| Interacting proteins: Q12913 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12913 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein tyrosine phosphatase DEP 1 . ^^^ Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein tyrosine phosphatase DEP 1 . ^^^ We have shown that the substrate trapping mutant form of DEP 1 interacted with a small subset of tyrosine phosphorylated proteins from lysates of the human breast tumor cell lines MDA MB 231 , T 47D , and T 47D / Met and have identified the hepatocyte growth factor / scatter factor receptor Met , the adapter protein Gab 1 , and the junctional component p 120 catenin as potential substrates . ^^^ When co expressed in 293 cells , the full length substrate trapping mutant form of DEP 1 formed a stable complex with the chimeric receptor colony stimulating factor 1 ( CSF ) Met and wild type DEP 1 dephosphorylated CSF Met . ^^^ Furthermore , we observed that DEP 1 preferentially dephosphorylated a Gab 1 binding site ( Tyr ( 1349 ) ) and a COOH terminal tyrosine implicated in morphogenesis ( Tyr ( 1365 ) ) , whereas tyrosine residues in the activation loop of Met ( Tyr ( 1230 ) , Tyr ( 1234 ) , and Tyr ( 1235 ) ) were not preferred targets of the PTP . ^^^ |
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| Interacting proteins: Q12913 and P08581 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that ( 1 ) bivalent Ab 1 arrests cell cycle progression of CD 148 transfected CHO cells at G ( 0 ) / G ( 1 ) phase , ( 2 ) coexpression of catalytically inactive CD 148 mutants attenuates the Ab 1 cell growth inhibition , and ( 3 ) bivalent Ab 1 suppresses phosphorylation of ERK1 / 2 kinases and Met tyrosine kinase as activated CD 148 does , with an increase in CD 148 associated tyrosine phosphatase activity . ^^^ |
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