| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| The 66 kd protein was unique , although it shared homology with the 70 kd neurofilament protein ( NF L ) and vimentin . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| This finding was all the more unexpected because comparative amino acid sequence data suggest a closer relationship of the 68 kDa neurofilament protein to desmin , vimentin , and glial fibrillary acidic protein than between any of these three proteins and the keratins . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| This clonal cell line was heterogeneous at 33 degrees C , producing the precursor neuronal cell marker nestin and the glial specific markers glial fibrillary acidic protein , vimentin and S100A1 , as well as weakly producing the neuronal cell markers 68 kDa neurofilament protein ( NF 68 ) and microtubule associated protein 2 ( MAP 2 ) in different subpopulations of cells . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Quantitative northern blotting was used to examine changes in the levels of mRNAs for the low , middle and high molecular weight neurofilament proteins ( NF L , NF M , NF H ) as well as peripherin , vimentin and glial fibrillary acidic protein ( GFAP ) . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| There is no compensatory increase in NF M , NF L , or vimentin levels as a result of the inhibition of peripherin synthesis . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| We show that NF M molecules missing up to 90 or 70 % of the nonhelical carboxy terminal tail or amino terminal head domains , respectively , incorporate readily into an intermediate filament network comprised either of vimentin or NF L , whereas deletions into either the amino or carboxy terminal alpha helical rod region generate assembly incompetent polypeptides . ^^^ Carboxy terminal deletions into the rod domain invariably yield dominant mutants which rapidly disrupt the array of filaments comprised of NF L or vimentin . ^^^ In contrast , the amino terminal deletions into the rod produce pseudo recessive mutants that perturb the wild type NF L or vimentin arrays only modestly . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| We have generated a set of amino and carboxy terminal deletions of the NF L neurofilament gene and determined the assembly properties of the encoded subunits after coexpression with vimentin or wild type NF L . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Dimers of desmin ( from chicken gizzard ) , vimentin ( from bovine lens tissue and cultured human fibroblasts ) and the neurofilament protein NF L ( from bovine brain ) as well as in vitro formed homodimers of human and rat cytokeratins numbers 8 ( A ) , 18 ( D ) and 19 ( `` 40K ' ' ) , are characterized by ultracentrifugation techniques ( sedimentation velocity and equilibrium ) , electron microscopy and chemical cross linking . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Therefore , both the number of introns and their arrangement in the genes coding NF L and NF M contrast sharply with the number and arrangement of introns in the genes of known sequence , encoding other members of the intermediate filament multigene family ( desmin , vimentin , glial fibrillary acidic protein and the acidic and basic keratins ) ; with the exception of a single truncated keratin gene that lacks an encoded tailpiece , these genes all contain eight introns , of which at least six are placed at homologous locations . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Along the structurally conserved coiled coil domains the two neurofilament proteins show only approximately 65 % sequence identity , a value similar to that seen when NF L and NF M are compared with mesenchymal vimentin . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Expressions of peripherin , the neurofilament protein NF L , vimentin , and cytokeratin 8 were analyzed by immunohistochemical methods on 12 human primary tumors and 3 tumor xenografts on nude mice . ^^^ Peripherin , NF L , and cytokeratin 8 were detected in tumoral cells , whereas vimentin was found exclusively in the stroma . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| With regard to cytoplasmic assembly properties , substitution of the head domain of lamin A for that of NF L did not substantially affect the ability of NF L to coassemble with vimentin in the cytoplasm . ^^^ In contrast , insertion of a 42 amino acid sequence unique to lamin rod domains into NF L profoundly affected NF L coassembly with vimentin indicating that the 42 amino acid insertion in lamins may be important for sorting lamins from cytoplasmic IF proteins . . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| At 9 weeks gestational age , immunoreactivity was evident for the microtubule associated proteins ( MAPs ) , MAP 2 and MAP 5 , low molecular weight ( Mr ) neurofilament ( NF ) protein ( NF L ) , poorly phosphorylated mid Mr NF protein ( NF M / P ) , vimentin , and alpha and beta tubulins within the somatodendritic domain of neurons of the hippocampal plate . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Wild type and mutant NF Ls localised to the Triton 10 100 insoluble fraction , which suggests that phosphorylation of Ser 55 does not inhibit assembly of NF L and NF L / vimentin polymers at or below the tetrameric stage . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Antibodies against alpha internexin , the three neurofilament subunits ( NF L , NF M , NF H ) , vimentin , and glial fibrillary acidic protein ( GFAP ) were used to determine the relative expression of these proteins at different post natal stages of mouse retinal development . alpha Internexin is widely distributed in the process of amacrine cells , horizontal cells and retinal ganglion cells before post natal day 5 ( P 5 ) . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Assembly properties of amino and carboxyl terminally truncated neurofilament NF H proteins with NF L and NF M in the presence and absence of vimentin . ^^^ To understand the assembly characteristics of the high molecular weight neurofilament protein ( NF H ) , carboxyl and amino terminally deleted NF H proteins were examined by transiently cotransfecting mutant NF H constructs with the other neurofilament triplet proteins , low and middle molecular weight neurofilament protein ( NF L and NF M , respectively ) , in the presence or absence of cytoplasmic vimentin . ^^^ The results confirm that NF H can coassemble with vimentin and NF L but not with NF M into filamentous networks . ^^^ Deletions from the amino terminus show that the N terminal head is necessary for the coassembly of NF H with vimentin , NF L , or NF M / vimentin . ^^^ However , headless NF H or NF H from which the head and a part of the rod is removed can still incorporate into an NF L / vimentin network . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| After two seconds under standard assembly conditions ( i . e . 25 mM Tris HCl ( pH 7 . 5 ) , 50 mM NaCl , 37 degrees C ) , vimentin , desmin and the neurofilament triplet protein NF L aggregated into similar types of `` unit length filaments ' ' ( ULFs ) , whereas cytokeratins ( CKs ) 8 / 18 already yielded long IFs at this time point , so the ionic strength had to be reduced . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| During differentiation , alpha IN immunoreactivity accumulated within axonal neurites following vimentin but , as previously describe in neurons in situ , before the appearance of NF L . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| A point mutation in the helix termination sequence resulted in complete filament aggregation when coexpressed with vimentin but showed limited coassembly with low and medium molecular weight NF proteins ( NF L and NF M , respectively ) . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| The IF proteins studied included the type 1 and type 2 cytokeratins K 8 , K 18 , and K 19 ; the type 3 proteins desmin , glial fibrillary acidic protein ( GFAP ) , peripherin , and vimentin ; and the type 4 neurofilament triplet protein L ( NF L ) . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| The high salt Triton insoluble cytoskeletal fraction is enriched in neurofilament subunits ( NF H , NF M and NF L ) , vimentin and glial fibrillary acidic protein ( GFAP ) , while the low salt Triton insoluble cytoskeletal fraction contains detergent insoluble cytoskeletal elements such as intermediate filament subunits and tubulins . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| We observed that ditelluride in the concentrations of 1 , 15 and 50 microM induced hyperphosphorylation of the high salt Triton insoluble neurofilament subunits ( NF M and NF L ) , glial fibrillary acidic protein ( GFAP ) and vimentin , without altering the immunocontent of these proteins . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| The distribution of NP 185 was compared with those of other cytoskeletal and cytoplasmic proteins of axons and synapses , namely synaptophysin , vimentin , neurofilament NF 68 , and the intermediate filaments of glial cells ( GFAP ) . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| The removed tumor , which was examined immunohistochemically , was positive for vimentin , GFAP , NF 68 , SYP , and S 100 ; and negative for CEA , desmin , and cytokeratin . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that reverse transcription PCR of RNA isolated from a single eye can detect the mRNAs for glial fibrillary acidic protein ( GFAP ) , vimentin , neurofilament light chain ( NF 68 ) and Thy 1 , all of whose promoters have been used to direct transgene expression in the CNS . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| Radiolabeled aRNA from single neurons was used to probe cDNA arrays containing the low ( NFL ) , medium ( NFM ) and high ( NFH ) molecular weight neurofilament isoform , alpha internexin , desmin , vimentin , peripherin ( PRPH ) , nestin , and glial fibrillary acidic protein ( GFAP ) cDNAs . ^^^ Increased expression of nestin , alpha internexin , PRPH , vimentin , NFL , NFM , and NFH mRNAs was found in DN when compared with the three control neuronal subtypes . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| In the retina , Syn expression starts in the nerve fiber and ganglion cell layers ( NFL and GCL ) at 15 weeks , remains there in up to 20 weeks , and spreads to other layers and may be colocalized with vimentin , GFA , or neurofilaments in the subsequent 16 weeks . ^^^ |
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| Interacting proteins: P07196 and P08670 |
Pubmed |
SVM Score :0.0 |
| We have examined the steady state levels of intermediate filament mRNA in amyotrophic lateral sclerosis using the RNAse protection assay ( NFL , NFM , NFH ; corrected against GAPDH ) or by PCR ( peripherin , alpha internexin , nestin , and vimentin ; corrected against beta actin ) . ^^^ |
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