| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of the gene for HGFA together with those for hepatocyte growth factor ( HGF ) and its receptor , c met , was investigated in each tissue element by RT PCR . ^^^ In the fetal rat gastrointestinal tract , mRNA signals for the HGFA gene were observed only in epithelia expressing c met mRNA . ^^^ During the period of morphogenesis and histodifferentiation in the gastrointestinal tract , enhanced expression of the genes for HGF and its receptor / c met was evident , with elevated HGFA mRNA level observed throughout the gastrointestinal tract except in the forestomach , where mRNA expression was barely detectable . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Its actions are dependent on activation by HGF activator ( HGFA ) and its binding to a specific HGF receptor ( c Met ) . ^^^ We examined the role of HGF , HGFA , and c Met in synovial tissues in rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) , and their localization and mRNA expression . ^^^ METHODS : Immunohistochemical staining , Western blotting , RT PCR , and in situ hybridization ( ISH ) for HGF , HGFA , and c Met were performed on synovial tissue specimens from 10 patients with RA and 4 with OA , and 2 healthy controls . ^^^ RESULTS : Immunohistochemical staining revealed that HGFA and c Met were strongly expressed in fibroblasts , macrophages , endothelial cells , and synovial lining cells . ^^^ RT PCR showed HGF , HGFA , and c Met mRNA in RA , OA , and control synovial tissue . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although the presence of hepatocyte growth factor and its c MET receptor have been reported in male mammalian reproductive tracts , our novel findings on the secretion of HGFA precursor from turkeys may help to elucidate the regulation of activated hepatocyte growth factor . . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| To determine whether these factors contribute to the distinct etiologies of fibrolamellar hepatocellular carcinoma and traditional hepatocellular carcinoma , we assayed hepatocyte growth factor , the hepatocyte growth factor receptor , and two hepatocyte growth factor activators , hepatocyte growth factor activator and urokinase type plasminogen activator , in hepatocellular carcinoma , fibrolamellar hepatocellular carcinoma , cirrhotic liver and normal liver . ^^^ Western blot analyses using antibodies against hepatocyte growth factor , hepatocyte growth factor receptor , phosphotyrosine , hepatocyte growth factor activator , urokinase type plasminogen activator receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen and plasmin were performed on membrane enriched fractions from the frozen tissue , as was collagen zymography for matrix metalloproteinase 2 and matrix metalloproteinase 9 . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tissue microarray analysis of hepatocyte growth factor / Met pathway components reveals a role for Met , matriptase , and hepatocyte growth factor activator inhibitor 1 in the progression of node negative breast cancer . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Enhanced MET phosphorylation and increased migratory activity were induced by the expression of HGFA in YKG 1 cells in vitro in the presence of thrombin , which is a known activator of proHGFA . ^^^ Consequently , the expression of HGFA in U 251 did not enhance the MET phosphorylation and following cellular response even with the thrombin treatment . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present study we have examined the expression of regulatory components of the HGF / MET pathway , including HGF activator ( HGFA ) , within the secondary lymphoid organ microenvironment . ^^^ We show that MET is expressed by both centroblasts and plasma cells , and that HGFA is expressed by plasma cells . ^^^ These findings suggest that HGF and HGFA provided by dark zone FDCs help to regulate the proliferation , survival , and / or adhesion of MET positive centroblasts . . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| To examine the role of the HGF system in epithelial invasion followed by loss of connective tissue attachment in periodontitis , mRNA expression of HGF , its receptor ( c met ) and HGFA in gingival tissues was monitored . ^^^ The gene expression of HGF and keratinocyte growth factor ( KGF ) in gingival connective tissue , and c met , HGFA and KGF receptor ( KGFR ) in gingival epithelial tissues was monitored using RT PCR . ^^^ All the epithelial samples expressed KGFR and c met , whereas 5 out of 10 samples expressed HGFA . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We examined the gene expression of HGFA , HAI 1 , HAI 2 , HGF and MET in a normal kidney by laser captured microdissection , followed by reverse transcriptase polymerase chain reaction . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , HGF / c Met autocrine activity requires the presence of a serine protease , the HGF activator ( HGFA ) , and , in some cells , the CD 44 transmembrane glycoprotein . ^^^ Here , we found that HGFA , HGF , c Met , and CD 44 are coexpressed in MPNSTs but their localization did not correlate with increased cell proliferation . ^^^ These data indicate that an HGF / c Met autocrine loop can promote MPNST invasion through a CD 44 independent mechanism and suggest that c Met , HGFA , and HGF are potential molecular targets to inhibit MPNST metastasis . . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| To help identify ways to moderate HGF / Met effects , we have determined the molecular structure of the protease domain of HGFA . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Taken together , these data indicate that HGF / MET signaling , and secretion of HGFA by DLBCL cells , contributes to lymphomagenesis in DLBCL . . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NYGM cells concomitantly expressed MET receptor tyrosine kinase ( a product of c met protooncogene ) and its ligand HGF / SF ( hepatocyte growth factor / scatter factor ) , as well as HGF activator and HGF activator inhibitors . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| Other changes in carcinoma were upregulation of MET and Ne dlg , and downregulation of HGFAC , desmin , and PDGFA . ^^^ The most prominent differences between advanced and local adenocarcinoma were upregulation of COL3A1 , CFGR , and MET in advanced carcinoma , and downregulation of HGFAC , FZD 3 , and BFL 1 in the same tumors . ^^^ |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04756 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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