| Interacting proteins: P08581 and Q96S59 |
Pubmed |
SVM Score :1.4617646 |
| We demonstrate that RanBPM can interact with MET in vitro and in vivo , and the interaction can be strengthened by HGF stimulation . 1.4617646^^^ |
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| Interacting proteins: P08581 and Q96S59 |
Pubmed |
SVM Score :0.71574512 |
| We show that , like RanBPM / RanBP9 , RanBP 10 interacts with the tyrosine kinase domain of MET via its SPRY domain and these two proteins can compete with each other to bind to MET . 0.71574512^^^ |
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| Interacting proteins: P08581 and Q96S59 |
Pubmed |
SVM Score :0.94120796 |
| RanBPM as a novel binding protein can interact with neurotrophin receptor p75NTR and tyrosine kinase receptor Met which has a similar tyrosine kinase structure as receptor TrkA has . 0.94120796^^^ |
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| Interacting proteins: P08581 and Q96S59 |
Pubmed |
SVM Score :0.0 |
| In our previous studies , we have found that two SPRY domain containing proteins , RanBP 9 and RanBP 10 , interact with MET through the SPRY domain . ^^^ |
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| Interacting proteins: P08581 and Q96S59 |
Pubmed |
SVM Score :0.0 |
| Serine / threonine kinase Mirk / Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran binding protein M . ^^^ In the current study , the Met adaptor protein Ran binding protein M ( RanBPM ) was identified as a Mirk binding protein by yeast two hybrid analysis . ^^^ RanBPM has been reported to bind to the tyrosine kinase domain of the hepatocyte growth factor ( HGF ) receptor Met , enhance Met downstream signaling , and enhance HGF induced A 704 kidney carcinoma cell invasion ( Wang , D . , Li , Z . , Messing , E . ^^^ Our findings suggest that Mirk plays a role in modulating cell migration through opposing the action of the Met signaling cascade adaptor protein RanBPM . . ^^^ |
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