Microarray analysis revealed 51 genes whose mRNA increased by at least 2 fold in PE01CDDP cells relative to PE 01 ( including FRA 1 , ETV 4 , MCM 2 , AXL , MT 3 , TRAP 1 , and FANCG ) , whereas 36 genes ( including IGFBP 3 , TRAM 1 , and KRT 4 and KRT 19 ) decreased by a similar amount . ^^^