| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The interaction of human blood coagulation factor 7 and tissue factor : the effect of anti factor 7 , anti tissue factor and diisopropylfluorophosphate . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The first epidermal growth factor domain of human coagulation factor 7 is essential for binding with tissue factor . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminal cytoplasmic domain of human tissue factor ( the essential cofactor for coagulation factor 7 ) is a prospective regulatory domain through which viable cells may control the expression of tissue factor activity . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor dependent autoactivation of human blood coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Is the WKS motif the tissue factor binding site for coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Initiation of the extrinsic pathway of blood coagulation : evidence for the tissue factor dependent autoactivation of human coagulation factor 7 . ^^^ Previous studies demonstrated proteolytic activation of human blood coagulation factor 7 by an unidentified protease following complex formation with tissue factor expressed on the surface of a human bladder carcinoma cell line ( J 82 ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor is a lipoprotein , expressed on the surface of cells , which binds coagulation Factor 7 or VIIa , leading to activation of Factors 10 and 9 with subsequent fibrin generation . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The PCA functioned as a tissue factor like substance , since it required coagulation factor 7 and factor 10 . rTNF also increased PCA in human monocytes in a dose and time dependent manner . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Blood coagulation factor 7 is a vitamin K dependent glycoprotein which in its activated form , factor VIIa , participates in the coagulation process by activating factor 10 and / or factor 9 in the presence of Ca2+ and tissue factor . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the high affinity cell surface receptor and obligatory cofactor for plasma coagulation factor 7 . ^^^ Tissue factor ( TF ) is the high affinity cell surface receptor and obligatory cofactor for plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Coagulation factor 7 covalently coupled to Sepharose proved to be an effective binding ligand for human tissue factor apoprotein , the specific cofactor of factor 7 for the activation of factor 10 and 9 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor accelerates the activation of coagulation factor 7 : the role of a bifunctional coagulation cofactor . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Activation of the coagulation factor 7 by tissue thromboplastin and calcium . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| In this study , we have characterized the relationship between the tissue factor activity of cultured cells derived from normal tissues and the number of receptors they possess for coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Chemical cross linking of activated coagulation factor 7 with soluble tissue factor : calcium ions are not essential for full amidolytic activity of the factor VIIa tissue factor complex after complex formation . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Genetic polymorphism ( Arg 353 > Gln ) in coagulation factor 7 gene and factor 7 levels ( coagulant activity , antigen and binding ability to tissue factor ) in 101 healthy Japanese . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor , the obligate cofactor for coagulation factor 7 , plays an essential role in hemostasis by initiating the extrinsic pathway of blood coagulation upon vascular damage , making it a promising target for new anticoagulant therapies in the treatment of thrombosis and sepsis . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided to show that binding is both specific for human coagulation factor 7 and can be utilized to detect factor 7 molecular variants with impaired tissue factor binding . . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the PCA in the RLE cells is similar to TF , which has glycoprotein as an active site and requires coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Incubation with these cells shortened the recalcification time in normal plasma ( also in the presence of antibodies against tissue factor ) or coagulation factor 7 , 8 , 9 or 10 deficient plasmas . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Identification of a calcium binding site in the protease domain of human blood coagulation factor 7 : evidence for its role in factor 7 tissue factor interaction . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor serves as the cellular receptor for circulating blood coagulation factor 7 and is the principal physiological initiator of blood coagulation . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Incomplete gamma carboxylation of human coagulation factor 7 : differential effects on tissue factor binding and enzymatic activity . ^^^ The integrity of the gamma carboxylic glutamic acid ( GLA ) residues of coagulation factor 7 are thought to be essential for both the interaction of factor 7 with its cell surface lipoprotein receptor tissue factor and for the activated protein to manifest its serine protease activity . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is a 48 kD transmembrane glycoprotein that triggers the extrinsic pathway of blood coagulation by interacting with the plasma coagulation factor 7 ( FVII ) . ^^^ Tissue factor ( TF ) is a 48 kD transmembrane glycoprotein that triggers the extrinsic pathway of blood coagulation by interacting with the plasma coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : In vivo , the coagulation pathway is triggered by formation of a high affinity complex between the tissue factor of the injured vascular wall and the activated form of blood coagulation factor 7 ( VIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The transmembrane protein tissue factor ( TF ) is the cell surface receptor for coagulation factor 7 ( FVII ) and activated factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| N 3 fatty acids supplementation did not affect the levels of fibrinogen , coagulation factor 7 or tissue factor pathway inhibitor ( TFPI ) , while plasminogen activator inhibitor ( PAI ) increased significantly ( Student ' s t test ; p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Coagulation factor 7 bound to its cofactor tissue factor is the physiological initiator of blood coagulation . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| TF forms a highly procoagulant complex with activated coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is a transmembrane glycoprotein that serves as an essential cofactor for plasma coagulation factor 7 . ^^^ Tissue factor ( TF ) is a transmembrane glycoprotein that serves as an essential cofactor for plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The international normalized ratio ( INR ) , developed by the World Health Organization in the early 1980s , is designed to eliminate problems in oral anticoagulant therapy caused by variability in the sensitivity of different commercial sources and different lots of thromboplastin to blood coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The starting point of blood coagulation in vivo is the formation of a complex between tissue factor ( TF ) , which is exposed following vascular disease or trauma , and activated blood coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Recombinant activated coagulation factor 7 ( rFVIIa ) ( NovoSeven ) was developed for treatment of bleeding in hemophilia patients with inhibitors ( antibodies ) against factors 8 or 9 . rFVIIa initiates the coagulation cascade by binding to tissue factor at the site of injury and causes the formation of sufficient amounts of thrombin to trigger coagulation . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor 7 ( FVII ) . ^^^ Tissue factor ( TF ) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Initiation of the coagulation serine protease cascade in mammalian cells is mediated by tissue factor ( TF ) , which is a cell surface receptor and cofactor for coagulation factor 7 ( FVII ) and its activated form FVII ( FVIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| One candidate protein to cause coronary NR is tissue factor ( TF ) , which is abundant in atherosclerotic plaque and a cofactor for activated plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| A frequent human coagulation Factor 7 mutation ( A294V , c 152 ) in loop 140s affects the interaction with activators , tissue factor and substrates . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) , a transmembrane receptor for the serine protease coagulation factor 7 ( a ) ( FVIIa ) , is the main initiator of the coagulation cascade . ^^^ Tissue factor ( TF ) , a transmembrane receptor for the serine protease coagulation factor 7 ( a ) ( FVIIa ) , is the main initiator of the coagulation cascade . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Among these , tissue factor and its ligand coagulation factor 7 , thrombin and its protease activated receptors , and type 2 trans membrane serine proteases seem to play a crucial role . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| TF is a transmembrane protein that serves as an essential cofactor for activated coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor 7 and tissue factor pathway inhibitor . ^^^ In such women the arterial intima can express tissue factor , and changes in coagulation factor 7 ( factor 7 ) and tissue factor pathway inhibitor ( TFPI ) may be deleterious . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the cellular receptor and cofactor for blood coagulation factor 7 ( FVII ) . ^^^ Tissue factor ( TF ) is the cellular receptor and cofactor for blood coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Weight loss significantly reduced circulating plasma TF ( 314 + / 181 vs . 235 + / 113 pg / mL , p = 0 . 04 ) , coagulation factor 7 ( 130 + / 22 % vs . 113 + / 19 % , p = 0 . 023 ) , and prothrombin fragment F1 . 2 ( 2 . 4 + / 3 . 4 vs . 1 . 14 + / 1 . 1 nM , p = 0 . 04 ) and normalized glucose metabolism in 50 % of obese patients preoperatively classified as diabetic or of impaired glucose tolerance . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) binds the zymogen ( 7 ) and activated ( VIIa ) forms of coagulation factor 7 with high affinity . ^^^ Tissue factor ( TF ) binds the zymogen ( 7 ) and activated ( VIIa ) forms of coagulation factor 7 with high affinity . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The interaction between cell surface tissue factor ( TF ) and the plasma coagulation factor 7 ( FVII ) initiates the coagulation network that leads to the generation of thrombin and the formation of a fibrin clot . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Biological markers of EC and hypercoagulability were measured and included thrombomodulin , tissue factor , tissue factor pathway inhibitor , von Willebrand factor ( vWF ) , coagulation factor 7 ( FVII ) , activated factor 7 , prothrombin fragment 1 + 2 ( F 1 + 2 ) , and D dimer . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The combination of a markedly prolonged partial thromboplastin time and Quick prothrombin time and failure of normal plasma to correct these tests , in the presence of a normal thrombin and prothrombin and proconvertin time , seems to be pathognomonic for a factor 5 inhibitor . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Oral contraceptives increase the levels of coagulation Factors 2 ( prothrombin ) , 7 ( proconvertin ) , 9 ( plasma thromboplastin component ) , and 10 ( Stewart factor ) which form the prothrombin complex or vitamin K dependent factors . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| According to an established protocol , adjustments in heparin sodium infusion rate were based on activated partial thromboplastin time ( PTT ) ; warfarin sodium dosage was adjusted using a proconvertin and prothrombin ( P & P ) method . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The three tests are Quick ' s prothrombin time , prothrombin and proconvertin method ( Owren ' s P & P ) and activated partial thromboplastin time test ( aPTT ) . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| Species differences of clotting factors in ox , dog , horse , and man : thromboplastin and proconvertin . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| The role of proconvertin and Stuart factor in the inactivation of tissue thromboplastin by serum . ^^^ |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08709 and P13726 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The interaction of human blood coagulation factor 7 and tissue factor : the effect of anti factor 7 , anti tissue factor and diisopropylfluorophosphate . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The first epidermal growth factor domain of human coagulation factor 7 is essential for binding with tissue factor . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The carboxyl terminal cytoplasmic domain of human tissue factor ( the essential cofactor for coagulation factor 7 ) is a prospective regulatory domain through which viable cells may control the expression of tissue factor activity . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor dependent autoactivation of human blood coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Is the WKS motif the tissue factor binding site for coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Initiation of the extrinsic pathway of blood coagulation : evidence for the tissue factor dependent autoactivation of human coagulation factor 7 . ^^^ Previous studies demonstrated proteolytic activation of human blood coagulation factor 7 by an unidentified protease following complex formation with tissue factor expressed on the surface of a human bladder carcinoma cell line ( J 82 ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor is a lipoprotein , expressed on the surface of cells , which binds coagulation Factor 7 or VIIa , leading to activation of Factors 10 and 9 with subsequent fibrin generation . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The PCA functioned as a tissue factor like substance , since it required coagulation factor 7 and factor 10 . rTNF also increased PCA in human monocytes in a dose and time dependent manner . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Blood coagulation factor 7 is a vitamin K dependent glycoprotein which in its activated form , factor VIIa , participates in the coagulation process by activating factor 10 and / or factor 9 in the presence of Ca2+ and tissue factor . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the high affinity cell surface receptor and obligatory cofactor for plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Coagulation factor 7 covalently coupled to Sepharose proved to be an effective binding ligand for human tissue factor apoprotein , the specific cofactor of factor 7 for the activation of factor 10 and 9 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor accelerates the activation of coagulation factor 7 : the role of a bifunctional coagulation cofactor . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| In this study , we have characterized the relationship between the tissue factor activity of cultured cells derived from normal tissues and the number of receptors they possess for coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Chemical cross linking of activated coagulation factor 7 with soluble tissue factor : calcium ions are not essential for full amidolytic activity of the factor VIIa tissue factor complex after complex formation . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Genetic polymorphism ( Arg 353 > Gln ) in coagulation factor 7 gene and factor 7 levels ( coagulant activity , antigen and binding ability to tissue factor ) in 101 healthy Japanese . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor , the obligate cofactor for coagulation factor 7 , plays an essential role in hemostasis by initiating the extrinsic pathway of blood coagulation upon vascular damage , making it a promising target for new anticoagulant therapies in the treatment of thrombosis and sepsis . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Evidence is provided to show that binding is both specific for human coagulation factor 7 and can be utilized to detect factor 7 molecular variants with impaired tissue factor binding . . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Incubation with these cells shortened the recalcification time in normal plasma ( also in the presence of antibodies against tissue factor ) or coagulation factor 7 , 8 , 9 or 10 deficient plasmas . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Identification of a calcium binding site in the protease domain of human blood coagulation factor 7 : evidence for its role in factor 7 tissue factor interaction . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor serves as the cellular receptor for circulating blood coagulation factor 7 and is the principal physiological initiator of blood coagulation . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Incomplete gamma carboxylation of human coagulation factor 7 : differential effects on tissue factor binding and enzymatic activity . ^^^ The integrity of the gamma carboxylic glutamic acid ( GLA ) residues of coagulation factor 7 are thought to be essential for both the interaction of factor 7 with its cell surface lipoprotein receptor tissue factor and for the activated protein to manifest its serine protease activity . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is a 48 kD transmembrane glycoprotein that triggers the extrinsic pathway of blood coagulation by interacting with the plasma coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : In vivo , the coagulation pathway is triggered by formation of a high affinity complex between the tissue factor of the injured vascular wall and the activated form of blood coagulation factor 7 ( VIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The transmembrane protein tissue factor ( TF ) is the cell surface receptor for coagulation factor 7 ( FVII ) and activated factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| N 3 fatty acids supplementation did not affect the levels of fibrinogen , coagulation factor 7 or tissue factor pathway inhibitor ( TFPI ) , while plasminogen activator inhibitor ( PAI ) increased significantly ( Student ' s t test ; p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Coagulation factor 7 bound to its cofactor tissue factor is the physiological initiator of blood coagulation . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is a transmembrane glycoprotein that serves as an essential cofactor for plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The starting point of blood coagulation in vivo is the formation of a complex between tissue factor ( TF ) , which is exposed following vascular disease or trauma , and activated blood coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Recombinant activated coagulation factor 7 ( rFVIIa ) ( NovoSeven ) was developed for treatment of bleeding in hemophilia patients with inhibitors ( antibodies ) against factors 8 or 9 . rFVIIa initiates the coagulation cascade by binding to tissue factor at the site of injury and causes the formation of sufficient amounts of thrombin to trigger coagulation . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the main initiator of the coagulation system and functions as a cell surface receptor for coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Initiation of the coagulation serine protease cascade in mammalian cells is mediated by tissue factor ( TF ) , which is a cell surface receptor and cofactor for coagulation factor 7 ( FVII ) and its activated form FVII ( FVIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| One candidate protein to cause coronary NR is tissue factor ( TF ) , which is abundant in atherosclerotic plaque and a cofactor for activated plasma coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| A frequent human coagulation Factor 7 mutation ( A294V , c 152 ) in loop 140s affects the interaction with activators , tissue factor and substrates . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) , a transmembrane receptor for the serine protease coagulation factor 7 ( a ) ( FVIIa ) , is the main initiator of the coagulation cascade . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Among these , tissue factor and its ligand coagulation factor 7 , thrombin and its protease activated receptors , and type 2 trans membrane serine proteases seem to play a crucial role . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor 7 and tissue factor pathway inhibitor . ^^^ In such women the arterial intima can express tissue factor , and changes in coagulation factor 7 ( factor 7 ) and tissue factor pathway inhibitor ( TFPI ) may be deleterious . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) is the cellular receptor and cofactor for blood coagulation factor 7 ( FVII ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Tissue factor ( TF ) binds the zymogen ( 7 ) and activated ( VIIa ) forms of coagulation factor 7 with high affinity . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The interaction between cell surface tissue factor ( TF ) and the plasma coagulation factor 7 ( FVII ) initiates the coagulation network that leads to the generation of thrombin and the formation of a fibrin clot . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Biological markers of EC and hypercoagulability were measured and included thrombomodulin , tissue factor , tissue factor pathway inhibitor , von Willebrand factor ( vWF ) , coagulation factor 7 ( FVII ) , activated factor 7 , prothrombin fragment 1 + 2 ( F 1 + 2 ) , and D dimer . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the PCA in the RLE cells is similar to TF , which has glycoprotein as an active site and requires coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| TF forms a highly procoagulant complex with activated coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| TF is a transmembrane protein that serves as an essential cofactor for activated coagulation factor 7 ( FVIIa ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Weight loss significantly reduced circulating plasma TF ( 314 + / 181 vs . 235 + / 113 pg / mL , p = 0 . 04 ) , coagulation factor 7 ( 130 + / 22 % vs . 113 + / 19 % , p = 0 . 023 ) , and prothrombin fragment F1 . 2 ( 2 . 4 + / 3 . 4 vs . 1 . 14 + / 1 . 1 nM , p = 0 . 04 ) and normalized glucose metabolism in 50 % of obese patients preoperatively classified as diabetic or of impaired glucose tolerance . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The combination of a markedly prolonged partial thromboplastin time and Quick prothrombin time and failure of normal plasma to correct these tests , in the presence of a normal thrombin and prothrombin and proconvertin time , seems to be pathognomonic for a factor 5 inhibitor . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Activation of the coagulation factor 7 by tissue thromboplastin and calcium . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Oral contraceptives increase the levels of coagulation Factors 2 ( prothrombin ) , 7 ( proconvertin ) , 9 ( plasma thromboplastin component ) , and 10 ( Stewart factor ) which form the prothrombin complex or vitamin K dependent factors . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| According to an established protocol , adjustments in heparin sodium infusion rate were based on activated partial thromboplastin time ( PTT ) ; warfarin sodium dosage was adjusted using a proconvertin and prothrombin ( P & P ) method . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The three tests are Quick ' s prothrombin time , prothrombin and proconvertin method ( Owren ' s P & P ) and activated partial thromboplastin time test ( aPTT ) . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The international normalized ratio ( INR ) , developed by the World Health Organization in the early 1980s , is designed to eliminate problems in oral anticoagulant therapy caused by variability in the sensitivity of different commercial sources and different lots of thromboplastin to blood coagulation factor 7 . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| Species differences of clotting factors in ox , dog , horse , and man : thromboplastin and proconvertin . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| The role of proconvertin and Stuart factor in the inactivation of tissue thromboplastin by serum . ^^^ |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13726 and P08709 |
Pubmed |
SVM Score :0.0 |
| NA |
|