| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| The IL 6 receptor system consists of an 80 kDa IL 6 receptor and a gp 130 which functions as a signal transducer not only for IL 6R but also for LIF , OSM , ciliary neurotrophic factor ( CNTF ) , and IL 11 receptors . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| Finally , to analyze the specificity of this antibody , the effects on signal transduction of IL 6 family cytokines such as interleukin 11 ( IL 11 ) , oncostatin M ( OSM ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) were examined using murine transfectant cell lines ( BaF / IL 6R , BaF / IL 11R , BaF / OSMR , BaF / LIFR and BaF / CNTFR ) that proliferate depending on IL 6 , IL 11 , OSM , LIF and human CNTF , respectively . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| CNTF induced proliferation was completely inhibited by antibodies to gp 130 interleukin 6 ( IL 6 ) transducer , unlike antibodies to IL 6 or IL 6 receptor ( IL 6R ) . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| Recent in vitro studies with IL 6 and CNTF have demonstrated that higher order hexameric receptor complexes are assembled in which signaling chain dimerization is accompanied by the dimerization of both the cytokine molecule and its specific receptor alpha subunits ( IL 6Ralpha or CNTFRalpha , respectively ) . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| They did not affect those of CNTF , LIF and OM , even when used at a very high concentration at which virtually all membrane IL 6R were bound to IL 6RA . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| We detected LIF , IL 11 , sgp 130 and a large amount of IL 6 , but not OSM , CT 1 , CNTF nor IL 6R in these culture supernatants . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| However , human CNTF can use both the membrane bound and the soluble human IL 6R as a substitute for its cognate alpha receptor and thus widen the target spectrum of human CNTF . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| Rat and human CNTF differ in their fine specificities : in addition to CNTFR , rat CNTF has been shown to activate the LIFR ( a heterodimer of LIFRbeta and gp 130 ) , whereas human CNTF can bind and activate a tripartite receptor comprising the IL 6 receptor alpha chain ( IL 6Ralpha ) and LIFR . ^^^ It shares the arginine residue with rat CNTF which prevents binding to IL 6Ralpha . ^^^ |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26441 and P08887 |
Pubmed |
SVM Score :0.0 |
| NA |
|