| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.66135159 |
| Interestingly , we observed a correlation between CD 126 and CD 130 expression with STAT 3 phosphorylation in CD4+CD25 T cells compared with Tregs after stimulation with IL 6 or H IL 6 , whereas the MAPK extracellular signal regulated kinase 1 / 2 were not activated by CD 130 dimerization . 0.66135159^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Anti IL 6R treated reconstituted SCID mice showed decreased levels of activated STAT 3 . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| In contrast , the IL6R protein and the downstream regulator STAT 3 were increased only in MCs after 24 h of NE infusion . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| CD4+CD25+ but not CD4+CD25 lung T cells selectively expressed the IL 6R alpha chain and showed IL 6 dependent STAT 3 phosphorylation . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Cotransfection with the gp 80 and / or gp 130 receptor revealed that the effect of H IL 6 on STAT 3 dependent gene transcription is restricted to the gp80 / gp130 receptor ratio . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Addition of soluble gp 80 was sufficient to restore IL 6 responsiveness in carcinoma cells as shown by enhanced activation of STAT 3 binding activity . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Activation of signal transducer and activator of transcription 3 ( STAT 3 ) only occurred via basolaterally located gp 80 , suggesting that endogenous gp 130 is also constrained to the basolateral plasma membrane . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Different levels of IL 6R protein were measured in various HD cell lines : L 428 and Dev cells were characterized by very low levels of gp 80 and gp 130 , on KMH 2 cells only gp 130 but no gp 80 was detected , whereas L 540 , L 591 , HDLM 2 , and L 1236 were positive for both gp 80 and gp 130 , suggesting a possible autocrine stimulation of STAT 3 . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| This global suppression of acute phase gene transcription may be explained by two PPARalpha dependent in vivo effects : 1 ) PPARalpha activation results in the down regulation of the IL 6 receptor components gp 80 and gp 130 in the liver , thereby reducing the phosphorylation and activation of the downstream transcription factors STAT 3 and c Jun that transduce the IL 6 signal ; and 2 ) PPARalpha reduces the basal expression of the transcription factors CCAAT enhancer binding protein alpha , beta , delta , which are responsible for immediate and maintained transcription of APR genes . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| However , EC are responsive to a combination of IL 6 and soluble IL 6R as measured by the activation of STAT 3 , chemokine expression , and augmentation of ICAM 1 . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| While searching for the possible cause of inhibited IL 6 / Stat3 signaling , we found that IL 6 receptor ( IL 6R & gp 130 ) was preserved , that nuclear Stat 3 protein content was lowered , and that IL 6 / Stat3 pathway inhibitors ( SOCS 1 , PIAS 3 ) were induced during the pre replicative Go G 1 period . . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| This also correlates with a decreased responsiveness to stimulation by interleukin 6 ( IL 6 ) , as determined by measurement of the status of IL 6R mediated STAT 3 ( Signal Transducer and Activator of Transcription 3 ) activation by this cytokine . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| In extra thyroidal tissues , the HGF / c met and IL 6 / IL 6 receptor ( IL 6R ) systems activate STAT 3 , a member of the signal transducers and activators of transcription ( STATs ) family . ^^^ To evaluate whether either system utilizes STAT 3 in thyroid nodules , we examined the immunohistochemical expression of HGF , c met , IL 6 , IL 6R , STAT 3 in 6 normal thyroids and in 68 thyroid nodules . ^^^ Since these cases are consistently HGF+ / c met+ and only one third of them co express IL 6 / IL 6R , STAT 3 expression correlates with the HGF / c met expression , not with the IL 6 / IL 6R expression . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 receptor ( IL 6R ) / signal transducer and activator of transcription 3 ( STAT 3 ) pathway contributes to the pathogenesis of multiple myeloma ( MM ) and protects MM cells from apoptosis . ^^^ Detailed pathway analysis revealed that BMSCs stimulate STAT 3 via the IL 6R , and mitogen activated protein ( MAP ) kinases via IL 6R independent mechanisms . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Moreover , induction of VEGF by diverse oncogenic growth stimuli , including IL 6R , c Src , Her2 / Neu , is attenuated in cells without Stat 3 signaling . ^^^ Furthermore , tumor cells ' in vivo angiogenic capacity induced by IL 6R , which simultaneously activates Jak / STAT and PI3K / Akt pathways , is abrogated when Stat 3 is inhibited . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| In cells treated with DFP , stimulation of Stat 3 phosphorylation was maintained for a longer period ( 150 min ) than in cells treated with IL6 / Il 6R , suggesting that the signal mediated by the DFP was more durable than that mediated by IL 6 / sIL 6R , although the signal transduction mechanisms are almost the same for both DFP and IL 6 / IL 6R . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| In these cells , PTX B neither down regulated the IL 6R nor prevented IL 6 induced signaling in terms of STAT 3 phosphorylation and DNA binding . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Signal transducer and activator of transcription 3 ( STAT 3 ) has been reported to be activated by interleukin 6 receptor ( IL 6R ) or epidermal growth factor receptor ( EGFR ) in head and neck squamous cell carcinomas ( HNSCC ) , which may have important implications for responsiveness to therapeutics targeted at EGFR , IL 6R , or intermediary kinases . ^^^ Signal transducer and activator of transcription 3 ( STAT 3 ) has been reported to be activated by interleukin 6 receptor ( IL 6R ) or epidermal growth factor receptor ( EGFR ) in head and neck squamous cell carcinomas ( HNSCC ) , which may have important implications for responsiveness to therapeutics targeted at EGFR , IL 6R , or intermediary kinases . ^^^ Suppressor of cytokine signaling 1 ( SOCS 1 ) has been implicated recently in the negative regulation of IL 6R / Janus activated kinase ( JAK ) mediated activation of STAT 3 , suggesting that SOCS 1 could affect alternative activation of STAT 3 by EGFR , IL 6R , and associated kinases . ^^^ We investigated whether epigenetic modification of SOCS 1 affects STAT 3 activation in response to IL 6R , EGFR , JAK , or mitogen activated protein kinase / extracellular signal regulated kinase kinase ( MEK ) mediated signal activation . ^^^ STAT 3 was predominantly activated by IL 6R via Jak1 / Jak2 in HNSCC lines UMSCC 9 and UMSCC 38 in association with transcriptional silencing of SOCS 1 by hypermethylation . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Human T cell leukemia virus type 1 Tax induces expression of interleukin 6 receptor ( IL 6R ) : Shedding of soluble IL 6R and activation of STAT 3 signaling . ^^^ Consequently , Tax mediated regulations of IL 6R and sIL 6R observed in HTLV 1 associated disorders may contribute to proliferation of HTLV 1 infected T cells through activation of inducible STAT 3 , and ultimately affect malignant growth and transformation of T cells by HTLV I . . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| Expression of IL 6 , the IL 6 receptor alpha chain ( IL 6Ralpha ) , and phosphorylated and unphosphorylated STAT 3 messenger RNAs ( mRNAs ) and proteins in all cells was determined . ^^^ Higher levels of IL 6Ralpha and STAT 3 transcription factors were observed in OVCA cells than in HOSE cells . ^^^ Increased IL 6Ralpha expression and constitutive STAT 3 activation may be associated with ovarian cancer . . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| In some cases , increased CD 126 expressing cells showed higher levels of STAT 3 phosphorylation on exposure to recombinant IL 6 . ^^^ |
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| Interacting proteins: P08887 and P40763 |
Pubmed |
SVM Score :0.0 |
| STAT 3 and STAT 1 activation in HER 14 cells was demonstrated to depend on EGF receptor kinase activity , rather than JAK 2 activity , while in both K721A and CD 126 cells ( NIH3T3 transfected with kinase dead EGF receptor , and EGF receptor lacking major autophosphorylation sites , respectively ) STAT 1 and STAT 3 tyrosine phosphorylation requires JAK 2 kinase activity . ^^^ Furthermore , STAT 3 is constitutively phosphorylated in K721A and CD 126 cells , and STAT 1 H2O2 stimulated activation in these cells is much more prominent than in HER 14 . ^^^ |
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