as CD 9 , CD 37 , CD 53 , and CD 63 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 9 antigen belongs to a new cell surface protein family which includes TAPA 1 and the platelet activation antigen CD 63 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Immunohistological methods were used to examine the relation between the metastatic potential of melanoma and expression of the neuroglandular antigen ( CD 63 ) and other members of this family of molecules , CD 53 , CD 37 , CD 9 and the target of an anti proliferative antibody ( TAPA 1 ) , as well as MHC class 1 and 2 antigens . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The organization of its gene closely resembles the organization of the genes for two other members of this protein family , TAPA 1 and CD 63 , which share with CD 9 respectively 45 and 25 % identity at the amino acid level . . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 63 associates with transmembrane 4 superfamily members , CD 9 and CD 81 , and with beta 1 integrins in human melanoma . ^^^ These results are the first to demonstrate an association between CD 63 and two other TM4SF members , CD 9 and CD 81 in 2 human melanoma cell lines . ^^^ We are also able to identify an association between CD 9 and CD 63 with beta 1 integrins in melanoma . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Staining of human tissues yielded additional results consistent with co localization of alpha 3 beta 1 and CD 9 , CD 63 , and CD 81 proteins . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 9 , CD 63 , CD 81 , and CD 82 are components of a surface tetraspan network connected to HLA DR and VLA integrins . ^^^ CD 9 , CD 63 , CD 81 , and CD 82 are glycoproteins of unknown function which belong to the tetraspan superfamily . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Thrombin activation resulted in significant increases in platelet surface expression of CD62P , CD 63 , CD 41 , CD 9 , and CD 36 in neonates and their healthy mothers . ^^^ Compared with neonates of healthy mothers , platelets from neonates of preeclamptic mothers expressed lower levels of CD62P , CD 63 , CD 9 , and CD 36 on activated platelets . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Localization of the transmembrane 4 superfamily ( TM4SF ) member PETA 3 ( CD 151 ) in normal human tissues : comparison with CD 9 , CD 63 , and alpha5beta1 integrin . ^^^ It has recently been shown that several members of the tetraspan superfamily , including CD 9 and CD 63 , associate with each other and with beta 1 integrins . ^^^ In this study , we examined the distribution of a recently identified tetraspan , PETA 3 ( CD 151 ) , and of CD 9 , CD 63 , alpha5beta1 , and the integrin beta 1 chain in normal human tissues by the indirect immunoperoxidase and alkaline phosphatase anti alkaline phosphatase techniques . ^^^ CD 9 was expressed on the plasma membrane of enterocytes in crypts and at the bases of the villi whereas CD 63 demonstrated a unique granular appearance concentrated in the apical cytoplasm below the brush border . ^^^ The findings of this study show co localization of PETA 3 with CD 9 , CD 63 , alpha5beta1 , and beta 1 in particular tissues , demonstrating that tetraspan / integrin complexes may occur . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
A brief overview indicates that some tetraspanins are found in virtually all tissues ( CD 81 , CD 82 , CD 9 , CD 63 ) , whereas others are highly restricted , such as CD 37 ( B cells ) or CD 53 ( lymphoid and myeloid cells ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The specificity of this interaction is demonstrated by the fact that other tetraspans , CD 63 , CD 81 , and CD 82 , do not associate with pre beta 1 , and CD 9 does not associate with immature human histocompatibility leukocyte antigen class 1 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 9 , CD 53 , CD 63 , CD 81 , and CD 82 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
These included an integrin ( alpha6beta1 ) and three different TM4SF proteins ( CD 9 , CD 63 , and NAG 2 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Expression of tetra spans transmembrane family ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 and CD 82 ) in normal and neoplastic human keratinocytes : an association of CD 9 with alpha 3 beta 1 integrin . ^^^ Tetra spans transmembrane family ( TSTF ) members ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 and CD 82 ) have potent effects on cell growth , motility and adhesion in various cells . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Double staining with toluidine blue and immunofluorescence using monoclonal antibodies ( mAbs ) revealed expression of stem cell factor ( SCF ) receptor ( c kit / CD117 ) , CD 9 , CD 29 , CD 33 , CD 43 , CD 44 , CD 54 , and CD 63 on HRMCs . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The tetraspanin superfamily ( or TM4SF ) includes CD 81 , CD 9 , CD 37 , CD 53 , CD 63 , CD 82 , CD 151 , and an increasing number of additional proteins . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 151 ( PETA 3 / SFA 1 ) is a member of the Transmembrane 4 Superfamily ( TM4SF ) of cell surface proteins and , like other TM4SF members CD 9 and CD 63 , is expressed by platelets , megakaryocytes and endothelial cells . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 81 , a molecule with 4 transmembrane domains , member of the tetraspan superfamily , is engaged , together with other tetraspans such as CD 9 , CD 53 , CD 63 , and CD 82 , in multimolecular complexes containing beta 1 integrins and major histocompatibility complex antigens . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 151 also associated with other tetraspans in an apparently cell type specific fashion , as defined by its co precipitation with CD 9 , CD 63 and CD 81 from M07e cells , but not from K 562 cells , which express similar levels of these proteins . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
In this study we show that another classical mild detergent , digitonin , dissociated most of these associated molecules , including integrins , from the tetraspans CD 9 , CD 37 , CD 53 , CD 63 , CD 82 , Co 029 , Talla 1 and NAG 2 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
A truncated soluble form of the hepatitis C virus E 2 glycoprotein , E 2661 , binds specifically to the surface of cells expressing human CD 81 ( hCD 81 ) but not other members of the tetraspanin family ( CD 9 , CD 63 , and CD 151 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The authors characterized immunohistologically the localization of six members of TSTF ( CD 9 , CD 37 , CD 53 , CD 63 , CD 81 , and CD 82 ) in the normal epithelium from esophagus to colon . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Double immunofluorescence staining showed that various TM4SF proteins , including CD 9 , CD 63 , CD 81 , CD 82 , and CD 151 are colocalized within dot like structures that are particularly abundant at the cell periphery . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
There is a correlation between invasive capability and changes in the expression of some proteins that are clustered in focal adhesion sites , as FAK , CD 82 , CD 9 or CD 63 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
RESULTS : Freshly isolated eosinophils expressed CD 9 , CD 37 , CD 53 , CD 63 and CD 81 . ^^^ Incubation with anti CD 9 mAb but not with anti CD 37 , CD 53 , CD 63 or CD 81 mAb induced significant eosinophil homotypic aggregation . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
GST fusion proteins containing the second extracellular domain of different tetraspanins ( CD 9 , CD 63 , CD 53 , CD 81 , A 15 or CO 029 ) were produced separately . ^^^ Several clones binding the fusion protein were identified for each construct tested : four anti CD 9 hybridoma clones , four anti CD 63 , two anti CD 53 , two anti CD 81 , three anti A 15 and one anti CO 029 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The tetraspanins CD 9 , KAI 1 / CD82 , and CD 63 are involved in metastasis suppression , an effect that may be related to their association with beta 1 integrins . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Immunoprecipitation experiments revealed that not only CD 9 but also other TM 4 proteins including CD 63 , CD 81 , and CD 82 associate with proHB EGF on the cell surface . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 37 is a membrane protein of the tetraspanin superfamily , which includes CD 9 , CD 53 , CD 63 , CD 81 , and CD 82 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here we demonstrate that at least five different TM4SF proteins ( CD 9 , CD 63 , CD 81 , CD 151 and A15 / TALLA1 ) can associate with a similar or identical 55 kDa type 2 PI 4 kinase . ^^^ CD 63 PI 4 kinase complexes were almost entirely intracellular , and thus are distinct from other TM4SF PI 4 kinase complexes ( e . g . involving CD 9 ) , which are largely located in the plasma membrane . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here we show that prototype complexes of CD 9 or CD 81 ( TM4SF proteins ) with alpha ( 3 ) beta ( 1 ) ( an integrin ) and complexes of CD 63 ( a TM4SF protein ) with phosphatidylinositol 4 kinase ( PtdIns 4 K ) may indeed localize within lipid raft like microdomains , as seen by three different criteria . ^^^ However , CD 9 alpha3beta1 , CD 81 alpha3beta1 , and CD 63 PtdIns 4 K complex formation itself was not dependent on localization into raftlike lipid microdomains . ^^^ In summary , prototype TM4SF protein complexes ( CD 9 alpha3beta1 , CD 81 alpha3beta1 , and CD 63 PtdIns 4 K ) can be solubilized as discrete units , independent of lipid microdomains , although they do associate with microdomains resembling lipid rafts . . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 9 and CD 63 belong to a tetramembrane spanning glycoprotein family called tetraspanin , and are involved in a wide variety of cellular processes , but the structure function relationship of this family of proteins has yet to be clarified . ^^^ CD 9 upregulates the diphtheria toxin ( DT ) binding activity of DTR / proHB EGF , while CD 63 does not upregulate the DT binding activity in spite of the fact that this protein also associates with DTR / proHB EGF on the cell surface . ^^^ CD 9 molecules localize on the cell surface , while those of CD 63 localize predominantly at lysosomes and intracellular compartments . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
CD 9 , CD 81 , CD 63 , and wild type CD 151 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
PMP stimulation of ECs increased CD 54 and CD 63 but not CD 9 , CD 29 , and CD 31 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Neither SETs nor LPS was able to modulate eosinophil surface expression of CD 9 , CD11a , CD 16 , CD 40 , CD 44 , or CD 63 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
However , the CD 151 tetra mutant showed markedly diminished associations with other cell surface proteins , including other transmembrane 4 superfamily proteins ( CD 9 , CD 63 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
All tetraspanins studied , CD 9 , CD 37 , CD 53 , CD 63 , CD 81 , CD 82 and CD 151 , were found to incorporate [ 3H ] palmitate . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
We report that TM4SF molecules CD 9 , CD 63 , and CD 81 are physically associated with c kit receptor tyrosine kinase in the human factor dependent myeloid cell line , MO7e . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
We evaluated the expression and function of four TM4SF , namely CD 9 , CD 81 , CD 63 and CD 151 , and their involvement in HSC migration , adhesion , and proliferation . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
These particles contain antigen presenting molecules ( MHC class 1 , MHC class 2 , and CD 1 ) , tetraspan molecules ( CD 9 , CD 63 , CD 81 ) , adhesion molecules ( CD11b and CD 54 ) , and costimulatory molecules ( CD 86 ) ; hence , providing them the necessary machinery required for generating a potent immune response [ J . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Tetraspan antigens presented a rather unique staining pattern in the human spleen , suggesting special roles for each ( CD 9 , CD 53 , CD 63 , CD 151 and CD 231 ) in certain locations . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
To this end , MHC molecules become incorporated into two types of membrane microdomains : ( 1 ) cholesterol and glycosphingolipid enriched domains , denoted lipid rafts , that preconcentrate MHC class 2 molecules ; and ( 2 ) microdomains made up of tetraspan proteins , such as CD 9 , CD 63 , CD 81 or CD 82 , that mediate enrichment of MHC class 2 molecules loaded with a select set of peptides . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
MOLM 16 revealed characteristics of the megakaryocytic lineage in terms of immunophenotyping being positive for CD 9 , CD 31 , CD 36 , CD 41 , CD 61 , CD62P , CD 63 , CD 110 , CD 151 , thrombospondin , von Willebrand factor ( vWf ) , and fibrinogen . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here we screened 30 lung cancer cell lines for expression of tetraspanins , CD 9 , CD 63 , CD 81 , CD 82 , CD 151 , and NAG 2 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
We describe the exact quantification of mRNAs coding for the tetraspanins CD 9 , CD 63 , CD 82 and CD 151 expressed by mammary carcinoma derived cell lines that were classified as invasive or non invasive according to their ability to penetrate collagen fibroblast gels in vitro . ^^^ The mean of beta 2 microglobulin normalized expression of CD 9 was about 10 fold higher than the mean calculated for CD 63 and about 20 fold higher than expression of CD 82 and CD 151 . ^^^ Grouping of cell lines in relation to threshold values of expression resulted in significant correlations for CD 63 ( Fisher ' s exact test p=0 . 004 ) and CD 151 ( p=0 . 02 ) but not for CD 82 ( p=0 . 065 ) and CD 9 ( p=0 . 168 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Pretreatment of primary macrophages with anti CD 63 MAb , but not MAbs to other macrophage cell surface tetraspanins ( CD 9 , CD 81 , and CD 82 ) , was shown to inhibit infection by several R 5 and dualtropic strains , but not by X 4 isolates . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
RESULTS : Human gingival fibroblasts express a wide surface molecular panel including mainly CD 59 , CD 99 , CD 9 , CD 95 , CD 55 , CD 63 , CD 26 , CD 117 , CD 71 and CD 86 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The largest number of these encoded surface proteins , including the unusual lectinlike receptors NKG2E and Ly 49L , several killer cell Ig like receptors , the integrin subunits alpha ( D ) , alpha ( 10 ) , beta 1 , and beta 5 , and multiple tetraspanins ( CD 9 , CD 151 , CD 53 , CD 63 , and TSPAN 5 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
We show that CD 63 , CD 9 , CD 81 , CD 82 , and CD 151 are present in immature DCs . ^^^ Whereas CD 9 and CD 81 are mostly expressed at the cell surface , CD 63 and CD 82 are also located in intracellular organelles . ^^^ Mabs against CD 9 , CD 63 , CD 81 , and CD 82 enhanced by 50 % the migration induced by the chemokines macrophage inflammatory protein 5 ( MIP 5 ) and MIP 1alpha . ^^^ These results suggest that CD 9 , CD 63 , CD 81 , and CD 82 could play a role in modulating the interactions between immature DCs and their environment , slowing their migratory ability . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Membranal and cytoplasmic expression of CD 9 , CD 53 , CD 63 , CD 81 , CD 82 and CD 151 in polymorphonuclears ( PMN ) , monocytes , B and T lymphocytes was assessed using flow cytometry . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Our results show that HACs express surface molecules belonging to different categories : integrins and other adhesion molecules ( CD49a , CD49b , CD49c , CD49e , CD49f , CD51 / 61 , CD 54 , CD 106 , CD 166 , CD 58 , CD 44 ) , tetraspanins ( CD 9 , CD 63 , CD 81 , CD 82 , CD 151 ) , receptors ( CD 105 , CD 119 , CD 130 , CD140a , CD 221 , CD 95 , CD120a , CD 71 , CD 14 ) , ectoenzymes ( CD 10 , CD 26 ) , and other surface molecules ( CD 90 , CD 99 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here , we show that palmitoylated integrins ( alpha 3 , alpha 6 , and beta 4 subunits ) and tetraspanins ( CD 9 , CD 81 , and CD 63 ) coexist in substantially overlapping complexes . ^^^ Also in palmitoylation deficient beta 4 , secondary associations with tetraspanins ( CD 9 , CD 81 , and CD 63 ) were diminished and cell surface CD 9 clustering was decreased , whereas core alpha6beta4 CD 151 complex formation was unaltered . ^^^ Instead , palmitoylation of beta 4 ( and of the closely associated tetraspanin CD 151 ) promotes CD 151 alpha6beta4 incorporation into a network of secondary tetraspanin interactions ( with CD 9 , CD 81 , CD 63 , etc . ) , which provides a novel framework for functional regulation . . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
RESULTS : The majority of pancreatic and colorectal tumors expressed the alpha 2 , alpha 3 , alpha 6 , beta 1 , and beta 4 integrins and the tetraspanins CD 9 , CD 63 , CD 81 , CD 151 , and CO 029 . ^^^ CD 63 , CD 81 , and beta 1 expression was observed at comparably high levels in healthy pancreatic tissue . alpha3beta1 frequently colocalized and coimmunoprecipitated with CD 9 , CD 81 , and CD 151 , whereas alpha6beta4 colocalized and coimmunoprecipitated mostly with CD 151 and CO 029 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Immunofluorescence microscopy indicates that the virus containing compartment in mature DCs ( mDCs ) co labels for the tetraspanins CD 81 , CD 82 , and CD 9 but contains little CD 63 or LAMP 1 . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
We observed that these plasma derived vesicles contain tetraspanin molecules such as CD 63 , CD 9 , CD 81 as well as class 1 and class 2 MHC molecules and Lamp 2 ( i . e . proteins that are known to be enriched in exosomes ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The surface expression of several tetraspanin antigens ( CD 9 , CD 37 , CD 53 , CD 63 , and CD 81 ) , and their interacting proteins ( CD 19 , CD 21 , and HLA DR ) were analyzed during normal B cell maturation and compared to a group of 67 B cell neoplasias . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Captured HIV 1 particles were rapidly endocytosed to tetraspan protein ( CD 9 , CD 63 ) positive endocytic compartments that were reminiscent of multivesicular endosomal bodies . ^^^ Furthermore , some of the endocytosed virus particles were constitutively released into the extracellular milieu in association with HLA DR 1 ( + ) , CD1b ( + ) , CD 9 ( + ) , and CD 63 ( + ) vesicles ( exosomes ) and could initiate productive infections of CD 4 ( + ) target cells . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
This study was undertaken to examine the tissue distribution of a broad spectrum of monoclonal antibodies ( mAbs ) containing tetraspan antigens ( CD 9 , CD 63 , CD 151 ) , endothelial cell antigens ( CD 31 , CD 36 , CD 105 , CD 106 , CD 146 ) , integrins ( CD49a f , CD 29 , CD 41 , CD 51 , CD 61 ) , CD 39 , CD 98 , CD 99 , CD 143 and , CD 147 supplied from fifth and sixth international workshops and conferences on human leukocyte differentiation antigens in a comparative manner in human OA and normal synovium . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here , we reveal the presence of tetraspanin enriched microdomains ( TEMs ) containing the tetraspanins CD 9 , CD 63 , CD 81 , and CD 82 at the plasma membrane . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Here , we show that recombinant soluble forms of the large extracellular domain ( EC 2 ) of human tetraspanins CD 9 , CD 63 , CD 81 , and CD 151 produced as fusion proteins with glutathione S transferase ( GST ) can all potently and completely inhibit R 5 HIV 1 infection of macrophages with 50 % inhibitory concentration values of 0 . 11 to 1 . 2 nM . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
The encoded protein belongs to a family of surface molecules , the tetra spans transmembrane protein superfamily , all displaying the four transmembrane domains , expressed on various cell types including lymphocytes ( CD 9 , CD 37 , CD 53 , TAPA 1 ) , melanoma cells ( ME 491 ) , and intestinal cells ( CO 029 ) . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Sequence analysis revealed that MRP 1 had strong similarity with a B cell surface antigen ( CD 37 ) , a melanoma associated antigen ( ME 491 ) , the target of an antiproliferative antibody ( TAPA 1 ) , a human tumor associated antigen ( CO 029 ) , and the Sm 23 antigen of the trematode parasite Schistosoma mansoni . . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
Comparison of SAS organization to human ME 491 , CD 9 , and CD 53 and murine CD 53 and TAPA 1 confirms that SAS is a member of this family of genes and is consistent with the theory that these genes arose through duplication and divergent evolution . . ^^^ |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
In this study , we investigated the relationships between these three genes , MRP 1 , KAI 1 , and ME 491 , in patients with non small cell lung cancers ( NSCLCs ) . ^^^ Moreover , we assessed the prognostic value of evaluating the expressions of MRP 1 , KAI 1 , and ME 491 simultaneously in NSCLCs . ^^^ Using a quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) analysis , we studied the expression of MRP 1 , KAI 1 , and ME 491 genes in these patients . ^^^ |
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Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P08962 and P21926 |
Pubmed |
SVM Score :0.0 |
NA |
|