Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.53346866
The pleiotropic cytokine interleukin 6 ( IL 6 ) interacts with the specific ligand binding subunit ( IL 6R alpha ) of the IL 6 receptor , and this complex associates with the signal transducing subunit gp 130 ( IL 6R beta ) . 0.53346866^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The authors report the use of the RNA / PCR method to examine in bladder cancer the expression of the human leukocyte antigen ( HLA ) class 2 gene family ( HLA DR , DQ , and DP ) as well as interleukin 6 ( IL 6 ) and the interleukin 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in myeloma / plasmacytoma . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) drives the sequential assembly of a receptor complex formed by the IL 6 receptor ( IL 6R alpha ) and the signal transducing subunit , gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We examined the changes in mRNA expression of granulocyte macrophage colony stimulating factor receptor beta subunit ( GM CSFR beta subunit ) , which was a common subunit of a high affinity interleukin 3 receptor ( IL 3R ) and a high affinity GM CSFR , and interleukin 6 receptor ( IL 6R ) during megakaryocyte development in a human megakaryocytic leukemia cell line ( CMK ) which could proliferate and / or differentiate in the presence of 12 O tetradecanoylphorbol 13 acetate ( TPA ) , IL 3 , GM CSF , and IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Down regulation of the interleukin 6 binding subunit ( gp 80 ) by its ligand . ^^^ Interleukin 6 ( IL 6 ) exerts its action via a cell surface receptor composed of an 80 kDa IL 6 binding protein ( gp 80 ) and a 130 kDa polypeptide involved in signal transduction ( gp 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
An analysis of the mechanism of generation of the soluble interleukin 6 receptor ( IL 6R ) has been performed . ^^^ Furthermore , the soluble IL 6R is unique in its ability to induce a biological signal in complex with the ligand interleukin 6 ( IL 6 ) on cells which by themselves do not bind IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The expression of 80 kDa interleukin 6 receptor ( IL 6R ) and the associated molecule gp 130 has been studied on human cell lines by FACS and Northern blot analysis . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A monoclonal antibody against the interleukin 6 receptor ( IL 6R ) has been used in a high sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We examined the effect of leukemia inhibitory factor ( LIF ) on the expression of interleukin 6 receptors ( IL 6R ) on mouse myelomonocytic leukemic M 1 cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Soluble interleukin 6 receptor ( sIL 6R ) was found to be spontaneously released from human myeloma cell line U 266 cells into culture supernatant , and was quantitatively measured with a fluorescence sandwich enzyme linked immunosorbent assay employing antibodies specific to IL 6R . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The Interleukin 6 dependent DNA binding protein gene ( transcription factor 5 : TCF 5 ) maps to human chromosome 20 and rat chromosome 3 , the IL 6 receptor locus ( IL6R ) to human chromosome 1 and rat chromosome 2 , and the rat IL 6 gene to rat chromosome 4 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
IL 6 signal transduction occurs when the liganded interleukin 6 receptor ( IL 6R ) interacts with glycoprotein ( gp ) 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In the present study , monoclonal antibodies against human gp 80 interleukin 6 receptor ( IL 6R ) were utilized to study the role of the IL 6R in the control of the IL 6 induced AGP synthesis in the human hepatoma Hep3B cell line . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
This was carried out by mating mice from interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) transgenic lines . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) interacts with a system of receptors , which include a 80 kDa IL 6 binding subunit ( IL 6R ) and a transducing element ( gp 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 receptor ( IL 6R ) is a member of the cytokine receptor superfamily characterised by the obligatory presence of WSXWS ( Trp Ser 10 Trp Ser ) sequence motif near the transmembrane domain . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Two candidate genes in the region the interleukin 6 receptor gene ( IL6R ) and the myeloid cell leukaemia 1 gene ( MCL 1 ) are involved in the differentiation of monocyte / macrophages into osteoclasts , the most likely site of the primary defect in pycnodysostosis . . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The serum levels of interleukin 6 ( IL 6 ) and the expression ( mRNA ) of the 80 kDa IL 6 receptor ( IL 6R ) were examined in three different models of acute inflammation . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Down regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex constituted by the ligand binding subunit IL 6 receptor alpha ( IL 6R alpha ) and the signal transducing beta chain gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We investigated the biochemical properties of the 80 kDa binding subunit ( gp 80 ) of the human interleukin 6 receptor ( IL 6R ) in the genetic environment of the amphibian Xenopus laevis . ^^^ Expression of the human interleukin 6 receptor alpha chain in Xenopus laevis oocytes . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
ATRA downregulated the cell surface expression of interleukin 6 receptor ( IL 6R ) and / or glycoprotein ( gp ) 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
All trans retinoic acid ( ATRA ) inhibits human myeloma cell growth in vitro , presumably through the down regulation of interleukin 6 receptors ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Expression patterns of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , and gp 130 genes in 39 patients with acute myeloid leukemia ( AML ) , in 23 patients with acute lymphoblastic leukemia ( ALL ) , and in 7 patients with acute mixed lineage leukemia ( AMLL ) were studied by quantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In addition , the effects on the expression of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) genes were investigated by the use of reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) mediates pleiotropic functions through specific receptors ( IL 6R ) composed of an 80 kDa binding protein , associated with a non ligand binding protein ( gp 130 ) which transduces the signal . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) exerts its action via a receptor complex composed of a ligand binding subunit ( gp 80 ) and a signal transducer ( gp 130 ) which both belong to the hematopoietic receptor super family . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) signal is transduced through a membrane glycoprotein gp 130 , which associates with the IL 6 receptor alpha chain ( IL 6R alpha ) in the presence of IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
To detect transcripts encoding the interleukin 6 receptor ( IL 6R ) molecule lacking the transmembrane ( TM ) domain , in various cell lines and peripheral blood mononuclear cells ( PBMC ) , we used the polymerase chain reaction ( PCR ) with primer pairs that flank the TM domain and which were selected to generate a 398 bp fragment . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The human interleukin 6 receptor ( IL 6R ) was differentially expressed on IL 6 dependent ( U 266 and SKO 007 ) and independent ( RPMI 8226 ) myeloma cells as well as melanoma cells ( A 375 C6 ) that are growth inhibited by IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A soluble interleukin 6 binding molecule derived from the gp 80 component of the multichain IL 6 receptor can be detected in biological fluids , and can act as an agonist of IL 6 activity . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Expression of interleukin 6 ( IL 6 ) and interleukin 6 receptor ( IL 6R ) mRNAs in rat brain during postnatal development . ^^^ Using RT PCR , the development profile of interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) mRNAs in rat brain was investigated . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Specific cytotoxicity of recombinant interleukin 6 pseudomonas exotoxin fusion protein ( IL 6 PE40 ) on LT 12 leukemic cells expressing high levels of interleukin 6 receptor ( IL6R ) ] . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We have studied the expression and regulation of the interleukin 6 receptor ( gp 80 ) and its signal transducer gp 130 in primary human blood monocytes . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The results suggest a model of transactivation cascade for HGFR such as interleukin 6 receptor ( IL 6R ) , IL 3R , GM colony stimulating factor receptor ( GM CSFR ) , and erythropoietin receptor ( EpR ) , whereby each HGF upmodulates the R ( s ) for distal acting HGF ( s ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The distribution of interleukin 6 ( IL 6 ) mRNA and IL 6 receptor ( IL 6R ) mRNA in the brain of adult male rats was studied at the light microscope level by in situ hybridization histochemistry using 35S labelled oligonucleotides . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
As an approach to understanding the interaction of interleukin 6 ( IL 6 ) and its 80 kDa receptor ( gp 80 ) , we have constructed chimeric human / murine IL 6 molecules , which were expressed in Escherichia coli and analyzed for biological activity and receptor binding . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
To exclude the possibility that the Interleukin 6 receptor ( IL6R ) on B cells is missing , its expression was measured by assessing the binding of a Phycoerythrin derivative of IL 6 by flow cytometry and correlated with various markers for B cells and T cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 ( IL 6 ) signal is transduced through membrane anchored gp 130 , which is associated with IL 6 receptor ( IL 6R ) in the presence of IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A part of the extracellular domain ( amino acids 145 345 ) of the human interleukin 6 receptor ( IL 6R ) was expressed in E . coli and the purified protein was used to raise antibodies in rabbits . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The therapeutic effects of a neutralizing monoclonal antibody ( mAb ) to the interleukin 6 receptor ( IL 6R ) were examined in the MRL lpr / lpr murine lupus nephritis model . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In addition we show that the soluble forms of the IL 6R and gp 130 released by transfected cells can form a ternary complex with interleukin 6 indicating that such complexes also may occur in vivo . . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The human interleukin 6 receptor alpha chain ( IL6R alpha ) gene was regionally mapped to chromosome 1 band q 21 by fluorescence in situ hybridization . ^^^ The human interleukin 6 receptor alpha chain gene is localized on chromosome 1 band q 21 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The ligand binding subunit ( gp 80 ) of the human interleukin 6 receptor ( IL 6R ) was transiently expressed in COS 7 cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Here , we report the analysis of the structure function relationship of the extracellular region of human interleukin 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Differential expression of interleukin 6 ( IL 6 ) and interleukin 6 receptor ( IL 6R ) mRNAs in rat hypothalamus . ^^^ Using the sensitive technique of reverse transcription followed by polymerase chain reaction ( RT PCR ) , the expression of interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in rat hypothalamus was investigated . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The biological functions of interleukin 6 ( IL 6 ) are mediated through a signal transducing component of the IL 6 receptor , gp 130 , which is associated with the ligand occupied IL 6 receptor ( IL 6R ) protein . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) / IL 6 receptor ( IL 6R ) plays a major role in autocrine / paracrine growth regulation of myeloma cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The steady state mRNA levels of the interleukin 6 receptor ( IL 6R , gp 80 ) and its signal transducing molecule , gp 130 , were examined in the rat hepatoma cell line , H 35 , stimulated by cytokines IL 6 , IL 1 , oncostatin M ( OSM ) and / or Dexamethasone ( Dex ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 ( IL 6 ) receptor complex is composed of two different subunits , the IL 6 binding protein ( IL 6R , gp 80 ) and the signal transducing component gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex with the ligand binding subunit IL 6Ralpha and the signal transducing chain gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In this study we aimed to examine a role for interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in peripheral nerve regeneration in vivo . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Expression of interleukin 6 receptor ( IL 6R ) and gp 130 mRNA in PC 12 cells and sympathetic neurons : modulation by tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The human interleukin 6 receptor ( IL 6R ) is expressed on cells as a transmembrane protein of 80 kDa ( gp 80 , ligand binding unit ) , or as a smaller soluble counterpart ( sIL 6R , approximately 55 kDa ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We here report that rapid and massive shedding of the interleukin 6 receptor ( IL 6R ) and the lipopolysaccharide receptor ( CD 14 ) occurs from primary and transfected cells attacked by two prototypes of pore forming bacterial toxins , streptolysin O and Escherichia coli hemolysin . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
CNTF induced proliferation was completely inhibited by antibodies to gp 130 interleukin 6 ( IL 6 ) transducer , unlike antibodies to IL 6 or IL 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Postnatal expression of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) mRNAs in rat sympathetic and sensory ganglia . ^^^ The postnatal expression of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) mRNAs in superior cervical ganglia ( SCG ) and dorsal root ganglia ( DRG ) of normal rats were studied by using RT PCR . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
AIMS : To study the expression of interleukin 2 receptor ( IL 2R ) , interleukin 4 receptor ( IL 4R ) and interleukin 6 receptor ( IL 6R ) on peripheral blood lymphocytes ( PBL ) in patients with systemic lupus erythematosus ( SLE ) ; to correlate the level of expression of these receptors with SLE disease activity . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In the present study , we analyze changes in the expression of various HSC markers ( Sca 1 and CD 34 ) , receptors ( c kit and interleukin 6 receptor [ IL 6R ] ) and adhesion molecules ( very late activation antigen 4 [ VLA 4 ] , lymphocyte function associated antigen 1 [ LFA 1 ] , and CD 44 ) after 5 FU injection . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The receptor for interleukin 6 ( IL 6 ) is characterized by a ligand binding glycoprotein 80 ( gp 80 ) transmembrane chain ( IL 6R ) which associates with a signal transducer gp 130 chain . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The soluble interleukin 6 receptor ( sIL 6R ) consists of the extracellular domain of the membrane bound IL 6 receptor ( gp 80 ) found on many types of cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A flow cytometric procedure was used to analyse the cell surface interleukin 6 receptor ( IL 6R ) based on the principle of detecting the binding of IL 6 to IL 6R . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Factor D has a unique NH 2 terminal domain with weak sequence homology with part of the mammalian interleukin 6 receptor alpha chain . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The authors examined the interleukin 6 concentrations and those of its soluble receptor ( IL 6 , IL 6R ) , of the tumour necrotizing factor alpha ( TNF alpha ) interferon gamma ( IFN gamma ) and of adhesion molecules ICAM 1 and VCAM 1 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interaction between interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) is the initial and most specific step in the IL 6 signaling pathway . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Previous reports have established the synthesis of interleukin 6 ( IL 6 ) and IL 6 receptors ( IL 6R ) in several human leukemia cells and found that IL 6 and the IL 6R could be expressed in cell lines with erythroid / megakaryocytic features . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The pleiotropic cytokine interleukin 6 ( IL 6 ) triggers the formation of a high affinity receptor complex constituted by the ligand binding subunit IL 6 receptor alpha ( IL 6R alpha ) and the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 mediates its pleiotropic effects by interacting with its membrane bound receptor ( gp 80 ) or the soluble counterpart gp 54 , resulting in activation of a complex that includes the transducer protein gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In the case of interleukin 6 ( IL 6 ) , the signal transducing complex is composed of the ligand IL 6 , the IL 6 receptor ( IL 6R , gp 80 , CD 126 ) , and at least two gp 130 ( CD 130 ) molecules . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Using the reverse transcriptase polymerase chain reaction ( RT PCR ) , we investigated the influence of restraint stress on the expression of the mRNA for interleukin 6 ( IL 6 ) and the mRNA for the IL 6 receptor ( IL 6R ) in the rat brain . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
BACKGROUND : The pleiotropic cytokine interleukin 6 mediates its multiple effects at the cell level through a multimeric receptor consisting of a binding protein ( gp 80 ) and a signal transducer ( gp 130 ) . ^^^ A soluble form of gp 80 ( sIL 6R or gp 55 ) is found released from the surface of cells and appears to possess interleukin 6 ( IL 6 ) agonist activity . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We have detected expression of interleukin 6 receptors ( IL 6R ) by primary leukemic cells from three of six patients with t ( 4 ; 11 ) + ALL . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) has been postulated as a possible mediator of bone loss after estrogen deficiency , and its signal is transduced via glycoprotein 130 ( gp 130 ) after binding IL 6 receptor ( IL 6R ) in the membrane of target cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Several investigators have recently reported that ATRA downregulates the production of interleukin 6 ( IL 6 ) and the expression of IL 6 receptor ( IL 6R ) and also inhibits the proliferation of myeloma cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
AIMS AND METHODS : The aims of the present study were to examine : ( 1 ) immune inflammatory markers , i . e . serum interleukin 6 ( IL 6 ) , IL 8 , IL 6 receptor ( IL 6R ) , IL 1R antagonist ( IL 1RA ) , gp 130 , and prostaglandin E 2 ( PGE 2 ) production by mitogen stimulated whole blood and the availability of plasma tryptophan in patients with primary sleep disorders , major depression and healthy volunteers ; and ( 2 ) the relationships between the availability of tryptophan and indicators of the immune inflammatory response system . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^ The mRNA expression of the neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptor components ( CNTFRalpha , LIFRbeta , IL 6Ralpha and gp 130 ) was examined in peripheral nerves after two different types of injury , crush and transection . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Anti human interleukin 6 ( human IL 6 ) and anti human IL 6 receptor ( IL 6R ) neutralising monoclonal antibodies ( mAbs ) are among the most promising human IL 6 specific inhibitors and have been shown to exert short term beneficial effects in clinical trials . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Binding of interleukin 6 to its receptor ( IL 6R ) induces the association of the IL 6R alpha chain ( IL 6Ralpha ) with a 130 kDa transmembrane glycoprotein , gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) on target cells binds to the specific IL 6 receptor ( IL 6R ) and subsequently induces homodimerization of the signal transducing protein gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 receptors ( IL 6R ) and interleukin 1 receptors ( IL 1R ) on lymphocyte surfaces were analyzed , using flow cytometry and dye labeled IL 6 and IL 1 beta , to examine the clinical and immunological significance of these receptors . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Levels of soluble CD 14 , interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , and C reactive protein ( CRP ) have been measured in plasma from 26 children with septic shock ( nine of whom had disseminated intravascular coagulation ) and from ten control children . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The soluble Interleukin 6 receptor ( sIL 6R ) is capable of conferring the Interleukin 6 ( IL 6 ) signal onto cells lacking the gp 80 ligand binding protein . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The expressions of mRNAs for interleukin 6 ( IL 6 ) and the IL 6 receptor ( IL 6R ) in the rat hypothalamus and midbrain during restraint stress . ^^^ Over the past few years , it has been reported that physical and psychological stress elevate plasma interleukin 6 ( IL 6 ) , and that neural cells can produce IL 6 and have receptors for IL 6 ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Regulation of interleukin 6 and interleukin 6R alpha ( gp 80 ) expression by murine immunoglobulin secreting B cell hybridomas . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) is the major growth factor for human myeloma cells , exerting its effect through the IL 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
There is some evidence that the pathophysiology of schizophrenia is related to activation of the inflammatory response system ( IRS ) , as indicated by increased serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , IL 1R antagonist ( IL 1RA ) and IL 2R and lower serum concentrations of CC 16 , an endogenous anti inflammatory protein with immunosuppressive and anti inflammatory effects . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interestingly , the complex of IL 6 and the soluble interleukin 6 receptor ( sIL 6R ) activates target cells that do not express the membrane bound IL 6R and therefore can not respond to IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) belongs to a family of cytokines using receptors sharing a common signal transducing chain , gp 130 and containing a specific ligand binding chain ( IL 6R alpha ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The role of the interleukin 6 / interleukin 6 receptor ( IL 6 / IL 6R ) system in regulating blast cell growth in 8 acute myeloblastic leukemia ( AML ) patient derived cell lines was investigated . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A humanized antibody to the human interleukin 6 receptor ( IL 6R ) , hPM 1 , blocked the interleukin 6 ( IL 6 ) functions in normal cynomolgus monkey lymphocytes in vitro . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Stimulation of the interleukin 6 ( IL 6 ) signalling pathway occurs via the IL 6 receptor glycoprotein 130 ( IL 6R gp 130 ) receptor complex and results in the regulation of acute phase protein genes in liver cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 ( IL 6 ) / gp 80 and hepatocyte growth factor ( HGF ) / met ligand / receptor systems have been shown to stimulate biliary epithelial cell ( BEC ) DNA synthesis in vitro . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A highly polymorphic CA repeat marker at the human interleukin 6 receptor ( IL6R ) locus . ^^^ A polymorphic dinucleotide ( CA ) sequence was isolated from a genomic clone containing the human interleukin 6 receptor ( IL6R ) gene . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The high affinity interleukin 6 ( IL 6 ) receptor is a hexameric complex consisting of two molecules each of IL 6 , IL 6 receptor ( IL 6R ) , and the high affinity converter and signaling molecule , gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Immunoadhesins of interleukin 6 and the IL 6 / soluble IL 6R fusion protein hyper IL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 receptor signaling . 1 . gp 80 and gp 130 receptor interaction in the absence of interleukin 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
As interleukin 6 ( IL 6 ) has been shown to have diverse effects on blast cell growth in acute myeloblastic leukemia ( AML ) , and as a soluble ( s ) form of IL 6 receptor ( IL 6R ) agonizes IL 6 effects in many cell types , we investigated whether sIL 6R was able to modulate clonogenic blast cell growth in AML . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The growth inhibition was postulated to result from a transcriptional downregulation of interleukin 6 receptor alpha ( IL 6Ralpha ) with IL 6Rbeta ( gp 130 ) unaffected . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Generation of ' truncated ' interleukin 6 receptor ( IL 6R ) mRNA by alternative splicing ; a possible source of soluble IL 6R . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Flow cytometric analysis revealed that most immature hematopoietic progenitors express gp 130 but not interleukin 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The expression of interleukin 6 receptor ( IL 6R ) has been investigated immunohistochemically in seven fetal brains with special reference to the ganglionic eminence ( GE ) , a part of the telencephalic proliferative zone . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor alpha ( IL 6Ralpha ) , IL 11Ralpha , and gp 130 low to negative primitive hematopoietic progenitors . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Circulating concentrations of soluble interleukin 6 receptors gp 80 and gp 130 in chronic renal failure and effects of renal replacement therapy . ^^^ No data are available on the concentrations of the circulating interleukin 6 ( IL 6 ) receptors gp 80 and gp 130 during chronic renal insufficiency . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
It has been previously shown that phorbol 12 myristate 13 acetate ( PMA ) , a potent differentiation inducer , induced the expression of both interleukin 6 ( IL 6 ) and IL 6 receptor alpha component ( IL 6Ralpha ) in K 562 leukemia cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , gp 130 ( the IL 6 signaling protein ) , IL 1R antagonist ( IL 1RA ) and leukemia inhibitory factor receptor ( LIFR ) were assayed in 22 nonpregnant women and in 91 pregnant women before delivery and 1 and 3 days after delivery . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
This study was carried out to examine ( 1 ) the serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , IL 1R antagonist ( IL 1RA ) and Clara Cell protein ( CC 16 ) , an endogenous anticytokine , in nonresponders to treatment with typical neuroleptics and ( 2 ) the effects of atypical antipsychotics on the above IRS variables . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 ( IL 6 ) receptor complex comprises the IL 6 receptor ( IL 6R , gp 80 ) and the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Soluble interleukin 6 receptor ( sIL 6R ) makes IL 6R negative T cell line respond to IL 6 ; it inhibits TNF production . ^^^ The receptor for interleukin 6 ( IL 6 ) consists of two subunits : a ligand specific IL 6Ralpha and gp 130 that is responsible for signal transduction . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Formation of osteoclast like cells in mouse bone marrow cultures induced by either 1 , 25 dihydroxyvitamin D ( 3 ) ( 1 , 25 ( OH ) ( 2 ) D ( 3 ) ) , parathyroid hormone ( PTH ) or prostaglandin E ( 2 ) ( PGE ( 2 ) ) , respectively , shows partial dependence on interleukin 6 receptor ( IL 6R ) activation . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 receptor alpha ( IL 6R ) and interleukin 8 receptor ( IL 8RB ) are widely expressed in adult human and murine tissues . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In experiments with TACE deficient ( TACE / ) fibroblasts we found that 4beta phorbol 12 myristate 13 acetate ( PMA ) induced shedding of the interleukin 6 receptor ( IL 6R ) is strongly reduced . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We examined the effects of single and repeated stress on the expression of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) mRNAs in the rat midbrain and hypothalamus using reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Serum levels of C reactive protein ( CRP ) , interleukin 1beta ( IL 1beta ) , interleukin 1 receptor antagonist ( IL 1RA ) , interleukin 6 ( IL 6 ) , tumor necrosis factor alpha ( TNF alpha ) , soluble interleukin 6 receptor ( sIL 6R , gp 80 ) , soluble tumor necrosis factor receptor 2 ( sTNFRII , p 75 ) , COMP and MIA were measured by ELISA . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 exerts its activity via two receptor subunits , IL 6R and glycoprotein 130 ( gp 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
BACKGROUND : Interleukin 6 ( IL 6 ) exerts its actions through a cell surface receptor system that consists of two transmembrane subunits : the IL 6 binding glycoprotein gp 80 ( IL 6R ) and the signal transducing component ( gp 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Skeletal muscle was found to express mRNAs encoding interleukin 1 type 1 and 2 receptors , interleukin 6 receptor ( IL 6R ) , and interferon gamma receptor by RT PCR , but these receptors were below limits of detection of ligand binding assay ( > or =1 fmol binding sites / mg protein ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The significance of interleukin 6 receptor ( IL 6R ) expression by cord blood ( CB ) and peripheral blood ( PB ) derived primitive haematopoietic progenitors was investigated . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The cytoplasmic domain of the interleukin 6 receptor gp 80 mediates its basolateral sorting in polarized madin darby canine kidney cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The addition of an antibody against the interleukin 6 receptor ( IL 6R ) blocked myeloma cell and myeloma cell conditioned media induced osteoblast recruitment ( p < 0 . 01 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 receptor alpha chain ( CD 126 ) is expressed by neoplastic but not normal plasma cells . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Signal transduction in response to interleukin 6 ( IL 6 ) requires binding of the cytokine to its receptor ( IL 6R ) and subsequent homodimerization of the signal transducer gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interaction of interleukin 6 ( IL 6 ) with its receptor ( IL 6R ) is not well understood . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The biosynthesis of interleukin 6 receptor ( IL 6R ) and gp 130 in vitro was blocked using specific antisense oligonucleotides ( ASO ) in HepG 2 liver cells and the efficacy of various ASOs was tested on the generation of IL 6 induced junB mRNA . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Because the mechanisms involved in the shedding of the interleukin 6 receptor alpha ( IL 6Ralpha ) in multiple myeloma are not known , we have investigated them in the XG 6 human myeloma cell line . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Expression of interleukin 6 , interleukin 6 receptor ( gp 80 ) , and the receptor ' s signal transducing subunit ( gp 130 ) in human normal pituitary glands and pituitary adenomas . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVES : The study objective was to assess the cardiac expression of interleukin 6 ( IL 6 ) and its receptor ( IL6R ) in advanced heart failure . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) induces B cell proliferation by binding to receptor complexes composed of a specific alpha receptor ( gp 80 ; CD 126 ) and the signal transducing receptor subunit gp 130 ( CD 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
To elucidate the function of the two cytokine binding modules ( CBM ) of the leukemia inhibitory factor receptor ( LIFR ) , receptor chimeras of LIFR and the interleukin 6 receptor ( IL 6R ) were constructed . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We measured the following IRS variables in patients with major depression ( n=36 ) , somatization syndrome ( SSI 8 ; n=37 ) , major depression and somatization ( n=40 ) and healthy controls ( n=37 ) : interleukin 6 ( IL 6 ) ; interleukin 1 receptor antagonist ( IL 1RA ) ; plasma soluble interleukin 6 receptor ( IL 6R ) ; soluble suppressor / cytotoxic antigen ( CD 8 ) ; leukemia inhibitory factor ( LIF R ) ; and Clara cell protein ( CC 16 ) , an endogenous anticytokine . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Recently , it was disclosed that all trans retinoic acid ( ATRA ) inhibits myeloma cell growth by downregulating the interleukin 6 ( IL 6 ) / IL 6 receptor ( IL 6R ) auto / paracrine loop , and upregulating p21 / Cip1 cyclin dependent kinase inhibitor ( CDK 1 ) , thereby inducing apoptosis with a decrease in Bcl 2 protein expression . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In this study we used immunohistochemistry to investigate the presence of transforming growth factor beta 1 ( TGF beta 1 ) , insulin like growth factor 1 ( IGF 1 ) , interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) and fibronectin in lumbar disc bioptic specimens from 30 patients with disc herniation ( protrusion type ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Proteolysis of interleukin 6 receptor ( IL 6R ) by Porphyromonas gingivalis cysteine proteinases ( gingipains ) inhibits interleukin 6 mediated cell activation . ^^^ Here we show that the interleukin 6 receptor ( IL 6R ) is rapidly and efficiently inactivated by gingipains , the arginine ( HRgpA and RgpB ) and lysine ( Kgp ) specific cysteine proteinases from Porphyromonas gingivalis . ^^^ This also correlates with a decreased responsiveness to stimulation by interleukin 6 ( IL 6 ) , as determined by measurement of the status of IL 6R mediated STAT 3 ( Signal Transducer and Activator of Transcription 3 ) activation by this cytokine . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Transcription levels of tumor necrosis factor receptor ( TNFR ) p 55 and p 75 , interleukin 6 receptor alpha ( IL 6Ralpha ) and transforming growth factor beta receptor 1 ( TGFbetaR 1 ) were quantified in cells exposed to an intensity of 0 . 1 or 0 . 8 mT for periods ranging from 30 min to 72 h . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE To investigate the characteristics and clinical value of serum tumor necrosis factor alpha ( TNF alpha ) and its receptor ( sTNF R ) , interleukin 1beta ( IL 1beta ) and its receptor ( IL 1R ) , interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in patients with pulmonary tuberculosis , and to evaluate their role in the immunopathogenesis of tuberculosis . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
One such cytokine , interleukin 6 ( IL 6 ) , exerts its actions via the IL 6 receptor ( IL 6R ) , which has alpha and beta subunits . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Hybridoma that produces rat anti mouse interleukin 6 receptor ( IL 6R ) antibody , MR 16 1 , was established by the fusion of mouse P3U1 myeloma cells and spleen cells from mouse soluble IL 6R ( sIL 6R ) immunized Wistar rat . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The activation of cells that do not express the membrane bound interleukin 6 6 receptor ( IL 6R ) by IL 6 and the soluble IL 6 receptor ( sIL 6R ) is termed transsignalling . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Cerebrospinal fluid and serum protein levels of tumour necrosis factor alpha ( TNF alpha ) interleukin 6 ( IL 6 ) and soluble interleukin 6 receptor ( sIL 6R gp 80 ) in multiple sclerosis patients . ^^^ The aim of this study was to evaluate soluble proteins of tumour necrosis factor alpha ( TNF alpha ) , interleukin 6 ( IL 6 ) and IL 6 receptor subunit gp 80 ( sIL 6R gp 80 ) , as markers of multiple sclerosis ( MS ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE : The in vivo effects of anti interleukin 6 ( anti IL 6 ) and anti interleukin 6 alpha receptor ( anti IL 6R ) monoclonal antibodies on immune response and survival rate of a burn with subsequent infection were assessed . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL 6 , the IL 6 alpha receptor ( IL 6Ralpha ) , and the shared signaling receptor gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE : To evaluate the mechanism and influence of thalidomide on interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) and its transmitting chain in multiple myeloma patients . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The role of interleukin 6 ( IL 6 ) in the growth of an androgen independent prostate cancer cell line ( PC 3 m ) was defined and the effect of dexamethasone , which was previously shown to modulate IL 6 / IL 6 receptor ( IL 6R ) on this procedure was investigated . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Co expression of interleukin 6 ( IL 6 ) and interleukin 6 receptor ( IL 6R ) in thyroid nodules is associated with co expression of CD 30 ligand / CD30 receptor . ^^^ Data on the expression of interleukin 6 ( IL 6 ) / interleukin 6 receptor ( IL 6R ) in thyroid nodules is scarce . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) is a growth factor of myeloma cells and its signaling is mediated via a cell surface receptor complex ( IL 6r ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The recently solved 10 ray structure of the extracellular portion of the interleukin 6 ( IL 6 ) receptor ( IL 6R ) revealed an IL 6R dimer in the crystal lattice which probably represents a physiological dimer . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Identification of novel SNPs in the interleukin 6 receptor gene ( IL6R ) . ^^^ The human interleukin 6 receptor ( IL6R ) is responsible for signal transduction of IL 6 that might have associations with immune diseases and various infectious diseases . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We previously showed that adenovirus vector mediated transient expression of both the human interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) genes , but not the IL 6 gene alone , in the rat lung induced lymphocytic alveolitis . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Using the recently engineered designer cytokine IC 7 , which induces an active heterodimer of the LIFR and gp 130 after binding to the IL 6R , and several receptor chimeras of the LIFR and the interleukin 6 receptor ( IL 6R ) carrying the CBM of the IL 6R in place of the COOH terminal LIFR CBM , we could assign individual receptor subdomains to individual binding sites of the ligand . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Because hydroxamic acid based metalloprotease inhibitors prevent shedding of both TNFR 1 and the interleukin 6 receptor ( IL 6Ralpha ) , we hypothesized that ARTS 1 might also regulate shedding of IL 6Ralpha , a member of the type 1 cytokine receptor superfamily that is structurally different from TNFR 1 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) activates cells by binding to the membrane bound IL 6 receptor ( IL 6R ) and subsequent formation of a glycoprotein 130 homodimer . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We analyzed expression of TNF alpha , IL 6 , tumor necrosis factor ( TNF RI , TNF RII ) and interleukin 6 ( IL 6R ) receptors in the brain , kidney , spleen , liver , muscle , ascite tumors and serum , from Yoshida AH 130 hepatoma bearing rats . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE : A novel recombinant interleukin 6 Pseudomonas exotoxin fusion protein , having targeted cytotoxicity for leukemic cells highly expressing IL6R has been molecularly designed and constructed in this study . ^^^ CONCLUSIONS : Two novel recombinant interleukin 6 Pseudomonas exotoxin fusion proteins IL6D24 PE40KDEL and IL6D24 Linker PE40KDEL have been successfully constructed and they can selectively kill the leukemic cells expressing highly IL6R . . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Human ES cells differentiate in the presence of members of the IL 6 family of cytokines including leukemia inhibitory factor ( LIF ) and IL 6 or in the presence of the designer cytokine hyper IL 6 , which is a complex of soluble interleukin 6 receptor ( IL 6R ) and IL 6 with greatly enhanced bioactivity . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The interleukin 6 receptor ( IL 6R ) / signal transducer and activator of transcription 3 ( STAT 3 ) pathway contributes to the pathogenesis of multiple myeloma ( MM ) and protects MM cells from apoptosis . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 is a multifunctional cytokine that exerts its biological activity through binding to an 80 Kd specific receptor ( IL 6Ralpha ) and a 130 Kd signal transducing unit ( gp 130 ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Embryos were produced by SCNT , intracytoplasmic sperm injection ( ICSI ) or under different conditions , and transcripts of genes for fibroblast growth factor receptor ( FGFr ) 2IIIc , FGFr72IIIb , 10 inactive specific transcript ( Xist ) , interleukin 6 ( IL 6 ) , IL 6 receptor ( IL6r ) alpha and c kit ligand , were detected by real time RT PCR . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE : To observe the effect of Chinese herbs for supplementing Shen and strengthening bone ( HB ) on myelogenic osteoclasts formation , and gene expression of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) and gp 130 in bone marrow . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
IL 6 acts on target cells via the ligand binding protein interleukin 6 receptor ( IL 6R ) and the affinity converting and signal transducing glycoprotein 130 ( gp 130 ) . ^^^ Soluble interleukin 6 receptor ( sIL 6R ) has an agonistic role because the soluble complex ( IL 6 / sIL 6R ) can activate cells that do not express IL 6R and an antagonistic role as it enhances the inhibitory activity of sgp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
All trans retinoic acid ( ATRA ) , a vitamin A derivative , was reported to suppress the interleukin 6 ( IL 6 ) production and to downregulate the IL 6 receptor ( IL 6R ) and / or its signal transducer glycoprotein 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) is a major growth factor for myeloma cells and retinoids have been shown to inhibit expression of the interleukin 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Interleukin 6 ( IL 6 ) is a pleiotropic cytokine , signaling intracellularly via its unique membrane bound receptor IL 6R and gp 130 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
We have demonstrated , by using a T cell transfer murine colitis model , that blocking interleukin 6 ( IL 6 ) signaling with monoclonal antibody ( mAb ) to IL 6 receptor ( IL 6R ) abrogated apoptosis resistance of lamina propria T cells , suppressed the expression of vascular adhesion molecules , and successfully prevented and treated intestinal inflammation . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A novel peptide specifically binding to interleukin 6 receptor ( gp 80 ) inhibits angiogenesis and tumor growth . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
A crystal structure of the ligand binding domains of gp 130 in complex with human interleukin 6 ( IL 6 ) and its a receptor ( IL 6Ralpha ) revealed a hexameric architecture in which the gp 130 membrane distal regions were approximately 100 A apart , in contrast to the close apposition seen between short cytokine receptor complexes . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Conversely , interleukin 6 ( IL 6 ) a potent cytokine inhibits myeloma cell apoptosis by activating GP 130 through the IL 6 receptor ( IL 6R ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The cytokine interleukin 6 ( IL 6 ) exerts it actions via the IL 6 receptor ( IL 6R ) in conjunction with the ubiquitously expressed gp 130 receptor . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
To characterize the biological activity of tocilizumab , a humanized anti human interleukin 6 receptor ( IL 6R ) monoclonal antibody , we examined its binding activity to both soluble IL 6R ( sIL 6R ) and membrane bound IL 6R ( mIL 6R ) and its neutralizing activity to other IL 6 family cytokines . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
To understand roles of interleukin 6 ( IL 6 ) family cytokines for pregnancy in mice , localization of IL 6 receptor ( IL 6R ) mRNA was investigated in non and early pregnant uteri by in situ hybridization . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In order to develop a new type of agonist for the interleukin 6 ( IL 6 ) signal , the gene encoding a directly fused protein ( DFP ) was constructed by joining the N terminal portion of IL 6 and the C terminal ( soluble ) portion of IL 6R ( sIL 6R ) without using a flexible polypeptide linker . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
FP 6 , a novel recombinant fusion protein of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) , was prepared in the methylotrophic yeast Pichia pastoris . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
This class of agents simultaneously suppresses in MM cells the expression and / or function of multiple levels of insulin like growth factor receptor ( IGF 1R ) and interleukin 6 receptor ( IL 6R ) signaling ( eg , IKK / NF kappaB , PI 3K / Akt , and Raf / MAPK ) and downstream effectors ( eg , proteasome , telomerase , and HIF 1alpha activities ) . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
These results suggest that a number of candidate genes located in the excluded regions , such as interleukin 6 receptor ( IL6R ) gene , type 1 collagen alpha 1 ( COL1A1 ) gene and bone morphogenetic protein 3 ( BMP 3 ) gene are unlikely to have a substantial effect on BMD variation in this Caucasian population . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Increased association with detergent resistant membranes / lipid rafts of apically targeted mutants of the interleukin 6 receptor gp 80 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
For the interleukin 6 receptor gp 80 and its signal transducer gp 130 , a preferential basolateral localization was demonstrated in Madin Darby canine kidney ( MDCK ) cells and two basolateral sorting signals were identified within the cytoplasmic domain of gp 80 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Signal transducer and activator of transcription 3 ( STAT 3 ) has been reported to be activated by interleukin 6 receptor ( IL 6R ) or epidermal growth factor receptor ( EGFR ) in head and neck squamous cell carcinomas ( HNSCC ) , which may have important implications for responsiveness to therapeutics targeted at EGFR , IL 6R , or intermediary kinases . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
The aim of this work was to study the expression of interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in the testis of rats with EAO and analyze whether IL 6 could be involved in germ cell apoptosis . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Human T cell leukemia virus type 1 Tax induces expression of interleukin 6 receptor ( IL 6R ) : Shedding of soluble IL 6R and activation of STAT 3 signaling . ^^^ Soluble interleukin 6 receptor ( sIL 6R ) was shown to circulate at elevated levels in HTLV 1 infected patients , and high expressions of IL 6R and sIL 6R by HTLV 1 infected T cells were clinically and experimentally associated with Tax activity . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Having established that leptin induced proliferation in a murine model of preneoplastic ( Apc ( Min / + ) ; IMCE ) colon epithelial cells but not normal ( Apc ( + / + ) ; YAMC ) cells , we hypothesized that the leptin associated IMCE cell proliferation was a result of autocrine interleukin 6 ( IL 6 ) production and ensuing IL 6 receptor ( IL 6R ) signaling . ^^^ Interleukin 6 induced IMCE cell proliferation was blocked by the addition of a neutralizing anti IL 6R antibody . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
AIM : To evaluate the immunohistochemical localization of interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) on tumor tissue specimens from patients with hepatocellular carcinoma ( HCC ) and the serum levels of IL 6 and sIL 6R in a group of patients with HCC as well as liver cirrhosis ( LC ) in a group of patients with LC alone and in a control group . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
OBJECTIVE : We hypothesize that genetic variations ( single nucleotide polymorphisms SNPs ) in the tumor necrosis factor alpha ( TNF alpha ) , TNF receptors ( TNFRI and TNFRII ) , interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) genes predict high risk status for spontaneous preterm birth ( sPTB ) in European American women . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
These abilities were inhibited to approximately 60 % by the addition of antibodies against interleukin 6 , or alpha chain ( gp 80 ) or beta chain ( gp 130 ) of IL 6 receptor . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
Structural requirements for gp 80 independence of human herpesvirus 8 interleukin 6 ( vIL 6 ) and evidence for gp 80 stabilization of gp 130 signaling complexes induced by vIL 6 . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
RESULTS : During the first week after BDL , there was marked upregulation of IL 6 mRNA and protein in the IL 6+ / + mice only in the vicinity of the biliary tree ; whereas , biliary / peri biliary IL 6R , HGF and met mRNA and protein increased in both groups . ^^^ IL 6 , HGF mRNA and protein localized to periductal inflammatory cells and stellate cells , while met and IL 6R protein were upregulated in the BEC and , to a lesser extent , in hepatocytes . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
In extra thyroidal tissues , the HGF / c met and IL 6 / IL 6 receptor ( IL 6R ) systems activate STAT 3 , a member of the signal transducers and activators of transcription ( STATs ) family . ^^^ To evaluate whether either system utilizes STAT 3 in thyroid nodules , we examined the immunohistochemical expression of HGF , c met , IL 6 , IL 6R , STAT 3 in 6 normal thyroids and in 68 thyroid nodules . ^^^ All these 14 STAT3+ cases expressed both HGF and c met , but only 5 PTC co expressed IL 6 and IL 6R and the 2 FA were IL 6+ but IL 6R . ^^^ Since these cases are consistently HGF+ / c met+ and only one third of them co express IL 6 / IL 6R , STAT 3 expression correlates with the HGF / c met expression , not with the IL 6 / IL 6R expression . ^^^
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
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NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA
Interacting proteins: P05231 and P08887 Pubmed SVM Score :0.0
NA