| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Coupling of Gab 1 to c Met , Grb 2 , and Shp 2 mediates biological responses . ^^^ Overexpression of a Gab 1 mutant deficient in Shp 2 interaction could also block HGF / SF induced activation of the MAPK pathway , suggesting that Shp 2 is critical for c Met / Gab1 specific signaling . . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We have found here a novel signaling pathway of c Met consisting of SHP 2 Rho that regulates the assembly and disassembly of stress fibers and focal adhesions in MDCK cells . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated that a single carboxyl terminal tyrosine residue , Tyr 489 , is essential for efficient transformation of Fr3T3 fibroblasts by Tpr Met and forms a multisubstrate binding site for Grb 2 , phosphatidylinositol 3 ' kinase , phospholipase Cgamma , SHP 2 , and an unknown protein of 110 kDa . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| The tyrosine phosphatase SHP 2 is required for sustained activation of extracellular signal regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase . ^^^ Gab 1 is a docking protein that couples the Met receptor with multiple signaling proteins , including phosphatidylinositol 3 kinase , phospholipase Cgamma , the adapter protein Crk , and the tyrosine specific phosphatase SHP 2 . ^^^ To elucidate the Gab 1 dependent signals required for epithelial morphogenesis , we undertook a structure function approach and demonstrate that association of Gab 1 with the tyrosine phosphatase SHP 2 is required for sustained Erk activation and for epithelial morphogenesis downstream from the Met receptor . ^^^ Moreover , SHP 2 catalytic activity is required , since the expression of a catalytically inactive SHP 2 mutant , C / S , abrogates sustained activation of Erk and epithelial morphogenesis by the Met receptor . ^^^ These data identify SHP 2 as a positive modulator of Erk activity and epithelial morphogenesis downstream from the Met receptor . . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| These studies reveal that binding of a pY peptide to the N SH 2 domain of SHP 2 is greatly enhanced by a large hydrophobic residue ( Trp , Tyr , Met , or Phe ) at the pY+4 and / or pY+5 positions , whereas binding to SHP 1 N SH 2 domain is enhanced by either hydrophobic or positively charged residues ( Arg , Lys , or His ) at these positions . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| This response requires that Gab 1 possess an intact Met binding motif , the pleckstrin homology domain , and the binding sites for phosphatidylinositol 3 kinase and tyrosine phosphatase SHP 2 , but not the Grb 2 and CrkII / phospholipase Cgamma binding sites . ^^^ |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
|