| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| STAT 1alpha / 1beta , STAT 3 and STAT 5 : expression and association with c MET and EGF receptor in long term cultures of human hepatocytes . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Immunoexpression of the hepatocyte growth factor ( HGF ) , HGF receptor ( c met ) and STAT 3 on placental tissues from malformed fetuses . ^^^ To characterize the possible relationship between the expression of the HGF / HGF R system with transcription factor STAT 3 , responsible for morphogenetic response of HGF stimulation , and the embryonic development alterations , we investigated , by immunohistochemistry , the expression of HGF , c met and STAT 3 in 9 placentas from malformed fetuses and 9 control placentas from non malformed fetuses . ^^^ The major and distinct patterns of expression characterizing the placentas from malformed fetuses were a higher percentage mean of stromal cells stained for HGF , c met and STAT 3 antibodies ( 60 % , 66 % and 54 % , respectively on fibroblast cells and 44 % , 57 % and 42 % , respectively on myofibroblast cells ) and a lower percentage mean of cytotrophoblast cells stained for the same antibodies ( 2 % , 2 % and 1 % , respectively ) , than in control placentas . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| HGF activates several downstream effectors of c Met such as the mitogen activated protein kinases extracellular signal regulated kinase 1 / extracellular signal regulated kinase 2 and phospholipase C gamma , whereas signal transducer and activator of transcription 3 is constitutively activated in neuroblastoma cells expressing c Met . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical expression of HGF , c MET and transcription factor STAT 3 in colorectal tumors . ^^^ By immunohistochemistry , we have investigated the expression of hepatocyte growth factor ( HGF ) , HGF R or c met and the transcritor factor STAT 3 in a series of 80 colorectal tumours ( 40 adenomas and 40 adenocarcinomas ) . ^^^ The expression of HGF , c met and STAT 3 was revealed in 40 / 40 ( 100 % ) of adenomas and in 26 / 40 ( 65 % ) of adenocarcinomas ; the remaining 14 / 40 ( 35 % ) carcinomas expressed c met but failed to express HGF and STAT 3 . ^^^ In adenomas , the HGF immunoreaction was high in 33 ( 82 . 5 % ) and moderate in 7 ( 17 . 5 % ) ; the c met staining was high in 3 ( 7 . 5 % ) and moderate in 37 ( 92 . 5 % ) ; and the STAT 3 reactivity was high in 25 ( 62 . 5 % ) and moderate in 15 ( 37 . 5 % ) . ^^^ In carcinomas , the HGF immunoreaction was moderate in 21 ( 80 . 7 % ) and low in 5 ( 19 . 2 % ) ; the c met staining was high in 14 ( 35 % ) , moderate in 25 ( 62 . 5 ) and low in 1 ( 2 . 5 % ) ; and the STAT 3 reactivity was moderate in 17 ( 65 . 3 % ) and low in 9 ( 34 . 6 % ) . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| In extra thyroidal tissues , the HGF / c met and IL 6 / IL 6 receptor ( IL 6R ) systems activate STAT 3 , a member of the signal transducers and activators of transcription ( STATs ) family . ^^^ To evaluate whether either system utilizes STAT 3 in thyroid nodules , we examined the immunohistochemical expression of HGF , c met , IL 6 , IL 6R , STAT 3 in 6 normal thyroids and in 68 thyroid nodules . ^^^ Since these cases are consistently HGF+ / c met+ and only one third of them co express IL 6 / IL 6R , STAT 3 expression correlates with the HGF / c met expression , not with the IL 6 / IL 6R expression . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate a role of Stat 3 in transducing survival signals downstream of tyrosine kinases such as Src , EGF R , and c Met , as well as cytokines such as IL 6 , in human nonsmall cell lung cancers . . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| In addition , PHA 665752 inhibited HGF stimulated or constitutive phosphorylation of mediators of downstream signal transduction of c Met , including Gab 1 , extracellular regulated kinase , Akt , signal transducer and activator of transcription 3 , phospholipase C gamma , and focal adhesion kinase , in multiple tumor cell lines in a pattern correlating to the phenotypic response of a given tumor cell . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| By using peptide immunoblot affinity assays and mirror resonance affinity analysis , we demonstrated that only phosphotyrosine ( Tyr ( P ) ) peptides containing +3 Gln ( not Leu , Met , Glu , or Arg ) bound to wild type Stat 3 . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Signal transducer and activator of transcription 3 ( STAT 3 ) has been shown to contribute to c Met mediated cell motility and is , thus , potentially involved in the control of invasive cell behavior . ^^^ Activation of the c Met receptor complex in fibroblasts drives invasive cell behavior by signaling through transcription factor STAT 3 . c Met is the receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^ Signal transducer and activator of transcription 3 ( STAT 3 ) has been shown to contribute to c Met mediated cell motility and is , thus , potentially involved in the control of invasive cell behavior . ^^^ We have functionally reconstituted c Met dependent signal transduction in fibroblasts with the aim of studying Met driven cell invasiveness and the role of STAT 3 in this phenomenon . ^^^ NGF stimulation of the heterologous receptor system evoked activation of STAT 3 as evidenced by tyrosine phosphorylation and the formation of STAT 3 clusters at the cell membrane . siRNA mediated ablation of STAT 3 expression resulted in a drastic reduction of c Met driven invasiveness , indicating an important role of STAT 3 in the control of this particularly relevant property of transformed cells . . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Western blot analyses and co immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , hepatocyte growth factor receptor ( MET ) , urokinase type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT 3 . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation was performed with antisera to signal transducers and activators of transcription 1 ( STAT 1 ) , STAT 3 , Janus kinase 1 ( Jak 1 ) , Shc , Grb 2 , Sos 1 , and HGF receptor ( met ) . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Requirement of Stat 3 signaling for HGF / SF Met mediated tumorigenesis . ^^^ Stat 3 is a downstream signaling molecule activated by HGF / SF Met signaling , and is reported to contribute to cell transformation induced by a diverse set of oncoproteins . ^^^ To address whether Stat 3 is required for HGF / SF Met mediated tumorigenesis and metastasis , we introduced a dominant negative form of Stat 3 , Stat3beta into the human leiomyosarcoma cell line SK LMS 1 . ^^^ Thus , Met signaling through Stat 3 provides an essential function for tumorigenic growth , which is manifested in vitro by loss of anchorage independent growth . . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| We hypothesize that increased autocrine HGF Met signaling is a critical downstream function of c Src Stat 3 activation in mammary tumorigenesis . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| ICAM 1 promoter activities induced by the overexpression of wild type JAK 1 and PLC gamma 2 were blocked by the PLCgamma 2 mutant or the dominant negative PKCalpha ( Lys > Arg ) , c Src ( Lys > Met ) , or STAT 1 ( Y701M ) mutants , but not by dominant negative STAT 3 ( DN ) mutants . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| MET or RON with the 2B mutation also constitutively phosphorylated STAT 3 . ^^^ Ectopic expression of wild type but not Thr ( p+1loop ) > Met substituted EPH family members constitutively phosphorylated STAT 3 . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| DCP was found to bind with cell surface receptor Met causing Met autophosphorylation and also to activate STAT 3 signaling pathway through Janus kinase 1 . ^^^ Small interfering RNAs against both STAT 3 and Met abrogated DCP induced cell proliferation . ^^^ The Met Janus kinase 1 STAT 3 signaling pathway may be a major signaling pathway for DCP induced cell proliferation . . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| Some genes whose expression was increased by overexpressed STAT 3 , but not by activated STAT 3 dimers , encode well known oncoproteins ( e . g . , MRAS and MET ) . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| The purified pseudopodial fraction contains phosphotyrosinated proteins , including Met and FAK , and various signaling proteins , including Raf 1 , MEK 1 , ERK 2 , PKBalpha ( Akt 1 ) , GSK3alpha , GSK3beta , Rb , and Stat 3 . ^^^ |
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| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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