| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| Cells treated with anti Fas also exhibited increased tyrosine phosphorylation of the c met growth factor receptor tyrosine kinase . ^^^ Immunoprecipitation experiments demonstrated that Fas associated with c erbB 2 and c met in untreated cells . ^^^ Treatment with anti Fas , however , significantly decreased Fas c erbB 2 and Fas c met association . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| A 62 % LOH was found at 7q31 in the FAs , suggesting , as other authors have proposed , that at least one TSG must be present in the vicinity of the c met locus . ^^^ |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| The expression of matrix metalloproteinase 2 ( MMP 2 ) , plasminogen activator inhibitor 1 ( PAI 1 ) and interleukin 1 ( IL 1 alpha ) were upregulated in the highly metastatic subpopulations , while the expression of carcinoembryonic antigen ( CEA ) , caspase 5 , Fas ligand , Prk / FNK , cyclin E , cyclin B 1 , Ki 67 , proliferating cell nuclear antigen ( PCNA ) , Smad 4 , macrophage proinflammatory human chemokine 3 alpha ( MIP 3 alpha ) / LARC , Met and CD 44 were downregulated . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| The involvement of MET in human tumors has been definitively established and can be achieved through several mechanisms , including MET interaction with unrelated membrane receptors , such as integrins , plexins , CD 44 , FAS and other RTKs . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| Activation of anti apoptotic regulators , such as the hepatocyte growth factor / Met receptor tyrosine kinase , as well as Raf , ERK1 / 2 , FLIP ( L ) , and the NF kappaB pathway , was elevated in response to Fas activation in livers from PTP1B null mice . ^^^ Using PTP1B deficient primary hepatocytes , we show that resistance to Fas mediated apoptosis is cell autonomous and that signals involving the Met , ERK1 / 2 , and NF kappaB pathways are required for cytoprotection . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| These include alterations in DNA ploidy , cellular proliferation markers ( PCNA , Ki 67 , Mcm 2 , MIB 1 , MIA , and CSE1L / CAS protein ) , nuclear morphology , the p 53 gene and its related molecule MD M 2 , other cell cycle regulators ( cyclin A , cyclin D , cyclin E , cdc 2 , p 27 , p 73 ) , oncogenes and their receptors ( such as ras , c myc , c fms , HGF , c met , and erb B receptor family members ) , apoptosis related factors ( Fas and FasL ) , as well as telomerase activity . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| Here the possible regulatory effect of the apoptosis mediated by hepatocyte growth factor ( HGF ) / scatter factor ( SF ) c Met Fas in EACC is discussed . ^^^ METHODS : We examined 17 EACC specimens for immunohistochemical expression of HGF / SF , c Met , caspase 3 and Fas . ^^^ CONCLUSIONS : High levels of HGF / SF result in binding of HGF / SF to c Met , releasing Fas to aggregate and bind to its death inducing signaling complex . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| Potential mechanisms for the differential response to IFN gamma versus Ad IRF 1 such as modulation of c Met or extracellular regulated kinase signaling , or altered expression of IRF 2 , Fas , or survivin were investigated , but none of these mechanisms can account for this observation . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| A mechanism of cell survival : sequestration of Fas by the HGF receptor Met . ^^^ |
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| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P25445 |
Pubmed |
SVM Score :0.0 |
| NA |
|