| MUC 20 suppresses the hepatocyte growth factor induced Grb 2 Ras pathway by binding to a multifunctional docking site of met . ^^^ We demonstrate here that the C terminus of MUC 20 associates with the multifunctional docking site of Met without ligand activation , preventing Grb 2 recruitment to Met and thus attenuating hepatocyte growth factor ( HGF ) induced transient extracellular signal regulated kinase 1 and 2 activation . ^^^ We further demonstrate that the cytoplasmic domain of MUC 20 has the ability to oligomerize and that the oligomerization augments its affinity for Met . ^^^ Taken together , these results suggest that MUC 20 is a novel regulator of the Met signaling cascade which has a role in suppression of the Grb 2 Ras pathway . . ^^^ |