| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| This study was designed to assess the interrelationship of cytokeratin P ( Cyto P ) , vimentin , epidermal growth factor receptor ( rEGF ) and tissue testosterone following androgen deprivation therapy . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| In order to evaluate more objective laboratory methods that may help practicing pathologists to discern malignancy in human adrenocortical neoplasms , we have examined cellular DNA content by flow cytometry and immunohistochemical distribution of c myc , vimentin , proliferating cell nuclear antigen ( PCNA ) , and epidermal growth factor receptor ( EGFR ) in 15 cases of human adrenocortical neoplasms ( nine carcinomas and six adenomas ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| The cell cycle and the expression of human beta 2 microglobulin , human EGF receptors ( EGF r ) , vimentin were simultaneously studied by flow cytometry . ^^^ Epithelial CaSki cells , derived from a human uterine carcinoma , expressing high levels of beta 2 microglobulin , EGF r and vimentin , were used as a positive control . ^^^ In mouse fibroblasts 3T3 . 4E only vimentin was expressed whereas in cells derived from fusion , human beta 2 microglobulin , human EGF r and vimentin were detected . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| We investigated normal oral epithelium and 20 oral squamous cell carcinomas with antibodies against oncogene products ( p 21 , EGF R ) and intermediate filaments ( cytokeratins 4 , 10 / 11 , 13 , 18 , Vimentin ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| The coordinate expression of the nuclear p 53 protein , cytoplasmic intermediate filament vimentin ( VIM ) and membrane epidermal growth factor receptor ( EGF R ) was significantly associated with oestrogen receptor immunocytochemical nuclear stain ( ER ICA ) negative breast carcinomas . ^^^ Vimentin and p 53 expression on epidermal growth factor receptor positive , oestrogen receptor negative breast carcinomas . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Relationship of epidermal growth factor receptor ( EGFR ) , proliferating cell nuclear antigen ( PCNA ) and vimentin expression and various prognostic factors in breast cancer patients . ^^^ Cytologic specimens ( FNA ) from 42 primary invasive ductal breast carcinomas and 22 matched specimens of cancer tissue were tested for EGFR status , PCNA index and vimentin expression by immunocytochemical staining , using an Extravidin Biotin method , and their relationship with various prognostic factors was investigated . ^^^ EGFR positivity , high PC 10 score and vimentin positivity were significantly correlated with high histologic grade . ^^^ The coordinate expression of EGFR , PCNA and vimentin was significantly associated with ER negative breast carcinomas . ^^^ Co expression of EGFR , PCNA and vimentin was determined in most cases . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| For immunostaining , antibodies reacting with epithelial membrane antigen ( EMA ) , pankeratin , vimentin , CA 125 , CA 19 9 , carcinoembryonic antigen ( CEA ) , alpha fetoprotein ( AFP ) , alpha 1 antitrypsin ( AT ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 , bcl 2 and p 53 proteins were used . ^^^ All the cases examined were positive for EMA and pankeratin , specific markers for epithelial tumors , negative for the non epithelial tumor marker , vimentin , and also positive for EGFR . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study in acquired cystic disease of the kidney expression of vimentin , epidermal growth factor , epidermal growth factor receptor and c erb B 2 gene product ] . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor ( EGFr ) status and the vimentin ( 5 ) status of malignant cells in pleural fluids from patients with breast cancer were determined using an immunoperoxidase labelling technique . ^^^ Expression of vimentin and epidermal growth factor receptor in effusions from patients with breast cancer ; correlation with oestrogen and progesterone receptor status . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| The `` metastatic ' ' and `` recurrent ' ' cell lines showed changes in comparison to the corresponding `` parental ' ' lines , which could be associated with a higher degree of de differentiation , such as the occurrence of vimentin and neuroectodermal proteins , loss of HLA ABC or HLA DR and increased expression of epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Significant numbers of thymidine labeled cells detected 2 h following thymidine injection in the subgranular region of the dentate gyrus and in the SER of the lateral ventricle stained positively for epidermal growth factor receptor , vimentin , and PSTAIR like immunoreactivity . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Neither some histochemical reactions nor the well preserved immunohistochemical reactivities of beta hCG , hPL , PLAP , AFP , cytokeratin , vimentin , desmin , factor 8 , CD 68 , MIB 1 ( growth fraction ) , EGF R , p 53 and c erbB 2 oncoproteins have disclosed specific chromosome anomalies . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : Cryosections of a hypopharyngeal carcinoma were compared in this respect with different cultivation systems ( 2 dimensional monolayers [ ML ] , 3 dimensional multicellular tumor spheroids [ MTS ] and substrate cultures on Gelita ) in regard to expression of cytokeratins ( CK ) 1 , 7 , 10 , 14 , 18 and 19 , vimentin , neurofilament ( NF ) kD 200 and 68 , ganglioside GD 2 , oncogene products ( P 53 mutant and wild ) , and membrane associated antigens ( HLA ABC and DR , epidermal growth factor receptor EGFR ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| It and its 7 clones all expressed cytokeratins 8 , 17 , 18 and 19 , vimentin , epithelial membrane antigen , S 100 , myoglobin , type 2 collagen , alpha smooth muscle actin , placental alkaline phosphatase and epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| We studied by simple and double immunolabeling techniques on tissue sections of normal human skin the phenotype of these cells and found them to express vimentin and Te 7 but none of the remaining markers sought ( factor XIIIa , von Willebrand factor , CD1a , CD 3 , CD 4 , CD 8 , CD 14 , CD 25 , CD 36 , CD 45 , CD 54 , CD 56 , LFA 1 , EGF R , S 100 protein , Mac 387 , and muscle specific actin ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| In vivo KL5B cells formed anaplastic invasive cancer with areas of glandular formation , overexpressed TGF alpha and EGFR , expressed cytokeratin , vimentin , laminin and alpha 1 antitrypsin and reacted strongly with L phytohemagglutinin and tomato lectin . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| By univariate analysis , we found that vimentin expression was inversely associated with keratin expression alone ( P = 0 . 0089 ) and directly related to histological grade ( P = 0 . 017 ) , nuclear grade ( P = 0 . 027 ) , Ki 67 growth fraction ( P = 0 . 024 ) , and epidermal growth factor receptor immunostaining ( P = 0 . 019 ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| RESULTS : SCRC 1 cells were reactive with antibodies to NSE , chromogranin A , bombesin , Bcl 2 , CD44s , CD44v6 , CD44v7 to 8 , vimentin and S 100 protein ( predominantly beta subunit ) , and were unreactive with antibodies to EMA , CD 54 , EGFR ( R 1 ) , URO 5 , URO 7 , URO 8 and URO 10 . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| These cells expressed cytokeratins , alpha 1 antitrypsin , transforming growth factor alpha , epidermal growth factor receptor , carbonic anhydrase 2 , vimentin , laminin , and showed binding to tomato lectin and Phaseolus vulgaris leukoagglutinin . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| However , later , all endocrine and exocrine cells were replaced by undifferentiated cells that expressed neuron specific enolase , chromogranin A , laminin , vimentin , cytokeratin 7 and 19 , alpha 1 antitrypsin , transforming growth factor alpha , and epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| The clinical histories , histologic features , and immunohistochemical staining patterns for glial fibrillary acidic protein , vimentin , p 53 , and epidermal growth factor receptor ( EGFR ) of three cases of congenital glioblastoma multiforme are given and previous case reports are reviewed . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| These 14 differentially expressed genes , only 6 of which have previously been associated with RCC , are related to tumour growth / survival ( EGFR , cyclin D 1 , insulin like growth factor binding protein 1 and a MLRQ sub unit homologue of the NADH : ubiquinone oxidoreductase complex ) , angiogenesis ( vascular endothelial growth factor , endothelial PAS domain protein 1 , ceruloplasmin , angiopoietin related protein 2 ) and cell adhesion / motility ( protocadherin 2 , cadherin 6 , autotaxin , vimentin , lysyl oxidase and semaphorin G ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| AIM : Several studies have investigated the expression of the cytokeratins ( CKs ) , vimentin , the epithelial growth factor receptor ( EGFR ) , the oestrogen receptor ( ER ) , and the progesterone receptor ( PgR ) , in breast cancer , but no study has directly compared p 53 mutations with these phenotypic and differentiation markers in the same case . ^^^ RESULTS : Thirteen cases ( eight DCIS and five IDC ) showed expression of CK 8 , CK 14 , CK 18 , vimentin , and EGFR , consistent with a stem cell phenotype , whereas 44 cases ( 27 DCIS and 17 IDC ) showed expression of CK 8 and CK 1 , weak or negative expression of CK 18 , but were negative for vimentin and EGFR , consistent with a luminal cell phenotype . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| KIT overexpression was correlated with vimentin and S 100 expression ( P=0 . 003 and P=0 . 005 ) , and EGFR overexpression was correlated with S 100 expression ( P=0 . 0001 ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Vimentin expression was also seen in the respective in situ components and correlated positively with the expression of SMA , CD 10 , CK 5 , p 53 , Mib 1 and EGFR . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| They were immunohistochemically ( IHC ) examined using antibodies for EGFR , platelet derived growth factor receptor ( PDGFR ) alpha , PDGFRbeta , parathyroid hormone ( PTH ) receptor , Ki 67 , cyclinD 1 , p 53 , and vimentin . ^^^ EGFR , p 53 and vimentin were highly expressed in ER ( ) / HER2 ( ) breast cancer cells ( p < 0 . 01 ) . ^^^ Overall , the ER ( ) / HER2 ( ) breast cancer showed the highest Ki 67 LI , the most frequent expression of EGFR , p 53 and vimentin , as well as the lowest expression of cyclinD 1 . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| In contrast , NSCLC lines having undergone EMT , expressing vimentin and / or fibronectin , were insensitive to the growth inhibitory effects of EGFR kinase inhibition in vitro and in xenografts . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry for estrogen receptor ( ER ) , HER 2 , EGFR , smooth muscle actin ( SMA ) , p 63 , CD 10 , cytokeratin 5 / 6 , cytokeratin 8 / 18 , and vimentin was performed on 18 basal like , 16 luminal , and 12 HER2+ tumors . ^^^ Most basal like tumors showed immunoreactivity for vimentin ( 17 / 18 ) , luminal cytokeratin 8 / 18 ( 15 / 18 ) , EGFR ( 13 / 18 ) , and cytokeratin 5 / 6 ( 11 / 18 ) , while positivity for the myoepithelial markers SMA ( 4 / 18 ) , p 63 ( 4 / 18 ) and CD 10 ( 2 / 18 ) was infrequent . ^^^ The most consistent immunophenotype seen in the basal like tumors was negativity for ER and HER 2 , and positivity for vimentin , EGFR , cytokeratin 8 / 18 , and cytokeratin 5 / 6 . ^^^ |
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| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Our immunohistochemical antibody panel included pan cytokeratin ( CK ) , basal cell type CKs ( 34betaE12 , CK5 / 6 , CK 14 , CK 17 ) and vimentin antibodies , antibodies to established ( SMA , CD 10 , p 63 , S 100 , maspin , calponin , GFAP , SM myosin ) , and novel ( CD 29 , 14 3 3sigma ) myoepithelial markers , as well as antibodies to CD 34 , desmin , h caldesmon , steroid receptors ( estrogen , progesterone , androgen ) , and EGFR ( Her 1 ) . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Many BRCA 1 related tumors have a distinct histological characteristics which together have been called `` basal like . ' ' Typically such tumors are ER , HER 2 and express cytokeratin 5 / 6 , cytokeratin 8 / 18 , EGFR and vimentin . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Stable expression of a periostin transgene in tumorigenic but non metastatic 293T cells caused cells to undergo fibroblast like transformation accompanied by increased expressions of vimentin , epidermal growth factor receptor ( EGFR ) , and matrix metalloproteinase 9 . ^^^ |
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| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| IHC revealed positive staining for CD 34 , EGFR and vimentin and , only in a few cases for CD 117 . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| Using quantitative real time PCR there was over expression of epidermal growth factor receptor , c myc , transforming growth factor alpha , vascular endothelial growth factor and vimentin , and under expression of TYRO 3 protein tyrosine kinase . ^^^ |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08670 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|