| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :1.0349055 |
| We measured the binding between OPN and integrin alpha 5 beta 3 with recombinant human OPN and the urinary form of human OPN , uropontin . 1.0349055^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Engagement of the osteoclast integrin alpha 5 beta 3 by osteopontin stimulates phosphatidylinositol 3 hydroxyl kinase activity . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Engagement of the osteoclast integrin alpha 5 beta 3 by osteopontin stimulates phosphatidylinositol 3 hydroxyl kinase activity . ^^^ Osteoclast adhesion via integrin alpha 5 beta 3 to the bone matrix protein osteopontin ( OPN ) results in stimulation of bone resorption . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Osteopontin ( OPN ) is an extracellular matrix protein that binds to integrin alpha 5 beta 3 . ^^^ Human embryonic kidney 293 cells adhere to human recombinant osteopontin ( glutathione S transferase osteopontin ; GST OPN ) using integrin alpha 5 beta 1 . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Binding of osteopontin to the osteoclast integrin alpha 5 beta 3 . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha 5 beta 3 potentiate bone resorption . ^^^ We conclude that both osteoclast adherence to bone and subsequent resorption of its matrix are dependent on interactions between the bone matrix proteins osteopontin and / or bone sialoprotein and the integrin alpha 5 beta 3 . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Osteopontin activation of c src in human melanoma cells requires the cytoplasmic domain of the integrin alpha 5 subunit . ^^^ The expression of osteopontin ( OPN or OP ) , a protein ligand for the integrin alpha 5 beta 3 , also correlates with metastatic potential of some tumors . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Selective alpha 5 beta 3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury : evidence for the functional importance of integrin alpha 5 beta 3 and osteopontin expression during neointima formation . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| To determine whether platelet adhesion to surfaces coated with the matrix protein osteopontin requires an agonist induced increase in the affinity of the integrin alpha 5 beta 3 for this ligand , we used laser tweezers to measure the rupture force between single alpha 5 beta 3 molecules on the platelet surface and osteopontin coated beads . ^^^ |
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| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical localization of integrin alpha 5 beta 3 and osteopontin suggests that they do not interact during embryo implantation in ruminants . ^^^ BACKGROUND : It has been suggested that trophoblast attachment requires co expression of integrin alpha 5 beta 3 and its ligand osteopontin at the fetal maternal interface . ^^^ Until now the expression patterns of integrin alpha 5 beta 3 and osteopontin in the pregnant bovine uterus were unknown . ^^^ The objectives of this study were to localize integrin alpha 5 beta 3 and osteopontin in bovine and sheep endometrium during the periimplantation period and to compare the distribution patterns using antibodies that had not yet been tested in sheep . ^^^ CONCLUSION : In ruminants , integrin alpha 5 beta 3 and osteopontin do not co localize at the fetal maternal interface indicating that these proteins could not interact to facilitate embryo attachment as has been proposed in other species . . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| To investigate receptors that recognize uncleaved and thrombin cleaved OPN , affinity chromatography was performed on placental extracts ; the cell surface integrin alpha 5 beta 3 bound to columns constructed either with native or thrombin cleaved OPN and was selectively eluted from each with soluble GRGDS peptide and EDTA . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| Cell attachment mediated through both OPN and the 28 kD peptide was blocked by the addition of GRGDSPA peptides or LM 609 , a monoclonal antibody to the integrin alpha 5 beta 3 , a receptor for vitronectin . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| In haptotaxis assays , antibody LM 609 to integrin alpha 5 beta 3 blocked > 80 % cell migration towards the GRGDS containing OPN fragment , implicating alpha 5 beta 3 as its principal functional receptor . ^^^ |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10451 and P08648 |
Pubmed |
SVM Score :0.0 |
| NA |
|