| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.70016936 |
| In this study we show that c met is co localised with beta catenin and E cadherin at regions of cell cell contact in human colon cancer ( HRT 18 and HT 115 ) and two breast cancer ( MCF 7 and MDA MB 231 ) cell lines . 0.70016936^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.5150605 |
| Matrigel also induced an increased association of beta catenin with Met ( hepatocyte growth factor receptor ) , whereas association with E cadherin remained unchanged . 0.5150605^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.87952645 |
| Tyrosine phosphorylated beta catenin was constitutively associated with c Met in the more metastatic cells , but was inducible only after HGF addition in the less metastatic cells . 0.87952645^^^ Thus , beta catenin association with activated c Met may contribute to a more aggressive liver metastatic phenotype of these cells . . 0.65796103^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| In order to investigate the relationships of expression and tyrosine phosphorylation of cadherin catenin molecules and expression of growth factor receptor tyrosine kinase with loose cell to cell adhesion , immunohistochemical staining for E cadherin , alpha and beta catenin , phosphorylated tyrosine residues and tyrosine kinase receptors , including c erbB 2 , epidermal growth factor receptor ( EGF R ) , c met and K sam , in 17 undifferentiated and 10 differentiated type human gastric cancers was performed . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Scatter factor / hepatocyte growth factor ( SF / HGF ) , on binding to its c met tyrosine kinase receptor , can induce invasion through tyrosine phosphorylation of beta catenin . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| We also studied for the first time c met expression in association with E cadherin and beta catenin expression . ^^^ METHODS AND RESULTS : Immunohistochemistry ( ABC HRP method ) was peformed for the detection of c met , E cadherin and beta catenin . c met immunoreactivity was observed in 58 % of cases and was associated with the lobular type of breast carcinomas ( P = 0 . 012 ) , low histological grade ductal carcinomas ( P = 0 . 05 ) , favourable prognostic and predictive factors such as oestrogen and progesterone receptor immunohistochemical expression and negative c erbB 2 expression ( P = 0 . 05 , P = 0 . 014 and P = 0 . 03 , respectively ) . c met immunoreactivity did not correlate with lymph node status , tumour size and stage of the disease . ^^^ When c met staining was compared with E cadherin and beta catenin expression , a statistical significant correlation was established between c met immunoreactivity and abnormal beta catenin expression ( P = 0 . 025 ) suggesting possible involvement of c met in the downregulation of the E cadherin catenin complex , possibly through tyrosine phosphorylation of beta catenin . ^^^ CONCLUSION : c met immunohistochemical expression seems to be associated with abnormal beta catenin expression , good prognostic and predictive factors and favourable outcome in breast cancer patients . . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Replicative myoblasts lacking A type lamins or emerin also have decreased levels of proteins important for muscle differentiation including pRB , MyoD , desmin , and M cadherin ; up regulated Myf 5 ; but no changes in Pax 3 , Pax 7 , MEF2C , MEF2D , c met , and beta catenin . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that beta catenin forms a complex with c Met ( HGF receptor ) that undergoes dissociation because of beta catenin tyrosine phosphorylation on stimulation by HGF . ^^^ The mechanisms of beta catenin activation in the 1 week study included loss of c Met beta catenin association as well as canonical beta catenin activation , leading to its nuclear translocation . ^^^ In the 4 week study , beta catenin activation was observed via canonical mechanisms , whereas the c Met beta catenin complex remained unchanged . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| While concentration of PGE 2 as well as expression of Cox 2 , HGF receptor ( c Met R ) , epidermal growth factor receptor ( EGFR ) , and beta catenin are all dramatically increased in colon cancers and implicated in their growth and invasion , the precise role of PGE 2 in the latter process remains unclear . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| HSC 39 signet ring cell carcinoma cell line harboring p 53 missense mutation has homozygous deletion of p16CDKN2 / MTS1 / INK4A and p15MTS2 , amplifications of c myc , c met , K sam and CD 44 gene and mutation in beta catenin gene . . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| These include loss of heterozygosity ( LOH ) at the chromosomal region 11p15 . 5 , LOH on chromosome arms 1p and 1q , activating mutations in exon 3 of the beta catenin gene , as well as overexpression of the c met oncogene , which encodes the hepatocyte growth factor receptor . ^^^ LOH 11p15 . 5 was found in 15 / 56 , LOH1p in 11 / 53 , LOH1q in 7 / 53 and beta catenin mutations in 25 / 55 HB . 13 / 23 HB had a c met overexpression . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the HGF receptor ( HGFR or c met ) and beta catenin was determined by immunoprecipitation and western blot analysis . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Using biochemical and immunohistochemical techniques , we have investigated P cadherin , beta catenin , c src and c met protein expression , and phosphorylation of beta catenin in a rat model of tongue cancer induced with 4 nitroquinoline 1 oxide . ^^^ These experiments demonstrate that cell cell adhesion in epithelial cells was reduced by phosphorylation of beta catenin and that beta catenin overexpression in nuclear and cytoplasmic compartments during carcinogenesis and the production of the c met product that is associated with the phosphorylation of beta catenin in tongue cancer . . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical studies included the analysis of p 53 , c Met , c erbB 2 , beta catenin , and cyclooxygenase 2 . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta catenin pathway . beta Catenin is an oncogenic protein involved in regulation of cell cell adhesion and gene expression . ^^^ We report a new cause of beta catenin accumulation involving oncogenic mutants of RON and MET receptor tyrosine kinases ( RTKs ) . ^^^ Cells transfected with oncogenic RON or MET were characterized by beta catenin tyrosine phosphorylation and accumulation ; constitutive activation of a Tcf transcriptional factor ; and increased levels of beta catenin / Tcf target oncogene proteins c myc and cyclin D 1 . ^^^ Interference with the beta catenin pathway reduced the transforming potential of mutated RON and MET . ^^^ Activation of beta catenin by oncogenic RON and MET constitutes a new pathway , which might lead to cell transformation by these and other mutant growth factor RTKs . . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| The mutational sites comprised one case each at codons 1299 ( GCT to ACT , Ala to Thr ) , 1412 ( GGA to AGA , Gly to Arg ) , and 1414 ( GTA to ATA , Val to Ile ) , in addition to one case with double point mutations at codon 1398 ( AGT to AAT , Ser to Asn ) and at codon 1413 ( ATG to ATA , Met to Ile ) , together with beta catenin mutation at codon 32 ( GAC to TAC , Asp to Tyr ) . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor induces Wnt independent nuclear translocation of beta catenin after Met beta catenin dissociation in hepatocytes . ^^^ We demonstrate novel association of beta catenin and Met , a tyrosine kinase receptor of HGF , at the inner surface of the hepatocyte membrane . ^^^ The source of beta catenin for translocation in hepatocytes is the Met beta catenin complex , which appears to be independent of the E cadherin beta catenin complex . ^^^ A loss of Met beta catenin association resulted in abrogation of nuclear translocation of beta catenin upon HGF stimulation . ^^^ This event is tyrosine phosphorylation dependent , and the association of Met and beta catenin is crucial for this event . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Constitutive Wnt / beta catenin signaling occurs in certain cancers from mutation of components of the pathway and from activating growth factor receptors , including RON and MET . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Our results show co expression of HGF and met protein , absence of E cadherin , high levels of beta catenin co immunolocalized to met at the cell membrane and moderate levels of gamma catenin and ezrin protein expression . ^^^ The WiT 49 cell line responded to recombinant human HGF by an increase in the expression of the met receptor , recruitment of the Gab 1 adapter protein to met and release of bound beta catenin from met . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Additionally , MET protein activated by the inactivation of VHL gene modified cell adherence , including N cadherin and beta catenin . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| MCF 7 ( breast carcinoma ) and MCF 10 ( immortalized mammary ) cells , we studied the possible mechanism ( s ) by which E cadherins modulate the signaling pathways downstream of Met , leading to beta catenin TCF transcriptional activity . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Met activation induces changes consistent with early invasion , such as down regulation of E cadherin , increased nuclear TCF / beta catenin signaling , and anchorage independent growth . ^^^ |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| Activation of the Wnt / beta catenin and hepatocyte growth factor / Met signaling has been implicated in various tumors . ^^^ This study examined changes in beta catenin and Met in paired pretreatment and post treatment hepatoblastoma tissues in relation to their effects on proliferation and target genes such as c myc and cyclin D 1 . ^^^ In this study we compared proliferation indices , beta catenin staining and its known molecular targets , c myc and cyclin D 1 , and Met , a tyrosine kinase receptor for hepatocyte growth factor in pretreatment and post treatment specimens . ^^^ |
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| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
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