Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Amplification of the c met gene , that encodes hepatocyte growth factor receptor , was examined on human esophageal , gastric and colorectal carcinomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto oncogene ( hepatocyte growth factor receptor ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Identification of the hepatocyte growth factor receptor as the c met proto oncogene product . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor receptor and the c met oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
C terminal truncated forms of Met , the hepatocyte growth factor receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We have detected a novel type of structural variant of the tyrosine kinase receptor for c met , also known as the hepatocyte growth factor receptor , in mouse tissues . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Signal transduction by the hepatocyte growth factor receptor , c met . ^^^ In this review of the hepatocyte growth factor receptor c met , the ability of the amino acid sequence of the receptor to dictate which signaling proteins are activated is described , with particular emphasis on association with the phosphatidylinositol 3 kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
By in situ hybridization , FGF 2 was also found to mediate the transcriptional activation of WT 1 and of the hepatocyte growth factor receptor gene , c met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The hepatocyte growth factor receptor ( HGFr ) transduces a wide range of biological signals , including mitogenesis , motogenesis and morphogenesis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of hepatocyte growth factor mRNA , and c met mRNA ( hepatocyte growth factor receptor ) in human liver tumours . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The aim of the present study was to evaluate messenger RNA expression of c met , a hepatocyte growth factor receptor gene , after gastric mucosal injury in rats . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We were also able to detect the hepatocyte growth factor receptor c met on MMR 1 cells by indirect immunofluorescence . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We examined mRNA expression for c met encoding hepatocyte growth factor receptor in 8 gastric carcinoma cell lines and 31 surgically resected gastric carcinoma tissues by Northern blot analysis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of the c met / hepatocyte growth factor receptor gene during rat liver regeneration induced by carbon tetrachloride . ^^^ And the c met protooncogene is reported to encode a hepatocyte growth factor receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In addition , human lesion derived spindle cells synthesize and secrete biologically active hepatocyte growth factor and express the hepatocyte growth factor receptor ( c MET ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
At week 1 , there was an increase in both hepatocyte growth factor ( HGF ) and hepatocyte growth factor receptor ( HGFR ) which colocalized in centrilobular hepatocytes ; in some mice or periportal hepatocytes in other mice . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The motogenic , mitogenic , and morphogenic responses were also elicited by triggering the structurally related hepatocyte growth factor receptor ( Met ) but not epidermal growth factor or platelet derived growth factor receptors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Induction of met proto oncogene ( hepatocyte growth factor receptor ) expression during human monocyte macrophage differentiation . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of Met / hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors . ^^^ Overexpression of the hepatocyte growth factor receptor ( Met / HGF receptor ) , a transmembrane tyrosine kinase encoded by the met proto oncogene , has been associated with tumor progression in different human carcinomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Immunohistochemical assays revealed that the peribiliary glands and antral type glands expressed not only cytokeratin and carbohydrate antigen 19 9 , but also c MET protein , the hepatocyte growth factor receptor which may be related , at least in part , to the cystic dilatation of the peribiliary glands . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
FGFR 4 , insulin like growth factor 2 receptor ( IGF2R ) and hepatocyte growth factor receptor ( HGFR ) could not be detected in both samples . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Activated ras and ret oncogenes induce over expression of c met ( hepatocyte growth factor receptor ) in human thyroid epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor receptor ( HGFR ) transcripts were also unchanged in both experimental groups . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Lack of hepatocyte growth factor receptor ( c met ) gene expression in fulminant hepatic failure livers before transplantation . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The HMC 1 human mast cell line expresses the hepatocyte growth factor receptor c met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Previously , we reported amplification of the protooncogene MET ( hepatocyte growth factor receptor ; 7q31 ) in more than 20 % of glioblastomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) was found to stimulate the growth and progression of gastric cancer cells through hepatocyte growth factor receptor ( HGFR ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Specifically , the epidermal growth factor receptor ( EGFR ) , p185HER2 / Neu and the hepatocyte growth factor receptor ( c Met ) appear to be linked to the process because they preferentially activate c Src in highly metastatic cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Structural and functional characterization of the mouse c met proto oncogene ( hepatocyte growth factor receptor ) promoter . ^^^ The c met gene encoding Hepatocyte Growth Factor Receptor is predominantly expressed in epithelial cell types and overexpressed in a variety of human and mouse neoplastic tissues and cell lines . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Higher grade tumours tended to express it in the cytoplasm , suggesting that the role of c Met as the hepatocyte growth factor receptor was blocked in higher grade tumours . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor , and urokinase type plasminogen activator receptor . ^^^ BACKGROUND : Hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor ( AMFR ) , and urokinase type plasminogen activator receptor ( uPAR ) are known to play important roles in tumor cell migration , invasion , and metastasis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We therefore characterized , by Northern blot and / or immunohistochemistry , the relative expression of three effectors involved in the invasion , angiogenesis , and dissemination of tumor cells in esophageal cancer versus nontumoral mucosae : ( a ) stromelysin 3 ( ST 3 ) , a member of the metalloproteinase family ; ( b ) basement membrane 40 / secreted protein acidic and rich in cysteine ( BM 40 / SPARC ) , an extracellular matrix associated protein involved in angiogenesis ; and ( c ) the hepatocyte growth factor receptor MET , which triggers the scattering of epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The tyrosine phosphorylation of hepatocyte growth factor receptor ( c MET ) occurred between 2 . 5 and 5 hr after the treatment . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In the present retrospective study , liver cell dysplasia ( LCD ) occurring in cirrhotic livers associated or not associated with hepatocellular carcinoma ( HCC ) was immunohistochemically analyzed for the expression of hepatocyte growth factor receptor ( c met protein ) , Rb ( retinoblastoma gene ) protein , E cadherin , and transforming growth factor beta 1 ( TGF beta 1 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Protein tyrosine phosphatase PTP S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The hepatocyte growth factor receptor gene , c met gene , was shown to be present in lymphocytes . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Another oncogene , c MET ( hepatocyte growth factor receptor ) , was universally expressed in either type of endothelial cells , but other oncogenes , k RAS and c ERBB 2 , were not expressed in either type . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The transforming gene product of the S 13 avian erythroblastosis virus , the env sea protein , is a member of the hepatocyte growth factor receptor family of tyrosine kinases comprising Met , Ron , and Sea . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Western blot analyses and co immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , hepatocyte growth factor receptor ( MET ) , urokinase type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT 3 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Amplification and overexpression of the hepatocyte growth factor receptor ( HGFR / MET ) in rat DMBA sarcomas . ^^^ We have previously determined that the loci for the hepatocyte growth factor ( Hgf ) and hepatocyte growth factor receptor ( Hgfr / Met ) , a protooncogene , are situated in this particular chromosome region . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
KS cells synthesize and secrete HGF and express the hepatocyte growth factor receptor ( c Met ) , thus providing an autocrine loop for tumor proliferation and neovascularization which can be enhanced by proinflammatory cytokines . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We have tested other mitogenic receptor tyrosine kinases as putative Grb 10 partners and have identified the activated forms of platelet derived growth factor ( PDGF ) receptor beta ( PDGFRbeta ) , hepatocyte growth factor receptor ( Met ) , and fibroblast growth factor receptor as candidates . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In addition , study of the Wilms ' tumor suppressor , WT 1 , is revealing much about the pathogenesis of Wilms ' tumor , urogenital development , and glomerular podocyte biology . c met , the gene encoding the hepatocyte growth factor receptor , has recently been identified as a causative gene for hereditary papillary renal cancer . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The untransformed stable cell line Met murine hepatocytes ( MMH ) , generated from liver explants of transgenic mice expressing a constitutively active truncated form of the human hepatocyte growth factor receptor ( cyto Met ) , represents an innovative tool for in vitro studies of liver function . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Stimulation of the hepatocyte growth factor receptor tyrosine kinase , Met , induces the inherent morphogenic program of epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
To further elucidate the physiologic role of PSM we have identified additional mitogenic receptor tyrosine kinases as putative PSM partners including platelet derived growth factor ( PDGF ) receptor ( PDGFR ) beta , hepatocyte growth factor receptor ( Met ) , and fibroblast growth factor receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
METHODS : An RT PCR plus Southern blot assay was used to detect mRNA of tumor markers in blood and tissues . mRNA expression of the tumor progression markers MET ( hepatocyte growth factor receptor gene c met ) , GalNAc T ( beta 1 , 4 N acetyl galactosaminyl transferase ) , and beta hCG ( beta human chorionic gonadotropin ) was evaluated in 9 pancreatic carcinoma cell lines , 13 tumor biopsy specimens , 5 nonmalignant pancreatic tissue specimens , and blood from 33 pancreatic carcinoma patients and 32 healthy donors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Transcriptional activation of the hepatocyte growth factor receptor ( c met ) gene by its ligand ( hepatocyte growth factor ) is mediated through AP 1 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
It is mainly synthesized in mesenchymal cells and acts on epithelial cells , where its actions are dependent on binding to a specific cell surface hepatocyte growth factor receptor ( c Met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Osteopontin induced , integrin dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor ( Met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The expression of Met / hepatocyte growth factor receptor gene in giant cell tumors of bone and other benign musculoskeletal tumors . ^^^ Overexpression of the hepatocyte growth factor receptor ( Met / HGF receptor ) , a transmembrane tyrosine kinase encoded by the MET proto oncogene , is involved in transformation and invasive behavior of human carcinomas and sarcomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We examined the ultrastructure of and c met ( hepatocyte growth factor receptor ) expression in dysplastic epithelial cells from this case to evaluate the efficacy of MMC treatment . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The epidermal growth factor receptor ( EGFR ) and the hepatocyte growth factor receptor ( c Met ) are two such receptor tyrosine kinases ( RTKs ) that have been causally implicated in colorectal carcinoma ( CRC ) progression and metastasis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
As a model system , we have investigated the metalloproteinase mediated cleavage of the hepatocyte growth factor receptor , Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The met protooncogene encodes the hepatocyte growth factor receptor ( HGFR , c met ) . ^^^ Expression and functional role of hepatocyte growth factor receptor ( C MET ) during postnatal rat testis development . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The c met proto oncogene , encoding the hepatocyte growth factor receptor , can be activated by various mechanisms . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Overexpression of hepatocyte growth factor receptor ( c met ) has been detected in many human tumors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The genes Cdk 6 ( cyclin dependent kinase 6 ) and Met ( hepatocyte growth factor receptor ) were located in the core of each amplified region and were amplified most recurrently and at the highest levels among the genes tested . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Increases in vascular endothelial growth factor ( VEGF ) receptors Flt 1 and Flk 1 / KDR , angiopoietin receptors Tie 1 , Tie 2 , and platelet derived growth factor receptor beta ( PDGF Rbeta ) , modest increases in epidermal growth factor receptor ( EGF R ) , and no increase in hepatocyte growth factor receptor ( c Met ) or fibroblast growth factor receptors ( FGF R ) were observed in isolated membranes during EC proliferation . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
InlB is a Listeria monocytogenes protein promoting entry in non phagocytic cells , and has been shown recently to activate the hepatocyte growth factor receptor ( HGFR or Met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Role of the hepatocyte growth factor receptor , c Met , in oncogenesis and potential for therapeutic inhibition . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor ( c met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
These include loss of heterozygosity ( LOH ) at the chromosomal region 11p15 . 5 , LOH on chromosome arms 1p and 1q , activating mutations in exon 3 of the beta catenin gene , as well as overexpression of the c met oncogene , which encodes the hepatocyte growth factor receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In this study of gastric cancer , we evaluated whether IGF 2 ( insulin like growth factor 2 ) , c MET ( hepatocyte growth factor receptor ) , MMP 7 ( matrix metalloproteinase 7 ) and MUC 1 , which are associated with nodal metastasis from primary tumor , are concerned with metastasis from nodal metastatic lesion to other nodes . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
It triggers bacterial entry by interacting with the hepatocyte growth factor receptor ( HGF R or Met ) and two other cellular components : gC1q R and proteoglycans . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We found that in cells expressing the endogenous proteins , Plexin B 1 ( the Sema 4D Receptor ) and Met ( the Scatter Factor 1 / Hepatocyte Growth Factor Receptor ) associate in a complex . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Increased tyrosine phosphorylation among a number of proteins was detected in MSV MDCK INV cells relative to untransformed and MSV transformed MDCK cells , especially for the hepatocyte growth factor receptor ( HGF R ) , otherwise known as c met proto oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Primary tumors were analyzed for p 53 expression using IHC staining and for beta human chorionic gonadotropin ( beta hCG ) , hepatocyte growth factor receptor ( c Met ) , and universal melanoma antigen ( uMAGE ) messenger RNA expression using reverse transcriptase polymerase chain reaction and electrochemiluminescence . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein tyrosine phosphatase DEP 1 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of extracellular signal regulated kinase ( ERK ) and hepatocyte growth factor receptor ( HGFR or c met ) was determined by immunoprecipitation and western blot analysis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Although RTKs are a large family , HER 2 , epidermal growth factor receptor ( EGFR ) , Met ( hepatocyte growth factor receptor ) , and others all have shown the ability to predict outcome . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The hepatocyte growth factor receptor tyrosine kinase Met promotes cell dissociation and the inherent morphogenic program of epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Additionally , cells have been identified with a keratin phenotype intermediate between basal and luminal cells that co express high levels of K 5 and K 18 ( K5 / 18 ) as well as hepatocyte growth factor receptor c MET . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The met oncogene , encoding the high affinity hepatocyte growth factor receptor , is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c Met and its complex with the microbial alkaloid K 252a . ^^^ The protooncogene c met codes for the hepatocyte growth factor receptor tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Embryonic Foxf 1 ( + / ) lungs exhibited diminished expression of hepatocyte growth factor receptor c Met , myosin 6 , the transcription factors SP 3 , BMI 1 , ATF 2 , and glucocorticoid receptor , and cell cycle inhibitors p 53 , p 21 ( Cip 1 ) , retinoblastoma , and p 107 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
SU 5416 is a potent inhibitor of hepatocyte growth factor receptor ( c Met ) and blocks HGF induced invasiveness of human HepG 2 hepatoma cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Prostate cancer and the met hepatocyte growth factor receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Their cellular ligands have been also identified : InlA interacts with the adhesion molecule E cadherin , while InlB interacts with the receptor for the globular head of the complement factor C1q ( gC1q R ) , with the hepatocyte growth factor receptor ( c Met ) and with glycosaminoglycans ( including heparan sulphate ) . ^^^ Their cellular ligands have been also identified : InlA interacts with the adhesion molecule E cadherin , while InlB interacts with the receptor for the globular head of the complement factor Clq ( gClq R ) , with the hepatocyte growth factor receptor ( c Met ) and with glycosaminoglycans ( including heparan sulphate ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Listeria monocytogenes uptake by nonphagocytic cells is promoted by the bacterial invasion proteins internalin and InlB , which bind to their host receptors E cadherin and hepatocyte growth factor receptor ( HGF R ) / Met , respectively . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Previously , we found that hepatocyte growth factor receptor ( c Met ) and alpha fetoprotein ( AFP ) expressing cells were present in adult rat bone marrow , and that these cells also expressed hematopoietic stem cell markers , such as CD 34 , Thy 1 , and c Kit . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Activation of c Met ( hepatocyte growth factor receptor ) in human gastric cancer tissue . c Met is a high affinity receptor for hepatocyte growth factor ( HGF ) and plays a crucial role in embryonic development , as well as in the process of tissue repair . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Parallel to the biochemical changes , there were progressive increases in the DNA repair enzyme APEX 1 , the cell cycle control proteins cyclin D 1 and D 3 , and the hepatocyte growth factor receptor Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Activation of the hepatocyte growth factor receptor Met induces a morphogenic response and stimulates the formation of branching tubules by Madin Darby canine kidney ( MDCK ) epithelial cells in three dimensional cultures . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In this study , we were able to demonstrate that hepatocyte growth factor receptor , c Met , is also a coreceptor for AAV 2 infection . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
RESULTS : Hepatocyte growth factor receptor c met , growth factor receptor bound protein 10 , B raf proto oncogene , and several mitogen activated protein kinase kinase genes were significantly up regulated in melanoma metastases and several melanoma cell lines relative to normal human melanocytes ( P = . 03 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Internalisation of the pathogenic bacterium Listeria monocytogenes involves interactions between the invasion protein InlB and the hepatocyte growth factor receptor , Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Increased hepatocyte growth factor receptor ( HGFR ) signaling correlates closely with neoplastic invasion and metastatic potential of many human cancers . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor is secreted by vascular endothelial cells and smooth muscle cells , and the hepatocyte growth factor receptor , c met , was also observed in these vascular cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Estradiol valerate decreased uterine FGF 7 ( fibroblast growth factor 7 ) and MET ( hepatocyte growth factor receptor ) expression and increased INHBA ( inhibin betaA ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Targeted inactivation of hepatocyte growth factor receptor c met in beta cells leads to defective insulin secretion and GLUT 2 downregulation without alteration of beta cell mass . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The interaction of InlB with the hepatocyte growth factor receptor , Met , is crucial for infection to occur . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This result was accompanied by a reduction in collagen synthesis , reduced levels of hepatocyte growth factor receptor MET and increased levels of the tumor suppressor protein WT 1 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Matrigel also induced an increased association of beta catenin with Met ( hepatocyte growth factor receptor ) , whereas association with E cadherin remained unchanged . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The increase in hepatic activity of urokinase type plasminogen activator was also accompanied by more activation of the hepatocyte growth factor receptor c Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Another invasion protein of the internalin family , InlB , subverts the signalling pathway of the hepatocyte growth factor receptor Met to induce endocytosis of the receptor and also to favour internalization of the bacteria in non polarized epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Mutational analysis of SSB 2 loop regions identified conserved structural determinants for its interaction with Par 4 and the hepatocyte growth factor receptor , c Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In HepG 2 hepatocarcinoma cells this fine regulation is not maintained ; we have then utilized Met murine hepatocytes ( MMH ) , isolated from the liver of transgenic mice expressing a truncated form of c Met ( hepatocyte growth factor receptor ) , that are immortalized but not transformed . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This study quantified the mRNA expression of three putative reference genes ( ubiquitin C , cyclophilin E , and porphobilinogen deaminase ) and the target gene hepatocyte growth factor receptor ( HGFR ) in matched colorectal tumour and normal mucosa samples . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This review is intended specifically for summarizing recent progress uncovering how the hepatocyte growth factor receptor c Met coordinates with integrins to transmit signals . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Within 5 min , PNA ( 25 microg / mL ) caused a 6 fold increase in phosphorylation of hepatocyte growth factor receptor c Met , known to co associate with CD44v6 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Here we report that FAK directly interacts with the hepatocyte growth factor receptor c Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Laser microdissection and quantitative reverse transcription polymerase chain reaction ( qRT PCR ) was used to quantify keratinocyte growth factor receptor ( KGFR ) , hepatocyte growth factor receptor ( HGFR ) , epidermal growth factor receptor ( EGFR ) and fibroblast growth factor receptor 1 ( FGFR 1 ) gene expression , and in situ RT PCR localized these increases to specific epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Autocrine alpha ( 5 ) beta ( 8 ) mediated TGF beta activation by fetal tracheal fibroblasts results in suppression of both transcription and secretion of hepatocyte growth factor , which is sufficient to affect phosphorylation of the airway epithelial hepatocyte growth factor receptor , c Met , as well as airway epithelial proliferation in a co culture model of the EMTU . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In contrast , the quantity of HGF and HGFR ( c met ) transcripts was highest in corneal fibroblasts and epithelial cells , respectively . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hematopoietic growth factor ( HGF ) dosages inducing peak clonogenetic effects are associated with partial / subtotal occupancy of the homologous HGF receptor ( HGFR ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of hepatocyte growth factor ( HGF ) and HGF receptor ( HGFR , product of the met proto oncogene ) mRNA were examined by nonisotopic in situ hybridization in a spectrum of benign and malignant human breast tissues . mRNA for both HGFR and HGF was detected in benign ductal epithelium . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Reverse transcription polymerase chain reaction ( RT PCR ) analysis was used to examine HGF expression in theca cells and the HGF receptor ( HGFR or c met ) in granulosa cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Using reverse transcription polymerase chain reaction , we detected HGF receptor ( HGFR ) mRNA in preimplantation embryos and in cultured blastocyst outgrowths . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We have fused the intracellular domain of the HGF receptor ( HGFR ) with three FK 506 binding protein ( FKBP ) domains and a membrane targeting signal . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In VMRC RCW , HGF receptor ( HGFR ) tyrosine kinase was constitutively active , and sequence analysis showed N375S , A1209G and V1290L mutations . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of the HGF receptor ( HGFR or c met ) and beta catenin was determined by immunoprecipitation and western blot analysis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
To examine the importance of prohibitin 1 and c Met / hepatocyte growth factor receptor ( HGFR ) expression in human cervical adenocarcinomas , 85 patients ( 69 with invasive adenocarcinoma [ ACA ] and 16 with adenocarcinoma in situ [ AIS ] ) were studied using immunohistochemistry . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We examined gene expression of hepatocyte growth factor ( HGF ) and HGF receptor ( HGFR ) , or product of proto oncogene c met ( c met ) , in smokers and nonsmokers with adenocarcinoma ( ADC ) by suppression subtractive hybridization and microarray techniques . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
A functional domain in the heavy chain of scatter factor / hepatocyte growth factor binds the c Met receptor and induces cell dissociation but not mitogenesis . ^^^ SF / HGF is the ligand of the c Met receptor tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Evidence for non covalent clusters of the c met proto oncogene product . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The proto oncogene c MET encodes a transmembrane tyrosine kinase receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^ Because HGF / SF is also a melanocyte mitogen , we investigated the biological role of HGF / SF , including c Met expression , activation and signal transduction , in normal and malignant human melanocytes . ^^^ Signal transduction by HGF / SF included phosphorylation of tyrosyl residues on c Met , a cascade of tyrosine phosphorylations on several other proteins and activation of microtubule associated protein kinase / extracellular signal regulated kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Overexpression of the c MET / HGF receptor gene in human thyroid carcinomas . ^^^ The receptor for Hepatocyte Growth Factor is a transmembrane tyrosine kinase encoded by the c MET oncogene . ^^^ Southern blot analysis also demonstrated that the c MET gene was not amplified nor rearranged . ^^^ These data suggest a role for the overexpression of c MET oncogene in the pathogenesis and progression of thyroid tumors derived from the follicular epithelium . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Subsequent typing of the progeny of an interspecies backcross revealed that Cftr is closely linked to the proto oncogene c met locus ( Met ) in the centromeric region of mouse Chr 6 , consistent with the observation that there is a conserved chromosomal segment on human chromosome 7 and mouse Chr 6 . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
To separate the role of [ HCO 3 ] from that of pH in inducing JCa we cultured calvariae for 3 h under three different neutral ( pH approximately 7 . 4 ) isohydric environments [ control ( Ctl ) , fully compensated Met ( C Met ) , or fully compensated Resp ( C Resp ) ] and two different acid ( pH approximately 7 . 1 ) isohydric environments ( Met or Resp ) . ^^^ During neutral pH ( Ctl , C Met , and C Resp ) there was JCa from bone during C Met ( decreased [ HCO 3 ] ) , no net flux during Ctl ( normal [ HCO 3 ] ) , and JCa into bone during C Resp ( increased [ HCO 3 ] ) ; and JCa was correlated inversely with [ HCO 3 ] ( r = 0 . 824 , n = 36 , P less than 0 . 001 ) . ^^^ JCa from bone during Met and Resp was greater than C Met and C Resp , respectively . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) is a fibroblast derived factor and has recently been shown to be a ligand for the c met proto oncogene , a member of the receptor class of tyrosine kinases . c met messenger RNA ( mRNA ) is predominantly expressed in epithelial cells , but has been detected in several murine hematopoietic progenitor cell lines , suggesting that HGF and met might function during hematopoiesis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
They are fibroblast growth factor ( FGF ) , hepatocyte growth factor ( HGF ) , and mast cell growth factor ( MGF ) , which activate the FGF receptor , c Met , and c Kit , respectively , known to be receptor tyrosine kinases . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The putative tyrosine kinase receptor encoded by the oncogene c met is activated ( tyrosine phosphorylated in vivo ) in the human gastric carcinoma cell line GTL 16 . ^^^ In this study we show that c met is part of an amplification unit measuring more than 3000 kb . ^^^ We have previously shown that the c met protein present in GTL 16 cells is indistinguishable from that found in other cells . ^^^ Kinase activation could be due to over expression of the normal c met protein or to the presence of activating mutation ( s ) . ^^^ To verify the primary structure of the c met protein in GTL 16 cells we sequenced a series of overlapping cDNAs obtained from GTL 16 cell RNA by reverse transcription and polymerase chain reaction . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Oxygen consumption ( VO 2 ) was studied during two maximal exercise tests ( MET ) performed on a cycle ergometer : one progressive ( P MET ) , the other constant ( C MET ) in 6 normal men and in 21 male outpatients with chronic obstructive lung disease ( COLD ) from 34 to 64 years old . ^^^ In 19 % of patients ( n = 4 ) the VO 2 was lower in the P MET by about 20 % than that observed in the C MET . ^^^ The execution of a second P MET in these 4 patients showed values superimposed on those obtained with C MET . ^^^ In patients in which these criteria were not met only the reproducibility of the VO 2 obtained in both the P MET and the C MET indicated that the maximal VO 2 for these 4 patients had been reached . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
PDGF independent activation of PDGF beta receptors in NIH 3T3 cells transformed by c met protooncogene . ^^^ We have previously reported that c met protooncogene , a member of a new class of receptor tyrosine kinase gene family , is transforming when overexpressed in NIH 3T3 cells . ^^^ In this paper , we report that the c met protooncogene transformed cells proliferate in a serum and growth factor free medium and exhibit constitutive tyrosine phosphorylation of several cellular proteins including the met protooncogene encoded p 145 and p 185 . ^^^ Taken together , our results demonstrate a PDGF independent phosphorylation and activation of PDGF beta receptor in NIH 3T3 cells transformed by c met protooncogene . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In the present study , we have analyzed the c met / HGF receptor expression in fetal hepatocytes and its modulation by growth factors and hormones . 20 day old fetal liver showed a barely expression of c met mRNA levels . ^^^ However , when fetal hepatocytes were incubated in the presence of HGF , a 10 fold increase in c met mRNA levels was observed 30 min after addition of the factor . ^^^ This HGF induced effect on c met expression was transient , losing its up regulatory effect after 24 hours and returning to the initial levels at 48 hours . ^^^ Transforming growth factor beta , a negative regulator of fetal liver growth , increased c met mRNA levels 48 hours after the addition of the factor , whereas glucocorticoids had a negative effect . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The expression of the HGF receptor , met , is high in normal breast epithelial cells and in dedifferentiated ( ER negative ) tumor cells but is reduced or lost in ER positive well differentiated epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We investigated the role of HGF / SF and its membrane receptor , the product of the c met protooncogene , in the early development of the metanephric kidney . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) was originally identified as an oncogene , Tpr Met , which consists of the cytoplasmic tyrosine kinase domain of the HGF / SF receptor ( Met ) fused down stream of sequences encoded by the tpr gene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) is a potent mitogen for renal tubular cells , and HGF and its receptor ( c met proto oncogene product , Met ) can induce lumen formation in epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Coexpression of the c met proto oncogene and hepatocyte growth factor in human pancreatic cancer . ^^^ The c met proto oncogene encodes a transmembrane tyrosine kinase receptor ( MET ) that has the capacity to modulate cell proliferation and differentiation ; it is activated by the hepatocyte growth factor . ^^^ Northern blot analysis of total RNA revealed that , by comparison with the normal pancreas , pancreatic cancers exhibited a 7 fold ( P < 0 . 01 ) increase in c met mRNA levels . ^^^ The concomitant over expression of c met and hepatocyte growth factor in human pancreatic cancers suggests that there is excessive activation of c met dependent signaling pathways that may contribute to pancreatic cancer cell growth in vivo . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) , the c met receptor and the behaviour of epithelial cells . ^^^ HGF / SF acts on target cells through binding to a cell surface , high affinity receptor with tyrosine kinase activity encoded by the c met proto oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Structural and functional domains critical for constitutive activation of the HGF receptor ( Met ) . ^^^ Site directed mutagenesis of either of the two tyrosine residues involved in the positive regulation of the catalytic activity upon phosphorylation ( Y 1234 or Y 1235 in the kinase domain of the HGF receptor ) , strongly impaired TRP MET transforming potential . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This study was aimed at assessing the presence of c met overexpression in human hepatocellular carcinoma and at determining whether this feature is associated with a definite clinical or pathological characteristic . ^^^ Expression of c met was determined by Northern blot hybridization of a specific probe ( human met proto oncogene ) in 18 tumoral and nontumoral liver samples obtained in 18 cirrhotic patients with hepatocellular carcinoma submitted to surgical treatment . ^^^ Eight of the 18 hepatocellular carcinomas exhibited c met overexpression , with an increase ranging between 2 fold and 10 fold when compared by densitometry with the surrounding liver . ^^^ By contrast , in the remaining 10 cases c met expression was almost identical to that of the surrounding nontumoral liver tissue . ^^^ Overexpression of c met was not related to either the age , sex , etiology or functional status of the underlying liver disease , or to the size of the tumor , to its differentiation degree or to the presence of pseudocapsule invasion and existence of additional neoplastic nodules . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Tyrosines 1234 1235 are critical for activation of the tyrosine kinase encoded by the MET proto oncogene ( HGF receptor ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
HGF SF has been found to be the ligand of the c met receptor tyrosine kinase ( Naldini et al . , EMBO J . 10 , 2867 2878 , 1991b ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Cross linking studies demonstrated that the truncated molecule competes with HGF for binding to the c met proto oncogene product . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Two types of SF / HGF receptors have recently been discovered in epithelial cells , the high affinity c Met receptor tyrosine kinase , and low affinity / high capacity binding sites , which are probably located on heparan sulfate proteoglycans . ^^^ Thus , it is likely that all known biological signals of SF / HGF are transduced through the receptor tyrosine kinase encoded by the c Met protooncogene . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Ron is a 1400 amino acid protein structurally similar to the 1408 amino acid product of the C MET proto oncogene , the receptor for hepatocyte growth factor and scatter factor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor ( HGF ) , HGF receptor ( MET ) , keratinocyte growth factor ( KGF ) , KGF receptor , and fibroblast growth factor ( FGF ) receptor 2 were produced in primary cultures of human corneal epithelial , stromal fibroblast , and endothelial cells , as well as ex vivo corneal epithelium , endothelial cells transfected with the SV 40 large T antigen , and control embryonic lung fibroblasts . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Characterization of a c met proto oncogene activated in human xeroderma pigmentosum cells after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) is the mesenchymal ligand of the epithelial tyrosine kinase receptor c Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
An 11 amino acid sequence from c met initiates epithelial chemotaxis via phosphatidylinositol 3 kinase and phospholipase C . ^^^ Interaction of hepatocyte growth factor with its high affinity receptor c met initiates a cascade of intracellular events leading to epithelial motility . ^^^ An 11 amino acid sequence from the c met receptor has been found to cause cell transformation in transfected fibroblasts ( Ponzetto , C . , Bardelli , A . , Zhen , Z . , Maina , F . , Dalla , Z . ^^^ We inserted this sequence into a mutant platelet derived growth factor receptor ( F 5 ) to determine if this region of c met can initiate cell motility and which signaling pathways it activates . ^^^ The platelet derived growth factor ( PDGF ) receptor / c met hybrid ( F 5 met ) initiated PDGF dependent chemotaxis in renal epithelial cells ( 8 . 0 + / 2 . 3 versus 70 . 5 + / 4 . 8 cells / mm2 ) , while the parental construct , F 5 , did not . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The TGF alpha receptor EGFr appears primarily to mediate a proliferative signal , whereas mitogenic , motogenic , and morphogenic effects have been attributed to activation of the HGF receptor Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) stimulates cell proliferation , motility , and morphogenesis by activation of its receptor , the c Met tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
C met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor ( HGF ) . ^^^ HGF / c met plays diverse role in regulation of cell growth , shape and movement . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The c met proto oncogene product is the tyrosine kinase receptor for hepatocyte growth factor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Interleukin 1 induces an autocrine loop hepatocyte growth factor / c Met in murine Kaposi like spindle cells . ^^^ Here we show that TTB cells co express hepatocyte growth factor ( HGF ) and its receptor , the product of the oncogene c Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Immunohistochemically , HGF , as well as the HGF receptor ( the met gene product ) , localized to significantly more rheumatoid synovial tissue lining cells than normal lining cells ( P < 0 . 05 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
C Met signalling in an HGF / SF insensitive variant MDCK cell line with constitutive motile / invasive behaviour . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The mechanistic basis of hepatocyte proliferation was elucidated as the chronic activation of the c met proto oncogene product . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Ontogeny of hepatocyte growth factor and c met / hgf receptor in rat pancreas . ^^^ The objective of this study was to characterize by Northern blot the HGF and c met mRNA expression in rat pancreas during development . ^^^ Pancreatic HGF and c met mRNA levels were higher between late fetal and 11 post natal days and then decreased to a very low level at 26 days . ^^^ We conclude that HGF gene expression and c met pancreatic gene expression are age dependent with the highest expression before weaning . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Met protein is a transmembrane 190 kD heterodimer with tyrosine kinase activity , encoded by c MET oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Molecular cloning of the Xenopus c met / hepatocyte growth factor receptor and its regional expression during early development . ^^^ Hepatocyte growth factor ( HGF ) , a ligand for c Met receptor tyrosine kinase , regulates the cell growth , migration and morphogenesis of a wide variety of cells , and plays important roles in organogenesis in embryos as well as regeneration of organs . ^^^ The open reading frame of Xenopus c met is 4 , 125 base pairs long and encodes a putative polypeptide of 1 , 375 amino acids . ^^^ During Xenopus embryogenesis , c met mRNA was expressed at a high level from the gastrula to the neurula stage , while HGF mRNA expression was seen from the early neurula stage . ^^^ Whole mount in situ hybridization showed that c met mRNA was specifically localized in the foregut region , mesenchymal tissue of the tailbud , and neural tissues in neurula embryos . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Participation of c met in the progression of human gastric cancers : anti c met oligonucleotides inhibit proliferation or invasiveness of gastric cancer cells . ^^^ The protooncogene c met encodes the receptor for hepatocyte growth factor ( HGF ) , a potent epithelial cell mitogen with scattering activity . ^^^ In this study , we first screened c met expression in human gastric carcinomas . ^^^ The incidence of c met expression increased with higher histopathological stages of the cancer . ^^^ Second , we examined functional roles of c met in cultured gastric carcinoma cells , using an antisense strategy . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) is a mesenchymally derived , multifunctional paracrine regulator possessing mitogenic , motogenic , and morphogenetic activities in cultured epithelial cells containing its tyrosine kinase receptor , Met . c met has been implicated in oncogenesis through correlation of expression with malignant phenotype in specific cell lines and tumors . ^^^ Most neoplasms , especially melanomas , demonstrated overexpression of both the HGF / SF transgene and endogenous c met , and had enhanced Met kinase activity , strongly suggesting that autocrine signaling broadly promotes tumorigenesis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Furthermore , macrophages expressed the transcript of HGF receptor encoded by the MET proto oncogene and migrated after HGF challenge . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of scatter factor and c met receptor in benign and malignant breast tissue . ^^^ Its receptor is a transmembrane tyrosine kinase encoded by the c met protooncogene . ^^^ To investigate the possible involvement of SF and c met in the evolution of breast carcinoma , the authors studied their expression in sections of human breast tissue . ^^^ METHODS : A variety of paraffin embedded tissue specimens ( of normal breast tissue tissue , benign hyperplasia , ductal carcinoma in situ [ DCIS ] , and invasive ductal carcinoma ) from 125 patients were immunoperoxidase stained using specific antisera against SF and c met . ^^^ CONCLUSIONS : SF and c met are overexpressed in breast carcinoma as compared with benign breast tissue , and they tend to be coexpressed in cancerous tissue . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) / scatter factor ( SF ) is the ligand for a tyrosine kinase cell surface receptor encoded by the MET protooncogene ( c MET ) . ^^^ HGF / SF can induce proliferation and motility in epithelial cells and promotes invasion of carcinoma cells and NIH3T3 fibroblasts transfected with both HGF / SF and c MET genes . ^^^ Our results show that HGF / SF and c MET also play a role in adhesion and invasion of human lymphoma cells . c MET mRNA is expressed in hemopoietic cells , such as hemopoietic progenitor cells ( CD34+ cells ) in bone marrow ( BM ) and mobilized peripheral blood , immature B cells in cord blood and BM , and germinal center B centroblasts . ^^^ In normal peripheral blood B cells , which are c MET , c MET expression was induced by PMA , ConA , HGF / SF , and Epstein Barr virus ( EBV ) infection . ^^^ Using immunohistochemistry , we detected c MET on the cell surface of large activated centroblasts in lymph nodes from patients with B non Hodgkin ' s lymphoma and Hodgkin ' s disease . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The c MET oncogene encodes the receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) , which is known to stimulate the invasive growth of epithelial cells cultured in vitro . ^^^ The c MET oncogene is expressed in several types of epithelial tissue including keratinocytes and is over expressed in a number of human carcinomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) is a heparin binding polypeptide that stimulates cell proliferation , motility , and morphogenesis by activation of its receptor , the c Met tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The growth factor / receptor combination of hepatocyte growth factor ( HGF ) / c met has been postulated to be critical for mesenchymal to epithelial conversion and tubule formation in the developing kidney . ^^^ These experiments suggest that the HGF / c met axis is not essential for epithelial cell development in the embryonic kidney and demonstrate that other growth factors are capable of supporting early tubulogenesis . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The HGF receptor family includes tyrosine kinases encoded by three oncogenes : MET , SEA and RON . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
To analyze the biological effects of HGF / SF receptor activation , we stably expressed the constitutively activated receptor catalytic domain ( p 65 ( tpr met ) ) in C 2 cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Seven primary culture lines all expressed c met and HGF mRNA , and secreted HGF . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Chromosomal localization of rat hepatocyte growth factor ( Hgf ) and HGF receptor ( Met ) and characterization of HGF receptor cDNA . ^^^ To obtain a probe for the mapping of the HGF receptor / Met gene , we cloned the complete coding region of the rat HGF receptor mRNA . ^^^ A full length probe of the coding part of the cDNA was used to map the rat HGF receptor / Met gene to Chr 4q21 by the FISH technique . ^^^ Therefore , the rat Hgf and HGF receptor / Met genes are located relatively close to each other , in a way similar to humans but not mice . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor and c MET in benign and malignant peripheral nerve sheath tumors . ^^^ HGF and its receptor , the c met proto oncogene product ( c MET ) have been implicated in the genesis and progression of several carcinomas and sarcomas . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Neoexpression of the c met / hepatocyte growth factor scatter factor receptor gene in activated monocytes . ^^^ Several B lymphoid and myeloid cell lines were found to express HGF SF or c met transcripts , while activity of both genes was mutually exclusive with the exception of low level coexpression in two B cell lines . ^^^ In contrast , c met expression was not detected in freshly isolated cells from peripheral blood , but was induced in monocytes by activation of monocytic or T cell function . ^^^ HGF SF incubation led to an increased c fos steady state transcript level in myeloblastic K 562 cells and moderately promoted cell viability of freshly isolated preactivated monocytes . c met expression is thus established in activated monocytes , in particular under conditions resembling inflammation , making these cells accessible to functional effects of HGF SF . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) plays important roles in mammalian development and tissue regeneration and acts on target cells through a specific receptor tyrosine kinase encoded by the c met proto oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Activation of the HGF receptor , encoded by the c MET protooncogene ( Met receptor ) , triggers motility , matrix invasion and branching morphogenesis in epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) is a potent mitogen , motogen , and morphogen for epithelial cells expressing its tyrosine kinase receptor , the c met proto oncogene product , and is required for normal development in the mouse . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
These findings suggest that HGF produced by the villous core may act in a paracrine fashion to regulate trophoblast development or function through the HGF receptor , Met . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of c met is a strong independent prognostic factor in breast carcinoma . ^^^ BACKGROUND : The c met protooncogene encodes the met protein , the receptor for scatter factor / hepatocyte growth factor , a growth factor that modulates the motility and stable interaction of the epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
These results suggest that mesenchymal cells , like epithelial cells , are able to express c met proto oncogene product , and the SW 1353 cell culture system can provide us with a potential avenue to identify genes responsible for MET . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
These in vitro effects of anti HGF antibodies and HGF were abolished by a disabling mutation of Met , the HGF receptor tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Immunoprecipitation was performed with antisera to signal transducers and activators of transcription 1 ( STAT 1 ) , STAT 3 , Janus kinase 1 ( Jak 1 ) , Shc , Grb 2 , Sos 1 , and HGF receptor ( met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor induced expression of ornithine decarboxylase , c met , and c myc is differently affected by protein kinase inhibitors in human hepatoma cells HepG 2 . ^^^ In HGF treated HepG 2 cells , we studied : ( 1 ) the expression patterns of early ( c myc , c jun , and c fos ) and delayed early ( ornithine decarboxylase and c met ) response genes and ( 2 ) the possible involvement of protein kinase transducers in the control of the expression of c met and of other genes eventually induced downstream . c met and c myc mRNAs peaked 1 2 h after HGF , while c jun and c fos mRNAs slightly increased at 1 h . ^^^ The mRNA expression of c jun was likely to undergo a negative regulation through a mechanism involving PI3K , while that of c met seemed to be almost independent from various protein kinases ( PI3K , pp 60 ( c src ) , and PKC ) . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The protein product of c met proto oncogene , Met , is a tyrosine kinase receptor for the hepatocyte growth factor ( HGF ) , also known as the scatter factor ( SF ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The gene defect for hereditary papillary renal carcinoma ( HPRC ) has recently been mapped to chromosome 7q , and germline mutations of MET ( also known as c met ) at 7q31 have been detected in patients with HPRC ( ref . 2 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
An alteration in at least one of the genes involved in control of renal differentiation is therefore a likely event in tumorigenesis , and indeed some of the genes involved in renal development , for example , hepatocyte growth factor ( HGF ) and its receptor c met , the transcription factor Wilms ' tumor gene ( WT 1 ) , and transforming growth factor beta family member bone morphogenetic protein ( BMP ) 7 , have also been implicated in various models of tumorigenesis . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Oncogenesis in this model was driven by creation of HGF / SF Met autocrine loops through forced expression of the transgenic ligand and apparent selection of melanocytes overexpressing endogenous receptor , rather than paracrine stimulation or mutational activation of c met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The c MET gene encodes the tyrosine kinase p190MET , the receptor for a molecule known as Scatter Factor ( SF ) or Hepatocyte Growth Factor ( HGF ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Immunohistochemistry studies were performed to investigate expression of c met and basic fibroblast growth factor ( bFGF ) proto oncogenes . ^^^ Only one Hrthle cell carcinoma and the two PC from the IS group , and one FC and the two PC from the ID group stained for the c met oncogene . ^^^ Expression of c met was greater ( 3+ ) in the four PC ( concerning 70 80 % of the tumor cells ) than in the other two cancers ( 1+ ; < 5 % of the tumor cells ) . ^^^ We conclude that activating mutations of ras , loss of DNA from the Rb locus and over expression of both c met and bFGF are of no pathogenetic relevance in driving thyroid tumorigenesis of iodine deficient areas . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The Met tyrosine kinase the HGF receptor induces cell transformation and metastasis when constitutively activated . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The hgf / sf positive clones exhibited different levels of biologically functional HGF / SF expression and up regulation of endogenous Met ( HGF / SF receptor ) expression . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) and epidermal growth factor ( EGF ) are primary mitogens for hepatocytes in culture . hepatocytes express the HGF receptor MET but not HGF itself . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Because hepatocyte growth factor / scatter factor ( HGF / SF ) has been shown to modulate glioma motility through an autocrine mechanism , and because microglia have been reported to express the HGF / SF receptor Met , we hypothesized that microglia recruitment by gliomas may also occur through the secretion of HGF / SF . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor and c MET are expressed in rat prepuberal testis . ^^^ The hepatocyte growth factor ( HGF ) receptor ( c MET ) is present in different mammalian tissues and transduces multiple biological effects . ^^^ We have studied HGF and c MET expression in prepuberal rat testis . c MET gene expression was found in total testis and in homogeneous cell populations , as demonstrated by Northern blotting . ^^^ In the seminiferous tubules , c MET gene was only expressed in the myoid cells . ^^^ In these cells , c MET was detectable and constantly expressed for at least six days of culture . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The proto oncogene c MET encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , a pleiotropic cytokine controlling growth , survival , motility , invasive migration , and differentiation of epithelial cells . ^^^ Like several other epithelial neoplasms , thyroid carcinomas have been found to overexpress c MET at both the mRNA and protein level . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
TPR MET , a transforming counterpart of the c MET proto oncogene detected in experimental and human cancer , results from fusion of the MET kinase domain with a dimerization motif encoded by TPR . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
HGF / SF and its receptor c MET play a minor role in the dissemination of human B lymphoma cells in SCID mice . ^^^ The MET protooncogene , c MET , encodes a cell surface tyrosine kinase receptor . ^^^ The ligand for c MET is hepatocyte growth factor ( HGF ) , also known as scatter factor ( SF ) , which is known to affect proliferation and motility of primarily epithelial cells . ^^^ Studies with epithelial and transfected NIH3T3 cells indicated that the HGF / SF c MET interaction promotes invasion in vitro and in vivo . ^^^ We previously demonstrated that HGF / SF induces adhesion of c MET positive B lymphoma cells to extracellular matrix molecules , and promoted migration and invasion in in vitro assays . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Regulatory molecules such as receptor tyrosine kinases like c Met ( ref . 6 ) and those encoded by homeobox containing genes , including c Met ( ref . 6 ) , Tbx 1 ( ref . 7 ) , Mox 2 ( ref . 8 ) , Six 1 and Six 2 ( ref . 9 ) , Pitx 2 , Pax 3 ( refs 10 , 11 ) and Lbx1h ( refs 12 , 13 ) , are expressed in migrating limb precursor cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The human first trimester trophoblast cell line ( ED 27 ) used in subsequent invasion studies was found to express c met messenger ribonucleic acid by RT PCR and Met protein by Western analysis , and underwent phosphorylation of tyrosine residues on Met with HGF exposure . ^^^ Hepatocyte growth factor ( HGF ) is a cytokine that is produced in the placental villous core and acts in a paracrine manner on trophoblasts that express the HGF receptor Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Its receptor MET is a transmembrane tyrosine kinase encoded by the C MET proto oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Overexpression of the hepatocyte growth factor ( HGF ) receptor ( Met ) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive / malignant human musculoskeletal tumors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We showed previously that the addition of exogenous hepatocyte growth factor ( HGF ) and the presence of fibronectin fibrils stimulate anchorage independent colony growth of a murine mammary carcinoma , SP 1 , which expresses both HGF and HGF receptor ( Met ; R . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
HGF was expressed in the branchial arches , whilst Met , which encodes an HGF receptor , was expressed by subpopulations of cranial motor neurons . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We previously demonstrated that the specific HGF receptor , MET , is induced in stimulated peripheral blood monocytes . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The gene expressions of c met and the anti apoptotic bcl 2 family , including bcl 2 , bcl 10 ( L ) and bcl w , were analysed in human colorectal adenomas and adenocarcinomas by using a quantitative polymerase chain reaction combined with reverse transcription . ^^^ In seven of 12 adenomas and seven of 11 carcinomas , the c met gene was overexpressed . ^^^ The c met mRNA level in human colorectal adenomas and carcinomas was correlated with bcl w but not with bcl 2 or with bcl 10 ( L ) mRNA level . ^^^ The administration of c met antisense oligonucleotides decreased Met protein levels in the LoVo human colon cancer cell line . ^^^ In the case of c met antisense treated cells , apoptotic cell death induced by serum deprivation was more prominent , compared to control or c met nonsense treated cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In the developing tooth , HGF is expressed in the cells of the dental papillae , and c Met , its receptor , in the cells of dental epithelia . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Expression of hepatocyte growth factor and c met in ulcerative colitis . ^^^ MATERIALS AND METHODS : HGF and c met gene expressions were quantified in colonic mucosal specimens from healthy control subjects , patients with UC and patients with UC associated colorectal cancer , using the competitive reverse transcription polymerase chain reaction . ^^^ Expression of c Met protein was analyzed immunohistochemically . ^^^ RESULTS : HGF and c met gene expressions were increased in inflamed mucosa of UC , compared with control subjects . ^^^ The c met gene was overexpressed in UC associated cancers and a high level of immunoreactivity of the c Met protein was immunohistochemically detected within the cancer cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor triggers a complex biological program leading to invasive cell growth by activating the c Met receptor tyrosine kinase . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
CrkII was found to be phosphorylated in response to hepatocyte growth factor / scatter factor ( HGF / SF ) and to associate with the beta subunit of the HGF receptor ( MET ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The MET ( also known as c met proto oncogene located at 7q31 34 has been shown to be amplified in human gliomas , and activating mutations within the tyrosine kinase domain of MET have been causally related to tumorigenesis in hereditary papillary renal cell carcinoma . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
MMH ( Met murine hepatocyte ) liver cells derived from transgenic mice expressing a truncated constitutively active form of human c Met are non transformed immortalized cell lines . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) is a ligand of the receptor tyrosine kinase encoded by the c Met protooncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Signal transduction by HGF receptor , the tyrosine kinase encoded by the MET oncogene , switches on a genetic program called ' invasive growth ' inducing epithelial cell dissociation , migration , growth , and ultimately leading to differentiation into branched tubular structures . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
A hammerhead ribozyme suppresses expression of hepatocyte growth factor / scatter factor receptor c MET and reduces migration and invasiveness of breast cancer cells . ^^^ PURPOSE : Hepatocyte growth factor / scatter factor ( HGF / SF ) , via its receptor c MET , has been implicated to play a pivotal role in breast cancer development and progression . ^^^ This study examined a transgene consisting of a combination of U1snRNA , hammerhead ribozyme , and antisense , designed to inhibit c met expression and its impact on the migration and in vitro invasion of breast cancer cells . ^^^ EXPERIMENTAL DESIGN : A hammerhead ribozyme targeting human c MET was cloned into a modified pZeoU1EcoSpe vector and transfected into breast cancer cells MDA MB 231 and MCF 7 by electroporation . ^^^ CONCLUSIONS : These data show that targeting c MET by way of a hammerhead ribozyme encoding antisense to c MET is an effective approach in reducing the invasiveness of breast cancer cells . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Surface levels of MET correlated with c met mRNA levels both in adult and cord blood when cultured . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
FAP 68 binding to Met requires the last 30 amino acids of the C terminal tail , which are unique to the HGF receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
ISH studies also revealed that fibroblasts at the wound edges and within the newly forming granulation tissue also expressed HGF and c met mRNA . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The protein product of c met proto oncogene , Met , is a tyrosine kinase receptor for the hepatocyte growth factor ( HGF ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
A mechanism of cell survival : sequestration of Fas by the HGF receptor Met . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Overexpression of c met as a prognostic indicator for transitional cell carcinoma of the urinary bladder : a comparison with p 53 nuclear accumulation . ^^^ PURPOSE : The c met proto oncogene encodes a receptor tyrosine kinase ( Met ) and has been shown to play a role in oncogenesis . ^^^ MATERIALS AND METHODS : We studied the mRNA expression and genomic alteration of c met in five bladder cancer cell lines . ^^^ RESULTS : Expression of c met mRNA tended to positively correlate with differentiation of cancer cell lines in the absence of point mutation . ^^^ CONCLUSION : The c met proto oncogene plays a more important role in the progression of bladder carcinogenesis than p 53 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor promotes hepatocarcinogenesis through c Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine . ^^^ Enhanced kinase activity of the HGF receptor , Met , was detected in most of these tumors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
K252a inhibits the oncogenic properties of Met , the HGF receptor . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Met protein , the high affinity HGF receptor , is overexpressed in a large proportion of cases of papillary carcinoma . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Role of the MET / HGF receptor in proliferation and invasive behavior of osteosarcoma . ^^^ Signal transduction downstream HGF receptor ( MET ) activation involves multiple pathways that account for mitogenesis , motility and morphogenesis in a cell type dependent fashion . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Detection of hepatocyte growth factor / scatter factor receptor ( c Met ) in axillary drainage after operations for breast cancer using reverse transcriptase polymerase chain reaction . ^^^ BACKGROUND : The diverse biological effects of hepatocyte growth factor / scatter factor ( HGF / SF ) are mediated by c Met , which is preferentially expressed on epithelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NK 4 also suppressed HGF / SF and MRC 5 induced tyrosine phosphorylation of the HGF / SF receptor Met as assessed by immunoprecipitation . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The N terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c met receptor . ^^^ HGF promotes cell proliferation , survival , motility , and morphogenesis through binding to its receptor , a transmembrane tyrosine kinase encoded by the MET proto oncogene ( c met ) . ^^^ We showed that ( 1 ) none of the isolated HGF kringle exhibits an anti angiogenic activity ; ( 2 ) N is a new anti angiogenic polypeptide ; ( 3 ) the inhibitory action of N is not specific toward HGF , because it antagonized the angiogenic activity of other growth factors , such as fibroblast growth factor 2 and vascular endothelial growth factor ; and ( 4 ) in contrast with full length HGF , N does not bind to the c met receptor in vitro , but fully retains its heparin binding capacity . ^^^ Our results suggest that N inhibits angiogenesis not by disrupting the HGF / c met interaction but rather by interfering with the endothelial glycosaminoglycans , which are the secondary binding sites of HGF . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This is corroborated by the detection of MET ( c met ) expression , a marker for the myogenic satellite cell lineage , in all RMS samples expressing wild type PAX7 . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Signaling by Met , the HGF receptor , is required for the rostral expansion of the pea 3 domain , while the onset of pea 3 expression is independent of met function . met expression is observed in pioneer neurons but does not precede that of pea 3 in recruited neurons . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Functional map and domain structure of MET , the product of the c met protooncogene and receptor for hepatocyte growth factor / scatter factor . ^^^ Little is known about the large ectodomain of MET , the product of the c met protooncogene and receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Infection depends on activation of the HGF receptor , MET , by secreted HGF . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Kim et al . , reduced c Met expression by an adenovirus expressing a c Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC 3 LN4 prostate tumor cells in an orthotopic nude mouse model . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The role of hepatocyte growth factor / c met interactions in the immune system . ^^^ This paper discusses expression of HGF and c met within the immune system and their interactions in the control of immune cell functions . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
These events result from overexpression of c met , leading to constitutive activation of Met signaling , despite the absence of the ligand SF / HGF . ^^^ Haploinsufficiency of c met rescues this phenotype , confirming the direct genetic link with Pax 3 . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor ( HGF ) , which is a ligand for the c met protooncogene product ( Met ) , stimulates proliferation and invasion of a large number of cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Met and Ron tyrosine kinases are members of the Scatter Factor Receptor family . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We demonstrate here that , compared to IOSE 29 , IOSE Ov 29 and IOSE Ov29 / T4 exhibited higher levels of the HGF receptor Met and an increasing duration of ERK1 / 2 activation with malignant progression , in conjunction with other neoplastic properties . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The Pax 3 and c met genes are necessary for the development of tongue , diaphragm , and limb muscles . ^^^ In this work , we re examined primary myogenesis in c met signaling mutants using a skeletal muscle specific lacZ transgene ( Mlc3f nlacZ 2E ) . ^^^ This strategy allowed us to identify precisely the shoulder , limb , tongue , and dermal muscles that need Met for development and to confirm that the morphological structure of epaxial and body wall muscles was normal , even in the most severe c met mutant . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Prognostic significance of hepatocyte growth factor and c MET expression in patients with diffuse large B cell lymphoma . ^^^ The expression and prognostic significance of hepatocyte growth factor ( HGF ) and its receptor c MET ( MET proto oncogene ) was analysed in 96 cases of diffuse large B cell lymphoma ( DLBCL ) . ^^^ Tissue sections were immunohistochemically stained for HGF and c Met . ^^^ The prognosis of HGF positive and c Met positive cases was significantly worse than negative cases ( HGF : P = 0 . 0036 ; c Met : P = 0 . 0002 ) . ^^^ In addition , in the low risk international prognostic index group , HGF negative and c Met negative cases had a significantly better prognosis than positive cases ( HGF : P = 0 . 0009 ; c Met : P < 0 . 0001 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Using RNA interference technology and adenovirus vectors carrying small interfering RNA constructs ( Ad Met small interfering RNA ) directed against mouse , canine , and human Met , we can knock down c met mRNA . ^^^ We further show that intratumoral infection with c met small interfering RNA adenovirus results in a substantial reduction in tumor growth . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
We identified low expression of c met ( immunohistochemistry ) as a predictive factor for complete response in nondiploid tumors ( P = 0 . 026 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Met ( the HGF receptor ) , actin , and total AnxI were increased in pseudopodial lysates on immunoblots . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The HGF receptor c Met is overexpressed in esophageal adenocarcinoma . ^^^ Sequence analysis found the kinase domain of c met to be wild type in all three EA cell lines . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
A selective small molecule c MET Inhibitor , PHA 665752 , cooperates with rapamycin . ^^^ PURPOSE : c MET is believed to be an attractive receptor target for molecular therapeutic inhibition . ^^^ TPR MET , a constitutively active oncogenic variant of MET , serves as excellent model for testing c MET inhibitors . ^^^ Here , we characterized a small molecule c MET inhibitor , PHA 665752 , and tested its cooperation with the mammalian target of rapamycin inhibitor as potential targeted therapy . ^^^ H 441 non small cell lung cancer ( NSCLC ) cells ( with activated c Met ) were also tested against both PHA 665752 and rapamycin . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NYGM cells concomitantly expressed MET receptor tyrosine kinase ( a product of c met protooncogene ) and its ligand HGF / SF ( hepatocyte growth factor / scatter factor ) , as well as HGF activator and HGF activator inhibitors . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Soluble HGF receptor ( MET ) and soluble u PAR ( u PA receptor ) inhibited the scHGF cleavage . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Recepteur d ' Origine Nantais ( RON ) is a distinct receptor tyrosine kinase in the c met proto oncogene family . ^^^ Biological effects of RON overexpression on cancer cells were investigated in vitro , and the prognostic significance of RON and / or c met protein ( MET ) expression was analysed in a bladder cancer cohort ( n=183 ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Amplification and overexpression of c erbB 2 , epidermal growth factor receptor , and c met in biliary tract cancers . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
As activating mutations in the MET proto oncogene ( the HGF receptor ) cause familial RCC , we investigated whether HAI 2 / SPINT2 might act as a RCC tumor suppressor gene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
This paper shows for the first time that human platelets express HGF receptor , the tyrosine kinase encoded by c MET gene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Up regulation of c met protooncogene product expression through hypoxia inducible factor 1alpha is involved in trophoblast invasion under low oxygen tension . ^^^ The c met protooncogene product ( Met ) , which is a high affinity receptor for hepatocyte growth factor , plays an important role in controlling the invasion of many types of cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Oligomerization induced differential dephosphorylation of c Met receptor tyrosine kinase . ^^^ To determine the impact of oligomerization on the ability of c MET RTK to undergo dephosphorylation , we examined the relative dephosphorylation kinetics of similarly phosphorylated dimeric TPR MET and monomeric cytoMET . ^^^ This was demonstrated by the rapid phosphorylation of unstimulated c MET on its activation loop and carboxy terminal tyrosines following pervanadate treatment of cells expressing c MET . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Hepatocyte growth factor / scatter factor ( HGF / SF ) is a multifunctional growth factor that is involved in invasive growth of tumor cells via its receptor MET , a protein product of c met proto oncogene . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
The multifunctional growth factor scatter factor / hepatocyte growth factor ( SF / HGF ) and its receptor tyrosine kinase c Met have emerged as key determinants of brain tumor growth and angiogenesis . ^^^ SF / HGF and c Met are expressed in brain tumors , the expression levels frequently correlating with tumor grade , tumor blood vessel density , and poor prognosis . ^^^ Overexpression of SF / HGF and / or c Met in brain tumor cells enhances their tumorigenicity , tumor growth , and tumor associated angiogenesis . ^^^ Conversely , inhibition of SF / HGF and c Met in experimental tumor xenografts leads to inhibition of tumor growth and tumor angiogenesis . ^^^ SF / HGF is expressed and secreted mainly by tumor cells and acts on c Met receptors that are expressed in tumor cells and vascular endothelial cells . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
However , the intracellular pathways controlling neuronal migration triggered by the HGF receptor Met have not been elucidated . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
In the normal breast , hepatocyte growth factor ( HGF ) is primarily expressed by stromal cells , and stimulates in a paracrine manner epithelial cells expressing the HGF receptor ( Met ) . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Pro metastatic signaling by c Met through RAC 1 and reactive oxygen species ( ROS ) . ^^^ Overexpression of the c Met / hepatocyte growth factor receptor ( HGF R ) proto oncogene and abnormal generation of intracellular oxygen species ( reactive oxygen species ( ROS ) ) have been linked , by independent lines of evidence , to cell transformation and to malignant growth . ^^^ By comparing two subpopulations of the B 16 mouse melanoma ( B 16 F0 and B 16 F10 ) endowed with different lung metastasis capacities ( low and high , respectively ) we found that both the expression / phosphorylation of c Met and the steady state levels of ROS positively correlated with metastatic growth . shRNA mediated downregulation of c Met in F 10 cells led to a parallel decrease in the generation of oxygen species and in metastatic capacity , suggesting that oxidants may mediate the pro metastatic activity of the HGF receptor . c Met activation by a ligand elicits the formation of oxidant species through the oxidase coupled small GTPase Rac 1 , a relevant downstream target of the HGF R . ^^^ Finally , genetic manipulation of the Rac ROS cascade at different levels demonstrated its crucial role in the pro metastatic activity of c Met in vivo . ^^^ Thus , we have outlined a novel cascade triggered by c Met and mediated by ROS , linked to metastasis and potentially targetable by new antimetastatic , redox based therapies . . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
Working with the LNCaP prostate cancer progression model , we found that these cells could respond to HGF stimulation , even in the absence of Met , the only known HGF receptor . ^^^ These HGF effects are not due to shifts in the expression levels of laminin binding integrins , nor can they be linked to expression of the known HGF receptor Met , as neither LNCaP nor clonally derived C 4 2 sub line contain any detectable Met protein . ^^^
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
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Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UMU9 and P08581	Pubmed	SVM Score :0.0
NA