| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for Hepatocyte Growth Factor is a transmembrane tyrosine kinase encoded by the c MET oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The met oncogene : from detection by transfection to transmembrane receptor for hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor and its relationship to hepatocyte growth factor and met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Identification of the hepatocyte growth factor receptor as the c met proto oncogene product . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor and the c met oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor up regulates met expression in rat fetal hepatocytes in primary culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) mRNA and its receptor ( c Met ) mRNA were detected in the fetal and adult rat brain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Modulation of hepatocyte growth factor and c met in the rat mammary gland during pregnancy , lactation , and involution . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Enhanced expression of hepatocyte growth factor and c Met mRNAs in isografts in experimental rat liver transplants . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Properties and functions of scatter factor / hepatocyte growth factor and its receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for hepatocyte growth factor has been identified as the Met tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c met expression in Long Evans Cinnamon rats with spontaneous hepatitis and hepatoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Concomitant expression of hepatocyte growth factor / scatter factor and the receptor c MET in human myeloma cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met protooncogene encodes a transmembrane tyrosine kinase receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ontogeny of hepatocyte growth factor and c met / hgf receptor in rat pancreas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Coexpression of hepatocyte growth factor and its receptor ( c met oncogene ) in HGL 4 glioblastoma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Enhanced expression of hepatocyte growth factor / c Met by myocardial ischemia and reperfusion in a rat model . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor ( HGFR ) transcripts were also unchanged in both experimental groups . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c MET in benign and malignant peripheral nerve sheath tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HMC 1 human mast cell line expresses the hepatocyte growth factor receptor c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Differential expression of Met / hepatocyte growth factor receptor in subtypes of non small cell lung cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Evidence for a functional hepatocyte growth factor receptor in human mesangial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor c met in human leukemia lymphoma cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , also known as scatter factor , binds the c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor receptor gene , c met gene , was shown to be present in lymphocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoperoxidase studies of hepatocyte growth factor ( HGF ) and its receptor , c met , were positive . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met proto oncogene encoding the receptor for the hepatocyte growth factor is expressed in several cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor , c met , transduces the HGF multiple biological activities . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Differential expression of hepatocyte growth factor and its receptor , c Met in the rat retina during development . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c met receptor in gastric mucosa during gastric ulcer healing . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor expression in rat testis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The met proto oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The c MET oncogene encodes the transmembrane tyrosine kinase receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both cancer cell lines expressed Met protein and did not express hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor ( HGF ) and c Met ( HGF receptor ) has been reported in many neoplasms . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Down regulation of MET , the receptor for hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met proto oncogene , encoding the hepatocyte growth factor receptor , can be activated by various mechanisms . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , c Met , are involved in cell transformation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.68673425 |
| The protein product of c met proto oncogene , Met , is a tyrosine kinase receptor for the hepatocyte growth factor ( HGF ) , also known as the scatter factor ( SF ) . 0.68673425^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.62674908 |
| The protein product of c met proto oncogene , Met , is a tyrosine kinase receptor for the hepatocyte growth factor ( HGF ) . 0.62674908^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.5399239 |
| In this study , we demonstrate that Met , the receptor tyrosine kinase for hepatocyte growth factor ( HGF ) , is expressed on VSMCs isolated from the intima of atherosclerotic plaques of carotid arteries . 0.5399239^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.61424896 |
| Inhibition by copper ( 2 ) binding of hepatocyte growth factor ( HGF ) interaction with its receptor Met and blockade of HGF / Met function . 0.61424896^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.7403289 |
| Interactions between hepatocyte growth factor ( HGF ) and its receptor , c Met , have been associated with invasion , metastasis and carcinogenesis in in vitro experiments . 0.7403289^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.86187304 |
| Myogenic precursor cells for the limb bud are recruited from the dermomyotome by the interaction of c met with its ligand scatter factor ( SF / HGF ) . 0.86187304^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.68990161 |
| Moreover , the c met proto oncogene product ( the c met protein ) possessing a tyrosine kinase domain was identified as a receptor for SF . 0.68990161^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.90119614 |
| Analysis of the HGF receptor using 125I HGF as a ligand showed that human keratinocytes expressed a single class of specific , saturable receptor for HGF in both low and physiological Ca2+ conditions , exhibiting a Kd = 17 . 3 pM and approximately 690 binding sites / cell under physiological Ca2+ . 0.90119614^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.52540099 |
| Two kringle HGF binds the HGF receptor , triggers its tyrosine kinase activity and behaves as a partial agonist , inducing motogenesis but not mitogenesis in target cells . 0.52540099^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.70752 |
| The MET proto oncogene , encoding the tyrosine kinase receptor for HGF , controls genetic programs leading to cell growth , invasiveness , and protection from apoptosis . 0.70752^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Biological responses to Hepatocyte Growth Factor are mediated by the tyrosine kinase receptor encoded by the Met oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :1.4842465 |
| HGF binds with high affinity to its specific tyrosine kinase receptor c met , thereby stimulating not only cell proliferation and differentiation , but also cell migration and tumorigenesis . 1.4842465^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.76227704 |
| CONCLUSION : HGFA , HGF , and c Met mRNA are expressed in synovial tissue in RA and OA , and HGF is activated by HGFA and binds to c Met on endothelial cells , inducing angiogenesis . . 0.76227704^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.58629859 |
| Deregulation of the interaction between HGF and its receptor c met during placentation may be the cause responsible for the growth retardation of the fetus due to the impaired placental functions . . 0.58629859^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of hepatocyte growth factor receptor ( c met ) has been detected in many human tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunolocalization of hepatocyte growth factor and its receptor ( c Met ) during mouse liver development . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The down regulated genes include c myc and c Met , the hepatocyte growth factor ( HGF ) receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) has multiple effects on target cells upon activation of its receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and its receptor c met in rat and rabbit vocal folds . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Functional role of hepatocyte growth factor receptor during sperm maturation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c Met ( HGF / c Met ) in adenoid cystic carcinoma of the human salivary gland . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , HGF receptor ( c met ) and the interleukin 6 ( IL 6 ) are expressed in thyroid nodules . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The role of hepatocyte growth factor / c met interactions in the immune system . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor of hepatocyte growth factor ( HGF ) , c met induces different physiological responses in several cell types . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a ligand for the c Met receptor , was not detected in the mRNA or protein of AME 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a ligand for the c Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met is the receptor for hepatocyte growth factor while Ron is that for macrophage stimulating protein . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c Met expression in rat and human liver fibrosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a cytokine whose multipotent actions are mediated by c Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) receptor is a transmembrane receptor tyrosine kinase encoded by the c met protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The higher expression of hepatocyte growth factor in bone marrow may contribute to the upregulation of c met . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met identification on human platelets : role of hepatocyte growth factor in the modulation of platelet activation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The interaction of InlB with the hepatocyte growth factor receptor , Met , is crucial for infection to occur . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Bovine hepatocyte growth factor and its receptor c Met : cDNA cloning and expression analysis in the mammary gland . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Biological responses of hepatocyte growth factor ( HGF ) are mediated by the Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ab induced ectodomain shedding mediates hepatocyte growth factor receptor down regulation and hampers biological activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met Independent Hepatocyte Growth Factor mediated regulation of cell adhesion in human prostate cancer cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Relative hepatocyte growth factor and c met mRNA and protein expression were higher in group 3 than in groups 1 and 2 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor Met has been detected in esophageal cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Role of scatter factor and the c met protooncogene in the pathogenesis of AIDS associated Kaposi ' s sarcoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The role of scatter factor and the c met proto oncogene in angiogenic responses . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of scatter factor and c met receptor in benign and malignant breast tissue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor receptor ( c Met ) as possible prognostic factor in patients with oral squamous cell carcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The specific activity of HGF / SF receptor ( c met ) mRNA also appears to peak at 6 days . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recently , a role has been assigned to HGF / SF and its receptor , c MET , in both normal and malignant hemopoiesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The MET proto oncogene encodes a transmembrane tyrosine kinase receptor for HGF ( p190MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor with Kd = 20 30pm is widely distributed in various epithelial cells including hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for HGF ( c met proto oncogene ) was expressed in rat type 2 cells and whole lung but not in macrophages . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These results suggest that HGF and c met may play a role in growth regulation in this organ . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor is the product of the c met proto oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF binds with high affinity to the receptor encoded by the MET protooncogene ( p190MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| High affinity HGF receptor , HGFR / met , was expressed in MLE 10 and all the derived cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by the proto oncogene c met is the high affinity receptor for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The diverse responses are transduced across the cell membrane by the met / HGF receptor , a product of c met protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor associates with the anti apoptotic protein BAG 1 and prevents cell death . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Differential expression of HGF and Met in human placenta . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ezrin is a substrate for the tyrosine kinase HGF receptor both in vitro and in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptors for HGF and MSP are the tyrosine kinases encoded by the homologous genes MET and RON . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Control of invasive growth by the HGF receptor family . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RT PCR and Western blot analysis confirmed that both tumor cell lines expressed c met , the receptor for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the specific receptor of HGF , c met , was also expressed in both cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These effects of HGF are mediated by the specific receptor c MET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recently , the expression of HGF and its receptor ( c met ) were observed in the intestinal tract . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor , c Met , was found in the corneal endothelial cell membranes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Finally , we determined c met ( the HGF receptor ) mRNA in the IEC 6 cells by Northern blot hybridization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We showed by RT PCR and western immunoblotting the presence of HGF receptor , c Met , in DHD / K12 cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The endocardial derived mesenchymal cells of the cushion tissue were found to express the c met HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met tyrosine kinase the HGF receptor induces cell transformation and metastasis when constitutively activated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Liver tumors and cultured tumor cell lines from dHGF transgenics showed high levels of HGF and c Met mRNA and protein . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both of these cells express c Met , the receptor for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor c met was expressed by all of the cell lines , as determined by northern blot . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoreactivity for HGF and the c Met receptor was clearly observed in neointimal SMCs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor mRNA expression was high in the surface and deep corpus mucosa , but low in the antrum . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Upon activation , the HGF receptor c Met binds and phosphorylates the multisite docking protein Gab 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The synergistic effect may be due to the fact that LPS upregulated the HGF receptor c met in thyroid , spleen , and colon . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of c Met , an HGF receptor , was observed in two of the four cell lines with high basal JNK activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , the HGF receptor is the only one known to associate directly with Gab 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A mechanism of cell survival : sequestration of Fas by the HGF receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Rat ascites hepatoma cell line of AH109A expressed HGF and c Met mRNAs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for HGF , c met , is also upregulated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of endogenous rat HGF and its receptor , c Met , was also induced in SGCs by human HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also showed that stromal cells themselves express HGF receptor c MET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of mRNA for HGF and its receptor , c Met , in the macrophages was investigated by RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF exerts its biological effects through transmembrane tyrosine kinase receptor ( c Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Sequential changes in HGF , TGF beta 1 and c Met protein expression in chronically over extended bladder ] . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Inhibiting HGF , its receptor c Met or the VLA 4 integrin may be beneficial to the myeloma patient . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Soluble HGF receptor ( MET ) and soluble u PAR ( u PA receptor ) inhibited the scHGF cleavage . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , Sca 1+ myocardial progenitor cells express c Met , a receptor for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Furthermore , 1 , 25 ( OH ) ( 2 ) D ( 3 ) was capable of stimulating HGF receptor phosphorylation in renal fibroblasts . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunohistochemical staining showed that these cells expressed c Met , the receptor for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A functional domain in the heavy chain of scatter factor / hepatocyte growth factor binds the c Met receptor and induces cell dissociation but not mitogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of c met proto oncogene in COS cells induces the signal transducing high affinity receptor for hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tissue distribution of hepatocyte growth factor receptor and its exclusive down regulation in a regenerating organ after injury . ^^^ Using 125I labeled hepatocyte growth factor ( HGF ) as a ligand , we examined the tissue distribution of the HGF receptor in adult rats . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The met proto oncogene is a member of the tyrosine kinase growth factor receptor family and is the receptor for hepatocyte growth factor ( HGF ) or scatter factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH 2 domains . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The renal expressions of the receptor gene ( c met ) for hepatocyte growth factor ( HGF ) were examined in unilateral nephrectomy ( UNX ) , renal ischemia or folic acid administration . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Amplification of the c met gene , that encodes hepatocyte growth factor receptor , was examined on human esophageal , gastric and colorectal carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for hepatocyte growth factor ( HGF ) is the product of the c met proto oncogene , a membrane spanning tyrosine kinase receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The membrane receptor for hepatocyte growth factor / scatter factor has been identified as the c met proto oncogene product . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expressions of mRNAs of hepatocyte growth factor ( HGF ) and its receptor ( c met ) and its effects were examined in cultured renal epithelial cell lines ( OK , LLCPK 1 , and MDCK cells ) and rat mesangial cells in primary culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF , also known as Scatter Factor ) is a powerful mitogen or motility factor in different cells , acting through the tyrosine kinase receptor encoded by the MET protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tumorigenicity of the met proto oncogene and the gene for hepatocyte growth factor . ^^^ The met proto oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a fibroblast derived factor and has recently been shown to be a ligand for the c met proto oncogene , a member of the receptor class of tyrosine kinases . c met messenger RNA ( mRNA ) is predominantly expressed in epithelial cells , but has been detected in several murine hematopoietic progenitor cell lines , suggesting that HGF and met might function during hematopoiesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| They are fibroblast growth factor ( FGF ) , hepatocyte growth factor ( HGF ) , and mast cell growth factor ( MGF ) , which activate the FGF receptor , c Met , and c Kit , respectively , known to be receptor tyrosine kinases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptors for nerve growth factor and hepatocyte growth factor have been identified as the Trk and Met tyrosine kinases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Defective posttranslational processing activates the tyrosine kinase encoded by the MET proto oncogene ( hepatocyte growth factor receptor ) . ^^^ The MET proto oncogene encodes a 190 kDa disulfide linked heterodimeric receptor ( p 190 alpha beta ) whose tyrosine kinase activity is triggered by the hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for hepatocyte growth factor , also known as scatter factor ( HGF / SF ) , has recently been identified as the 190 kDa heterodimeric tyrosine kinase encoded by the MET proto oncogene ( p190MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) stimulates the tyrosine kinase activity of the receptor encoded by the proto oncogene c MET . ^^^ This prompted us to test the hypothesis of a functional interaction between the c MET receptor and Hepatocyte Growth Factor ( HGF ) , a heparin binding polypeptide consisting of heavy and light chains of 65 and 35 kDa . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| C terminal truncated forms of Met , the hepatocyte growth factor receptor . ^^^ The MET proto oncogene encodes a transmembrane tyrosine kinase of 190 kDa ( p190MET ) , which has recently been identified as the receptor for hepatocyte growth factor / scatter factor . p190MET is a heterodimer composed of two disulfide linked chains of 50 kDa ( p 50 alpha ) and 145 kDa ( p 145 beta ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a natural ligand for the c met protooncogene product , has mitogenic , motogenic and morphogenic activities for various cell types and functions as a organotrophic factor for regeneration of the liver , kidney and lung . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have detected a novel type of structural variant of the tyrosine kinase receptor for c met , also known as the hepatocyte growth factor receptor , in mouse tissues . ^^^ The deleted region in the cytoplasmic domain of c metsm contains a sequence motif ( S985ARS ) for protein kinase C phosphorylation that has recently been shown to play a key role in the down regulation of hepatocyte growth factor receptor kinase activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , the product of c MET proto oncogene , are highly expressed in both fetal and adult lung , though their physiologic functions in the lung are largely unknown . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and Met receptor expression in human pancreatic carcinogenesis . ^^^ We have used immunohistochemistry to evaluate the clinicopathological significance of hepatocyte growth factor ( HGF ) and Met / HGF receptor expression in ductal lesions of 46 human pancreata . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression is repressed at 1 hour for transcripts that encode receptors for fibronectin ( FN ) , epidermal growth factor , and hepatocyte growth factor ( c met ) , and the secreted proteins FN and osteopontin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The association of hepatocyte growth factor ( HGF ) with its high affinity receptor , c met , has been shown to induce mitogenesis , motogenesis , and morphogenesis in renal epithelial cells ( L . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Signal transduction by the hepatocyte growth factor receptor , c met . ^^^ In this review of the hepatocyte growth factor receptor c met , the ability of the amino acid sequence of the receptor to dictate which signaling proteins are activated is described , with particular emphasis on association with the phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and its receptor ( c MET ) in prostatic carcinoma . ^^^ Hepatocyte growth factor ( scatter factor ) and its receptor , the c met proto oncogene product ( c MET ) , have been implicated in embryogenesis , tissue reorganization , and tumor progression . ^^^ In this investigation , we assessed the expression of hepatocyte growth factor ( HGF ) and c MET in prostatic tissues and cell lines and also determined the effect of purified recombinant HGF on cell proliferation and scattering of prostatic carcinoma cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a natural ligand for the c met protooncogene product , is a multipotent polypeptide which elicits mitogenic , motogenic , and morphogenic activities for various types of cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interaction between cell adhesion molecules in the c met expressed tumor cells and hepatocyte growth factor from stromal cells is implicated in the morphogenesis of two types of gastric cancer . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the proto oncogenes c met and c kit and their ligands , hepatocyte growth factor / scatter factor and stem cell factor , in SCLC cell lines and xenografts . ^^^ We examined a panel of 25 small cell lung cancer ( SCLC ) cell lines and nude mouse xenografts for expression of the proto oncogenes c met and c kit , and for expression of the corresponding ligands , hepatocyte growth factor ( HGF ) ( also known as scatter factor ( SF ) ) , and stem cell factor ( SCF ) , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The cell dissociation and motility triggered by scatter factor / hepatocyte growth factor are mediated through the cytoplasmic domain of the c Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met oncogene product is a cell surface receptor , which ligand is believed to be the hepatocyte growth factor . ^^^ Expression of the hepatocyte growth factor receptor in the regenerating rat liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By in situ hybridization , FGF 2 was also found to mediate the transcriptional activation of WT 1 and of the hepatocyte growth factor receptor gene , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol 3 OH kinase to the hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene c met product ( c MET ) is a receptor tyrosine kinase and functions as a receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The data on the regulatory genes demonstrate , in particular , the importance of the Wilms ' tumour gene , WT 1 , in nephrogenesis , the growth stimulating interaction between the hepatocyte growth factor and its receptor , c met , and the differences between uninduced and induced metanephric mesenchyme . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET oncogene encodes the receptor for hepatocyte growth factor ( HGF ) scatter factor , a multifunctional cytokine able to mediate morphogenesis as well as invasive growth of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Type 3 : keratinocyte growth factor ( KGF ) and hepatocyte growth factor ( HGF ) were expressed exclusively by fibroblasts and their respective receptors , KGFR and c met , were predominantly expressed by epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a potent mitogen for renal tubular cells , and HGF and its receptor ( c met proto oncogene product , Met ) can induce lumen formation in epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Because the hepatocyte growth factor is a most potent mitogen in hepatocytes , possible involvement of c met expression in hepatocarcinogenesis is suspected . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Coexpression of the c met proto oncogene and hepatocyte growth factor in human pancreatic cancer . ^^^ The c met proto oncogene encodes a transmembrane tyrosine kinase receptor ( MET ) that has the capacity to modulate cell proliferation and differentiation ; it is activated by the hepatocyte growth factor . ^^^ The concomitant over expression of c met and hepatocyte growth factor in human pancreatic cancers suggests that there is excessive activation of c met dependent signaling pathways that may contribute to pancreatic cancer cell growth in vivo . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis and molecular modeling of the N terminal kringle containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c Met receptor . ^^^ The hepatocyte growth factor receptor ( HGFr ) transduces a wide range of biological signals , including mitogenesis , motogenesis and morphogenesis . ^^^ We recently localized a region within the N terminal 175 amino acids of hepatocyte growth factor ( HGF ) , termed HGF / NK1 , that is necessary and sufficient for binding to the HGFr . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor mRNA , and c met mRNA ( hepatocyte growth factor receptor ) in human liver tumours . ^^^ We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c met proto oncogene protein product , in a series of human primary and secondary liver tumours and adjacent non neoplastic liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) / scatter factor ( SF ) is a potent mitogenic factor or motility factor in different cells , acting through the tyrosine kinase receptor encoded by the met protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF ) / Scatter Factor secreted from sinusoidal endothelial cells and Kupffer cells in liver activates the c Met tyrosine kinase receptor expressed on hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a ligand for the c met protooncogene product , is a pleiotropic cytokine which elicits mitogenic , motogenic and morphogenic activities . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RON , a cDNA homologous to the hepatocyte growth factor ( HGF ) receptor gene ( MET ) , encodes a putative tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Regional expression of hepatocyte growth factor / c met in experimental renal hypertrophy and hyperplasia . ^^^ Hepatocyte growth factor ( HGF ) and its high affinity receptor , c met , have been found to increase in the whole kidney of the rat following several types of renal injury or renal hypertrophy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In gastric carcinoma , amplification and abnormal expression of the c met gene encoding receptor for hepatocyte growth factor ( HGF ) may contribute to the tumor progression and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analysis of the hepatocyte growth factor receptor in regeneration and oncogenesis of hepatocytes ] . ^^^ The Met proto oncogene product is a tyrosine kinase receptor whose ligand is hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF ) / Scatter Factor ( SF ) is a secretory glycoprotein from stromal fibroblasts which binds to the transmembrane c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to evaluate messenger RNA expression of c met , a hepatocyte growth factor receptor gene , after gastric mucosal injury in rats . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET proto oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , also known as scatter factor , a potent mitogen and motogen for epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein ( c MET ) in human brain tissues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The MET gene , encoding the tyrosine kinase receptor for Hepatocyte Growth Factor , is a potentially harmful oncogene overexpressed in a significant fraction of human cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Using PCR , hepatocyte growth factor ( HGF ) and c met ( HGF receptor ) expression were analyzed in the developing mouse kidney . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We were also able to detect the hepatocyte growth factor receptor c met on MMR 1 cells by indirect immunofluorescence . ^^^ This effect of hepatocyte growth factor , as a single cytokine , may be important in the early assemblage of kidney , since we were able to detect mRNA transcripts encoding c met from mouse embryo metanephric kidneys . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET proto oncogene product is a transmembrane tyrosine kinase receptor which was recently shown to transmit an array of important cellular responses induced by Hepatocyte Growth Factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene c met encodes a heterodimeric ( alpha , beta ) tyrosine kinase receptor which binds the hepatocyte growth factor ( HGF ) . ^^^ The Met / hepatocyte growth factor receptor ( HGFR ) gene is overexpressed in some cases of human leukemia and lymphoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined mRNA expression for c met encoding hepatocyte growth factor receptor in 8 gastric carcinoma cell lines and 31 surgically resected gastric carcinoma tissues by Northern blot analysis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Our previous studies have suggested that a derivative of hepatocyte growth factor ( HGF ) , HGF / NK2 , containing the coding sequences for the N terminal hairpin and first two kringle domains , is sufficient to mediate high affinity binding to the HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Transfer of motogenic and invasive response to scatter factor / hepatocyte growth factor by transfection of human MET protooncogene . ^^^ The MET protooncogene encodes p190MET , a tyrosine kinase which is the receptor for a molecule known as scatter factor or hepatocyte growth factor ( SF / HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET proto oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , also known as scatter factor , a powerful mitogen and motility factor for epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the c met / hepatocyte growth factor receptor gene during rat liver regeneration induced by carbon tetrachloride . ^^^ And the c met protooncogene is reported to encode a hepatocyte growth factor receptor . ^^^ In this study , we demonstrated that expression of the c met gene / hepatocyte growth factor gene was enhanced , with a distinct peak , following carbon tetrachloride administration , i . e . , the gene expression was activated at 6 hours after the treatment , then decreased , and again increased . ^^^ The present study suggested that this gene could be responding to liver regeneration and that the hepatocyte growth factor receptor plays an important role in regulating cell cycle progression prior to elevation of deoxynucleic acid synthesis during liver regeneration . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a highly potent growth stimulator of hepatocytes and c met proto oncogene has recently been identified as its high affinity receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ron is a 1400 amino acid protein structurally similar to the 1408 amino acid product of the C MET proto oncogene , the receptor for hepatocyte growth factor and scatter factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the met / hepatocyte growth factor / scatter factor receptor and its ligand during differentiation of murine P 19 embryonal carcinoma cells . ^^^ The met proto oncogene is a member of the family of tyrosine kinase growth factor receptors and was recently identified as a receptor for hepatocyte growth factor and scatter factor ( HGF / SF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor ( HGF ) , HGF receptor ( MET ) , keratinocyte growth factor ( KGF ) , KGF receptor , and fibroblast growth factor ( FGF ) receptor 2 were produced in primary cultures of human corneal epithelial , stromal fibroblast , and endothelial cells , as well as ex vivo corneal epithelium , endothelial cells transfected with the SV 40 large T antigen , and control embryonic lung fibroblasts . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Internalization and degradation of hepatocyte growth factor in hepatocytes with down regulation of the receptor / c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor . ^^^ We have previously shown that , in mouse NIH / 3T3 cells , it is necessary to coexpress the gene for human hepatocyte growth factor / scatter factor ( HGF / SFhu ) with its receptor , the human met protooncogene ( methu ) , to activate the transforming activity of the receptor ( S . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cell density dependent regulation of hepatocyte growth factor receptor on adult rat hepatocytes in primary culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , interaction between cell adhesion molecules in tumor cells expressing c met and hepatocyte growth factor ( HGF ) from stromal cells is linked with morphogenesis of two histological types of stomach cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c met genes during hepatic differentiation and liver development in the rat . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and its receptor ( the product of the c met protooncogene ) are believed to be necessary for the normal growth and development of many tissues and organs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor ( HGF ) and HGF receptor ( HGFR , product of the met proto oncogene ) mRNA were examined by nonisotopic in situ hybridization in a spectrum of benign and malignant human breast tissues . mRNA for both HGFR and HGF was detected in benign ductal epithelium . ^^^ Coexpression of hepatocyte growth factor and receptor ( Met ) in human breast carcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c met mRNAs during rat chemically induced hepatocarcinogenesis . ^^^ The receptor for hepatocyte growth factor ( HGF ) , a potent hepatocyte mitogen , is the product of the protooncogene c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , human lesion derived spindle cells synthesize and secrete biologically active hepatocyte growth factor and express the hepatocyte growth factor receptor ( c MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c sea proto oncogene is a member of the Met / hepatocyte growth factor / scatter factor family of receptor protein tyrosine kinases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A family of transmembrane proteins with homology to the MET hepatocyte growth factor receptor . ^^^ SEX shares significant homology with the extracellular domain of the receptors encoded by the oncogenes MET , RON , and SEA [ hepatocyte growth factor ( HGF ) receptor family ] . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Primary hepatocytes respond to the proliferating signals of Hepatocyte Growth Factor ( HGF ) through activation of the tyrosine kinase activity of the met ( p 145 ) receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) induced cell migration is negatively modulated by epidermal growth factor through tyrosine phosphorylation of the HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland , tears , and cornea . ^^^ Hepatocyte growth factor receptor protein was expressed in the glandular alveolar and interlobular ductal cells in the lacrimal gland and all three cell types of the cornea . ^^^ PURPOSE : The purpose of this study was to characterize the expression of hepatocyte growth factor ( HGF ) and HGF receptor proteins in lacrimal gland , tears , and cornea . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| STK belongs to the hepatocyte growth factor receptor family and was identified as the receptor for macrophage stimulating protein ( MSP ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The patterns of gene expression for hepatocyte growth factor ( HGF ) and its receptor , c Met , were revealed in the tooth germ of rat mandibular molars using RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Levels of myc , fos , Ha ras , met and hepatocyte growth factor mRNA during regenerative cell proliferation in female mouse liver and male rat kidney after a cytotoxic dose of chloroform . ^^^ In this experiment , we examined the levels of the myc , fos , Ha ras , met and hepatocyte growth factor mRNA in livers of female B6C3F ( 1 ) mice and kidneys of male F 344 rats to detect changes in gene expression following a single , cytotoxic gavage dose of chloroform in corn oil . ^^^ Livers of female mice showed large transient increases in levels of myc and fos mRNA while levels of Ha ras , met and the hepatocyte growth factor gene mRNA remained near control levels . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interaction of hepatocyte growth factor with its high affinity receptor c met initiates a cascade of intracellular events leading to epithelial motility . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a potent epithelial mitogen whose actions are mediated through its receptor , the proto oncogene c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of transforming growth factor alpha / epidermal growth factor receptor , hepatocyte growth factor / c met and acidic fibroblast growth factor / fibroblast growth factor receptors during hepatocarcinogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| At week 1 , there was an increase in both hepatocyte growth factor ( HGF ) and hepatocyte growth factor receptor ( HGFR ) which colocalized in centrilobular hepatocytes ; in some mice or periportal hepatocytes in other mice . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of c Met , the receptor for hepatocyte growth factor ( HGF ) , and the biological roles of HGF were examined in cultured human glioma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF / SF ) stimulates cell proliferation , motility , and morphogenesis by activation of its receptor , the c Met tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| C met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor ( HGF ) . ^^^ C met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a ligand for c Met tyrosine kinase , is a stromal derived regulator of growth , motility , and morphogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met proto oncogene product is the tyrosine kinase receptor for hepatocyte growth factor . ^^^ Analysis of the hepatocyte growth factor receptor in regeneration and oncogenesis of the liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions : its specific receptor c met does . ^^^ Increased levels of expression of hepatocyte growth factor ( HGF ) and its specific receptor c met have been shown in the liver of several benign and malignant pathologies , both in experimental models and humans . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We discovered that cellular adherence activated the protein tyrosine kinase of the cell surface receptor Met , whose ligand is hepatocyte growth factor and scatter factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The positive rates ( % ) for mRNA expression for normal / UC were : epidermal growth factor ( EGF ) 65 / 53 , transforming growth factor ( TGF ) alpha 100 / 87 , TGF beta 1 60 / 33 , insulin like growth factor 1 45 / 33 , platelet derived growth factor A 55 / 67 , basic fibroblast growth factor 0 / 0 , hepatocyte growth factor ( HGF ) 50 / 53 , EGF receptor 20 / 27 , erb B 2 75 / 73 , and HGF receptor ( c MET ) 55 / 67 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The motogenic , mitogenic , and morphogenic responses were also elicited by triggering the structurally related hepatocyte growth factor receptor ( Met ) but not epidermal growth factor or platelet derived growth factor receptors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Extensive and diverse studies have established that hepatocyte growth factor ( HGF ) , a ligand for the c met protooncogene product of receptor tyrosine kinase , is a mesenchymal or stromal derived multipotent polypeptide which mediates epithelial mesenchymal interactions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These cells express epithelial and ureteric ( Dolichos lectin staining , c ret , c met without hepatocyte growth factor ) specific markers , which identifies them as authentic UB cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor , C Met in human digestive tissues and different gastric and colonic cancer cell lines ] . ^^^ OBJECTIVES AND METHODS : Hepatocyte growth factor ( HGF ) and its receptor c Met exert mitogene and motogene activities in digestive tissues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a ligand for Met tyrosine kinase , is a mesenchyme or stroma derived multipotent factor that regulates the growth , motility , and morphogenesis of various types of cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Gene expressions of c met and hepatocyte growth factor in chronic liver disease and hepatocellular carcinoma . ^^^ BACKGROUND / AIMS : The roles of c met proto oncogene and hepatocyte growth factor in human livers have not been shown . ^^^ METHODS : Gene expressions of both c met and hepatocyte growth factor were quantified in livers with chronic active hepatitis and in cirrhotic livers with hepatocellular carcinoma as well as in normal controls , using competitive reverse transcription polymerase chain reaction . ^^^ Hepatocyte growth factor expression was increased in some patients with chronic active hepatitis compared with controls , and there was a significant correlation between c met expression and hepatocyte growth factor expression . ^^^ CONCLUSIONS : These findings suggest that hepatocyte growth factor may be involved in the regeneration of hepatocytes via paracrine mechanism in chronic active hepatitis , while in regulation of c met expression in hepatocellular carcinoma tissues may be independent of hepatocyte growth factor stimulation . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Induction of met proto oncogene ( hepatocyte growth factor receptor ) expression during human monocyte macrophage differentiation . ^^^ The met proto oncogene encodes the cell surface receptor for hepatocyte growth factor ( HGF ) and transmits its multifunctional signals such as regulation of cell proliferation , motility , and morphogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c Met / hepatocyte growth factor receptor in pulmonary adenocarcinomas : an evaluation of their expression as prognostic markers . ^^^ The expression of hepatocyte growth factor ( HGF ) and its receptor , c Met , was investigated immunohistologically in tissue specimens of patients with a pulmonary adenocarcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Since hepatocyte growth factor / scatter factor ( HGF / SF ) has been reported to promote keratinocyte migration and proliferation , key events in wound repair , and since HGF / SF is produced by dermal fibroblasts and its c Met receptor is expressed by basal keratinocytes in wounded skin , we have studied the effects of HGF / SF upon keratinocyte metalloproteinase expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Localisation of hepatocyte growth factor and its receptor ( c met ) protein and mRNA in human term placenta . ^^^ Hepatocyte Growth Factor ( HGF ) is a potent mitogen , morphogen and motogen to both endothelial and epithelial cell types and is linked to a tyrosine kinase , proto oncogene , c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interleukin 1 induces an autocrine loop hepatocyte growth factor / c Met in murine Kaposi like spindle cells . ^^^ Here we show that TTB cells co express hepatocyte growth factor ( HGF ) and its receptor , the product of the oncogene c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This investigation was performed to determine whether ethanol affects induction on Chang liver cells of the c met protooncogene product ( c met ) , a cell surface receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although the expression of hepatocyte growth factor ( HGF ) and its receptor , proto oncogene c met , has been demonstrated in the central nervous system ( CNS ) , the function of HGF in the CNS was not fully understood . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of Met / hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors . ^^^ Overexpression of the hepatocyte growth factor receptor ( Met / HGF receptor ) , a transmembrane tyrosine kinase encoded by the met proto oncogene , has been associated with tumor progression in different human carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c met receptor expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , the Met tyrosine kinase , are determinants of placenta , liver , and muscle development . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , which is identical to scatter factor ( SF ) through coupling to its receptor the product of c met oncogene , was found to induce proliferation of A 549 lung carcinoma cell line , accompanied by release of prostaglandin E 2 ( PGE 2 ) . ^^^ The hepatocyte growth factor receptor kinase mediated phosphorylation of lipocortin 1 transduces the proliferating signal of the hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and its receptor c met in multiple myeloma . ^^^ We have examined whether the hepatocyte growth factor ( HGF ) / c met receptor ligand pair is expressed in freshly isolated and highly purified myeloma cells and whether HGF can be found in the sera of myeloma patients . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interaction between cell adhesion molecules in the c met expressed cancer cells and hepatocyte growth factor from stromal cells is involved in morphogenesis of gastric cancer . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Additionally , 42 FHF rats were killed in batches of six rats each 2 , 6 , 12 , 18 , 24 , 30 , and 36 hours postoperatively to evaluate changes in blood chemistry ( glucose , lactate , liver function tests , prothrombin time ) and to assess liver regenerative response in the residual omental liver lobes ( weight , protein content , incorporation of bromodeoxyuridine [ BrdU ] , expression of proliferation cell nuclear antigen [ PCNA ] , mitotic activity ) , plasma levels of hepatocyte growth factor ( HGF ) and transforming growth factor beta ( TGF beta 1 ) , and tissue expression of the HGF and it ' s receptor c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Molecular cloning of the Xenopus c met / hepatocyte growth factor receptor and its regional expression during early development . ^^^ Hepatocyte growth factor ( HGF ) , a ligand for c Met receptor tyrosine kinase , regulates the cell growth , migration and morphogenesis of a wide variety of cells , and plays important roles in organogenesis in embryos as well as regeneration of organs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The protooncogene c met encodes the receptor for hepatocyte growth factor ( HGF ) , a potent epithelial cell mitogen with scattering activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor and its receptor c met : localisation and expression in the human placenta throughout pregnancy . ^^^ Hepatocyte growth factor ( HGF ) , also known as scatter factor , acts via the c met receptor resulting in pronounced effects on certain epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Utilizing the hepatocyte growth factor tyrosine kinase receptor , c met , the present review examines how growth factor receptors activate intracellular signaling pathways , which can then regulate the events necessary for epithelial cells to disassemble their existing structure , undergo extensive shape change and cell body movement , and reassemble into a polarized epithelium . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that the c met protooncogene product , a tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , is increased in the kidney of the diabetic rat . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Functional expression of these oncoproteins induced the adenoma to carcinoma conversion , overexpression of the hepatocyte growth factor ( HGF ) receptor Met , but failed to confer invasiveness in vivo and in vitro , or to produce alterations in cell proliferation and differentiation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of genes for hepatocyte growth factor ( HGF ) , its receptor c met proto oncogene , c myc proto oncogene , and albumin was analyzed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have shown previously that hepatocyte growth factor ( HGF ) , which is produced by lung fibroblasts , is a potent mitogen and motogen for both normal and neoplastic bronchial epithelium , and that expression of the HGF receptor , the c met proto oncogene protein , is uniformly found in the human bronchial epithelium and in non small cell lung carcinomas ( NSCLCs ; P . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) / scatter factor ( SF ) is the ligand for a tyrosine kinase cell surface receptor encoded by the MET protooncogene ( c MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) has been shown to function as a potent mitogen for a variety of cells , transducing its signal through the c met tyrosine kinase receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor induces proliferation , motility and differentiation of epithelial cells through the tyrosine kinase receptor encoded by the MET protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor , the c met proto oncogene , in hepatocellular carcinoma . ^^^ The c met proto oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , a potent mitogen and motogen for epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Therefore , we examined the effect of phosphorylated rat fetuin ( phosphofetuin ) on DNA synthesis in rat hepatocytes in culture in the presence of human hepatocyte growth factor ( HGF ) , since the human receptor of HGF , c Met , is known to contain a tyrosine kinase domain in its intracellular domain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical assays revealed that the peribiliary glands and antral type glands expressed not only cytokeratin and carbohydrate antigen 19 9 , but also c MET protein , the hepatocyte growth factor receptor which may be related , at least in part , to the cystic dilatation of the peribiliary glands . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor c met proto oncogene in hepatocellular carcinoma . ^^^ The c met proto oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , a potent mitogen and motogen for epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| FGFR 4 , insulin like growth factor 2 receptor ( IGF2R ) and hepatocyte growth factor receptor ( HGFR ) could not be detected in both samples . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The growth factor / receptor combination of hepatocyte growth factor ( HGF ) / c met has been postulated to be critical for mesenchymal to epithelial conversion and tubule formation in the developing kidney . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Developmental expression and functionality of hepatocyte growth factor and c Met in human fetal digestive tissues . ^^^ BACKGROUND & AIMS : Hepatocyte growth factor ( HGF ) and its receptor c Met are presumed to play a morphogenic role during embryogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Modifications of the hepatocyte growth factor / c met pathway by constitutive expression of transforming growth factor alpha in rat liver epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of Met tyrosine kinase by hepatocyte growth factor is essential for internal organogenesis in Xenopus embryo . ^^^ Hepatocyte growth factor ( HGF ) specifically activates Met tyrosine kinase receptor , leading to mitogenic , motogenic , and morphogenic responses in a wide variety of cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Polymerase chain reaction was used to measure the exclusive epithelial and stromal cell products , c met and hepatocyte growth factor ( HGF ) , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activated ras and ret oncogenes induce over expression of c met ( hepatocyte growth factor receptor ) in human thyroid epithelial cells . ^^^ Hepatocyte Growth Factor ( HGF ) receptor , encoded by the protooncogene c met , is overexpressed in many human tumours , including those of thyroid epithelium . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met and ron proto oncogenes encode the cell surface receptors for hepatocyte growth factor ( HGF ) and hepatocyte growth factor like ( HLP ) protein , respectively , and induce mitogenesis , motogenesis , morphogenesis , and metastatic activity in various cell types . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Because hepatocyte growth factor ( HGF ) , a ligand for the c Met proto oncogene product , is a mesenchymal or stromal derived factor that induces mitogenic , motogenic , and morphogenic responses , we examined the mechanisms involved in tumor stromal interactions in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor / scatter factor ( HGF / SF ) receptor which is a transmembrane protein encoded by the Met oncogene , possesses intrinsic tyrosine kinase activity which transduces the mitogenic , morphogenic and the scattering effect of HGF / SF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Association of the multisubstrate docking protein Gab 1 with the hepatocyte growth factor receptor requires a functional Grb 2 binding site involving tyrosine 1356 . ^^^ The receptor for hepatocyte growth factor has been identified as the Met tyrosine kinase . ^^^ Upon stimulation with hepatocyte growth factor , the Met beta subunit becomes highly phosphorylated on tyrosine residues , one of which , tyrosine 1356 within the carboxyl terminus , is crucial for dissociation , motility , and branching tubule formation in Madin Darby canine kidney epithelial cells . ^^^ To investigate additional signaling molecules that are activated by the Met receptor , we have identified hepatocyte growth factor induced phosphoproteins in tubular epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene c met encodes a transmembrane tyrosine kinase receptor for hepatocyte growth factor and is expressed in normal kidney tissue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Chromosomal localization of rat hepatocyte growth factor ( Hgf ) and HGF receptor ( Met ) and characterization of HGF receptor cDNA . ^^^ The Met protooncogene encodes the tyrosine kinase receptor for the hepatocyte growth factor ( HGF ) , a potent mitogen for hepatocytes and other epithelial cells produced by mesenchymal cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Lack of hepatocyte growth factor receptor ( c met ) gene expression in fulminant hepatic failure livers before transplantation . ^^^ To gain insight into liver regeneration mechanisms in fulminant hepatic failure , we compared gene expression of hepatocyte growth factor , its receptor c met , c myc , and albumin in human normal ( 4 cases ) and fulminant ( 14 cases ) livers by reverse transcription polymerase chain reaction . ^^^ In normal livers , hepatocyte growth factor gene was not expressed , whereas c met , c myc and albumin genes were always expressed . ^^^ In fulminant hepatic failure , hepatocyte growth factor gene was expressed in 1 of 14 cases , c met in none of 14 cases , c myc in 10 of 14 cases , and albumin in 3 of 14 cases . ^^^ Lack of its receptor ( c met ) expression may explain a poor response of fulminant hepatic failure livers to exogenous hepatocyte growth factor that normally promotes liver growth and regeneration . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor stimulates motility , chemotaxis and mitogenesis in ovarian carcinoma cells expressing high levels of c met . ^^^ A proportion of ovarian carcinomas markedly overexpress the proto oncogene c met , which encodes the receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here we report that Smadl , which mediates BMP signals , is also a target of mitogenic growth factor signalling through epidermal growth factor and hepatocyte growth factor receptor protein tyrosine kinases ( RTKs ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| After this procedure , lack of regenerative response in the residual viable liver tissue ( omental lobes ) was associated with elevated plasma hepatocyte growth factor ( HGF ) and transforming growth factor beta ( TGF beta 1 ) levels and delayed expression of HGF and c met mRNA in the remnant liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) stimulates cell proliferation , differentiation and migration by binding to its receptor , MET R . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Roles of hepatocyte growth factor and its receptor Met during gastric ulcer healing in rats . ^^^ The roles of hepatocyte growth factor ( HGF ) and Met / HGF receptor during gastric ulcer healing were studied in rats . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Previously , we reported amplification of the protooncogene MET ( hepatocyte growth factor receptor ; 7q31 ) in more than 20 % of glioblastomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here we report that mice expressing signaling mutants of the hepatocyte growth factor ( HGF ) receptor , the Met tyrosine kinase , show a striking reduction of sensory nerves innervating the skin of the limbs and thorax , implicating the HGF / Met system in sensory neuron development . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Effect of hepatocyte growth factor on cell cycle and c met expression in human gastric cancer cells . ^^^ Hepatocyte growth factor ( HGF ) was found to stimulate the growth and progression of gastric cancer cells through hepatocyte growth factor receptor ( HGFR ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Specifically , the epidermal growth factor receptor ( EGFR ) , p185HER2 / Neu and the hepatocyte growth factor receptor ( c Met ) appear to be linked to the process because they preferentially activate c Src in highly metastatic cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tumor angiogenesis , hepatocyte growth factor , and c Met expression in endometrial carcinoma . ^^^ BACKGROUND : This study was designed to evaluate the significance of tumor angiogenesis and angiogenic factors such as hepatocyte growth factor ( HGF ) and c Met in determining the prognoses of 93 patients with endometrial carcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of MET , the c met encoded receptor for hepatocyte growth factor , has not been investigated in proliferative biliary diseases of human liver , including hepatolithiasis and cholangiocarcinoma . ^^^ These data show for the first time that overexpression of MET is a common feature of hyperplastic and neoplastic biliary epithelial cells in human liver and suggest that MET / hepatocyte growth factor may be playing an important role in human biliary hyperplasia and in cholangiocarcinogenesis in vivo . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Comparative analysis of expression of hepatocyte growth factor and its receptor , c met , in gliomas , meningiomas and schwannomas in humans . ^^^ Expression of hepatocyte growth factor ( HGF ) and c met , a proto oncogene that encodes a receptor for HGF , was examined in 45 cases of human primary intracranial tumors by means of RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Other genes such as c met and its ligand hepatocyte growth factor are also involved in normal development and tumorigenesis , suggesting that tumors arise as a result of altered functions that are reflective of events that occur during nephrogenesis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the hepatocyte growth factor and c met in normal thyroid , non neoplastic , and neoplastic nodules . ^^^ We have examined the coexpression of hepatocyte growth factor ( HGF ) and its receptor ( HGF R or c met ) in an archival series of 63 paraffin embedded thyroid specimens plus one lymph node metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Structural and functional characterization of the mouse c met proto oncogene ( hepatocyte growth factor receptor ) promoter . ^^^ The c met gene encoding Hepatocyte Growth Factor Receptor is predominantly expressed in epithelial cell types and overexpressed in a variety of human and mouse neoplastic tissues and cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor stimulates chemotaxis and growth of malignant mesothelioma cells through c met receptor . ^^^ Hepatocyte growth factor ( HGF ) and its receptor c met are present in several human tissues but their expression in mesothelial cells has not been examined . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a natural ligand for the c met protooncogene product , exhibits mitogenic , motogenic , and morphogenic activities for regeneration of the liver , kidney , and lung . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Higher grade tumours tended to express it in the cytoplasm , suggesting that the role of c Met as the hepatocyte growth factor receptor was blocked in higher grade tumours . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The differential expression of hepatocyte growth factor and met in human placenta . ^^^ Met is the tyrosine kinase receptor for the ligand hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The role of hepatocyte growth factor ( HGF ) and its receptor , c met , in proliferation and differentiation of satellite cells was studied in primary cultures of chicken skeletal muscle satellite cells and a myogenic C 2 cell line . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF / SF ) has all the characteristics of a molecule suitable for functioning in regulatory networks of motility , such as the spermatogenic epithelium , where spermatogenic cells must migrate between the cells of Sertoli , and it exerts its effect through binding of its high affinity receptor ( c met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , also known as scatter factor is a pleiotropic factor that is mainly produced by mesenchymal cells and acts on cells of epithelial origin which express the HGF receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression and function of c Met , a receptor for hepatocyte growth factor , during T cell development . ^^^ The c Met oncoprotein is a cell surface receptor for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The relation between the growth patterns of gastric carcinoma and the expression of hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor , and urokinase type plasminogen activator receptor . ^^^ BACKGROUND : Hepatocyte growth factor receptor ( c met ) , autocrine motility factor receptor ( AMFR ) , and urokinase type plasminogen activator receptor ( uPAR ) are known to play important roles in tumor cell migration , invasion , and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and c met transcript expression in IECs and fibroblasts was examined by RT PCR and Northern blotting ; protein expression was evaluated by immunoblotting . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have studied the role of hepatocyte growth factor ( HGF ) / Met signaling in the development of sympathetic neuroblasts and neurons . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and Met / HGF receptors in patients with gastric adenocarcinoma . ^^^ In this study hepatocyte growth factor ( HGF ) and Met / HGF receptors were localized in 32 gastric cancer and adjacent normal gastric tissues by the avidin biotin peroxidase complex technique . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We therefore characterized , by Northern blot and / or immunohistochemistry , the relative expression of three effectors involved in the invasion , angiogenesis , and dissemination of tumor cells in esophageal cancer versus nontumoral mucosae : ( a ) stromelysin 3 ( ST 3 ) , a member of the metalloproteinase family ; ( b ) basement membrane 40 / secreted protein acidic and rich in cysteine ( BM 40 / SPARC ) , an extracellular matrix associated protein involved in angiogenesis ; and ( c ) the hepatocyte growth factor receptor MET , which triggers the scattering of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The tyrosine phosphorylation of hepatocyte growth factor receptor ( c MET ) occurred between 2 . 5 and 5 hr after the treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor stimulated renal tubular mitogenesis : effects on expression of c myc , c fos , c met , VEGF and the VHL tumour suppressor and related genes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the urokinase plasminogen activator / urokinase plasminogen activator receptor system and redistribution of E cadherin are associated with hepatocyte growth factor induced motility of pancreas tumor cells overexpressing Met . ^^^ Because hepatocyte growth factor ( HGF ) is a potent mitogen for normal human exocrine pancreas cells ( NPCs ) in vitro , we have analyzed the expression of HGF and its receptor , Met , in NPC and pancreas cancer cells and studied its effects in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor is a tyrosine kinase transmembrane protein encoded by the c met proto oncogene . ^^^ The human hepatocyte growth factor receptor gene : complete structural organization and promoter characterization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor induced expression of ornithine decarboxylase , c met , and c myc is differently affected by protein kinase inhibitors in human hepatoma cells HepG 2 . ^^^ Binding of hepatocyte growth factor ( HGF ) to its receptor Met induces autophosphorylation and activation of the tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present retrospective study , liver cell dysplasia ( LCD ) occurring in cirrhotic livers associated or not associated with hepatocellular carcinoma ( HCC ) was immunohistochemically analyzed for the expression of hepatocyte growth factor receptor ( c met protein ) , Rb ( retinoblastoma gene ) protein , E cadherin , and transforming growth factor beta 1 ( TGF beta 1 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We studied another protein tyrosine kinase receptor , c MET , and its ligand hepatocyte growth factor ( HGF ) , also known as scatter factor ( SF ) , which play a similar role in hematopoiesis . c MET mRNA is expressed in immature human BM HPCs ( CD34+CD33 or CD34+CD38 ) , but not in more mature HPCs ( CD34+CD33+ or CD34+CD38+ ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is normally expressed by mesenchymal cells while its receptor , c Met , is expressed in epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In primary cultured hepatocytes stimulated with hepatocyte growth factor ( HGF ) or epidermal growth factor ( EGF ) , GRB 2 linked HGF receptor or EGF receptor , respectively , to Sos which activated the mitogen activated protein kinase ( MAPK ) cascade . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cooperative interaction between alpha and beta chains of hepatocyte growth factor on c Met receptor confers ligand induced receptor tyrosine phosphorylation and multiple biological responses . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) accelerates renal tubule cell regeneration and induces tubulogenic differentiation via the intracellular tyrosine kinase ( TK ) domain of its receptor , the proto oncogene c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RNA was extracted by standard methods and preparations were probed for protooncogenes , c myc , c fos , and for hepatocyte growth factor , and its receptor , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase receptor Met and its ligand , hepatocyte growth factor ( HGF ) / scatter factor are involved in the etiology and progression of a number of human cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a mesenchymally derived polypeptide cytokine that acts through its tyrosine kinase c met receptor and is an important mediator of these interactions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We previously reported the expression of hepatocyte growth factor ( HGF ) , a ligand for c MET , at the level of mRNA and protein in human prostate tissues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ontogeny of hepatocyte growth factor ( HGF ) and its receptor ( c met ) in human placenta : reduced HGF expression in intrauterine growth restriction . ^^^ Mouse gene knockout studies show that an absence of either hepatocyte growth factor ( HGF ) or its receptor , c met , leads to intrauterine death secondary to severe IUGR with deficient placentation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The aim of this study was to investigate the expression of hepatocyte growth factor ( HGF ) and its receptor ( c met ) during bladder tumorigenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activated rat stellate cells express c met and respond to hepatocyte growth factor to enhance transforming growth factor beta 1 expression and DNA synthesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To understand the interaction between hepatocyte growth factor ( HGF ) and its receptor c Met on various bone and soft tissue tumors , their expressions were investigated by western blot analysis , immunohistochemistry and enzyme immunoassay . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Coexpression of hepatocyte growth factor and c Met proto oncogene product in synovial sarcoma . ^^^ Hepatocyte growth factor acts as a mediator between the mesenchymal and epithelial tissues because HGF is produced by mesenchymal cells and c Met is mainly expressed on various epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the current study , we show that c met is expressed at some level in wild type WB F 344 cells and in all of the spontaneously transformed tumor cell lines , and that 9 / 16 of the tumor cell lines have acquired hepatocyte growth factor ( HGF ) expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The interleukin 6 ( IL 6 ) / gp 80 and hepatocyte growth factor ( HGF ) / met ligand / receptor systems have been shown to stimulate biliary epithelial cell ( BEC ) DNA synthesis in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase PTP S binds to the juxtamembrane region of the hepatocyte growth factor receptor Met . ^^^ We reported previously that a protein tyrosine phosphatase ( PTP ) activity is associated with the immunoprecipitated hepatocyte growth factor ( HGF ) receptor , also known as Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| An alteration in at least one of the genes involved in control of renal differentiation is therefore a likely event in tumorigenesis , and indeed some of the genes involved in renal development , for example , hepatocyte growth factor ( HGF ) and its receptor c met , the transcription factor Wilms ' tumor gene ( WT 1 ) , and transforming growth factor beta family member bone morphogenetic protein ( BMP ) 7 , have also been implicated in various models of tumorigenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Role of hepatocyte growth factor and its receptor c met in multiple myeloma . ^^^ Recently , we reported that a new cytokine , hepatocyte growth factor ( HGF ) , and its receptor c met are related to this disease . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET gene encodes the tyrosine kinase p190MET , the receptor for a molecule known as Scatter Factor ( SF ) or Hepatocyte Growth Factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression and amplification of hepatocyte growth factor ( HGF ) receptor ( Met ) have been detected in many types of human cancers , suggesting a critical role for Met in growth and development of malignant cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of c Met / hepatocyte growth factor receptors in human prostatic adenocarcinoma . ^^^ Hepatocyte growth factor ( HGF ) and c met proto oncogene product ( c Met ) have varied biological functions in different tissues and have been implicated in mitogenic , motogenic and morphogenic responses in both organ regeneration and carcinogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Of interest for a hepatic parasite , the CRD had sequence identity to the receptor binding domain of hepatocyte growth factor ( HGF ) and competed with HGF for binding to the c Met HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of the gene for HGFA together with those for hepatocyte growth factor ( HGF ) and its receptor , c met , was investigated in each tissue element by RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor in human RPE cells : implications in proliferative vitreoretinopathy . ^^^ PURPOSE : To determine whether hepatocyte growth factor ( HGF ) receptor ( HGFR ) is expressed in retinal pigment epithelial ( RPE ) cells and to test whether RPE cells are responsive to HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| After cDNA synthesis , polymerase chain reaction was initiated using specific primers for alternate forms of the following receptors : hepatocyte growth factor ( HGFR ) , keratinocyte growth factor ( KGFR ) , and transforming growth factor beta receptor 2 ( TGFbetaR 2 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : This study searched for the mRNA expression pattern of six tyrosine and serine / threonine kinase receptors [ hepatocyte growth factor ( HGFR ) , fibroblast growth factor ( FGFR ) , epidermal growth factor ( EGFR ) , insulin like growth factor ( IGF ) 1R , transforming growth factor ( TGF ) betaR 1 , TGF betaR 2 ] together with the five somatostatin receptors in human gastroenteropancreatic neuroendocrine tumours ( gastrinomas , insulinomas , tumours with carcinoid syndrome , functionally inactive neuroendocrine tumours ) using reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Another oncogene , c MET ( hepatocyte growth factor receptor ) , was universally expressed in either type of endothelial cells , but other oncogenes , k RAS and c ERBB 2 , were not expressed in either type . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Hepatocyte growth factor ( HGF ) and its c met receptor comprise a signaling system that has been implicated in tissue repair and regeneration . ^^^ Up regulation of hepatocyte growth factor receptor : an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Several lines of evidence show that hepatocyte growth factor ( HGF ) and its receptor MET play a significant role in the progression of various cancers including renal cell carcinoma ( RCC ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the hepatocyte growth factor ( HGF ) receptor tyrosine kinase , Met , induces mitogenesis , motility , invasion , and branching tubulogenesis of epithelial and endothelial cell lines in culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The role of hepatocyte growth factor and its receptor c Met in multiple myeloma and other blood malignancies . ^^^ The cytokine hepatocyte growth factor ( HGF ) and its receptor c Met are a ligand receptor pair with important functions in a communicative interplay between HGF producing , mesenchymal cells and c Met expressing target cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The transforming gene product of the S 13 avian erythroblastosis virus , the env sea protein , is a member of the hepatocyte growth factor receptor family of tyrosine kinases comprising Met , Ron , and Sea . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor and hepatocyte growth factor receptor activity in serum free cultures of human hepatocytes . ^^^ Western blot analyses and co immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , hepatocyte growth factor receptor ( MET ) , urokinase type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT 3 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and epidermal growth factor ( EGF ) are primary mitogens for hepatocytes in culture . hepatocytes express the HGF receptor MET but not HGF itself . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor / scatter factor and its receptor c Met in brain tumors : evidence for a role in progression of astrocytic tumors ( Review ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met protein encoded by MET oncogene is the high affinity receptor for hepatocyte growth factor ( HGF ) / scatter factor ( SF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor ( HGF ) and HGF receptor ( c met ) proteins in liver diseases : an immunohistochemical study . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : The overall goal of this study was to investigate the role of the hepatocyte growth factor ( HGF ) / Met pathway in the pathophysiology of invasive endometrial carcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The RON receptor type tyrosine kinase , a member of the hepatocyte growth factor receptor family , is a receptor for macrophage stimulating protein ( MSP ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor interacts with both heparan and dermatan sulphates , in addition to its specific signalling receptor , Met . ^^^ These findings suggest that hepatocyte growth factor activity is not only critically dependent upon the presence of glycosaminoglycan , but specifically requires an intact proteoglycan structure located in close apposition to cell surface Met . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Amplification and overexpression of the hepatocyte growth factor receptor ( HGFR / MET ) in rat DMBA sarcomas . ^^^ We have previously determined that the loci for the hepatocyte growth factor ( Hgf ) and hepatocyte growth factor receptor ( Hgfr / Met ) , a protooncogene , are situated in this particular chromosome region . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c MET are expressed in rat prepuberal testis . ^^^ The hepatocyte growth factor ( HGF ) receptor ( c MET ) is present in different mammalian tissues and transduces multiple biological effects . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) elicits pleiotropic cellular responses by binding to c met , a PTK transmembrane receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Hepatocyte growth factor ( HGF ) , a ligand for the c Met receptor tyrosine kinase , plays a role as organotrophic factor for regeneration of various organs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| KS cells synthesize and secrete HGF and express the hepatocyte growth factor receptor ( c Met ) , thus providing an autocrine loop for tumor proliferation and neovascularization which can be enhanced by proinflammatory cytokines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Clinical significance of hepatocyte growth factor and c Met expression in extrahepatic biliary tract cancers . ^^^ Hepatocyte growth factor ( HGF ) / c Met expression is known to be correlated with poor prognosis in several cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene c MET encodes the tyrosine kinase receptor for hepatocyte growth factor ( HGF ) , a pleiotropic cytokine controlling growth , survival , motility , invasive migration , and differentiation of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) modulates the growth and movement of diverse cell types upon binding to its receptor , encoded by the proto oncogene c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have tested other mitogenic receptor tyrosine kinases as putative Grb 10 partners and have identified the activated forms of platelet derived growth factor ( PDGF ) receptor beta ( PDGFRbeta ) , hepatocyte growth factor receptor ( Met ) , and fibroblast growth factor receptor as candidates . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , study of the Wilms ' tumor suppressor , WT 1 , is revealing much about the pathogenesis of Wilms ' tumor , urogenital development , and glomerular podocyte biology . c met , the gene encoding the hepatocyte growth factor receptor , has recently been identified as a causative gene for hereditary papillary renal cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The untransformed stable cell line Met murine hepatocytes ( MMH ) , generated from liver explants of transgenic mice expressing a constitutively active truncated form of the human hepatocyte growth factor receptor ( cyto Met ) , represents an innovative tool for in vitro studies of liver function . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and receptor ( c met ) in normal and malignant astrocytic cells . ^^^ BACKGROUND : Hepatocyte growth factor ( HGF ) is a multifunctional peptide that binds to a specific receptor , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The ligand for c MET is hepatocyte growth factor ( HGF ) , also known as scatter factor ( SF ) , which is known to affect proliferation and motility of primarily epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Papillary thyroid cancer ( PTC ) , but neither the follicular nor the anaplastic histotype [ follicular thyroid cancer ( FTC ) , anaplastic thyroid cancer ( ATC ) ] , overexpresses simultaneously the protooncogene HGF ( hepatocyte growth factor ) and its receptor HGF R ( or c met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also confirmed the presence of Flt 1 , KDR / FIk 1 , and their ligand vascular endothelial growth factor , c Met and its ligand hepatocyte growth factor ( HGF ) , and Tie 1 , Tie 2 / Tek by immunohistochemistry and RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met proto oncogene encodes a transmembrane tyrosine kinase receptor ( Met ) that has the capacity to regulate cell proliferation and differentation and it is activated by hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reversion of human glioblastoma malignancy by U 1 small nuclear RNA / ribozyme targeting of scatter factor / hepatocyte growth factor and c met expression . ^^^ BACKGROUND : Expression of scatter factor ( SF ) , also known as hepatocyte growth factor ( HGF ) , and its receptor , c met , is often associated with malignant progression of human tumors , including gliomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have investigated the role of hepatocyte growth factor ( HGF ) , the high affinity ligand for Met , in mutant Met mediated cell transformation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recently , much attention has been focused upon the role of hepatocyte growth factor ( HGF ) and its receptor c met in the induction of tubulogenesis by epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interferon gamma upregulates the c Met / hepatocyte growth factor receptor expression in alveolar epithelial cells . ^^^ Hepatocyte growth factor ( HGF ) is a potent mitogen for alveolar epithelial cells and has been reported to be capable of repressing the fibrosing process by connecting to the c Met / HGF receptor on alveolar epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interaction of the hepatocyte growth factor ( HGF ) with its receptor , the Met tyrosine kinase , results in invasive growth , a genetic program essential to embryonic development and implicated in tumor metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| No significant change of hepatocyte growth factor ( HGF ) mRNA level was detected , contrasting with the decrease both at mRNA and protein levels in the expression of the c Met / HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met receptor is a p190MET tyrosine kinase proto oncoprotein that through its binding to its ligand , designated hepatocyte growth factor ( HGF ) , induces mitogenic , motogenic , and morphogenic activities in a variety of cell types . ^^^ Incubation of human sperm with hepatocyte growth factor ( HGF ) or MAb 2 to c met receptor enhanced the degree of tyrosine phosphorylation / autophosphorylation of the c met receptor up to 5 . 1 fold . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor ( HGF ) and its tyrosine kinase receptor , c Met , is positively correlated with breast carcinoma progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the hepatocyte growth factor receptor tyrosine kinase , Met , induces the inherent morphogenic program of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Using rat GEC in culture , we demonstrated that sublytic C5b 9 induced tyrosine phosphorylation of the epidermal growth factor receptor ( EGF R ) , Neu , fibroblast growth factor receptor 2 , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : Five normal and 14 osteoarthritic human cartilage samples graded histomorphologically by Mankin Score , were studied by radioactive in situ hybridization and immunohistochemistry for the expression of Hepatocyte growth factor and the c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a cytokine that is produced in the placental villous core and acts in a paracrine manner on trophoblasts that express the HGF receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both E cadherin , a cell cell adhesion molecule , and c Met , the hepatocyte growth factor ( HGF ) / scatter factor ( SF ) receptor , were colocalized at cell cell adhesion sites of MDCK cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Sequential changes of hepatocyte growth factor in the serum and enhanced c Met expression in the myocardium in acute myocardial infarction . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To further elucidate the physiologic role of PSM we have identified additional mitogenic receptor tyrosine kinases as putative PSM partners including platelet derived growth factor ( PDGF ) receptor ( PDGFR ) beta , hepatocyte growth factor receptor ( Met ) , and fibroblast growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF ) activates migration and proliferation of endothelial cells and is angiogenic , acting through the tyrosine kinase receptor encoded by the Met protooncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here we have investigated the expression status and functional integrity of the Met tyrosine kinase receptor and of its ligand hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor ( HGF ) / scatter factor and its receptor c MET correlates with poor prognosis in synovial sarcoma . ^^^ The hepatocyte growth factor ( HGF ) / c MET signaling system plays an important role in the carcinogenesis of various organs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : An RT PCR plus Southern blot assay was used to detect mRNA of tumor markers in blood and tissues . mRNA expression of the tumor progression markers MET ( hepatocyte growth factor receptor gene c met ) , GalNAc T ( beta 1 , 4 N acetyl galactosaminyl transferase ) , and beta hCG ( beta human chorionic gonadotropin ) was evaluated in 9 pancreatic carcinoma cell lines , 13 tumor biopsy specimens , 5 nonmalignant pancreatic tissue specimens , and blood from 33 pancreatic carcinoma patients and 32 healthy donors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the hepatocyte growth factor ( HGF ) receptor ( Met ) and presence of a truncated and activated intracellular HGF receptor fragment in locally aggressive / malignant human musculoskeletal tumors . ^^^ Enhanced hepatocyte growth factor ( HGF ) receptor ( Met ) signaling has been suggested to play an important role in the development and progression of various epithelial and nonepithelial tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Transcriptional activation of the hepatocyte growth factor receptor ( c met ) gene by its ligand ( hepatocyte growth factor ) is mediated through AP 1 . ^^^ Hepatocyte Growth Factor ( HGF ) exerts its biological effects via binding and activating a transmembrane protein tyrosine kinase receptor known as c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We showed previously that the addition of exogenous hepatocyte growth factor ( HGF ) and the presence of fibronectin fibrils stimulate anchorage independent colony growth of a murine mammary carcinoma , SP 1 , which expresses both HGF and HGF receptor ( Met ; R . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In rat liver epithelial cells constitutively expressing transforming growth factor alpha ( TGFalpha ) , c Met is constitutively phosphorylated in the absence of its ligand , hepatocyte growth factor . ^^^ We conclude that c Met associates with EGFR in tumor cells , and this association facilitates the phosphorylation of c Met in the absence of hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is implicated in placental development ; hgfr and hgf null mutant embryos develop placental insufficiency and lethality at 11 . 5 days ( E11 . 5 ) after fertilization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As a step to investigate mechanisms underlying subsequent intestinal repair , we have examined the expression profiles of hepatocyte growth factor ( HGF ) and its receptor c met , two molecules previously implicated in tissue repair , in comparison to the histopathological and proliferative changes in a rat model of methotrexate induced small intestinal mucositis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To clarify the pathogenesis and histogenesis of PEL by investigating ( 1 ) the lymphoma karyotype ; ( 2 ) the expression status of the Met tyrosine kinase receptor and of its ligand hepatocyte growth factor ( HGF ) ; ( 3 ) the molecular profile of EBV , with particular focus on mutations of EBNA 1 genes , which are thought to affect viral tumorigenicity in EBV infected neoplasms displaying the latency 1 phenotype . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor signal coupling to various transcription factors depends on triggering of Met receptor and protein kinase transducers in human hepatoma cells HepG 2 . ^^^ Hepatocyte growth factor ( HGF ) regulates a wide variety of biological activities by binding to the tyrosine kinase receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of tyrosine kinases often leads to malignant transformation . c met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Differential expression of hepatocyte growth factor and its receptor ( c Met ) in a rat artificial anus model . ^^^ It is mainly synthesized in mesenchymal cells and acts on epithelial cells , where its actions are dependent on binding to a specific cell surface hepatocyte growth factor receptor ( c Met ) . ^^^ In the present study , we examined the localization of hepatocyte growth factor and c Met during the process of repair in a rat artificial anus model , and attempted to clarify the cell types that express hepatocyte growth factor or c Met messenger RNA by in situ hybridization . ^^^ Throughout the repair process , hepatocyte growth factor and c Met immunoreactivities were more prominently localized in the squamous cells of the skin than in colonic ductal cells . ^^^ Competitive reverse transcription polymerase chain reaction analysis revealed that hepatocyte growth factor mRNA was maximal on day 14 after the operation ; however , c Met mRNA expression had two peaks , on day 1 and day 7 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Growth of this cell line was significantly accelerated by hepatocyte growth factor ( HGF ) and expression of its receptor c met was confirmed by the reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A sensitive quantification method for evaluating the level of hepatocyte growth factor and c met / HGF receptor mRNAs in the nervous system using competitive RT PCR . ^^^ Using synthetic RNA competitors , we developed a competitive RT PCR to evaluate the absolute amount of hepatocyte growth factor ( HGF ) and c met / HGF receptor mRNAs in neural tissues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , the ligand for the Met receptor tyrosine kinase , is a potent modulator of epithelial mesenchymal transition and dispersal of epithelial cells , processes that play crucial roles in tumor development , invasion , and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor c met in the ovine uterus . ^^^ The objective of this study was to determine if hepatocyte growth factor ( HGF , scatter factor ) and its receptor c met were present in the ovine uterus and to characterize their temporal and spatial expression during the estrous cycle and pregnancy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Modulation of estrogen production and 17beta hydroxysteroid dehydrogenase type 1 , cytochrome P 450 aromatase , c met , and protein kinase Balpha messenger ribonucleic acid content in rat ovarian granulosa cells by hepatocyte growth factor and follicle stimulating hormone . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Hepatocyte growth factor ( HGF ) , also called scatter factor , stimulates growth and motility in nonocular endothelial cells and smooth muscle cells through its receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| No alteration in the levels of hepatocyte growth factor ( HGF ) or its receptor c MET was recognized between parental lines and their resistant variants . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Osteopontin induced , integrin dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor ( Met ) . ^^^ Hepatocyte growth factor ( HGF ) induces cell migration of several mammary epithelial cell ( MEC ) lines , via activation of its cognate receptor ( Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of Met / hepatocyte growth factor receptor gene in giant cell tumors of bone and other benign musculoskeletal tumors . ^^^ Overexpression of the hepatocyte growth factor receptor ( Met / HGF receptor ) , a transmembrane tyrosine kinase encoded by the MET proto oncogene , is involved in transformation and invasive behavior of human carcinomas and sarcomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The MET and KDR genes encode the tyrosine kinase receptors for Hepatocyte Growth Factor ( HGF ) and Vascular Endothelial Growth Factor ( VEGF ) respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of MET , the receptor for hepatocyte growth factor ( HGF ) , has been associated with androgen insensitive prostate cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Hepatocyte growth factor ( HGF ) stimulates proliferation , migration and morphogenesis of epithelial cells by specific binding to its receptor c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| At the molecular level , hepatocyte growth factor ( HGF ; produced by mesenchyme ) and its c met tyrosine kinase receptor ( expressed on epithelial cells ) participate in this paracrine dialogue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) elicits pleiotropic effects on various types of cells through the c Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These factors include hepatocyte growth factor ( HGF ) and its receptor c MET , and urokinase plasminogen activator ( uPA ) and its receptor uPAR , basic fibroblast growth factor ( bFGF ) , TGF alpha and TGF beta 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PA and c MET mRNA expression is co ordinately enhanced while hepatocyte growth factor mRNA is down regulated in human hepatocellular carcinoma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor met autocrine loop enhances tumorigenicity in a human lung adenocarcinoma cell line . ^^^ Hepatocyte growth factor ( HGF ) is a multifunctional cytokine with effects on the proliferation , motility , and differentiation of cells that express its receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Effects of hepatocyte growth factor anti sense oligodeoxynucleotides or met D / D genotype on mouse molar crown morphogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Uterine hepatocyte growth factor ( HGF ) , the ligand for c met , and FGFR2IIIb mRNA expression was substantially lower in NOR ewes , but expression of FGF 7 and FGF 10 mRNAs , ligands for FGFR2IIIb , was unaffected . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c met in ulcerative colitis . ^^^ OBJECTIVE AND DESIGN : This study was designed to determine if the hepatocyte growth factor ( HGF ) Met system is involved in the repair process of inflamed mucosa of ulcerative colitis ( UC ) and in the development of UC associated colorectal cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We further demonstrated that matriptase can convert hepatocyte growth factor / scattering factor to its active form , which can induce scatter of Madin Darby canine kidney epithelial cells and can activate c Met tyrosine phosphorylation in A 549 human lung carcinoma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor triggers a complex biological program leading to invasive cell growth by activating the c Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , c Met , are known to induce mitosis and cell movement and to promote tumor progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Impaired response to hepatocyte growth factor in FRTL 5 rat thyroid cells expressing a functional hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The interaction of hepatocyte growth factor ( HGF ) with c Met has been implicated in morphogenesis of the kidney , lung , mammary gland , liver , placenta , and limb bud . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met , the hepatocyte growth factor ( HGF ) receptor , promotes a morphogenic program in epithelial cell lines in matrix cultures . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present work , we investigated the localisation of the hepatocyte growth factor ( HGF ) receptor ( c Met ) during wound repair and evaluated the effect of recombinant HGF ( rHGF ) on cell migration by using an in vitro model of airway epithelial wound repair . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PROBLEM : Hepatocyte growth factor ( HGF ) exists abundantly in seminal plasma and its receptor , c met , is expressed on spermatozoa . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Treatment of mammalian cells with InlB protein or infection with L . monocytogenes induces rapid tyrosine phosphorylation of Met , a receptor tyrosine kinase ( RTK ) for which the only known ligand is Hepatocyte Growth Factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This study demonstrates a significant concentration dependent stimulatory effect of LDL on hepatocyte growth factor ( HGF ) synthesis ( maximum release : 423 + / 16 % of control ) and HGF receptor mRNA expression in cultured human coronary artery endothelial cells ( HCAEC ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined the ultrastructure of and c met ( hepatocyte growth factor receptor ) expression in dysplastic epithelial cells from this case to evaluate the efficacy of MMC treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor function and c Met expression in human lens epithelial cells . ^^^ PURPOSE : Hepatocyte growth factor ( HGF ) and its receptor c met perform a multitude of functions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Bone marrow ( BM ) cells originally include alpha fetoprotein ( AFP ) and c Met [ a receptor for hepatocyte growth factor ( HGF ) ] expressing cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It induced protein tyrosine phosphor ylation of hepatocyte growth factor ( HGF ) receptor ( c Met ) or epidermal growth factor receptor ( EGFR ) , which increased progressively to a maximum level at 30 min in Panc 1 cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor ( EGFR ) and the hepatocyte growth factor receptor ( c Met ) are two such receptor tyrosine kinases ( RTKs ) that have been causally implicated in colorectal carcinoma ( CRC ) progression and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Aberrant expression of hepatocyte growth factor and its receptor , c Met , during sex hormone induced prostatic carcinogenesis in the Noble rat . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a ligand of the receptor tyrosine kinase encoded by the c Met protooncogene . ^^^ Anti apoptotic signaling by hepatocyte growth factor / Met via the phosphatidylinositol 3 kinase / Akt and mitogen activated protein kinase pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We show that CB 3717 / folate induces the expression of the hepatocyte growth factor ( HGF ) / c Met signalling system in injured kidneys in which a significant , but transient , elevation of the HGF mRNA level occurs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , each SN was cut into multiple sections for cytokeratin immunohistochemical ( CK IHC ) staining and for RT PCR and electrochemiluminescent detection of three markers : beta chain human chorionic gonadotropin , hepatocyte growth factor receptor , and universal melanoma associated antigen . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor in acute tubular necrosis . ^^^ In acute tubular necrosis , there are early transient increases in circulating and local bioactive hepatocyte growth factor ( HGF ) levels and renal HGF receptor ( c MET ) gene expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As a model system , we have investigated the metalloproteinase mediated cleavage of the hepatocyte growth factor receptor , Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Proto oncogene MYC , mapped to chromosomal band 8q24 and the genes for hepatocyte growth factor ( HGF at 7q21 ) and its receptor , MET , at chromosomal band 7q31 , have an important role in the biology and growth of normal and neoplastic liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : VK 3 induced phosphorylation of hepatocyte growth factor receptor ( c met ) , epidermal growth factor receptor ( EGFR ) , or external signal regulated kinase ( ERK ) , which increased progressively to a maximum level at 30 minutes , in a dose dependent manner and occurred at growth inhibitory concentrations . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have previously shown coexpression of hepatocyte growth factor ( HGF ) and its receptor Met in the invasive tumor front of human breast carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression and functional role of hepatocyte growth factor receptor ( C MET ) during postnatal rat testis development . ^^^ The met protooncogene encodes the hepatocyte growth factor receptor ( HGFR , c met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a pleiotropic factor that is mainly produced by mesenchymal cells and acts on cells of epithelial origin which express the HGF receptor c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met protein and hepatocyte growth factor ( HGF ) in papillary carcinoma of the thyroid : evidence for a pathogenetic role in tumourigenesis . ^^^ Met protein positive papillary carcinoma cells may produce hepatocyte growth factor ( HGF ) and may activate HGF through the urokinase type plasminogen activator ( uPA ) bound to urokinase type plasminogen activator receptor ( uPA R ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met protein is a tyrosine kinase receptor for hepatocyte growth factor ( HGF ) . c Met has morphogenic , mitogenic , and motogenic properties and is overexpressed in many solid tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its specific receptor , MET , are expressed in the developing and adult mammalian brain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met and its ligand hepatocyte growth factor scatter factor ( HGF / SF ) , which mediate mitogenicity , tumorigenicity , and angiogenesis , were used as a model . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Trans resveratrol did not decrease the level of the hepatocyte growth factor receptor c met and did not impede the hepatocyte growth factor induced increase in c met precursor synthesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF / SF ) receptor , Met , regulates mitogenesis , motility , and morphogenesis in a cell type dependent fashion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Dissociation of heparan sulfate and receptor binding domains of hepatocyte growth factor reveals that heparan sulfate c met interaction facilitates signaling . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The expression of transforming growth factor beta 1 ( TGF beta 1 ) , TGF beta receptor type 2 , hepatocyte growth factor alpha ( HGF alpha ) , c met , p 53 , and N CAM was higher in the areas of MPNST than in the neurofibromatous areas in four , five , five , eight , five , and three of the eight cases , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined the role of the hepatocyte growth factor ( HGF ) / c met system on invasion and metastasis of oral squamous cell carcinoma ( SCC ) cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) protects c met expressing Burkitt ' s lymphoma cell lines from apoptotic death induced by DNA damaging agents . ^^^ In this paper , we show that pretreatment of Burkitt ' s lymphoma cell lines expressing the c met protooncogene with hepatocyte growth factor ( HGF ) protects them from death induced by DNA damaging agents commonly used in tumour therapy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to investigate the expression of hepatocyte growth factor ( HGF ) and its c Met receptor under such experimental conditions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for hepatocyte growth factor ( Met ) is not expressed in the normal thyroid but it is overexpressed in most thyroid carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Invasiveness of hepatocellular carcinoma cell lines : contribution of hepatocyte growth factor , c met , and transcription factor Ets 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both adult and cord blood monocytes constitutively express hepatocyte growth factor ( HGF ) receptor , MET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor / scatter factor , its activator , inhibitors and the c Met receptor in human cancer cells . ^^^ The present study examined the expression of HGF / SF , HGFA , the two inhibitors to HGFA action known as hepatocyte growth factor activator inhibitors type 1 and 2 ( HAI 1 and HAI 2 ) , and the HGF / SF receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ligand regulated binding of FAP 68 to the hepatocyte growth factor receptor . ^^^ We have used the yeast two hybrid system to identify proteins that interact with the intracellular portion of the hepatocyte growth factor ( HGF ) receptor ( Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We found that in SV 40 positive malignant mesothelioma cells , the hepatocyte growth factor ( HGF ) receptor ( Met ) was activated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Other components such as osteoprotegerin ( OPG ) and possibly the ligand receptor pair hepatocyte growth factor ( HGF ) and c met may counteract this destruction , we have measured the levels of OPG , and HGF c met , in serum , synovial fluid ( SF ) , and cartilage from patients with rheumatoid arthritis ( RA ) and other arthritides . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Amyotrophic lateral sclerosis : evidence for intact hepatocyte growth factor / met signalling axis . ^^^ Hepatocyte growth factor ( HGF ) is a secreted cytokine which is expressed in the central nervous system ( CNS ) together with its specific receptor MET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It is well known that binding of hepatocyte growth factor ( HGF ) to its receptor ( c Met ) regulates gastric cancer progression and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Focal enhancement of expression of c Met / hepatocyte growth factor receptor in the myocardium in human myocardial infarction . ^^^ To determine the distribution and expression level of hepatocyte growth factor ( HGF ) specific receptor , c Met , in human myocardial infarction . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The genes Cdk 6 ( cyclin dependent kinase 6 ) and Met ( hepatocyte growth factor receptor ) were located in the core of each amplified region and were amplified most recurrently and at the highest levels among the genes tested . ^^^ In the sixth tumor , which carried amplified sequences of Met but not of Cdk 6 , coexpression of Met and the normally silent hepatocyte growth factor gene ( Hgf ; the ligand of Met ) was observed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increases in vascular endothelial growth factor ( VEGF ) receptors Flt 1 and Flk 1 / KDR , angiopoietin receptors Tie 1 , Tie 2 , and platelet derived growth factor receptor beta ( PDGF Rbeta ) , modest increases in epidermal growth factor receptor ( EGF R ) , and no increase in hepatocyte growth factor receptor ( c Met ) or fibroblast growth factor receptors ( FGF R ) were observed in isolated membranes during EC proliferation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| InlB is a Listeria monocytogenes protein promoting entry in non phagocytic cells , and has been shown recently to activate the hepatocyte growth factor receptor ( HGFR or Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined the expression of hepatocyte growth factor ( HGF ) mRNA and its receptor , c met mRNA , in the dorsal root ganglia ( DRG ) and spinal cord of naive adult rats using in situ hybridization histochemistry ( ISHH ) and the reverse transcription polymerase chain reaction ( RT PCR ) technique . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| C met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma . ^^^ The membranous tyrosine kinase receptor c met and its natural ligand hepatocyte growth factor are prominent mitogens , motogens and morphogens for hepatocytes and many other cell types in vitro as well as in vivo . ^^^ To clarify the significance of the c met / hepatocyte growth factor system in the development and spread of combined hepatocellular and cholangiocarcinoma , surgical specimen from 30 patients , consisting of 4 double cancers , 20 combined types and 6 mixed types , were examined immunohistochemically . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of both hepatocyte growth factor ( HGF ) and its tyrosine kinase receptor met has been demonstrated in normal tissues and their neoplastic counterparts , implicating these factors in normal development and tumour progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Role of the hepatocyte growth factor receptor , c Met , in oncogenesis and potential for therapeutic inhibition . ^^^ Stimulation of c Met via its ligand hepatocyte growth factor also known as scatter factor ( HGF / SF ) , leads to a plethora of biological and biochemical effects in the cell . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its specific c met receptor constitute a paired signaling system that plays an important role in renal development and in the maintenance of normal adult kidney structure and functions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increase in hepatocyte growth factor receptor tyrosine kinase activity in renal carcinoma cells is associated with increased motility partly through phosphoinositide 3 kinase activation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor ( c met ) . ^^^ Hepatocyte growth factor ( scatter factor ) is an angiogenic growth factor that binds to its cellular transmembrane receptor , c met . ^^^ The shedding of c met may represent a novel mechanism for regulating the mitogenic , motogenic , and morphogenic effects of hepatocyte growth factor . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Epitope of somatic mutations in the hepatocyte growth factor receptor naturally processed and presented by HLA A 2 on human hepatocellular carcinoma ] . ^^^ The most promising candidate for T cell epitope was nonamers peptide ( SLIVHLNEV ) , derived from met / hepatocyte growth factor receptor , point mutation was 1180F to L . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , Met , regulate a number of biological functions in epithelial and nonepithelial cells , such as survival , motility , proliferation , and tubular morphogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These include loss of heterozygosity ( LOH ) at the chromosomal region 11p15 . 5 , LOH on chromosome arms 1p and 1q , activating mutations in exon 3 of the beta catenin gene , as well as overexpression of the c met oncogene , which encodes the hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study of gastric cancer , we evaluated whether IGF 2 ( insulin like growth factor 2 ) , c MET ( hepatocyte growth factor receptor ) , MMP 7 ( matrix metalloproteinase 7 ) and MUC 1 , which are associated with nodal metastasis from primary tumor , are concerned with metastasis from nodal metastatic lesion to other nodes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although the upregulation / amplification of the hepatocyte growth factor ( HGF ) receptor , c met , has been frequently observed in colon cancer metastasis , the actual functional significance of the feature in the liver metastatization is not yet known . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cell surface proteoglycan syndecan 1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Temporal and spatial occurrence of hepatocyte growth factor ( HGF ) and its cognate receptor c Met in the mouse mandibular development was investigated by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c Met inhibition by hepatic cell hypoxia : a potential mechanism for liver regeneration failure in experimental cirrhosis . ^^^ Hepatocyte growth factor ( HGF ) and c Met expressions were determined by reverse transcriptase polymerase chain reaction , Northern blot , and Western blot . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Modulation of the c Met / hepatocyte growth factor pathway in small cell lung cancer . ^^^ The c Met receptor tyrosine kinase and its ligand HGF ( hepatocyte growth factor ) have been shown to be involved in angiogenesis , cellular motility , growth , invasion , and differentiation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c Met tyrosine kinase receptor and its ligand , Hepatocyte Growth Factor / Scatter Factor , have been implicated in human cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Selective cyclooxygenase 2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration triggered c Met / hepatocyte growth factor receptor induction and extracellular signal regulated kinase 2 activation . ^^^ Esophageal ulceration triggered increases in : esophageal epithelial cell proliferation ; expression of COX 2 ( but not COX 1 ) ; hepatocyte growth factor ( HGF ) and its receptor , c Met ; and activation of extracellular signal regulated kinase 2 ( ERK 2 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Given that high titers of hepatocyte growth factor , the specific ligand for Met , are excreted in the urine and tend to reflect disease activity of bladder cancer , we performed this study to examine the clinical significance of Met in human bladder cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor promotes hepatocarcinogenesis through c Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , Met , play a crucial role in regulating adult skeletal myoblast proliferation and differentiation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / Scatter Factor ( HGF / SF ) mediated stimulation of the Met receptor tyrosine kinase results in pleiotropic cellular effects including proliferation , morphogenesis , motility and invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both tumor susceptibility gene 101 ( TSG 101 ) / human VPS ( hVPS ) 28 and hepatocyte growth factor receptor substrate ( Hrs ) cytosolic complexes bind ubiquitin agarose . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor induces Wnt independent nuclear translocation of beta catenin after Met beta catenin dissociation in hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We , and others , have recently shown that high levels of expression of hepatocyte growth factor ( HGF ) and its receptor Met are associated with invasive human breast cancer and may be causally linked to metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Signaling domains derived from receptors for interleukin 6 ( gp 130 ) , hepatocyte growth factor ( c met ) , epithelial growth factor ( EGF R ) , and thrombopoietin ( mpl ) triggered monkey hepatocytes to enter the cell cycle . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We demonstrate localization of hepatocyte growth factor ( HGF ) receptor c MET in intermediate cells in both normal and malignant prostate epithelium . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to show that hepatocyte growth factor ( HGF ) and HGF receptor ( c met protein ) play an important role in the cancer growth and infiltration in scirrhous gastric cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increase in the beta chain of hepatocyte growth factor ( HGF beta ) precedes c met expression after bleomycin induced lung injury in the rat . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Establishment of a new human synovial sarcoma cell line , FU SY 1 , that expresses c Met receptor and its ligand hepatocyte growth factor . ^^^ FU SY 1 cells in vitro were rather small , exhibited a spindle or polygonal shape without conspicuous pleomorphism , and expressed c Met and hepatocyte growth factor ( HGF ) as determined by immunocytochemistry . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study , reverse transcription / polymerase chain reaction was used to screen human pulp for the mRNAs encoding receptors for androgen ( AR ) , estrogens ( ERbeta ) , and hepatocyte growth factor ( HGF : c Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Localization and functional role of hepatocyte growth factor ( HGF ) and its receptor c met in the rat developing cerebral cortex . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here we report on the expression of the receptor tyrosine kinase c met in DC . c Met is the high affinity receptor for scatter factor ( SF ) / hepatocyte growth factor , and ligand activated c met exhibits mitogenic , morphogenic andmotogenic activity in vivo and in vitro . c Met is signaling competent in DC since it is effectively tyrosine phosphorylated in response to SF ligand . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although the presence of hepatocyte growth factor and its c MET receptor have been reported in male mammalian reproductive tracts , our novel findings on the secretion of HGFA precursor from turkeys may help to elucidate the regulation of activated hepatocyte growth factor . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the Met receptor tyrosine kinase through its ligand , hepatocyte growth factor , stimulates cell spreading , cell dispersal , and the inherent morphogenic program of various epithelial cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MET is a receptor protein tyrosine kinase ( RPTK ) for hepatocyte growth factor ( HGF ) , which is a multifunctional cytokine controlling cell growth , morphogenesis , and motility . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction was performed on each sample with primers for rat epidermal growth factor , epidermal growth factor receptor ( ErbB ) , heparin binding epidermal like growth factor , hepatocyte growth factor , hepatocyte growth factor receptor , keratinocyte growth factor , betacellulin , amphiregulin , and neuregulin alpha . ^^^ Keratinocyte growth factor and hepatocyte growth factor receptor demonstrated polymerase chain reaction products at all time points tested . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It triggers bacterial entry by interacting with the hepatocyte growth factor receptor ( HGF R or Met ) and two other cellular components : gC1q R and proteoglycans . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoexpression of the hepatocyte growth factor ( HGF ) , HGF receptor ( c met ) and STAT 3 on placental tissues from malformed fetuses . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor c Met are expressed in inappropriately high abundance in gliomas and are further upregulated during the transition from low to high grade malignancy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We found that in cells expressing the endogenous proteins , Plexin B 1 ( the Sema 4D Receptor ) and Met ( the Scatter Factor 1 / Hepatocyte Growth Factor Receptor ) associate in a complex . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor Met are frequently over expressed in non small cell lung carcinomas ( NSCLC ) , but their potential role in tumor progression is not clearly known . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor ( c met ) in skin fibroblasts from patients with systemic sclerosis . ^^^ OBJECTIVE : To determine the effect of excessive induction of hepatocyte growth factor ( HGF ) / c met signaling in fibroblasts derived from patients with systemic sclerosis ( SSc ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) is a pleiotropic cytokine whose action is mediated by c met , a glycoproteic receptor with tyrosine kinase activity which transduces its multiple biological activities including cell proliferation , motility and differentiation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , the ligand for the receptor tyrosine kinase c Met , is composed of an alpha chain containing four Kringle domains ( K 1 K4 ) and a serine protease domain like beta chain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increased tyrosine phosphorylation among a number of proteins was detected in MSV MDCK INV cells relative to untransformed and MSV transformed MDCK cells , especially for the hepatocyte growth factor receptor ( HGF R ) , otherwise known as c met proto oncogene . ^^^ Autocrine activation of the hepatocyte growth factor receptor / met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present study , we found that hepatocyte growth factor ( HGF ) receptor ( c Met ) and alpha fetoprotein expressing cells were present in adult rat bone marrow . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , c Met , have been reported to be related to the proliferation of carcinoma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development . ^^^ Hepatocyte growth factor ( HGF ) and Met are involved in mediating these responses in other tissues and are coexpressed in the cerebellum . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Angiostatin has structural similarities to hepatocyte growth factor ( HGF ; `` scatter factor ' ' ) , a promoter of angiogenesis , that induces proliferation and migration of both endothelial and smooth muscle cells via its cell surface receptor , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The PKHD 1 gene products are members of a novel class of proteins that share structural features with hepatocyte growth factor receptor and plexins and that belong to a superfamily of proteins involved in regulation of cell proliferation and of cellular adhesion and repulsion . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Primary tumors were analyzed for p 53 expression using IHC staining and for beta human chorionic gonadotropin ( beta hCG ) , hepatocyte growth factor receptor ( c Met ) , and universal melanoma antigen ( uMAGE ) messenger RNA expression using reverse transcriptase polymerase chain reaction and electrochemiluminescence . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We investigated the expression pattern and underlying mechanism that controls hepatocyte growth factor ( HGF ) receptor ( c met ) expression in normal kidney and a variety of kidney cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein tyrosine phosphatase DEP 1 . ^^^ We have shown that the substrate trapping mutant form of DEP 1 interacted with a small subset of tyrosine phosphorylated proteins from lysates of the human breast tumor cell lines MDA MB 231 , T 47D , and T 47D / Met and have identified the hepatocyte growth factor / scatter factor receptor Met , the adapter protein Gab 1 , and the junctional component p 120 catenin as potential substrates . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) signaling via its receptor , the proto oncogene Met , alters cell proliferation and motility and has been associated with tumor metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of extracellular signal regulated kinase ( ERK ) and hepatocyte growth factor receptor ( HGFR or c met ) was determined by immunoprecipitation and western blot analysis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoexpression of hepatocyte growth factor and c Met receptor in the eutopic endometrium predicts the activity of ectopic endometrium . ^^^ MAIN OUTCOME MEASURE ( S ) : The immunoreactions of hepatocyte growth factor ( HGF ) , its receptor , c Met , vascular endothelial growth factor ( VEGF ) , proliferating cell nuclear antigen ( PCNA ) , and von Willebrand factor ( VWF ) in eutopic and ectopic endometrium were examined , and their relation with different revised American Society for Reproductive Medicine ( r ASRM ) stages and the morphology of endometriosis was evaluated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To determine whether these factors contribute to the distinct etiologies of fibrolamellar hepatocellular carcinoma and traditional hepatocellular carcinoma , we assayed hepatocyte growth factor , the hepatocyte growth factor receptor , and two hepatocyte growth factor activators , hepatocyte growth factor activator and urokinase type plasminogen activator , in hepatocellular carcinoma , fibrolamellar hepatocellular carcinoma , cirrhotic liver and normal liver . ^^^ Antibodies against urokinase type plasminogen activator , urokinase type plasminogen activator receptor , hepatocyte growth factor and hepatocyte growth factor receptor were used to analyze immunoperoxidase stained slides from the paraffin blocks . ^^^ Western blot analyses using antibodies against hepatocyte growth factor , hepatocyte growth factor receptor , phosphotyrosine , hepatocyte growth factor activator , urokinase type plasminogen activator receptor , urokinase type plasminogen activator , plasminogen activator inhibitor 1 , fibrinogen and plasmin were performed on membrane enriched fractions from the frozen tissue , as was collagen zymography for matrix metalloproteinase 2 and matrix metalloproteinase 9 . ^^^ Furthermore , 8 / 9 fibrolamellar hepatocellular carcinomas demonstrated hepatocyte growth factor receptor levels similar to normal , whereas 8 / 9 hepatocellular carcinomas and 11 / 12 cirrhotic livers exhibited either an increase or decrease . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor receptor , matrix metalloproteinase 11 , tissue inhibitor of metalloproteinase 1 , and fibronectin are up regulated in papillary thyroid carcinoma : a cDNA and tissue microarray study . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the c Met proto oncogene and its possible involvement in liver invasion in adult T cell leukemia . c Met is a tyrosine kinase receptor for hepatocyte growth factor and suggested to be involved in oncogenesis ormetastatic phenotypes in many malignancies . ^^^ The expressed c Met should be functional , because hepatocyte growth factor could induce the autophosphorylation of c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and c Met in cervical intraepithelial neoplasia : overexpression of proteins associated with oncogenic human papillomavirus and human immunodeficiency virus . ^^^ Hepatocyte growth factor ( HGF ) and its receptor , c Met , promote cell proliferation and are involved in tumor progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To elucidate biologic functions of hepatocyte growth factor and the c Met receptor in cutaneous wound healing , we analyzed expression and localization of hepatocyte growth factor and c Met receptor and used a strategy to neutralize endogenous hepatocyte growth factor in a cutaneous wound healing model in mice . ^^^ Following excision of full thickness skin on the dorsum of mice , expression of both hepatocyte growth factor and the c Met receptor increased transiently in cutaneous tissues . ^^^ Expressions of hepatocyte growth factor increased as early as 2 d postwounding and reached a peak on day 2 , whereas the c Met receptor expression reached a peak 2 4 d postwounding . ^^^ Immunolocalization of the c Met receptor indicated that c Met receptor expression was upregulated in keratinocytes , vascular endothelial cells , and myofibroblasts in granulation tissue , hence these are potential target cells of hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Western blotting revealed that acidic and basic fibroblast growth factor ( FGF ) enhanced and hepatocyte growth factor ( HGF ) reduced c Met expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) receptor , the product of the c met protooncogene , is transcriptionally regulated by a wide variety of cytokines as well as extracellular environmental cues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By immunohistochemical staining of tumor cells from 26 patients , VEGFR 1 was detected in 24 ( 92 % ) , VEGFR 2 in five ( 19 % ) , Tie 2 in 14 ( 54 % ) , and c Met , a specific receptor of hepatocyte growth factor ( HGF ) in 23 patients ( 88 % ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a stromal derived cytokine that plays a crucial role in invasion and metastasis of tumor cells through the interaction with HGF receptor , c Met , which is frequently overexpressed in pancreatic cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a mesenchyme derived pleiotropic growth factor and a powerful stimulator of angiogenesis , which acts on cells by binding to the c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a ligand of c Met receptor , stimulates activation of cellular kinases via phosphatidylinositol 3 kinase ( PI 3 kinase ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We previously showed that OPN induced cell migration of mammary epithelial cells ( MEC ) depends on binding to cell surface integrins and involves activation of the hepatocyte growth factor ( HGF ) receptor , Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that c Met is abundantly expressed in the NCI H 69 SCLC cell line and now have determined the downstream effects of stimulating c Met via its ligand hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tissue microarray analysis of hepatocyte growth factor / Met pathway components reveals a role for Met , matriptase , and hepatocyte growth factor activator inhibitor 1 in the progression of node negative breast cancer . ^^^ Numerous studies have demonstrated that overexpression of Met , the hepatocyte growth factor ( HGF ) receptor , plays an important role in tumorigenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Low levels of hepatocyte growth factor and transforming growth factor alpha mRNAs were found concomitantly in highly differentiated tumors , whereas overexpression of mRNAs for the cognate receptors c met and epidermal growth factor receptor were found in poorly differentiated tumors and primarily in patients with early tumor recurrence . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is a pleiotropic cytokine operating through activation of the proto oncogene c met and is a factor of poor prognosis in various cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although RTKs are a large family , HER 2 , epidermal growth factor receptor ( EGFR ) , Met ( hepatocyte growth factor receptor ) , and others all have shown the ability to predict outcome . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Since prostaglandins are inducers of hepatocyte growth factor ( HGF ) , we examined the effect of rebamipide on the expression of HGF , c met , cyclooxygenase 2 ( Cox 2 ) and subtype of the prostaglandin E 2 receptor ( EP 2 ) in acetic acid induced gastric ulcer , a model of human ulcer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Proteasomal activity is required for Met receptor degradation after acute stimulation with hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor receptor tyrosine kinase Met promotes cell dissociation and the inherent morphogenic program of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Additionally , cells have been identified with a keratin phenotype intermediate between basal and luminal cells that co express high levels of K 5 and K 18 ( K5 / 18 ) as well as hepatocyte growth factor receptor c MET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c Met in the anterior horn cells of the spinal cord in the patients with amyotrophic lateral sclerosis ( ALS ) : immunohistochemical studies on sporadic ALS and familial ALS with superoxide dismutase 1 gene mutation . ^^^ To clarify the trophic mechanism of residual anterior horn cells affected by sporadic amyotrophic lateral sclerosis ( SALS ) and familial ALS ( FALS ) with superoxide dismutase 1 ( SOD 1 ) mutations , we investigated the immunohistochemical expression of hepatocyte growth factor ( HGF ) , a novel neurotrophic factor , and its receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Upon hepatocyte growth factor stimulation , its receptor c Met is rapidly internalized via clathrin coated vesicles and traffics through an early endosomal compartment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met tyrosine kinase , a high affinity receptor for hepatocyte growth factor ( HGF ) , plays a crucial role in controlling invasive growth and is often overexpressed in cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The met oncogene , encoding the high affinity hepatocyte growth factor receptor , is the only known gene inherited in human cancer that is invariably associated with somatic duplication of the mutant locus . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In biochemical assays , SU 10944 exhibits potent inhibitory activity against VEGFR 1 ; weak activity against other related subgroup members , including stem cell factor receptor ( SCFR ) , platelet derived growth factor receptor beta ( PDGFRbeta ) , and fibroblast growth factor receptor 1 ( FGFR 1 ) ; and no detectable activity against other protein tyrosine kinases such as epidermal growth factor receptor ( EGFR ) , Src , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) was suggested to play an important role in the regulation of mitogenesis , motogenesis , angiogenesis , migration and invasion for various types of cells , and acts through a specific membrane receptor encoded by c met proto oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its receptor , the c Met tyrosine kinase , play roles in cancer invasion and metastasis in a wide variety of tumor cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : The c met tyrosine kinase receptor and its ligand hepatocyte growth factor are involved in cell survival , proliferation , motility , and invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The N terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical expression of hepatocyte growth factor and c Met / HGF receptor in benign and malignant human prostate tissue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It is known that stimulation of c Met via its natural ligand , hepatocyte growth factor ( also known as scatter factor , HGF / SF ) results in a plethora of biological and biochemical effects in the cell . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Activation of the Met receptor tyrosine kinase through its ligand , hepatocyte growth factor ( HGF ) , promotes an epithelial mesenchymal transition and cell dispersal . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , the expression of vascular endothelial growth factor ( VEGF ) A , placental growth factor , hepatocyte growth factor , and c Met mRNA was quantified by phosphor image analysis of in situ hybridization reactions . ^^^ While hepatocyte growth factor and placental growth factor were not up regulated , c Met expression was increased up to 2 . 5 fold and the median VEGF A expression was elevated 4 fold ( p = 0 . 003 ) in this series of colorectal tumours . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The cytokine hepatocyte growth factor ( HGF ) / scatter factor 1 and its cognate receptor , Met , are involved in the etiology and progression of many types of cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RanBPM has been reported to bind to the tyrosine kinase domain of the hepatocyte growth factor ( HGF ) receptor Met , enhance Met downstream signaling , and enhance HGF induced A 704 kidney carcinoma cell invasion ( Wang , D . , Li , Z . , Messing , E . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We recently reported overexpression of hepatocyte growth factor ( HGF ) and its receptor met in a series of Wilms ' tumours with higher levels in homotypic metastatic cases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The semi quantitative RT PCR indicated an enhanced expression of the hepatocyte growth factor and its receptor c met in breast and bone marrow stromata of cancer patients . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recent data indicate that the signalling activity of the Met receptor for hepatocyte growth factor is affected by association with cell specific surface molecules , namely the alpha6beta4 integrin , Plexin B 1 and CD 44 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c Met and its complex with the microbial alkaloid K 252a . ^^^ The protooncogene c met codes for the hepatocyte growth factor receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction showed expression of markers of both hepatocyte and biliary epithelial phenotypes ( cytokeratins 7 , 18 , and 19 , albumin and AAT , hepatocyte growth factor receptor , transforming growth factor beta receptor type 2 , gamma glutamyl transpeptidase , biliary glycoprotein ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increased expression of the hepatocyte growth factor ( HGF ) receptor ( c met ) and urokinase type plasminogen ( uPA ) correlated with the development and metastasis of cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Fibroblast growth factors ( FGF ) , hepatocyte growth factor ( HGF ) and their receptors , FGFR and c Met , are essential components of the regulatory networks between the epithelium and mesenchyme in embryonic lung , but their respective roles in tumour growth are not clear . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Embryonic Foxf 1 ( + / ) lungs exhibited diminished expression of hepatocyte growth factor receptor c Met , myosin 6 , the transcription factors SP 3 , BMI 1 , ATF 2 , and glucocorticoid receptor , and cell cycle inhibitors p 53 , p 21 ( Cip 1 ) , retinoblastoma , and p 107 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c Met receptor tyrosine kinase and its ligand , hepatocyte growth factor ( HGF ) , have been implicated in the development and progression of several human cancers and are attractive targets for cancer therapy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of hepatocyte growth factor ( HGF ) , also called scatter factor ( SF ) , and its receptor c Met are associated with poor prognosis for cancer patients . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Because RMS cells also express the tyrosine kinase receptor c MET , the specific ligand hepatocyte growth factor ( HGF ) that is secreted in bone marrow and lymph node stroma , we hypothesized that the c MET HGF axis modulates the metastatic behavior of RMS cells as well . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the hepatocyte growth factor ( HGF ) receptor c met results in the regulation of cell matrix interactions , including the MAPK dependent stimulation of epithelial cell morphogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MET is a receptor protein tyrosine kinase for hepatocyte growth factor , a multifunctional cytokine controlling cell growth , morphogenesis , and motility . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , a cytokine involved in tumorigenesis and most metastases , initiates cell migration by binding to the protooncogene c Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Hepatocyte growth factor ( HGF ) and its receptor MET have been implicated in kidney development and renal cell carcinoma ( RCC ) progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| CD 44 independent hepatocyte growth factor / c Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro . ^^^ Malignant peripheral nerve sheath tumors ( MPNSTs ) are invasive peripheral nerve neoplasms that express both the receptor tyrosine kinase c Met and its ligand hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Inhibition of human non small cell lung tumors by a c Met antisense / U6 expression plasmid strategy . c Met is a receptor tyrosine kinase whose activation by hepatocyte growth factor ( HGF ) can lead to transformation and tumorigenicity in a variety of tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Post ischemic delayed expression of hepatocyte growth factor and c Met in mouse brain following focal cerebral ischemia . ^^^ We investigated long term changes in the expression of protein and mRNA of hepatocyte growth factor ( HGF ) and its receptor c Met in mouse brain after permanent occlusion of the middle cerebral artery , by using immunohistochemistry and quantitative reverse transcription polymerase chain reaction . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Furthermore , abrogation of the chemoattractant gradient concentration by addition of hepatocyte growth factor ( HGF ) recombinant protein , a cognate ligand of c Met receptor , reduces the MSH induced effect on motility . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , which is a ligand for the c met protooncogene product ( Met ) , stimulates proliferation and invasion of a large number of cells . ^^^ Hepatocyte growth factor / Met system promotes endometrial and endometriotic stromal cell invasion via autocrine and paracrine pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met protein , the high affinity receptor for hepatocyte growth factor ( HGF ) , was highly expressed by the tumour cells of 64 well differentiated papillary carcinomas of the thyroid . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor , encoded by the MET oncogene , is expressed in approximately 70 % of human ovarian carcinomas and overexpressed in 30 % of cases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Increased expression of the hepatocyte growth factor ( HGF ) receptor ( MET ) is associated with high grade prostatic adenocarcinoma and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Changes in expression of hepatocyte growth factor ( HGF ) and its receptor , MET , are associated with formation and malignant progression of human tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that , on cells fulfilling the criteria for hepatic stem cells , the hepatocyte growth factor receptor c Met is expressed specifically in the developing mouse liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Pulmonary expression of the hepatocyte growth factor receptor c Met shifts from medial to intimal layer after cavopulmonary anastomosis . ^^^ CONCLUSIONS : After cavopulmonary anastomosis , pulmonary artery expression of the hepatocyte growth factor receptor c Met and one of its downstream effectors , Bcl 2 , had increased in the intimal layer and decreased in the medial layer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The activation and phosphorylation of Met , the receptor tyrosine kinase ( RTK ) for hepatocyte growth factor , initiates the recruitment of multiple signaling proteins , one of which is c Cbl , a ubiquitin protein ligase . c Cbl promotes ubiquitination and enhances the down modulation of the Met receptor and other RTKs , targeting them for lysosomal sorting and subsequent degradation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) secretion from fibroblasts remained unchanged after irradiation , whereas exposure of pancreatic cancer cells to supernatant from irradiated fibroblasts resulted in increased phosphorylation of c Met ( HGF receptor ) and mitogen activated protein kinase activity , possibly or partially via increased expression of c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of hepatocyte growth factor receptor and epidermal growth factor receptor of human hepatocytes can be maintained in a ( 3D ) collagen sandwich culture system . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that a constitutive , physical association of the Met receptor and the alpha ( 6 ) beta ( 4 ) integrin exists on the surface of invasive carcinoma cells and that hepatocyte growth factor ( HGF ) mediated invasion is dependent on alpha ( 6 ) beta ( 4 ) ( Trusolino , L . , Bertotti , A . , and Comoglio , P . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met tyrosine kinase receptor and its ligand , hepatocyte growth factor ( HGF ) , play important roles in normal development and in tumor growth and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| They expressed high levels of CD 29 , CD 63 , CD 81 , CD 122 , CD 164 , hepatocyte growth factor receptor ( cMet ) , bone morphogenetic protein receptor 1B ( BMPR1B ) , and neurotrophic tyrosine kinase receptor 3 ( NTRK 3 ) and were negative for CD 34 , CD 36 , CD 45 , CD 117 ( cKit ) and HLADR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the hepatocyte growth factor ( HGF ) Met system in papillary thyroid cancer : biological effects of HGF in thyroid cancer cells depend on Met expression levels . ^^^ Met , the receptor for hepatocyte growth factor ( HGF ) , is overexpressed in approximately 90 % papillary thyroid carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Lack of association between the hepatocyte growth factor receptor , c met , and the anti apoptotic action of bag 1 in endothelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Structural and functional basis of the serine protease like hepatocyte growth factor beta chain in Met binding and signaling . ^^^ Hepatocyte growth factor ( HGF ) , a plasminogen related growth factor , is the ligand for Met , a receptor tyrosine kinase implicated in development , tissue regeneration , and invasive tumor growth . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Metastatic squamous cell carcinoma cells that overexpress c Met exhibit enhanced angiogenesis factor expression , scattering and metastasis in response to hepatocyte growth factor . ^^^ In the present study , we explored molecular pathways coactivated with Gro 1 / KC , and identified a transcript that encodes c Met , the receptor for hepatocyte growth factor / scatter factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , cisplatin , contrary to CB 3717 , does not induce renal hepatocyte growth factor ( HGF ) / c Met expression being without effect on HGF mRNA level and significantly down regulating c Met transmembrane receptor message . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) / Met has been suggested to be one of them based primarily on immunohistochemical studies . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By combining flow cytometry and clonal analysis , we show here that a possible pancreatic stem or progenitor cell candidate that resides in the developing and adult mouse pancreas expresses the receptor for the hepatocyte growth factor ( HGF ) c Met , but does not express hematopoietic and vascular endothelial antigens such as CD 45 , TER 119 , c Kit , and Flk 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| SU 5416 is a potent inhibitor of hepatocyte growth factor receptor ( c Met ) and blocks HGF induced invasiveness of human HepG 2 hepatoma cells . ^^^ CONCLUSIONS : Inhibition of various solid tumors growth and metastasis by SU 5416 may be partially attributed to blocking activation of the hepatocyte growth factor receptor . . ^^^ Because of the overwhelming evidence favoring the role of aberrant hepatocyte growth factor ( HGF ) / Met signaling in the pathogenesis of various human cancers , various inhibitor strategies have been employed to therapeutically target this receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MUC 20 suppresses the hepatocyte growth factor induced Grb 2 Ras pathway by binding to a multifunctional docking site of met . ^^^ We demonstrate here that the C terminus of MUC 20 associates with the multifunctional docking site of Met without ligand activation , preventing Grb 2 recruitment to Met and thus attenuating hepatocyte growth factor ( HGF ) induced transient extracellular signal regulated kinase 1 and 2 activation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The effect of a stimulation by a C5a agonist upon the synthesis of a growth factor / receptor pair ( hepatocyte growth factor / c Met ) was also evaluated . ^^^ Our data demonstrated an up regulated expression of hepatocyte growth factor and c Met mRNAs , but we failed to observe a direct mitogenic effect of C5a in culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Prostate cancer and the met hepatocyte growth factor receptor . ^^^ The hepatocyte growth factor / scatter factor ( HGF / SF ) and its receptor , the Met protein tyrosine kinase , form a classic ligand receptor system for epithelial mesenchymal communications in the normal and cancerous prostate . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Their cellular ligands have been also identified : InlA interacts with the adhesion molecule E cadherin , while InlB interacts with the receptor for the globular head of the complement factor C1q ( gC1q R ) , with the hepatocyte growth factor receptor ( c Met ) and with glycosaminoglycans ( including heparan sulphate ) . ^^^ Their cellular ligands have been also identified : InlA interacts with the adhesion molecule E cadherin , while InlB interacts with the receptor for the globular head of the complement factor Clq ( gClq R ) , with the hepatocyte growth factor receptor ( c Met ) and with glycosaminoglycans ( including heparan sulphate ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Listeria monocytogenes uptake by nonphagocytic cells is promoted by the bacterial invasion proteins internalin and InlB , which bind to their host receptors E cadherin and hepatocyte growth factor receptor ( HGF R ) / Met , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The competitive inhibitory effects of NK 4 ( a specific hepatocyte growth factor ( HGF ) antagonist ) on the interaction between HGF and the c Met / HGF receptor has been shown in HGF mediated invasion of some distinct types of human cancer cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / c Met signaling promotes the progression of experimental human neuroblastomas . ^^^ Here , we report that cultured human neuroblastoma cells express the hepatocyte growth factor ( HGF ) and its receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Loss of function experiments reveal that Met and its ligand , hepatocyte growth factor , are required for the correct morphogenesis of the hypaxial muscles in which met is expressed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , coordinated regulation of invasive growth as a whole is specifically accomplished by Hepatocyte Growth Factor , a soluble factor which acts through the tyrosine kinase receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of c met in oral SCC promotes hepatocyte growth factor induced disruption of cadherin junctions and invasion . ^^^ Hepatocyte growth factor ( HGF ) , the ligand for the c met proto oncogene product , is a multifunctional protein that enhances tumor cell motility , extracellular matrix invasion , and mitogenic or morphogenic activities of various cell types . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Previously , we found that hepatocyte growth factor receptor ( c Met ) and alpha fetoprotein ( AFP ) expressing cells were present in adult rat bone marrow , and that these cells also expressed hematopoietic stem cell markers , such as CD 34 , Thy 1 , and c Kit . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND & OBJECTIVE : Hepatocyte growth factor ( HGF ) plays an important role in the regulation of migration , invasion , and angiogenesis of cancer via the activation of its receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A selective c met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL 6 cells and prevents migration and adhesion of myeloma cells . ^^^ PURPOSE : We wanted to examine the role of the hepatocyte growth factor ( HGF ) receptor c Met in multiple myeloma by applying a novel selective small molecule tyrosine kinase inhibitor , PHA 665752 , directed against the receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Prognostic significance of hepatocyte growth factor and c MET expression in patients with diffuse large B cell lymphoma . ^^^ The expression and prognostic significance of hepatocyte growth factor ( HGF ) and its receptor c MET ( MET proto oncogene ) was analysed in 96 cases of diffuse large B cell lymphoma ( DLBCL ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of c Met ( hepatocyte growth factor receptor ) in human gastric cancer tissue . c Met is a high affinity receptor for hepatocyte growth factor ( HGF ) and plays a crucial role in embryonic development , as well as in the process of tissue repair . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and c met was found to be progressively reduced from 24 hours after infection , during which time we detected no modification in messenger RNA ( mRNA ) levels of transforming growth factor ( TGF ) alpha . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Parallel to the biochemical changes , there were progressive increases in the DNA repair enzyme APEX 1 , the cell cycle control proteins cyclin D 1 and D 3 , and the hepatocyte growth factor receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the hepatocyte growth factor receptor Met induces a morphogenic response and stimulates the formation of branching tubules by Madin Darby canine kidney ( MDCK ) epithelial cells in three dimensional cultures . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By immunohistochemistry , we have investigated the expression of hepatocyte growth factor ( HGF ) , HGF R or c met and the transcritor factor STAT 3 in a series of 80 colorectal tumours ( 40 adenomas and 40 adenocarcinomas ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study , we were able to demonstrate that hepatocyte growth factor receptor , c Met , is also a coreceptor for AAV 2 infection . ^^^ Hepatocyte growth factor receptor is a coreceptor for adeno associated virus type 2 infection . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for hepatocyte growth factor ( HGF ) , Met , controls a programme of invasive growth that combines proliferation with various moto and morphogenetic processes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis of c Met expression in human colorectal cancer : overexpression is associated with advanced stage cancer . c Met , the receptor of hepatocyte growth factor is known to be responsible for the motility and mitogenesis of epithelial cells including cancer cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF ( hepatocyte growth factor ) , a heterodimeric glycoprotein composed of alpha and beta chains , exerts biological activities through the c Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The SPRY domain containing SOCS box protein 1 ( SSB 1 ) interacts with MET and enhances the hepatocyte growth factor induced Erk Elk 1 serum response element pathway . ^^^ In the present study , we explored the function of SSB proteins in the regulation of the hepatocyte growth factor ( HGF ) MET signaling . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Novel hepatocyte growth factor ( HGF ) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met integrin induced signalling pathway in endothelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor , Met , has established oncogenic properties ; however , its expression and function in esophageal adenocarcinoma ( EA ) remain poorly understood . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Hepatocyte growth factor receptor c met , growth factor receptor bound protein 10 , B raf proto oncogene , and several mitogen activated protein kinase kinase genes were significantly up regulated in melanoma metastases and several melanoma cell lines relative to normal human melanocytes ( P = . 03 ) . ^^^ Among the up regulated genes , phosphorylated growth factor receptor bound protein 10 is known to serve a molecular switch turning on the mitogen activated protein kinase pathway in response to hepatocyte growth factor receptor binding . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Examination of hepatocyte growth factor ( HGF ) , and its receptor Met , both of which provide a mitogenic signal for hepatocyte division , showed increased HGF activity in Timp 1 ( / ) regenerating livers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The SH 2 domian containing inositol 5 phosphatase ( SHIP ) 2 binds to c Met directly via tyrosine residue 1356 and involves hepatocyte growth factor ( HGF ) induced lamellipodium formation , cell scattering and cell spreading . ^^^ In this paper , we show for the first time that the SH 2 domain containing inositol 5 phosphatase ( SHIP ) 2 binds directly to the hepatocyte growth factor ( HGF / SF ) receptor , c Met , via phosphotyrosine 1356 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here the possible regulatory effect of the apoptosis mediated by hepatocyte growth factor ( HGF ) / scatter factor ( SF ) c Met Fas in EACC is discussed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Internalisation of the pathogenic bacterium Listeria monocytogenes involves interactions between the invasion protein InlB and the hepatocyte growth factor receptor , Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mammalian ligand of Met , hepatocyte growth factor , promotes cell motility and morphogenesis in a manner dependent on phosphorylation of two docking site tyrosines at positions 1349 and 1356 in the receptor ' s cytoplasmic tail . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and its receptor Met are induced in crescentic glomerulonephritis . ^^^ Hepatocyte Growth Factor ( HGF ) is an injury induced effector of tissue repair that causes cell migration , growth and transdifferentiation via its receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of hepatocyte growth factor and its receptor c met , correlates with severity of pathological injury in experimental alcoholic liver disease . ^^^ Expression of hepatocyte growth factor ( HGF ) and its receptor , c met is up regulated in various forms of liver injury . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We show that sublethal doses of irradiation up regulated the expression of the hepatocyte growth factor ( HGF ) and its receptor c Met in some neuroblastoma cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In normal cellular context , hepatocyte growth factor ( HGF ) regulates MET kinase activation and mediates cell proliferation , migration and motility . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor encoded by the Met oncogene controls a genetic program known as `` invasive growth ' ' responsible for several developmental processes and involved in cancer invasion and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Increased hepatocyte growth factor receptor ( HGFR ) signaling correlates closely with neoplastic invasion and metastatic potential of many human cancers . ^^^ Hepatocyte growth factor receptor signaling is initiated by binding the physiological ligand HGF or the internalin B ( InlB ) protein of Listeria monocytogenes . ^^^ Hepatocyte growth factor receptor internalization was prevented by overexpression of dominant negative mutants of dynamin 1 and epidermal growth factor phosphorylation substrate 15 , but not caveolin 1 , the GTPase Arf 6 or the cholesterol chelating drug Nystatin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor is secreted by vascular endothelial cells and smooth muscle cells , and the hepatocyte growth factor receptor , c met , was also observed in these vascular cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Consistent with reports implicating hepatocyte growth factor ( HGF ) / Met receptor signaling in MM , all 14 human and murine MM cell lines had HGF inducible AKT activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present study , we enriched a subset of umbilical cord blood beta ( 2 ) m ( ) c Met ( + ) cells ( UCBCCs ) and investigated the combination effect of liver nonparenchymal cells ( cirrhotic fat storing cells [ CFSCs ] ) and hepatocyte growth factor ( HGF ) on the induction of UCBCCs into hepatocyte like cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The proto oncogene , c Met , encodes the high affinity receptor for hepatocyte growth factor ( HGF ) or scatter factor ( SF ) . c Met and HGF are each required for normal mammalian development and have been shown to be particularly important in cell migration , morphogenic differentiation , and organization of three dimensional tubular structures ( e . g . renal tubular cells , gland formation , etc . ) as well as cell growth and angiogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c Met proto oncogene is the receptor for hepatocyte growth factor ( HGF ) , which is a member of the tyrosine kinase family . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the expression of hepatocyte growth factor ( HGF ) mRNA and its receptor ( c Met ) mRNA in brain astrocytomas and their relationships with tumor proliferation , angiogenesis , clinical pathology and prognosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met oncogene , encoding the RTK for hepatocyte growth factor ( HGF ) , controls genetic programs leading to cell growth , invasion and protection from apoptosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These clonogenic cells and early committed progeny possess a hepatocyte growth factor ( HGF ) c Met and an insulin like growth factor 1 ( IGF 1 ) IGF 1 receptor system that can be activated to induce their migration , proliferation , and survival . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor regulates many cellular functions acting through c met , its specific receptor with tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Estradiol valerate decreased uterine FGF 7 ( fibroblast growth factor 7 ) and MET ( hepatocyte growth factor receptor ) expression and increased INHBA ( inhibin betaA ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Targeted inactivation of hepatocyte growth factor receptor c met in beta cells leads to defective insulin secretion and GLUT 2 downregulation without alteration of beta cell mass . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MEASUREMENTS AND MAIN RESULTS : The 60 % oxygen mediated lung injury was associated with increased lung mRNAs for hepatocyte growth factor and c Met , relative to air exposed control lungs , at Day 7 after birth . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Presence of autocrine hepatocyte growth factor Met signaling and its role in proliferation and migration of SNU 484 gastric cancer cell line . ^^^ Autocrine stimulation via coexpression of hepatocyte growth factor ( HGF ) and its receptor ( Met ) has been reported in many human sarcomas , but few in carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) and its c met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic beta cell survival , proliferation , and function . ^^^ Beta cell specific ablation of the hepatocyte growth factor receptor results in reduced islet size , impaired insulin secretion , and glucose intolerance . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Stimulation of c MET via its natural ligand hepatocyte growth factor / scatter factor ( HGF / SF ) leads to a plethora of biological and biochemical effects in the cell . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The TrkB mediated invasiveness involved the upregulation of the hepatocyte growth factor ( HGF ) and its receptor c Met , resulting in an autocrine loop . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A comparative analysis of the gene expression of purified lymphatic endothelial cells ( LEC ) versus blood vascular endothelial cells ( BVEC ) revealed that LEC express significantly higher levels of hepatocyte growth factor receptor ( HGF R ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met protooncogene product ( Met ) , which is a high affinity receptor for hepatocyte growth factor , plays an important role in controlling the invasion of many types of cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF / SF ) is a multifunctional growth factor that is involved in invasive growth of tumor cells via its receptor MET , a protein product of c met proto oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Signaling by the multifunctional cytokine hepatocyte growth factor ( HGF ) and its receptor MET has been shown to induce integrin mediated adhesion of B cells to VCAM 1 , which is expressed by FDCs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Inappropriate expression of the receptor tyrosine kinase Met and its ligand hepatocyte growth factor ( HGF ) / scatter factor ( SF ) is usually associated with an aggressive solid tumor phenotype ( angiogenesis , invasiveness , and metastasis ) and poor clinical prognosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor / c met axis . ^^^ Unlike migration of BM cells to stroma , myofiber induced migration of BM derived cells was not affected by stromal derived factor 1 ( SDF 1 ) neutralization or CXCR 4 blocking antibody , but could be reduced by addition of c met blocking antibody and augmented by hepatocyte growth factor ( HGF ) , the putative ligand for c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Hepatocyte growth factor / scatter factor ( HGF / SF ) and its receptor , c Met , play important roles in tumor development and progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This result was accompanied by a reduction in collagen synthesis , reduced levels of hepatocyte growth factor receptor MET and increased levels of the tumor suppressor protein WT 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor , c Met , and transforming growth factor beta 1 mRNA levels in the left ventricle were then analyzed by real time quantitative reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both Ki ras mutation and hepatocyte growth factor ( HGF ) receptor Met overexpression occur at high frequency in colon cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Matrigel also induced an increased association of beta catenin with Met ( hepatocyte growth factor receptor ) , whereas association with E cadherin remained unchanged . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The c met receptor and its ligand hepatocyte growth factor have been shown to be involved in tumor invasiveness and metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Inappropriate activation of MET , the receptor tyrosine kinase for hepatocyte growth factor ( HGF ) , has been implicated in tumorigenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , 9 cis RA induced hepatocyte growth factor ( HGF ) mRNA expression and protein secretion , stimulated HGF promoter activity , and activated c met receptor phosphorylation . ^^^ Hepatocyte growth factor receptor signaling mediates the anti fibrotic action of 9 cis retinoic acid in glomerular mesangial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cardiac stem cells and early committed cells ( CSCs ECCs ) express c Met and insulin like growth factor 1 ( IGF 1 ) receptors and synthesize and secrete the corresponding ligands , hepatocyte growth factor ( HGF ) and IGF 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reported coreceptors include alphaVbeta 5 integrin , fibroblast growth factor receptor 1 ( FGFR 1 ) , and hepatocyte growth factor ( c Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the Wnt / beta catenin and hepatocyte growth factor / Met signaling has been implicated in various tumors . ^^^ In this study we compared proliferation indices , beta catenin staining and its known molecular targets , c myc and cyclin D 1 , and Met , a tyrosine kinase receptor for hepatocyte growth factor in pretreatment and post treatment specimens . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The increase in hepatic activity of urokinase type plasminogen activator was also accompanied by more activation of the hepatocyte growth factor receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) / Met signaling controls cell migration , growth and differentiation in several embryonic organs and is implicated in human cancer . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OPN induces cell migration in cancer cells , in part through activation of the hepatocyte growth factor ( HGF ) receptor ( Met ) and its signaling pathway . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| X Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor / C met pathway via Akt signaling . ^^^ We hypothesized that the hepatocyte growth factor ( HGF ) activation in colorectal cancer via c Met receptor regulates IAP proteins through Akt signaling . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Expression of the Met receptor and its ligand , hepatocyte growth factor ( HGF ) , has been observed in 74 % to 100 % and 40 % to 85 % of malignant pleural mesothelioma ( MPM ) specimens , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Therefore , the frequently observed up regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogenic conversion . beta 4 integrin stimulates proliferation and survival of epithelial cells and is overexpressed in human carcinomas , often in concomitance with up regulation of the Met tyrosine kinase receptor for hepatocyte growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Another invasion protein of the internalin family , InlB , subverts the signalling pathway of the hepatocyte growth factor receptor Met to induce endocytosis of the receptor and also to favour internalization of the bacteria in non polarized epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis of SSB 2 loop regions identified conserved structural determinants for its interaction with Par 4 and the hepatocyte growth factor receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A hepatocyte growth factor competitive Met antagonist inhibits receptor activation and proliferation in tumor cells harboring the Met deletion , suggesting the important role played by ligand dependent Met activation and the potential for anticancer therapy . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Functional analysis of c Met / hepatocyte growth factor pathway in malignant pleural mesothelioma . c Met receptor tyrosine kinase ( RTK ) has not been extensively studied in malignant pleural mesothelioma ( MPM ) . ^^^ Expression in MPM tissues by immunohistochemistry was increased ( 82 % ) in MPM in general compared with normal . c Met was internalized with its ligand hepatocyte growth factor ( HGF ) in H 28 MPM cells , with robust expression of c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF ) and its protooncogene receptor c Met regulate osteoclast function by activating pp 60 ( c Src ) kinase and alpha ( 5 ) beta 3 integrin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In HepG 2 hepatocarcinoma cells this fine regulation is not maintained ; we have then utilized Met murine hepatocytes ( MMH ) , isolated from the liver of transgenic mice expressing a truncated form of c Met ( hepatocyte growth factor receptor ) , that are immortalized but not transformed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the normal breast , hepatocyte growth factor ( HGF ) is primarily expressed by stromal cells , and stimulates in a paracrine manner epithelial cells expressing the HGF receptor ( Met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Contact inhibition of hepatocyte growth regulated by functional association of the c Met / hepatocyte growth factor receptor and LAR protein tyrosine phosphatase . ^^^ Using primary cultured hepatocytes , we investigated the mechanisms of contact inhibition that decrease the mitogenic activity of hepatocyte growth factor ( HGF ) , focusing on the regulation of c Met / HGF receptor activation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The blebbing response was dependent on autocrine HGF ( hepatocyte growth factor ) activation of c Met and prevented by inhibition of RhoA , ROCK and p 38 MAPK ( p 38 mitogen activated protein kinase ) , but not ERK ( extracellular signal regulated kinase ) or PI3K ( phosphoinositide 3 kinase ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) receptor , Met , is a strong prognostic indicator of breast cancer patient outcome and survival , suggesting that therapies targeting Met may have beneficial outcomes in the clinic . ( ) Epigallocatechin 3 gallate ( EGCG ) , a catechin found in green tea , has been recognized as a potential therapeutic agent . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor / c Met dependent human tumors . c Met is a well characterized receptor tyrosine kinase for hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor and the Met system as a mediator of tumor stromal interactions . ^^^ Hepatocyte growth factor ( HGF ) , a ligand for the Met receptor tyrosine kinase , plays a definitive role , particularly in the progression to invasive and metastatic cancers , predominantly as a stroma derived paracrine mediator . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) / c Met signaling is thought to be a key pathway in both melanocyte development and melanoma metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Extent of over expression of hepatocyte growth factor receptor in colorectal tumours is dependent on the choice of normaliser . ^^^ This study quantified the mRNA expression of three putative reference genes ( ubiquitin C , cyclophilin E , and porphobilinogen deaminase ) and the target gene hepatocyte growth factor receptor ( HGFR ) in matched colorectal tumour and normal mucosa samples . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) , also known as scatter factor ( SF ) , and its receptor , the c Met tyrosine kinase , play roles in cancer invasion and metastasis in a wide variety of tumor cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) accelerates tissue regeneration and ameliorates tissue fibrosis through its ligand c Met receptor tyrosine kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of hepatocyte growth factor ( HGF ) receptor , encoded by the Met oncogene , is elevated in ovarian and a variety of cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : Hepatocyte growth factor ( HGF ) and its receptor Met are involved in the initiation , progression , and metastasis of numerous systemic and central nervous system tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This review is intended specifically for summarizing recent progress uncovering how the hepatocyte growth factor receptor c Met coordinates with integrins to transmit signals . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Several studies have suggested a possible role of the hepatocyte growth factor ( HGF ) / c Met system in lung tumor development and progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Within 5 min , PNA ( 25 microg / mL ) caused a 6 fold increase in phosphorylation of hepatocyte growth factor receptor c Met , known to co associate with CD44v6 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c Met in the course of cirrhosis development in rats . ^^^ Hepatocyte growth factor ( HGF ) and its specific receptor , c Met , play a pivotal role in hepatocyte proliferation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : Hepatocyte growth factor ( HGF ) , its receptor , c Met , vascular endothelial growth factor ( VEGF ) and transforming growth factor beta 1 ( TGF beta 1 ) mRNA expression in both liver tissue and isolated liver cells were investigated after biliary obstruction ( BO ) by quantitative reverse transcription polymerase chain reaction ( RT PCR ) using a LightCycler . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatocyte growth factor ( HGF ) is a pleiotropic cytokine that influences mitogenesis , motility and differentiation of many different cell types by its tyrosine kinase receptor c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined gene expression of hepatocyte growth factor ( HGF ) and HGF receptor ( HGFR ) , or product of proto oncogene c met ( c met ) , in smokers and nonsmokers with adenocarcinoma ( ADC ) by suppression subtractive hybridization and microarray techniques . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / c met signaling in regulating urokinase plasminogen activator in human stomach cancer : A potential therapeutic target for human stomach cancer . ^^^ BACKGROUND : Up regulation of the hepatocyte growth factor ( HGF ) , its transmembrane tyrosine kinase receptor ( c Met ) , and urokinase type plasminogen activator ( uPA ) , is associated with the development and metastasis of various types of cancers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In contrast , depletion of hepatocyte growth factor receptor substrate ( Hrs ) only modestly inhibits EGF degradation , does not induce tubulation of the early endosome , and causes the generation of enlarged MVBs that retain the ability to fuse with the lysosome . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : C Met , a receptor tyrosine kinase , and its ligand , hepatocyte growth factor , are critical in cellular proliferation , motility , and invasion and are known to be overexpressed in gliomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The c Met tyrosine phosphorylation in PLC / PRF / 5 hepatoma cells was increased by treatment with 20 ng / mL hepatocyte growth factor ( HGF ) , and extracellular signal regulated kinase ( ERK ) was also activated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The MET proto oncogene encodes a transmembrane tyrosine kinase receptor that mediates multiple functions such as migration , cycling and survival by binding to hepatocyte growth factor ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| On binding to the cell surface receptor tyrosine kinase ( TK ) known as c Met , hepatocyte growth factor ( HGF ) stimulates mitogenesis , motogenesis , and morphogenesis in a wide range of cellular targets including , epithelial and endothelial cells , hematopoietic cells , neurons , melanocytes , and hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Here we report that FAK directly interacts with the hepatocyte growth factor receptor c Met . ^^^ Direct interaction of focal adhesion kinase ( FAK ) with Met is required for FAK to promote hepatocyte growth factor induced cell invasion . ^^^ Met FAK interaction leads to FAK activation and subsequent contribution to hepatocyte growth factor induced cell motility and cell invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This process depends on nitric oxide ( NO ) production , release of hepatocyte growth factor ( HGF ) from the extracellular matrix , and presentation of HGF to the c met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Laser microdissection and quantitative reverse transcription polymerase chain reaction ( qRT PCR ) was used to quantify keratinocyte growth factor receptor ( KGFR ) , hepatocyte growth factor receptor ( HGFR ) , epidermal growth factor receptor ( EGFR ) and fibroblast growth factor receptor 1 ( FGFR 1 ) gene expression , and in situ RT PCR localized these increases to specific epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the c Met receptor tyrosine kinase through its ligand , hepatocyte growth factor ( HGF ) , promotes mitogenic , motogenic , and morphogenic cellular responses . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor ( HGF ) is mesenchymal derived growth factor acting through a transmembrane tyrosine kinase receptor , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor tyrosine kinase Met and its ligand hepatocyte growth factor are clustered at excitatory synapses and can enhance clustering of synaptic proteins . ^^^ The receptor protein tyrosine kinase Met and its ligand , hepatocyte growth factor , regulate cellular morphology , intercellular adhesion , and interactions among junctional proteins in numerous cell types . ^^^ We report that Met is clustered at excitatory synapses and that treatment of neurons with hepatocyte growth factor can enhance expression and clustering of synaptic proteins . ^^^ These results suggest a novel role for Met and hepatocyte growth factor in regulating synapses . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As we suggest possible directions for drug development , we propose the receptor for the hepatocyte growth factor , Met , as an ideal target for tackling cancer progression . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Autocrine alpha ( 5 ) beta ( 8 ) mediated TGF beta activation by fetal tracheal fibroblasts results in suppression of both transcription and secretion of hepatocyte growth factor , which is sufficient to affect phosphorylation of the airway epithelial hepatocyte growth factor receptor , c Met , as well as airway epithelial proliferation in a co culture model of the EMTU . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Pancreatic carcinoma cells overexpress the insulin like growth factor 1 ( IGF 1 ) receptor ( IGF IR ) and the hepatocyte growth factor ( HGF ) receptor , c Met , which are both known to mediate tumor cell migration and invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor differently influences Met E cadherin phosphorylation and downstream signaling pathway in two models of breast cells . ^^^ E cadherins are implicated in cell adhesion , and also in cell signaling by associating with tyrosine kinase receptors such as Met , the hepatocyte growth factor ( HGF ) receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of hepatocyte growth factor and its receptor c Met in nasal polyps . ^^^ OBJECTIVES : To investigate the expression and distribution of hepatocyte growth factor ( HGF ) and c Met proteins in normal nasal mucosa and in nasal polyps and to evaluate the possible effects of HGF and c Met on the development of nasal polyps . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor and the c met receptor : a paradigm for mesenchymal / epithelial interaction . ^^^ Recent studies suggest that scatter factor and its receptor ( c met ) mediate mesenchyme / epithelia signalling and even interconversion . ^^^ In this mini review , we will discuss how scatter factor and c met may mediate interactions between mesenchyme and epithelia during embryogenesis , organ repair , and neoplasia . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor ( SF ) is an invasogenic and angiogenic cytokine the cellular receptor of which is encoded by a proto oncogene ( c met ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of c Met receptor and hepatocyte growth factor / scatter factor in synovial sarcoma and epithelioid sarcoma . ^^^ Overexpression of c Met receptor / hepatocyte growth factor ( scatter factor ) system ( c Met / HGF / SF ) as a physiologically paracrine cellular signaling system is thought to be involved in the progression of malignant tumours . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also demonstrated that SW 1353 cells not only secreted hepatic growth factor ( HGF ) / scatter factor ( SF ) but also expressed large amounts of p140c met , the receptor tyrosine kinase for HGF / SF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of scatter factor and its receptor ( c met ) in oral squamous cell carcinoma . ^^^ HYPOTHESIS : Scatter factor ( SF ) is a pleiotropic growth factor that recently has been shown to induce epithelial cell proliferation , random motility , and invasion via interaction with its receptor , a tyrosine kinase encoded by the c met proto oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that Pax 3 , together with the c Met receptor tyrosine kinase and its ligand Scatter Factor ( SF ) are necessary for the migration of hypaxial muscle precursors in mice . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Semaphorins , the plexin family of semaphorin receptors , and scatter factor receptors share evolutionarily conserved protein modules , such as the semaphorin domain and Met Related Sequences ( MRS ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In lymph node metastases of head and neck squamous cell carcinomas ( HNSCC ) , we found mutations in the MET oncogene , which encodes the tyrosine kinase receptor for Scatter Factor , a cytokine that stimulates epithelial cell motility and invasiveness during embryogenesis and tissue remodeling . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF ( Scatter factor 1 ) and MSP ( Scatter Factor 2 ) bind to tyrosine kinase receptors encoded by the proto oncogenes MET and RON . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scatter factor ( SF ) , secreted by fibroblasts , has a paracrine action on epithelial cells and binds the trans membrane c met receptor inducing loss of adhesion , cell motility and invasiveness in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , shrew 1 was partially translocated in response to scatter factor ( ligand of receptor tyrosine kinase c met ) from the plasma membrane to the cytoplasm where it still colocalized with endogenous E cadherin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both semaphorins and plexins share structural homology with the extracellular domain of c Met , a member of the scatter factor family of receptors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Mig 7 expression was more specific than Met expression , the RTK that binds Scatter factor and is used as a marker of poor progression , in endometrial carcinoma as compared to normal endometrial tissue samples . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Semaphorins and plexins share structural homologies with scatter factor receptors , a family of tyrosine kinase receptors for which Met is the prototype . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| They act by binding a family of transmembrane receptors known as plexins , which belong to the c Met family of scatter factor receptors but lack an intrinsic tyrosine kinase domain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We report the following findings : ( a ) mouse SF exhibits species related differences in biological activities relative to the human factors ; ( b ) human SF and hrHGF show significant overlap in biological activities ( i . e . , hrHGF stimulates motility of multiple normal and carcinoma cell types , whereas human SF stimulates DNA synthesis in several normal cell types ) ; ( c ) the three factors contain common antigenic determinants ; and ( d ) all three proteins stimulate rapid phosphorylation of tyrosine residues on the c met protooncogene protein product ( the putative receptor for HGF ) and on another protein with Mr 110 , 000 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for SF , the c met protein , was expressed by ECs , dermal dendrocytes , and KS tumor cells in vitro and in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both SF and its proto oncogene ( c met ) encoded receptor were detected in bladder carcinoma tissue sections by immunostaining . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF SF and its receptor proto oncogene c met are expressed in a variety of normal embryonic and adult tissues of mouse , rabbit , rat , human and probably other vertebrates . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF SF has been found to be the ligand of the c met receptor tyrosine kinase ( Naldini et al . , EMBO J . 10 , 2867 2878 , 1991b ) . ^^^ These data indicate that a functional domain in the N terminal region and / or the first two kringle domains of HGF SF is sufficient for binding to and activation of the met receptor ( Hartmann et al . , Proc . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These responses are transduced through the c met protooncogene product , a transmembrane tyrosine kinase that functions as the SF receptor . ^^^ We hypothesize that tumor suppressor gene mutations may contribute to the activation of an SF IF > SF > c met pathway , leading to an invasive and angiogenic tumor phenotype . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Human glioblastoma cells expressed both SF and its receptor ( c met protein ) in vivo , as demonstrated by immunohistochemistry . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF / SF ) is a pleiotropic effector for cells expressing the Met tyrosine kinase receptor . ^^^ In this investigation , we show that pancreatic oval cells express Met and exhibit a proliferative response to HGF / SF . ^^^ This study supports the involvement of HGF / SF Met signaling in the growth , migration , and morphogenesis of pancreatic oval cells and may have important implications for the expansion and morphogenic differentiation of these cells during developmental , regenerative , and neoplastic growth . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We hypothesize that tumor suppressor gene mutations may contribute to activation of an SF > c met signalling pathway , leading to an invasive and angiogenic tumor phenotype . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Human gliomas express SF and its receptor c met , but their role in the malignant progression of these tumors has not been defined . ^^^ To examine this , 9L glioma cells that express c met but not SF were transfected with human SF cDNA , and their behavior in vitro and in vivo was examined . ^^^ Reverse transcriptase PCR of RNA from i . c . gliomas revealed that only 9L SF gliomas expressed SF and both 9L neo and 9L SF gliomas expressed the c met SF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Human breast cancer cells express SF and c met in vivo ; but human breast cancer cell lines do not produce SF in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As expected based on these biologic responses to SF , 10 / 10 glioma lines and 4 / 4 NMVEC lines expressed mRNA for c met , the SF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Protection required functional SF receptor ( c Met ) , but was not dependent on p 53 . ^^^ Furthermore , Bcl XL levels were not down regulated by ADR in MDA MB 231 breast cancer cells , consistent with the finding that SF failed to protect these cells against ADR , despite the fact that they contain functional c Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As a first step toward identifying the mechanisms involved in mediating such cytokine dose dependent effects , we have now investigated the kinetics of SF receptor ( c kit ) internalization by human Mo7e cells exposed to different extracellular concentrations of soluble SF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Chemically generated NK 4 ( from recombinant human HGF / SF ) was found to be able to inhibit HGF induced activation ( tyrosine phosphorylation ) of the HGF / SF receptor cMET but was itself unable to activate cMET . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This fascinating cytokine transduces its activities via its receptor encoded by the c met oncogene , coupled to a number of transducers integrating the HGF / SF signal to the cytosol and the nucleus . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Erythropoiesis is severely impaired in mice with inactivating mutations in the Steel factor ( SF ) gene ( Sl / Sl mice ) or in c kit , in the SF receptor gene ( W / W mice ) , and in mice with null mutations in the genes for either erythropoietin ( EPO ) or the erythropoietin receptor ( EPO R ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| An Erk activation assay also demonstrated stimulation of the MAP kinase pathway downstream of the Met receptor following addition of both HGF / SF and ascidian DS to the glycosaminoglycan deficient CHO 745 mutant cell line . ^^^ Furthermore , the activation of Met and the MAP kinase pathway by HGF / SF and ascidian DS leads to a cellular response in the form of migration . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mature form of SF controls invasive cues in both physiological and pathological processes through activation of its receptor , the Met tyrosine kinase . ^^^ We provide evidence that ( a ) uncleavable SF inhibits both protease mediated pro SF conversion and active SF induced Met activation ; ( b ) local expression of uncleavable SF in tumors suppresses tumor growth , impairs tumor angiogenesis , and prevents metastatic dissemination ; and ( c ) systemic expression of uncleavable SF dramatically inhibits the growth of transplanted tumors and abolishes the formation of spontaneous metastases without perturbing vital physiological functions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , the receptor for HGF was identified as the product of the proto oncogene , c MET , a tyrosine kinase containing transmembrane protein . c MET expression has been reported in a variety of adult and embryonic mouse tissues . ^^^ Other studies demonstrated the presence of HGF and c MET mRNA in total fetal rat , and in fetal and neonatal rat liver . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the 160 kDa HGF binding surface protein on Meth A cells is the c met protein . ^^^ Furthermore , tyrosine phosphorylation of the c met protein was stimulated by HGF treatment of Meth A cells , suggesting that it may be involved in the signal transduction of the growth inhibition of Meth A cells by HGF . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor was recently identified as the product of c met protooncogene , which encodes a 190 kDa transmembrane protein possessing tyrosine kinase domain . ^^^ HGF receptor with a Kd of 20 to 30 pM is widely distributed in various epithelial cells including hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analysis of HGF variants was accomplished by defining their ability to induce DNA synthesis on hepatocytes in primary culture and to compete with wild type HGF for binding to a soluble form of the HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To investigate target cell specificity and to examine whether multiple actions of HGF are related to properties of the HGF receptor on target cells , we examined the effects of HGF on cell growth and motility and analyzed the HGF receptor in various species of cells . ^^^ High affinity HGF receptor with Kd values of 20 25 pM was detected at 40 720 sites / cell in MDCK , A 431 , PAM 212 , Lu 99 , and IM 9 cells , but not in fibroblasts and hematopoietic cells . ^^^ Northern blots revealed that cells possessing a high affinity HGF receptor expressed c MET / HGF receptor mRNA . ^^^ The multiple biological activities of HGF may be exerted through a high affinity HGF receptor linked to multiple distinct intracellular signaling pathways . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These results suggest that HGF acts only in a regenerating organ after injury through the control mechanisms governing HGF receptor . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We analyzed changes in HGF mRNA and its receptor , the c met proto oncogene product , in the liver , kidney and lung during late fetal and postnatal development in rats . ^^^ The number of HGF receptors / ng plasma membrane protein at the maximal level was highest in the liver and lowest in the lung . c met / HGF receptor mRNA in the liver was also low during late gestation or in early neonatal periods and increased postnatally . ^^^ Since HGF mRNA and HGF receptor levels changed differently in liver , kidney and lung , the expression of HGF and its receptor may be independently regulated in each organ . ^^^ However , in these organs , HGF mRNA and the HGF receptor increased within a few weeks of birth , HGF may play roles in organ growth , organ maturation and the maintenance of tissue homeostasis during the postnatal period , presumably through its potential to act as mitogen , motogen and morphogen . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To investigate whether or not HGF is involved in renal regeneration , we examined changes in HGF mRNA , HGF activity , and HGF receptor in the rat kidney following unilateral nephrectomy or treatment with carbon tetrachloride ( CCl 4 ) . ^^^ The HGF receptor was greatly diminished 24 h after the operation , and recovery to 60 % of the normal level was evident 1 week after the operation . ^^^ Because the decrease in HGF binding may result from internalization of the HGF receptor , the HGF may bind to its receptor in vivo and act as a mitogen for renal epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the Met / HGF receptor in normal and neoplastic human tissues . ^^^ In this paper , the physiological role of the human Met / HGF receptor is investigated by studying its specific distribution in normal and neoplastic tissues . ^^^ The tissue distribution of the Met / HGF receptor indicates that this molecule is involved in growth control of epithelial cells other than hepatocytes and suggests that its increased expression may confer a growth advantage to neoplastic cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cross linking studies demonstrated that the truncated molecule competes with HGF for binding to the HGF receptor , which has been identified as the c met protooncogene product . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Affinity cross linking of the receptor with 125I HGF revealed the HGF receptor in rat liver membranes to be a polypeptide of Mr approximately 220 , 000 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Therefore , we investigated endogenous HGF production and its specific receptor ( c met ) in vascular tissues . ^^^ Our results revealed the expressions of HGF and its receptor ( c met ) mRNA in endothelial cells , VSMC and neointimal VSMC of rat assessed by RT PCR . ^^^ HGF and c met mRNA were also detected in human aortic endothelial cells and VSMC . ^^^ Of importance , the existence of local HGF system ( HGF and c met ) was also observed in vivo in intact abdominal aorta of SD and Wistar rats . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of c met , specific HGF receptor was demonstrated by the esophageal cells , suggesting that the effect of HGF was mediated by its specific receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , in situ hybridization experiments showed that HGF receptor mRNA is highly expressed in embryonic erythroid cells ( megaloblasts ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of the HGF receptor , met , is high in normal breast epithelial cells and in dedifferentiated ( ER negative ) tumor cells but is reduced or lost in ER positive well differentiated epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present study , we show that the mouse liver in the middle and / or late stage of the fetal life expresses both HGF and c met ( its receptor ) messages . ^^^ HGF and c met mRNA are coexpressed not only in the adherent layers of fetal liver long term cultures ( FL LTCs ) and adult bone marrow long term cultures ( BM LTCs ) , but also in the stromal cell lines MS 5 and PA 6 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analysis by reverse transcription polymerase chain reaction demonstrated the presence of the c met gene , the receptor for HGF , in all three cell types . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The pleiotropic effects of HGF are mediated by its binding to a specific high affinity receptor , c Met . ^^^ Although co incubation of HGF with sulfated compounds that enhanced HGF dependent mitogenesis did not alter the binding isotherm of HGF for the c Met receptor in a solid phase assay , an increase in autophosphorylation of the c Met receptor in intact A 549 cells was observed upon their addition . ^^^ These findings indicate that heparin like molecules can stabilize HGF oligomers , which may facilitate c Met receptor dimerization and activation . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although c met protein was expressed in the cytotrophoblast , this receptor was not detectable in the syncytiotrophoblast by immunohistochemical methods . c met mRNA was detected in placental cell line ( tPA 30 1 ) and 4 choriocarcinoma cell lines ( BeWo , Jar , Jeg 3 , and NUC 1 ) , but HGF mRNA was absent in these cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of phospholipase C gamma in c met / HGF receptor stimulated hepatocytes : comparison with HepG 2 hepatocarcinoma cells . ^^^ The results suggests that PLC gamma in normal hepatocytes was activated by HGF through tyrosine kinase of HGF receptor . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , signal for the c met proto oncogene encoding the HGF receptor is not detectable in the limb bud at stages 17 to 24 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A gene for the HGF receptor , c met , is detected in the intestinal tract and the liver , as well as in gastric carcinoma cells . ^^^ The purpose of the present study was to elucidate the effects of HGF on the morphogenesis of cultured gastric mucosal cells and to evaluate the role of HGF and c met in the healing process in rat gastric mucosa . ^^^ HGF messenger RNA was not detected , but c met was expressed in the mucosa . ^^^ These results indicate that HGF plays important roles in the morphogenesis of gastric mucosal cells and that the HGF receptor gene participates in the healing process of gastric mucosa . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| After ligand induced tyrosine phosphorylation , the HGF receptor associates with the Shc adaptor , via the SH 2 domain . ^^^ Site directed mutagenesis of the HGF receptor indicates that phosphotyrosines Y1349VHV and Y1356VNV can work as docking sites for Shc . ^^^ After stimulation of the HGF receptor , Shc is phosphorylated on Y317VNV , generating an high affinity binding site for Grb 2 ( Kd = 15 nM ) . ^^^ This duplicates the high affinity binding site for Grb 2 present on the HGF receptor ( Y1356VNV ) . ^^^ These data show that Shc is a relevant substrate of the HGF receptor , and works as an ' amplifier ' of the motogenic as well as of the mitogenic response . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis confirmed the expression of specific HGF receptor mRNA ( c met ) by gastric epithelial cells but not by gastric fibroblasts . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The supposed mitogenic effect of HGF was analyzed by comparing c met pp overexpression with the Ki 67 index , whereas anti OV 6 antibody was used for comparison with the presence of OCs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recently the HGF receptor , c met protooncogene product , has been shown to be expressed in developing limb buds ( Sonnenberg , E . , D . ^^^ The responsiveness of chondrocytes to HGF / SF was also supported by the observation that they expressed the HGF / SF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analyses using Northern blot and RT PCR revealed that HGF mRNA was expressed only in mesenchymes but not in epithelia of the gastro intestinal tract while expression of c met ( HGF receptor ) gene was observed in both tissues . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation and immunoblotting of HGF receptor / c met showed that c met is expressed at high level in SP 1 cells , and is phosphorylated following HGF ligation . ^^^ Furthermore , the mitogenic effect of 3T3 L 1 CM requires HGF receptor ligation and activation of tyrosine kinase signaling cascades in SP 1 cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The crucial step for HGF activation is the extracellular hydrolysis of the Arg 494 Val495 bond , which converts pro HGF into alpha beta HGF , the high affinity ligand for the Met receptor . ^^^ On the cell membrane , the uPA HGF complex was bound to the Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c MET oncogene encodes the receptor for the Hepatocyte Growth Factor / Scatter Factor ( HGF ) , a cytokine that stimulates the invasive growth of normal and neoplastic cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / SF receptor mRNA was detected in both HME and HMS cells . mRNAs were also detected in normal breast and breast carcinoma tissues , as well as breast carcinoma and transformed breast epithelial cell lines . ^^^ Alternative cDNA sequences that are predicted to code for a soluble KGF receptor and a membrane bound , truncated HGF / SF receptor were detected in breast epithelial cells and breast tissues . ^^^ Reverse transcriptase polymerase chain reaction and hot blotting were used to detect HGF , HGF / SF ( met ) receptor , KGF , and KGF receptor mRNAs in human mammary epithelial ( HME ) and stromal ( HMS ) cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| All other growth factors and their receptors examined ( TGF alpha , EGFR , c met and c erbB 2 ) remained constant and were not affected by HGF treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Rat Schwann cells express c met mRNA , encoding the HGF receptor , but not HGF mRNA , implying that HGF might act as a paracrine Schwann cell growth factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF is a member of a structural family distinct from the chemokines , whose only known receptor is the tyrosine kinase c Met . ^^^ HGF induces tyrosine phosphorylation on T cells apparently via a distinct receptor , since no c Met is detectable by surface staining , PCR , or anti phosphotyrosine immunoprecipitation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In quiescent mIMCD 3 cells , the high affinity receptor for HGF , c met , was expressed in a nonphosphorylated state . ^^^ Thus mIMCD 3 cells , which undergo HGF dependent mitosis , scattering , and branching tubulogenesis , express the c met receptor in a highly regulated state and therefore should make an excellent model for examining the mechanisms of HGF dependent tubulogenesis in the renal collecting duct . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Strong homology exists in the primary structure of HGF among the three species of mouse , rat and human ( more than 90 % ) , especially in Kringle 1 of the alpha chain which is assumed to be an essential domain for binding of HGF to its receptor , c MET , a proto oncogene product . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The results suggest a model of transactivation cascade for HGFR such as interleukin 6 receptor ( IL 6R ) , IL 3R , GM colony stimulating factor receptor ( GM CSFR ) , and erythropoietin receptor ( EpR ) , whereby each HGF upmodulates the R ( s ) for distal acting HGF ( s ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor for HGF has been identified as the product of the oncogene c met , raising the possibility that this gene plays a key role in facilitating cellular invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This procedure also released HGF from the c Met protein , which is a component of the high affinity receptor . ^^^ In addition , heparitinase digestion of hepatocytes reduced the HGF bound to c Met protein . ^^^ Furthermore , excess heparin added during the binding of 125I HGF to hepatocytes , significantly diminished HGF bound to c Met protein . ^^^ These results suggest that HGF is bound to c Met protein and that its mitogenic activity is regulated by heparin like molecules on hepatocytes . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tyrosines 1234 1235 are critical for activation of the tyrosine kinase encoded by the MET proto oncogene ( HGF receptor ) . ^^^ In stable transfectants expressing the HGF / SF receptor with single substitution of either Tyr 1234 or Tyr 1235 the response to HGF / SF was impaired . ^^^ These data show that Tyr 1234 and Tyr 1235 are critical for the activation of the HGF / SF receptor kinase both in vitro and in response to the ligand in intact cells . . ^^^ The tyrosine kinase encoded by the MET proto oncogene ( p190MET ) is the receptor for Hepatocyte Growth Factor / Scatter Factor ( HGF / SF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Because both the cytokine and receptor are found in the gastrointestinal tract , we have studied the effects of HGF / SF on transformed gut epithelial cells which express c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Structure , biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells . ^^^ The p190MET HGF receptor is expressed in several epithelial tissues and it is often overexpressed in neoplastic cells . ^^^ HGF is the ligand for p190MET , the receptor tyrosine kinase encoded by the MET proto oncogene . ^^^ This was proved by HGF binding to immunopurified p190MET , chemical cross linking of radiolabelled ligand , HGF induced tyrosine phosphorylation of p190MET , and reconstitution of high affinity binding sites for HGF into insect cells infected with a recombinant baculovirus carrying the human MET cDNA . p190MET is a 190 kDa heterodimer of two ( alpha beta ) disulfide linked protein subunits . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Cross linking studies demonstrated that the truncated molecule competes with HGF for binding to the c met proto oncogene product . ^^^ HGF mediates its effects by activation of a membrane spanning tyrosine kinase , recently identified as the met proto oncogene product . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of c met mRNA correlated well with the existence of a high affinity HGF receptor . ^^^ Scatchard analysis of specific binding of [ 125I ] HGF revealed expression of a high affinity HGF receptor on NFS 60 and DA 3 cells , but not on FDC P 1 cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This is consistent with data indicating that one of the HGF receptors is identical to the c met protooncogene product , which is known to possess TK activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These marked increases in HGF mRNA and HGF activity and the concomitant down regulation of HGF receptor occurred before the marked compensatory DNA synthesis in bronchial and alveolar epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c met proto oncogene product was recently identified to be an HGF receptor . ^^^ Transfection of c met cDNA into COS cells provided further evidence that the c met product is a functional high affinity receptor for HGF capable of transducing the mitogenic signal of HGF . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hematopoietic growth factor ( HGF ) dosages inducing peak clonogenetic effects are associated with partial / subtotal occupancy of the homologous HGF receptor ( HGFR ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These various biological activities of HGF are presumably transduced through the same receptor , c Met , which is a member of the tyrosine kinase receptor family . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| On the other hand , the uptake clearance by PC fell on coadministering an excess ( 80 micrograms / kg ) of unlabeled HGF , while no change was observed for NPC , indicating that a saturable process for the hepatic handling of HGF exists only in PC where the HGF receptor is expressed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analyses of cross linking of HGF to the receptor indicated that the antisense oligonucleotide inhibited the downregulation of HGF receptor subsequent to HGF addition . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor mRNA is detected in the mesoderm of the headfold stage and persists in myocardial precursors of the ventricles and atria ( but not in the outflow tract smooth muscle cells ) through the 14 somite stage at approximately 8 . 75 days after fertilization ( day E8 . 75 ) . ^^^ At the headfold stage , between E7 . 5 and E8 . 0 , HGF receptor mRNA was detected in myocardial cells before fusion at the ventral midline . ^^^ HGF ligand and receptor mRNA transcripts are coexpressed in the embryo , except in the headfold state ( when only the HGF receptor can be detected ) and in the heart at the 14 to 18 somite stage ( when only HGF ligand can be detected ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The TGF alpha receptor EGFr appears primarily to mediate a proliferative signal , whereas mitogenic , motogenic , and morphogenic effects have been attributed to activation of the HGF receptor Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The developmental profile of the expression of the genes for the two growth factors and their receptors were different , indicating a difference in their roles ; the genes for HGF and c met , the receptor for HGF , are expressed mainly during the morphogenetic period , while the genes for KGF and its receptor mainly after the morphogenetic period . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These results make HGF the most potent defined mitogen for human thyrocytes to date , and suggest that upregulated HGF / met signalling may confer a significant growth advantage even in neoplastic thyroid cells , consistent with the finding of increased met expression in many thyroid carcinomas . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We show that the HGF receptor is expressed by human primary osteoclasts , by osteoclast like cell lines , and by osteoblasts . ^^^ In osteoclasts , HGF receptor activation is followed by increase in intracellular Ca2+ concentration and by activation of the pp60c Src kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemically , HGF , as well as the HGF receptor ( the met gene product ) , localized to significantly more rheumatoid synovial tissue lining cells than normal lining cells ( P < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although HGF elaboration and action generally follow a paracrine model , chondrocytes appear capable of both expressing and responding to HGF . mRNA encoding the HGF receptor ( c met ) was detected in both growth cartilage and derived chondrocyte cultures . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| STK / RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family . ^^^ Mutations at two C terminal tyrosine residues , Y 1330 and Y 1337 , in the counterpart of the multifunctional docking site of the HGF receptor abolished both MSP induced growth and apoptosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis showed that the contents of mRNAs for transforming growth factor alpha ( TGF alpha ) and c met / hepatocyte growth factor ( HGF ) receptor increased with BBN treatment . ^^^ A rat bladder tumor cell line , NBT 2 , expressed both TGF alpha and c met mRNAs , and HGF showed apparent scattering and growth stimulating effects on the cells . ^^^ These results indicate the possibility that TGF alpha produced by a bladder cancer , in addition to urinary EGF , plays a role in the development of bladder cancer , and that enhanced cell motility due to activation of the c met / HGF receptor participates in the invasion and metastasis of the cancer cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The interaction between cell adhesion molecules in the c met overexpressed tumor cells and HGF from activated fibroblast may be involved in the progression and the morphogenesis of stomach cancer . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| On the other hand , HGF receptor was identified as the product of the c met proto oncogene , which encodes a 190 kDa transmembrane protein possessing tyrosine kinase domain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of brush border antigen as well as molecular markers of kidney differentiation Wt 1 , Lim 1 , Hgf and c met , c ret , Shh , Wnt 4 , Wnt7b , and Wnt 11 were analyzed in explants by whole mount and tissue section in situ hybridization following 1 9 days in culture . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Furthermore , macrophages expressed the transcript of HGF receptor encoded by the MET proto oncogene and migrated after HGF challenge . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In mice , HGF and c met ( its receptor ) mRNA are coexpressed in the fetal liver in the middle and late stages , when hemopoiesis is most active . ^^^ HGF and c met mRNA are also expressed in the stromal cells of both fetal liver and bone marrow . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Its receptor , RON tyrosine kinase , is a new member of the HGF receptor family . ^^^ Here we show that in contrast to the HGF receptor , which was expressed at the basolateral surface , RON was localized at the apical surface of ciliated epithelia in the airways and oviduct . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By selecting appropriate phenotypic criteria it will be possible to further dissect the stem cell compartment and eventually establish the , possibly heterogeneous , HGF receptor phenotype of pluripotent stem cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| BM stromal cells were shown to constitutively produce HGF and also to express the c MET / HGF receptor . ^^^ In addition , expression of c MET on the stromal cells suggests the presence of an autocrine mechanism , operating through HGF , among stromal cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A member of the Met / HGF receptor family is expressed in a BMP 4 like pattern in the ectoderm of Xenopus gastrulae . ^^^ Sequence comparison of XHR with other members of the Met / HGF receptor family as well as in situ expression analyses suggest that XHR represents a novel member of this family of receptor type tyrosine kinases . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Involvement of HGF and its receptor ( c met ) is evident in animal models of acute lung injury produced by hydrochloride inhalation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| TGF beta and HGF were detected in the gastric fibroblast derived CM , and TGF beta receptor and C met ( HGF receptor ) were expressed on OCUM 2D cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of HGF and c met / HGF receptor mRNA in brains of normal rats and in phaeochromocytoma cells PC 12 of rats treated with NGF ] . ^^^ Gene expression of HGF and c met proto oncogene was examined during rat brain development and in cultured PC 12 cells , using reverse transcriptase ( RT ) polymerase chain reaction ( PCR ) technique . ^^^ The both mRNAs of HGF and c met proto oncogene were remained at low levels in the middle and late stages of gestation ( E 13 and E 18 ) . ^^^ Both HGF mRNA and c met photo oncogene mRNA were transiently expressed between day 2 and day 5 , and disappeared in cultured PC 12 cells treated with NGF . ^^^ The neurites of PC 12 cells that were treated with anti sense oligonucleotides of HGF and c met proto oncogene , were shorter and fewer in number than untreated control cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor family : unconventional signal transducers for invasive cell growth . ^^^ The HGF receptor family includes tyrosine kinases encoded by three oncogenes : MET , SEA and RON . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Several growth factors ( TGF alpha , HGF ) and their receptors ( EGFR , MET , ERBB 2 ) were expressed in the primitive IBS cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met / Hepatocyte Growth Factor ( HGF ) receptor tyrosine kinase is oncogenically activated through a rearrangement that creates a hybrid gene Tpr Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor , the product of the c met protooncogene , is expressed mainly by epithelial cells . ^^^ Increased expression of the HGF receptor has been observed in various tumors . ^^^ To investigate the expression of the HGF receptor in the pancreas , we analyzed rat and human normal tissue and pancreatic carcinoma by Western blot analysis . ^^^ In summary , our results demonstrate strongly increased HGF receptor expression in pancreatic carcinoma and support the assumption that HGF could act as a growth promoting factor on this cancer via stimulation of tyrosine kinases . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Although the signaling of HGF is mediated through the cell membrane receptor c Met , the molecular mechanism of downstream signal transduction remains obscure . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of the c Met / HGF receptor in human breast carcinoma : correlation with tumor progression . ^^^ Hepatocyte growth factor / scatter factor ( HGF / SF ) induces cell motility and tissue remodeling of various epithelial cells through its receptor , the product of the proto oncogene c met . ^^^ In an analysis of a panel of human breast carcinoma cell lines , we found that moderately differentiated cell lines did not express detectable levels of c Met and were not responsive to HGF . ^^^ Sensitivity to HGF / SF also correlated with expression of the c Met 9 kb mRNA . ^^^ When the moderately differentiated and c Met negative T47D cell line was transfected with c DNA for c met , the transfectants showed delayed cell scattering and migratory response to HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Basolateral rhHGF treatment produced a decrease in HGF receptor ( c met ) expression but had no effect on c met mRNA levels . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor was tyrosine phosphorylated in all cell lines , indicating that it is functionally active and capable of signaling events . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , the localization of HGF mRNA and c met protein was analyzed using in situ hybridization and immunohistochemical staining , respectively . ^^^ HGF mRNA was localized to placental mesenchymal cells , whereas c met protein was demonstrated on cytotrophoblast . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This brief overview begins with an introduction of the major principles of HGF receptor signaling : this is followed by a discussion of the consequences of HGF receptor signaling defects for the development of disorders of the hematopoietic system and the presentation of clinical examples of such diseases . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mitogenic activity of HGF is mediated by its binding to a high affinity receptor , c Met . ^^^ The binding of HGF to heparin or heparin like molecules may induce oligomerization of HGF and facilitate c Met dependent mitogenesis [ Zioncheck et al . ( 1995 ) J . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / SF signals through its receptor which is coded by the c met proto oncogene . ^^^ We hypothesized that altered expression of the HGF / SF receptor , c met , may be involved in the pathogenesis of certain renal cell carcinomas . ^^^ Future studies should evaluate the biological significance of the HGF / SF c met pathway in normal renal physiology , and renal cancer growth and progression . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Seven primary culture lines all expressed c met and HGF mRNA , and secreted HGF . ^^^ Expression of HGF and Met increased with malignant progression of gliomas , suggesting that gliomas stimulated their invasive proliferation by autocrine HGF production . ^^^ Neurons and vasculature were HGF positive , and Met positive glioma cells gathered around them . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To understand the regularity of changes of gene expression about HGF and its receptor ( HGFR ) in experimental hepatomas model of Wistar rats and the relationship between this change and tumor biological behaviour . ^^^ METHODS : The gene expression of HGF and HGFR in the canceration course of rats was determined by using experimental hepatomas model of Wistar rats established by diethylnitrosamine ( DENA ) , with digoxigenin labled probe . ^^^ RESULTS : The positive expression of HGF and HGFR was found in rats liver tissues , but it was different in distinct stages . ^^^ CONCLUSIONS : There are close relations between the gene expression of HGF and HGFR and evolution course during the canceration of rats liver . ^^^ HGF and HGFR systems play an important role in regulating tumor growth and metastasis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the present study , we observed HGF and mRNA expression in human endometrium and mRNA expression in cultured endometrial epithelial cells of the c met gene by reverse transcription polymerase chain reaction and Southern blot hybridization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , since neither the HGF nor c met `` knockout ' ' mice show abnormal kidney branching morphogenesis , we sought to analyze the relative importance of HGF in in vitro branching morphogenesis compared with other factors secreted by the embryonic kidney . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The MET oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor / scatter factor ( HGF ) , known to stimulate invasive growth of epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| During lung development , HGF and its receptor , c Met , are expressed in close proximity in mesenchymal cells and epithelial cells , respectively . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this work we have isolated , characterized and used as agonists two monoclonal antibodies ( mAbs ) directed against the extracellular domain of HGF receptor to investigate the requirements for receptor activation and for the different biological responses . ^^^ Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor tyrosine kinase works through a Src homology ( SH 2 ) docking site that can activate several signalling pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the HGF receptor , encoded by the c MET protooncogene ( Met receptor ) , triggers motility , matrix invasion and branching morphogenesis in epithelial cells . ^^^ Gab 1 coupling to the HGF / Met receptor multifunctional docking site requires binding of Grb 2 and correlates with the transforming potential . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Both the EGF R and the c met proto oncogene receptor , to which HGF binds , were immunoprecipitated from H 441 cells . ^^^ Incubation with HGF resulted in phosphorylation of its c met proto oncogene receptor in type 2 and H 441 cells , and also increased cell number and tritiated thymidine incorporation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The present study investigated the effects of HGF on the proliferation and ionic currents of two human gastric adenocarcinoma cell lines , which were found to express different amounts of HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A Western blot analysis demonstrated higher levels of 190 kDa c MET product ( HGF receptor ) of GB d 1 , GB h 3 and GB d 2 than that of FU GBC 1 . ^^^ These results thus suggest that , in addition to the importance of the proteolytic activity , the cellular motility induced via the HGF / HGF receptor system is essential for the invasive progression of gallbladder carcinoma cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The effect of HGF on in vivo DNA synthesis in these cells and also its effect on tyrosine phosphorylation of the HGF receptor protein ( c Met ) in liver carcinoma were examined . ^^^ Tyrosine phosphorylation of c Met by HGF was analyzed by Western blot . ^^^ Tyrosine phosphorylation of c Met in carcinoma cells was unaffected by HGF administration . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These results indicate that HGF likely stimulates lipid biosynthesis and lipoprotein secretion in hepatocytes through its tyrosine kinase associated receptor , c met , and accelerates the progress of cell maturation in liver regeneration . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , the presence of local HGF system ( HGF and its specific receptor , c met ) was observed in EC and VSMC of rat and human in vitro as well as in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of the HGF receptor c met proto oncogene ( c met ) by Western blot analysis , and also determined the effects of HGF on cell scattering , and the mechanisms of invasion and proliferation , by microscopic observation , the matrigel invasion chamber assay , and the MTT assay . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In concurrence with these findings , PB down regulated expression of the HGF receptor ( c met ) and suppressed production of the autocrine growth factor transforming growth factor alpha ( TGF alpha ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF initiates its biological effects by interaction with specific transmembrane receptors , the c Met proto oncogene , possessing an intracellular tyrosine kinase domain . ^^^ Consistent with the known tyrosine kinase activity of the c Met receptor , the mitogenic and motogenic effects of HGF were inhibited by PTKIs in a dose dependent manner with the following order of potency : geldanamycin > herbimycin A > genestein > MDC . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mitogenic effects were not related to the ras genotype of these cell lines , but the inhibitory effect was more commonly observed in cell lines with relatively high levels of Met / HGF receptor ( HGFR ) expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation was performed with antisera to signal transducers and activators of transcription 1 ( STAT 1 ) , STAT 3 , Janus kinase 1 ( Jak 1 ) , Shc , Grb 2 , Sos 1 , and HGF receptor ( met ) . ^^^ Phosphorylated HGF receptor coimmunoprecipitated with Shc , Grb 2 , and Sos 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c met and fibronectin expression . ^^^ Interestingly , both c met transcript and c met protein were increased in HGF transfected cells , suggesting that HGF amplifies its own action via stimulation of c met expression . ^^^ Autocrine expression of HGF and c met in renal epithelial cells also stimulated fibronectin gene expression , which was totally blocked by incubation with a neutralizing anti HGF but not a pan specific anti TGF beta antibody , suggesting that it is independent of TGF beta production . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| All these cells expressed c Met , the membrane receptor for HGF , and their c Met would be activated to be phosphorylated upon addition of HGF . ^^^ In conclusion , HGF could stimulate the growth of certain human hepatoma cells , probably through activation of c Met and MAPKs . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To investigate the intracellular signal pathways after activation of the HGF receptor c Met in primary cultured rat neocortical cells , in vitro kinase assays were performed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analysis was used to examine HGF expression in theca cells and the HGF receptor ( HGFR or c met ) in granulosa cells . ^^^ Both HGF and HGFR were detected throughout follicular development in small ( < 5 mm ) , medium ( 5 10 mm ) , and large ( > 10 mm ) sized follicles . ^^^ Steady state levels of HGF and HGFR mRNAs were determined using sensitive quantitative RT PCR assays . ^^^ Developmental regulation of HGF in theca cells and HGFR in granulosa cells was analyzed in freshly isolated small , medium , and large sized follicles . ^^^ Observations demonstrate that expression of HGF ( in theca cells ) and HGFR ( in granulosa cells ) was highest in large sized follicles . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , the presence of local HGF system ( HGF and its specific receptor , c met ) was observed in vascular cells and cardiac myocytes in vitro as well as in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor , the Met tyrosine kinase , both in vivo and in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive HGF was observed in the conditioned medium of MC , but not epithelial cells , while the specific receptor of HGF , c met , was expressed in epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Reiterated selection in vivo of B 16 murine melanoma cells for enhanced liver metastatic ability yielded a cel line ( B 16 LS9 ) dramatically overexpressing a constitutively active hepatocyte growth factor / scatter factor ( HGF / SF ) receptor , the product of the c met proto oncogene . ^^^ Most likely because of their overexpressing c met , B 16 LS9 cells appear to be more responsive than parental B 16 F1 cells to HGF stimulation , in terms of motility , invasion , and growth . ^^^ In fact , while MSH induces , at the transcriptional level , an increase in the production of both c met and tyrosinase , HGF / SF , in contrast , promotes a decrease in the expression of both c met and tyrosinase , however at a posttranscriptional level . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It has become clear that papillary carcinomas of the thyroid often express the receptor for c Met / hepatocyte growth factor ( HGF ) receptor , but little is known about the role of the HGF and c Met system in the pathogenesis of thyroid carcinoma . ^^^ In this study , the expression of c Met / HGF receptor was evaluated in thyroid tissue by western blot and immunohistochemistry , and compared with the concentration of HGF . ^^^ The densitometrically measured expression of c Met had no relation to tumor stage in papillary carcinoma , but did correlate to the concentration of HGF in papillary carcinomas . ^^^ In conclusion , in thyroid lesions , c Met was highly expressed specifically in the cytoplasm of papillary carcinomas . c Met expression was not related to the aggressiveness of the tumor but was related to the concentration of HGF , which was probably derived from the stroma . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Regulation of the HGF receptor c met in the thyroid gland . ^^^ The biological and clinical significance of HGF and its receptor c met in the thyroid is currently under study . ^^^ We developed a quantitative differential RT PCR method in order to examine HGF receptor regulation using RNA of about 50 cells per analysis . ^^^ We conclude that expression of the HGF receptor is under control of paracrine growth factors activating tyrosine kinase dependent pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation and down regulation of the HGF receptor ( c Met proto oncogene product ) were observed for the cells from both monolayer and spheroid cultures , but Ras activation was partly blocked in spheroids . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Growth factors ( EGF , TGF alpha , HGF ) and growth factor receptors ( EGF R , c met , CCK ) are expressed at levels not found in the normal pancreas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Downregulation could also be observed for HGF receptor density in isolated liver plasma membrane , assessed by Western blot analysis by means of anti receptor antibody , 30 min after injection of excess unlabeled HGF , supporting the hypothesis that the overall elimination of HGF from the systemic circulation can be affected by a change in HGF receptor density on the liver cell surface . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The objective of the present study was to characterize the expression of two hepatotrophic growth factor / receptor systems [ transforming growth factor alpha / epidermal growth factor receptor ( TGF alpha / EGFR ) and hepatocyte growth factor / c met receptor ( HGF / c met ) ] , both of which are implicated in the development of human liver tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF activates its specific cellular receptor , c met , through an aggregation mechanism potentiated by heparan sulfate glycosaminoglycans . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study , the immunohistochemical localization of HGF and of its receptor , c Met , revealed that HGF was distributed in the proliferating mesenchymal cells in the dental papillae and that c Met was continuously expressed in the epithelial cells during the development of rat incisors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / NK4 competitively inhibited the binding of HGF to Met / HGF receptors on GB d 1 human gallbladder carcinoma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the corresponding receptors , only c met , the HGF binding protein , showed higher mRNA and protein levels , whereas the expression of the other receptors did not change . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It is a paracrine factor that is produced by mesenchymal cells ; epithelial and endothelial cells respond to HGF through its receptor , the c met protein . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Non cytotoxic concentrations of TAC 101 inhibited the JHH 7 invasion induced by HGF and down regulated the expression of c MET protein in a concentration dependent manner . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor mRNA and EGF receptor mRNAs were expressed at low levels in unwounded cornea epithelium . ^^^ Following scrape injury , expression of HGF receptor mRNA and KGF receptor mRNA were markedly upregulated in the corneal epithelium , while no significant increase in EGF receptor mRNA expression was noted . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF / SF ) signaling through the tyrosine kinase receptor , MET , is capable of promoting the proliferation , increasing the motility , and maintaining high tyrosinase activity and melanin synthesis of melanocytes in vitro . ^^^ To investigate whether HGF / SF MET signaling is involved in the development of neural crest derived melanocytes , transgenic embryos , ubiquitously overexpressing HGF / SF , were analyzed . ^^^ We utilized an in vitro neural crest culture assay to further explore the role of HGF / SF MET signaling in neural crest development . ^^^ To examine whether HGF / SF MET signaling is required for the proper development of melanocytes , embryos with a targeted Met null mutation ( Met / ) were analysed . ^^^ These results demonstrate that HGF / SF MET signaling influences , but is not required for , the initial development of neural crest derived melanocytes in vivo and in vitro . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In immunoblot analyses , c met protein ( a receptor of HGF ) was detected in the CD34+ / CD45+ cells , although the expression levels were different among samples . ^^^ Our present study suggests that stimulation of the HGF / c met signal is concomitant with induction of c met protein by SCF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the responses to HGF addition in fetal hepatocyte cultures were observed in terms of growth stimulation and down regulated of the Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of Met by its ligand HGF has been shown to elicit both mitogenic and motogenic responses in thyrocytes in vitro . ^^^ None of these cell lines expressed HGF mRNA , and addition of suramin did not affect the level of tyrosine phosphorylation of Met in unstimulated cells , suggesting the absence of autocrine stimulatory pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Differential signaling by alternative HGF isoforms through c Met : activation of both MAP kinase and PI 3 kinase pathways is insufficient for mitogenesis . ^^^ We studied postreceptor signaling by these HGF isoforms in the human breast epithelial cell line 184B5 , and in murine myeloid progenitor 32D cells transfected with c Met , the human HGF receptor ( 32D / c Met ) . ^^^ HGF stimulated DNA synthesis in 184B5 and 32D / c Met cells , while HGF / NK2 was mitogenically inactive , despite the ability of HGF / NK2 to stimulate c Met autophosphorylation , mitogen activated protein kinase ( MAPK ) , and phosphatidylinositol 3 kinase ( PI3K ) in both cell systems . ^^^ These data suggest that ( 1 ) alternative HGF isoforms signaling through c Met generate both common and distinct biological responses , ( 2 ) the extent and duration of ligand stimulated c Met and MAPK activities are dependent on the cellular context and are not predictive of mitogenic signaling , and ( 3 ) in at least some HGF target cells , the activation of both MAPK and PI3K signaling pathways is insufficient for mitogenesis elicited through c Met . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The plasma clearance of HGF became saturated as the steady state plasma concentration ( Cpss ) increased , but complete saturation was not achieved , even when the Cpss ( approximately 1000 pM ) was much higher than the dissociation constant for the HGF receptor ( 20 40 pM ) , which has been identified as one of the major clearance sites for HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , these cells express mRNA for both HGF and its receptor c MET , suggesting that this autocrine loop might contribute to the invasiveness of the tumour from which CAL 72 originated . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , hollow spheres showed intensive immunoreactivity for the HGF receptor ( c met ) and its ligand ( HGF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Transcription of HGF and its receptor , c met , was detected by reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In FHF rats , lack of regeneration of the residual liver was associated with delayed expression of HGF and HGF receptor c met and elevated blood HGF and TGF beta 1 levels . ^^^ The latter effect was associated with accelerated expression of HGF and c met mRNA in the liver and lowering of blood HGF and TGF beta 1 levels . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In stratified squamous epithelial cells , these receptors include epidermal growth factor receptor ( EGFR ) that binds both EGF and transforming growth factor alpha ( TGFalpha ) , and c met whose ligand is hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Changes in the expression of mRNAs of HGF , c met , TGF alpha , and epidermal growth factor receptor ( EGFR ) by treatment with HGF and TGF alpha were observed . ^^^ Treatment with HGF slightly enhanced the expression of c met mRNA only in COLO 357 cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor , c Met , was minimally phosphorylated in control livers , but a biphasic increase in phosphorylation was observed at 1 5 min after PHx and 60 min postsurgery . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Our results indicated that stimulation by CD 44 induces `` outside in signaling , ' ' which consists of a direct pathway via CD 44 and an alternate pathway through the induction of c Met expression via HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The epithelial cells of a proportion of ovarian tumours , and some ovarian carcinoma cell lines , express high levels of the HGF receptor , c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Moreover , the presence of a local HGF system ( HGF and its specific receptor , c met ) has been demonstrated in vascular cells both in vitro and in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Mandibular arches microdissected from mouse embryos at the 10th day of gestation were cultured for 10 days with or without HGF , HGF plus HGF receptor ( c met ) antisense oligodeoxyribonucleotide , or HGF plus c met sense oligodeoxyribonucleotide in the media . ^^^ The expression of intrinsic HGF and c met in the cultured mandibles was confirmed by reverse transcriptase polymerase chain reaction . ^^^ Furthermore , immunohistochemistry demonstrated that both HGF and c met were localized in areas of the mesenchymal tissue forming bone and cartilage . ^^^ Addition of c met antisense oligodeoxyribonucleotide partially inhibited the HGF induced enhancement of bone and cartilage formation , whereas addition of c met sense oligodeoxyribonucleotide had no effect . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor , c met , protein and mRNA , which were faintly expressed in hypoglossal neurons under normal conditions , gradually increased and reached maximal levels 2 weeks after the axotomy . ^^^ Administration of HGF reduced this c met upregulation almost to normal levels . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A mouse fibroblast line cycles between monolayer and spheroid forms , regulates Met and HGF expression , and releases an attachment and growth promoting substance . ^^^ Over time in culture , spheroids express increasing levels of met , the Met ligand SF / HGF and cytokeratin , an epithelial marker , in comparison to monolayers . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor is cMet , an oncogene , and it initiates tyrosine phosphorylation in cellular signal transduction . ^^^ Recently , proteasomes were found to degrade the HGF receptor , cMet . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the liver , both HGF in the hepatocytes and c met on the membrane of the hepatocytes were positive . ^^^ No HGF was detected but c met was clearly detected on the cell membrane of the hepatocytes . ^^^ HGF was positive in non parenchymal cells and c met was positive in the cytoplasm of the hepatocytes . ^^^ The HGF / c met system is thought to be involved in the mechanism of regeneration . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Involvement of the Met receptor in the HGF induced migratory response was suggested by the observation that the agonistic anti Met monoclonal antibody ( MAb ) DO 24 was equally effective . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| All the biological responses induced by HGF / SF are elicited by binding to its receptor , a transmembrane tyrosine kinase encoded by the MET proto oncogene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In Kupffer cell depleted mice , the number of HGF expressing cells decreased in the regenerating liver , and expressions of HGF and its receptor ( c met ) as well as other growth factors / cytokines were less prominent than in control mice . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : RT PCR was used to examine the expression of mRNA for eight growth factors ( EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 , beta 3 ) and two growth factor receptors ( KGFR and HGFR ) in human AM preserved at 80 degrees C for one month . ^^^ RESULTS : RT PCR revealed that human AM expresses mRNA for EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 , beta 3 , KGFR and HGFR , while ELISAs showed that it contains EGF , TGF alpha , KGF , HGF , bFGF , TGF beta 1 , beta 2 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor / Scatter Factor ( HGF / SF ) is a heterodimeric molecule that plays a key role in the regulation of migration , invasion and angiogenesis in cancer , via activation of its receptor , c met . ^^^ HT 115 cells were shown to express the HGF / SF receptor mRNA and protein . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The possibility that HGF / Met interaction has a biological role in vivo was investigated in serial sections of six tumors immunostained for CD1a+ , Met protein , and HGF . ^^^ It was found that all six tumors were intensely and diffusely positive for Met protein , that HGF staining was present in tumor cells of the advancing edge , and that HGF+ / Met+ tumor cell nests were infiltrated by CD1a+ dendritic cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF was expressed in the branchial arches , whilst Met , which encodes an HGF receptor , was expressed by subpopulations of cranial motor neurons . ^^^ Mice with targetted disruptions of HGF or Met showed defects in the navigation of hypoglossal motor axons into the branchial region . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor directly activates PI 3 kinase , Ras and STAT signalling pathways and phosphorylates the adaptator GRB 2 Associated Binder 1 ( Gab 1 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Next , we investigated in vivo expression of VEGF receptor 2 and HGF receptor in retrolental membranes from 16 patients with stage 5 ROP . ^^^ Both VEGF receptor 2 and HGF receptor proteins were detected mainly in posterior portions of the membrane as well as in vessel walls and along the retinal interface where angiogenesis was active . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Upregulation of HAI 1 may serve to downregulate the proliferative response after initial activation of MET receptor by HGF / scatter factor after an injury . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocellular carcinoma ( HCC ) often metastasizes , and the c Met / HGF receptor is highly expressed by HCC cells . ^^^ The aim of this study was to investigate the signaling pathways associated with the motogenic effect of HGF on HCC cells via c Met . ^^^ HGF stimulated the motility of Hep3B , HepG 2 , and Huh 7 cells in a dose dependent manner in association with tyrosine phosphorylation of c Met and activation of phosphatidylinositol 3 kinase ( PI 3 K ) . ^^^ These results indicate that HGF stimulates the migration of HCC cells through the tyrosine phosphorylation of c Met via activation of PI 3 K . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We previously demonstrated that the specific HGF receptor , MET , is induced in stimulated peripheral blood monocytes . ^^^ After stimulation of MET expressing monocytes with recombinant HGF , the gene expression profile of peripheral blood mononuclear cells and monocytes was significantly modulated , especially with regard to genes involved in cell movement . ^^^ The HGF activated invasiveness and the altered gene expression profile suggest a proinflammatory role for HGF stimulation of monocytes and support the hypothesis that the HGF / MET signaling system plays an important part in the activation of the nonspecific cellular inflammatory response . ( Blood . 2000 ; 95 : 3964 3969 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : During the first week after BDL , there was marked upregulation of IL 6 mRNA and protein in the IL 6+ / + mice only in the vicinity of the biliary tree ; whereas , biliary / peri biliary IL 6R , HGF and met mRNA and protein increased in both groups . ^^^ IL 6 , HGF mRNA and protein localized to periductal inflammatory cells and stellate cells , while met and IL 6R protein were upregulated in the BEC and , to a lesser extent , in hepatocytes . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In both the CCs and BECs , exogenous HGF or IL 6 induced phosphorylation of met or gp 130 , respectively , and a concentration dependent increase in DNA synthesis . ^^^ However , the CCs but not BECs , continued to grow in basal serum free medium ( SFM ) and spontaneously produced both IL 6 and HGF under these conditions , which resulted in auto phosphorylation of gp 130 and met , respectively ; and neutralizing anti HGF or anti IL 6 alone inhibited CC growth , indicative of autocrine growth control circuits . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Similarly , in rat cardiac fibroblasts , HGF inhibited the expression and production of TGF beta , whereas HGF upregulated its specific receptor , c met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also used RT PCR to analyze the expression patterns of the four tyrosine kinase FGF receptors ( FGFR 1 FGFR4 ) and of the HGF receptor ( c met ) in the myofiber cultures . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The morphogenetic capacity of HGF was assessed in collagen gel cultures , expression of the HGF receptor c Met by Western blot analysis , and cadherin expression by immunofluorescence microscopy . ^^^ There was no difference in c Met or E and P cadherin expression between C 4I and C 4II cultures , but the lines differed in their signal transduction responses to HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Studies investigating the growth factor requirements of committed progenitors have shown hypersensitivity to a number of haemopoietic growth factors ( HGF ) in vitro and several HGF receptor and signalling molecule alterations have been reported . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| CrkII was found to be phosphorylated in response to hepatocyte growth factor / scatter factor ( HGF / SF ) and to associate with the beta subunit of the HGF receptor ( MET ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In vitro , HGF can induce trophoblast DNA synthesis and the localization of HGF A to the peri villous trophoblast layer ( which expresses c met , the HGF receptor ) suggests that it may be responsible for activation of pro HGF at this site . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of c Met in developing rat hippocampus : evidence for HGF as a neurotrophic factor for calbindin D expressing neurons . ^^^ Here we show that c Met , the receptor for HGF , is expressed in developing rat hippocampus , with the highest levels during the first postnatal weeks . ^^^ Immunohistochemical studies showed that c Met , calbindin D and HGF immunoreactive cells are all present in the dentate gyrus and partly colocalize within neurons . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the expression of CD 44 HS on B cells strongly promotes HGF induced signaling , resulting in an HS dependent enhanced phosphorylation of Met , the receptor tyrosine kinase for HGF , as well as downstream signaling molecules including Grb 2 associated binder 1 ( Gab 1 ) and Akt / protein kinase B ( PKB ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : The level of activity of the HGF / c met axis was examined in rats following 5 / 6 nephrectomy at multiple time points . ^^^ RESULTS : An increase in renal and systemic production of HGF coupled with an increase in renal c met was observed in rats with remnant kidneys . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The Met receptor is widely expressed in embryonic and adult epithelial tissues ; its ligand ( hepatocyte growth factor / scatter factor , HGF / SF ) is expressed in the mesenchymal component of various organs . ^^^ The generation of hgf and met null mice has revealed an essential role for this ligand receptor pair in the development of the placenta , liver , and limb muscles . ^^^ Mice expressing a Met receptor with partial loss of signaling function survived until birth and revealed novel aspects of HGF / SF Met function during muscle development . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The inhibition of EGF and HGF receptor tyrosine kinase activity by lavendustin A was confirmed by Western blotting . ^^^ These data suggest that EGF and HGF reduce ET 1 release via EGF and HGF receptor tyrosine kinase activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of hepatocyte growth factor / scatter factor ( HGF / SF ) in the extracellular milieu is a critical limiting step in the HGF / SF induced signaling pathway mediated by Met receptor tyrosine kinase , which has potentially important roles in tumor biology and progression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Several lines of evidence indicate that hepatocyte growth factor / scatter factor ( HGF / SF ) and its receptor , c Met , may play an important role in progression of human glioma . ^^^ In this study , effects of HGF / SF on urokinase type plasminogen activator ( uPA ) mediated proteolysis network were examined in c Met positive human glioma cell lines . ^^^ Since concomitant expression of HGF and its receptor c Met are frequently observed in malignant gliomas , these results suggest that HGF / SF participates in invasive process of malignant glioma cells not only by its motility stimulating activity but also through enhanced degradation of the extracellular matrix induced by autocrine activation of uPA proteolysis network . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF activates the tyrosine kinase receptor c met , initiating a series of complex events that regulate cell morphology , cell cell interactions , and cell matrix interactions and eventually result in the formation of branching tubular structures . ^^^ In this study , we investigated whether formin is involved in the HGF / c met signaling pathway of in vitro tubulogenesis in renal epithelial cells . mIMCD 3 cells were analyzed by reverse transcription PCR and found to express formin 4 mRNA . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of HGF and c met mRNA in paired samples of first and second trimester fetal liver and placenta was compared using a quantitative ribonuclease protection assay . ^^^ RESULTS : HGF and c met mRNA were expressed at similar levels in liver and placenta , with expression increasing from 9 to 16 weeks ' gestation . ^^^ Fetal liver expresses abundant HGF mRNA during the first and second trimester and expression increases in line with receptor ( c met ) expression , suggesting that hepatic growth and development are independent of placental HGF . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF and VEGF activated the Met / HGF receptor and the KDR / VEGF receptor , respectively , whereas NK 4 inhibited HGF induced Met tyrosine phosphorylation but not VEGF induced KDR phosphorylation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Monocyte activation by endotoxin and IL 1beta results in the up regulation of the HGF receptor expression and in the induction of cell associated pro HGF convertase activity , thus enhancing cell responsiveness to the factor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| All five samples expressed IL 1alpha , 1beta , IL 6 , IL 8 , IL 11 , TGF beta 1 , PDGF A and aFGF , and receptors for EGF ( c erbB ) , KGF , HGF ( c met ) and IL 6 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Since autocrine regulation of HGF Met is implicated in many forms of human cancer , we investigated whether the predisposition to develop ovarian cancer in women with hereditary ovarian cancer syndromes involves changes in the expression of HGF Met by the tissue of origin of epithelial ovarian cancers , the ovarian surface epithelium ( OSE ) . ^^^ HGF and Met mRNA were concomitantly expressed by NFH OSE from only three of 32 women but in FH OSE from eight of 13 women , and also in five of five IOSE and two of three ovarian cancer lines . ^^^ The results show that FH OSE cultures differ from NFH OSE by increased stability of Met expression and by HGF secretion . ^^^ In analogy with other cell types where an autocrine HGF Met loop has been implicated in tumorigenic transformation , this change in FH OSE may play a role in the enhanced susceptibility to ovarian carcinogenesis in women with hereditary ovarian cancer syndromes . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Gab 1 phosphorylation : a novel mechanism for negative regulation of HGF receptor signaling . ^^^ Signal transduction by HGF receptor , the tyrosine kinase encoded by the MET oncogene , switches on a genetic program called ' invasive growth ' inducing epithelial cell dissociation , migration , growth , and ultimately leading to differentiation into branched tubular structures . ^^^ These data provide a novel negative mechanism for the HGF receptor signaling pathways and highlight a potentially useful target for inhibitors of invasive growth . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Many additional transcripts allied with groups 1 and 2 had known or proposed roles in kidney development and included LIM 1 , POD 1 , GFRA 1 , WT 1 , BCL 2 , Homeobox protein A 11 , timeless , pleiotrophin , HGF , HNF 3 , BMP 4 , TGF alpha , TGF beta 2 , IGF 2 , met , FGF 7 , BMP 4 , and ganglioside GD 3 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that sciatic nerve ligation induces an increase of the HGF receptor , c met , mRNA in the distal segment of the sciatic nerve to the ligation site and a delayed elevation in the proximal segment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Caco 2 cells were found to express HGF receptor but not HGF and to secrete several proteases , namely matrix metalloproteinase 1 ( MMP 1 ) , MMP 2 , possibly MMP 9 and urokinase plasminogen activator ( uPA ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In FHF rats , lack of hepatocyte proliferation was associated with delayed expression of HGF and HGF receptor c met . ^^^ Since the c met promoter region has Sp 1 binding sites , we decided to examine whether in FHF rats down regulation of c met is associated with decreased Sp 1 function and whether changes in blood HGF , IL 6 , and TGFbeta 1 levels might be responsible for these effects . ^^^ Additionally , the effects of treatment with TGF beta 1 , IL 6 , or a combination of both on c met expression and Sp 1 DNA binding were studied in HGF induced rat hepatocyte cultures . ^^^ This study suggests that following massive loss of hepatocyte mass in rats , early increase in blood IL 6 and TGFbeta 1 levels may weaken the expression of HGF receptor c met in surviving hepatocytes through suppression of Sp 1 DNA binding . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In kinetic studies , HGF downregulated c met protein / HGF receptor expression of adult monocytes in lower concentrations and at shorter incubation time as compared with that of cord blood . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We observed that increased HGF was correlated with higher levels of angiogenesis factors interleukin ( IL ) 8 and vascular endothelial growth factor ( VEGF ) in serum of patients with head and neck squamous cell carcinoma ( HNSCC ) as compared with that in normal volunteers and hypothesized that HGF may regulate angiogenesis factor production by tumor cells through the activation of its receptor c Met , which is expressed by HNSCC cells . ^^^ The increase in induction of these factors by HGF corresponded to an increase in phosphorylation of c Met in HNSCC . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We identified expression of c Met HGF receptor in adult cardiac myocytes , which can be rapidly tyrosine phosphorylated in response to HGF treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| ISH studies also revealed that fibroblasts at the wound edges and within the newly forming granulation tissue also expressed HGF and c met mRNA . ^^^ To begin to examine the involvement of HGF and MSP in healing of cutaneous wounds we have mapped the temporal expression of these two molecules and their receptors , MET and RON respectively , in adult rat excisional wounds . ^^^ The number of cells staining positively for HGF and MET significantly increased in response to wounding . ^^^ HGF staining and mRNA peaked at 7 days postwounding whereas MET was upregulated earlier , peaking after 3 days . ^^^ Both HGF and MET protein were observed in fibroblasts of the dermis and in the newly forming granulation tissue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By means of single and dual color FISH on metaphase , prometaphase , and interphase chromatin , 15 genes in rat Chr 4q11 q 23 ( Cdk 5 , Hgf , Dmtf 1 , Abcb 1 , Cyp 51 , Cdk 6 , Tac 1 , Asns , Cav 1 , Met , Wnt 2 , Cftr , Smoh , Braf , Arhgef 5 ) were mapped and aligned . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have fused the intracellular domain of the HGF receptor ( HGFR ) with three FK 506 binding protein ( FKBP ) domains and a membrane targeting signal . ^^^ We show that , in mouse hepatocyte progenitors , FKBP HGFR dimerization elicits the differentiative side of the HGF response , including cell scatter , morphogenesis , and protection from apoptosis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A signaling adapter function for alpha6beta4 integrin in the control of HGF dependent invasive growth . alpha6beta4 integrin and the Met receptor for HGF have been shown independently to promote invasive growth . ^^^ In carcinoma cells expressing Met alone , HGF does not exert significant biological effects . ^^^ Following Met activation , alpha6beta4 is tyrosine phosphorylated and combines with Shc and PI3K , generating an additional signaling platform that potentiates HGF triggered activation of Ras and PI3K dependent pathways . ^^^ In the presence of an alpha6beta4 mutant defective for Shc recruitment , Met can not sustain HGF mediated responses . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : The significant increase of HGF and c met expression suggests an essential role of this growth factor in the morphological changes during the development of chronic pancreatitis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Ganglioside GD1a inhibits HGF induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c Met . ^^^ The expression of the HGF receptor c Met on FBJ S 1 cells , FBJ LL cells , transfectants and a mock transfectant was almost the same . ^^^ The level of tyrosine phosphorylation of c Met after HGF stimulation in FBJ S 1 cells , GD1a pretreated FBJ LL cells and a GD1a expressing transfectant was significantly lower than in FBJ LL cells and a mock transfectant . ^^^ These findings suggested that GD1a inhibits the HGF induced motility of FBJ LL cells through suppression of tyrosine phosphorylation of c Met . ^^^ The c Met in the cells was autophosphorylated by stimulation with HGF , but after treating the cells with GD1a , the HGF induced autophosphorylation of c Met was suppressed . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| By immunocytochemical analysis , we demonstrated that c Met immunoreactivity was present in cultured OECs , and c Met anti serum significantly sequestered the activity of HGF on OECs proliferation , suggesting that HGF induced proliferation of OECs is mediated by the c Met receptor . ^^^ These results demonstrate that HGF is a novel mitogen for rat OECs in vitro , and HGF / c Met system is involved in regulating OECs growth and development . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also observed HGF and HGF receptor ( c met ) mRNA expression in cultured bovine endometrial stromal and epithelial cells by RT PCR . ^^^ RT PCR revealed that mRNA of HGF is expressed only in stromal cells , and that c met mRNA is expressed in both stromal and epithelial cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , HGF and c met ( HGF receptor ) mRNAs in HLMECs and HUVECs were examined by the RT PCR method . ^^^ HGF and c met mRNAs were clearly detected in HLMECs before and after treatment with IL 1beta , but not in HUVECs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| All melanocytic cells expressed the HGF receptor c Met , and autocrine HGF caused constitutive activation of c Met , MAPK and PI3K . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The expression of both HGF and its c met receptor genes is rapidly upregulated after acute renal injury induced by folic acid . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met tyrosine kinase , the receptor for HGF / SF , is important in various cellular functions , including proliferation , mitogenesis , formation of branching tubules , angiogenesis , and tumor cell invasion and metastasis . ^^^ However , the role of Met / HGF signaling pathway in nasopharyngeal carcinoma ( NPC ) has not been evaluated . ^^^ In this study , we determined the expression profile and clinical correlation of Met / HGF in 66 cases of advanced NPC and the activation mechanisms of Met receptor in five NPC cell lines . ^^^ All of the five NPC cell lines tested did not express hgf mRNA but expressed met mRNA , and tyrosine phosphorylation of Met protein was mainly induced by exogenous HGF stimulation in these cells . ^^^ These results indicate that : ( a ) high Met protein expression level correlates with poorer survival in late stage NPC and serves as an independent prognostic indicator ; and ( b ) the Met receptor in NPC is activated by its paracrine ligand HGF from the interstitial tissues rather than by an autocrine loop or its activating mutation . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To study expression of HGF and its receptor c Met , reverse transcription polymerase chain reaction ( RT PCR ) , Western blot analysis , and immunohistochemical staining were performed on eyes enucleated at 6 , 12 , 24 , 48 , and 96 hours after reperfusion . ^^^ RESULTS : RT PCR and Western blot analyses showed upregulation of HGF and c Met HGF receptor mRNA at 6 , 12 , 24 , and 48 hours after reperfusion , compared with the normal rat retina . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A proposed HGF antagonist , NK 4 ( an amino terminal kringle domain peptide of HGF ) , inhibits tumor growth / invasion through the competition of HGF binding to its receptor , c Met , and acts as an angiogenesis inhibitor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / NK1 , a splice variant of HGF / SF , has been reported to have either antagonistic or agonistic effects with regard to c Met signaling depending on the cell type . ^^^ Additionally , the dimerization of the HGF / SF receptor ( c Met ) by the ligand HGF / NK1 is facilitated by heparin and related sulfonated sugars on the cell surface , whereas heparin is not required for HGF / SF mediated dimerization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| High concentrations of HGF or overexpression of its cellular receptor c Met in cancer have been reported . ^^^ In addition , cells that expressed high levels of Ets 1 and c Met exhibited an extremely motile phenotype by HGF stimulation in vitro . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In support of this divergent effect of ERK on Gab1 / PI3K association following HGF and EGF stimulation , U 0126 decreased the HGF stimulated association of p 85 and the Gab 1 c Met binding domain but did not alter the EGF stimulated association of p 85 and the c Met binding domain . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that the SH 2 domain containing inositol 5 ' phosphatase ( SHIP ) 1 binds to c Met , and potentiated HGF mediated branching tubulogenesis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We investigated genomic amplification on chromosomes 7 and 8 by comparative genomic hybridization ( CGH ) and protein expression of relevant oncogenes ( EGFR , HGF , MET , CTSB , MYC ) by immunohistochemistry ( IHC ) in 22 esophageal and 22 gastric cardia carcinomas . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined interactions between cell signaling events elicited by HGF and the cytokine interleukin ( IL ) 4 , in the IL 3 dependent murine myeloid cell line 32D transfected with the human HGF receptor , c Met . ^^^ IL 4 did not enhance HGF dependent tyrosine phosphorylation of c Met or Shc . ^^^ IL 4 enhancement of HGF signaling was partially blocked in 32D / c Met cells treated with inhibitors of MEK 1 or c Src kinases , completely blocked by expression of a catalytically inactive mutant of Janus kinase 3 ( Jak 3 ) , and increased in 32D / c Met cells overexpressing STAT 6 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Importantly , HGF and its receptor c Met have been found to be associated with metastasis of human head and neck squamous cell carcinoma ( HNSCC ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These include alterations in DNA ploidy , cellular proliferation markers ( PCNA , Ki 67 , Mcm 2 , MIB 1 , MIA , and CSE1L / CAS protein ) , nuclear morphology , the p 53 gene and its related molecule MD M 2 , other cell cycle regulators ( cyclin A , cyclin D , cyclin E , cdc 2 , p 27 , p 73 ) , oncogenes and their receptors ( such as ras , c myc , c fms , HGF , c met , and erb B receptor family members ) , apoptosis related factors ( Fas and FasL ) , as well as telomerase activity . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The receptor of HGF is the product of c met proto oncogene with tyrosine kinase activity that mediates the transduction of multiple biological signals of HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| K252a inhibits the oncogenic properties of Met , the HGF receptor . ^^^ Here we show that nanomolar concentrations of K252a prevent HGF mediated scattering in MLP 29 cells ( 30 nM ) , reduce Met driven proliferation in GTL 16 gastric carcinoma cells ( 100 nM ) , and cause reversion in NIH3T3 fibroblasts transformed by the oncogenic form of the receptor , Tpr Met ( 75 nM ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Up regulation of transmembrane tyrosine kinase receptors c met , IGFR 1 , IGFR 2 and EGFR family related ligands such as HB EGF , TGFa , amphiregulin and neuregulin as well as c met ligand HGF point to a possible role of this system in metastasis . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF secretion by alveolar macrophages and the expression of the HGF receptor by alveolar epithelial cells in pulmonary fibrosis were also evaluated . ^^^ The expression of the HGF receptor was greatly increased in the fibrotic lung , supporting the local function of HGF secreted by neutrophils . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| IL 6 may act in cellular proliferation activating transduction signals and Ras / Map cascade or the HGF / c met axis . ^^^ The renal expression of c met ( Western Blot ) and circulating levels of HGF ( ELISA ) were also determined . ^^^ Gly ARF rats have high circulating levels of HGF that is targeted to act in the injured kidneys by the IL 6 overexpressed renal c met . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunostaining and Western blotting revealed expression of both HGF and the HGF receptor ( c Met ) by cultured oligodendrocytes . ^^^ These observations show that a functional HGF / c Met system is present in oligodendrocytes , which can influence the growth , development , and cytoskeletal organization of oligodendrocytes . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of HGF and c Met were examined by in situ hybridization , ELISA , or immunohistochemical staining . ^^^ RESULTS : After HVJ HGF gene transfer , endogenous HGF and c Met were up regulated in UUO kidneys . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte growth factor / scatter factor ( HGF ) and its receptor tyrosine kinase Met are key regulators of epithelial motility and morphogenesis . ^^^ Recent studies indicate that the HGF / Met pathway also plays a role in B cell differentiation , whereas uncontrolled Met signaling may lead to B cell neoplasia . ^^^ These observations prompted us to explore HGF / Met signaling in B cells . ^^^ In addition , we demonstrate that c Cbl mediates HGF induced ubiquitination of Met . ^^^ Our findings identify c Cbl as a negative regulator of HGF / Met signaling in B cells , mediating ubiquitination and , consequently , proteosomal degradation of Met , and suggest a role for Cbl in Met mediated tumorigenesis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In subtypes of ameloblastomas , reduced expression of HGF , c Met and TGF beta and increased reactivity for TGF beta receptors were detected in keratinizing cells in acanthomatous ameloblastomas , and granular cells in granular cell ameloblastomas demonstrated little or no expression of HGF , TGF beta or their receptors . ^^^ Activated HGF / c Met pathway and reduced TGF beta signaling in CCOTs and ameloblastic carcinomas may be associated with the malignant potential of these epithelial odontogenic tumors . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , the specific HGF receptor , c met , was also increased by PGI ( 2 ) treatment . ^^^ Overall , this study demonstrated that treatment with a PGI ( 2 ) analogue restored endothelial dysfunction in DM rats , accompanied by the induction of vascular HGF and c met expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Deregulation of cell turnover occurs in these organs , with enhanced proliferation in cystic epithelium , accompanied by PAX 2 , BCL 2 and HGF receptor expression , and apoptosis in surrounding mesenchyme , which transdifferentiates under the influence of transforming growth factor beta 1 into smooth muscle instead of forming nephrons . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MG 63 cells also express HGF receptor ( c Met ) mRNA , suggesting an autocrine action of HGF . ^^^ Nonneutralized cells displayed constitutive phosphorylation of c Met and the mitogen activated protein kinases mitogen / extracellular signal regulated kinase ( MEK ) 1 and extracellular signal regulated kinase ( Erk ) 1 / 2 , which were inhibited by anti HGF antibody . ^^^ Addition of HGF to MG 63 cells treated with neutralizing HGF antibody induced rapid phosphorylation of c Met , MEK 1 , and Erk1 / 2 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Analysis of IGF 1 receptor ( IGF IR ) and HGF SF ( c met ) receptor expression showed significantly higher expression of both receptors in normal liver compared with an HCC specimen . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Binding of InlB to the HGF receptor results in mitogen activated protein ( MAP ) kinase and phosphoinositide 3 kinase activation , followed by changes in the organization of the actin cytoskeleton . ^^^ Whereas stimulation with equivalent concentrations of HGF and InlB elicits similar activation of the HGF receptor , we observed striking differences in downstream activation of MAP kinase . ^^^ The leucine rich repeat region , which was previously shown to be sufficient for binding and activation of the HGF receptor , lacks the ability to super activate the Ras MAP kinase pathway . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the HGF receptor ( HGFR or c met ) and beta catenin was determined by immunoprecipitation and western blot analysis . ^^^ HGF induced a MAP kinase dependent ARPE 19 cell migration , which is accompanied with a transient increase of c jun expression and concomitant increases of MAP kinase activity , tyrosine phosphorylation of HGFR and beta catenin , increased cytosolic levels of beta catenin , and transactivation activity of beta catenin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met protein , the high affinity HGF receptor , is overexpressed in a large proportion of cases of papillary carcinoma . ^^^ Met protein , the high affinity HGF receptor , is overexpressed in a large proportion of cases of papillary carcinoma . ^^^ These findings are consistent with the possibility that HGF Met protein interaction is one of the molecular mechanisms promoting the vascularization of papillary carcinoma of the thyroid . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Of the two lots of tumor derived fibroblasts obtained from two pancreatic cancer patients , the fibroblasts capable to produce HGF could initiate an apparent invasion stimulating response in strong c Met expressed Suit 2 and Panc 1 cells but not in faint expressed Mia PaCa 2 and BxPC 3 cells . ^^^ A specialized HGF antagonist , NK 4 would effectively inhibit the fibroblast mediated invasive growth , thus proving the key role of the paracrine fashioned HGF / c Met pathway in the tumor stromal interaction . ^^^ This in vitro study sketched out the interaction between cancerous and stromal compartments with an emphasis on HGF / c Met signal pathway , thus possibly helping to unveil the more complicated mutual modulation in vivo between pancreatic cancer and host mesenchymal tissues . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Activation of the c Met receptor for HGF and of focal adhesion kinase ( FAK ) was investigated by immunoprecipitation with anti phosphotyrosine antibody , gel electrophoresis , and immunostaining on Western blot . ^^^ HGF was found in RPE CM , suggesting an autocrine loop for invasion through its c Met receptor . ^^^ FAK and c Met were both phosphorylated in RPE cells in culture , and phosphorylation was inhibited by antibodies neutralizing either N cadherin or HGF . ^^^ CONCLUSIONS : The present investigation provides evidence for an autocrine HGF / c Met loop that stimulates RPE cell invasion into collagen through FAK . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It is also demonstrated that c met , specific receptor of HGF , was expressed in the injection site . ^^^ Intensive expression of c met was found in the site to which HGF encoded plasmid was injected . ^^^ These evidences for the exogenous expression of HGF and its receptor c met may implicate an application of naked plasmid mediated HGF for neuronal disease as well as the other neurotrophic factors . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In glomeruli of normal rats , mesangial cells barely expressed the c Met / HGF receptor . ^^^ However , when mesangioproliferative glomerulonephritis was induced in rats by the administration of an anti Thy 1 . 1 antibody , glomerular HGF expression transiently decreased along with mesangiolysis , and activation of mesangial cells was associated with upregulation of the c Met receptor . ^^^ Activated mesangial cells in culture also expressed the c Met / HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To examine the role of the HGF system in epithelial invasion followed by loss of connective tissue attachment in periodontitis , mRNA expression of HGF , its receptor ( c met ) and HGFA in gingival tissues was monitored . ^^^ The gene expression of HGF and keratinocyte growth factor ( KGF ) in gingival connective tissue , and c met , HGFA and KGF receptor ( KGFR ) in gingival epithelial tissues was monitored using RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : In human endothelial cells , HGF significantly stimulated the matrix degrading pathway , such as the production of matrix metalloprotease 1 ( MMP 1 ) through its specific receptor , c met . ^^^ In addition , HGF also significantly increased HGF itself and its specific receptor , c met . ^^^ Importantly , transfection of antisense ets 1 oligodeoxynucleotides ( ODN ) resulted in a significant reduction in MMP 1 , HGF and c met . ^^^ CONCLUSIONS : Here , we demonstrated that HGF stimulated the expression of MMP 1 , VEGF , HGF itself , and c met in human endothelial cells and vascular smooth muscle cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Endothelial function was evaluated by the vasodilator response to acetylcholine , and the expression of vascular HGF and its receptor , c met , was examined by immunohistochemistry . ^^^ The present data demonstrated the improvement of endothelial dysfunction by Ang 2 blockade in SHR SM , accompanied by an increase in vascular HGF and c met . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have investigated the influence of Ki ras oncogene on Met / hepatocyte growth factor ( HGF ) receptor signaling in human carcinoma cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF binds to and activates Met receptor tyrosine kinase . ^^^ In MDCK cells expressing GFRalpha 1 but no Ret , GDNF stimulates branching but not chemotactic migration , whereas both branching and chemotaxis are promoted by GDNF in the cells coexpressing Ret and GFRalpha 1 , mimicking HGF / Met responses in wild type MDCK cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| An interesting candidate signal is hepatocyte growth factor / scatter factor ( HGF ) , since its receptor Met is expressed on MM cells , while HGF is produced by BM stromal cells and by some MM cell lines , enabling para or autocrine interaction . ^^^ Taken together , our data indicate that HGF is a potent myeloma growth and survival factor and suggest that the HGF / Met pathway is a potential therapeutic target in MM . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Role of the MET / HGF receptor in proliferation and invasive behavior of osteosarcoma . ^^^ Signal transduction downstream HGF receptor ( MET ) activation involves multiple pathways that account for mitogenesis , motility and morphogenesis in a cell type dependent fashion . ^^^ Two lines showed activation of PKB / AKT that is known to be involved in migration mediated by HGF receptor . ^^^ We analyzed the effect of the MET receptor activation in five human osteosarcoma cell lines evaluating the levels of HGF dependent activation of MAPK and PKB / AKT as biochemical readouts of mitogenic and invasive responses , respectively . ^^^ Both the HGF dependent responses were reverted by the specific MET inhibitor K252a . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| It has been suggested in the animal model that increased expression of HGF receptor , c Met tyrosine kinase in the epithelial cells during kidney development may induce a growth of dysplastic epithelia and result in RD . ^^^ Markedly increased expression of HGF receptor , c Met tyrosine kinase in renal dysplasia suggests that HGF may be involved in the development of renal dysplasia . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| KM12C cells express c Met with low levels of tyrosine phosphorylation in the absence of HGF . ^^^ The high metastatic cells express a c Met that is constitutively tyrosine phosphorylated , they have increased colony formation , and are minimally responsive to HGF relative to the parental cells . ^^^ Tyrosine phosphorylated beta catenin was constitutively associated with c Met in the more metastatic cells , but was inducible only after HGF addition in the less metastatic cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor and transforming growth factor alpha ( TGF alpha ) / epidermal growth factor ( EGF ) receptor activation were decreased in hypertrophied livers , suggesting that IL 6 induced liver growth was independent of these known hepatocyte mitotic pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / SF stimulation also enhanced the tyrosine phosphorylation of HGF receptors ( c Met ) and focal adhesion kinase ( FAK ) on SAS cells , but C 3 completely inhibited the phosphorylation of FAK . ^^^ These results suggest that the activation of FAK caused by phosphorylation of c Met may mediate the HGF / SF induced motility of human oral SCC cells , and that Rho protein regulates the tyrosine phosphorylation of FAK through translocation from the nucleus to the membrane . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In ovarian carcinoma samples and cell lines we did not find mutations in RON and MET gene kinase domain , nor coexpression of RON and MET receptor ligands ( MSP and HGF , respectively ) . ^^^ We show that motility and invasiveness of ovarian cancer cells coexpressing MET and RON receptors were elicited by HGF and , to a lesser extent , by MSP . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Signaling by Met , the HGF receptor , is required for the rostral expansion of the pea 3 domain , while the onset of pea 3 expression is independent of met function . met expression is observed in pioneer neurons but does not precede that of pea 3 in recruited neurons . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| On the contrary , treatment with TGF alpha or TPO had no significant effects on [ 3H ] thymidine incorporation into the oval cells . c Met protein was phosphorylated at the tyrosine residues after the HGF treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF and the HGF receptor , c Met , are expressed simultaneously in MM cell lines and in freshly isolated MM cells , suggesting a possible role for HGF in MM cell proliferation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF and the HGF receptor , c Met , are expressed simultaneously in MM cell lines and in freshly isolated MM cells , suggesting a possible role for HGF in MM cell proliferation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Continuous intraperitoneal delivery of HGF led to both increased serum human HGF levels and c Met tyrosine phosphorylation within the colonic mucosa . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| While concentration of PGE 2 as well as expression of Cox 2 , HGF receptor ( c Met R ) , epidermal growth factor receptor ( EGFR ) , and beta catenin are all dramatically increased in colon cancers and implicated in their growth and invasion , the precise role of PGE 2 in the latter process remains unclear . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor is the transmembrane tyrosine kinase encoded by c MET proto oncogene . ^^^ Various lines of evidence suggest that the HGF / c MET receptor system plays essential roles in monocyte macrophage function , mammalian development , angiogenesis and organ regeneration . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Expression and agonist induced activation of the HGF receptor c Met was detected in rat renal interstitial fibroblasts ( NRK 49F ) by reverse transcription polymerase chain reaction ( RT PCR ) analysis and immune complex / immunoblot assay . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mechanism of STC 1 inhibitory effects on HGF induced endothelial migration seem to occur secondary to receptor activation because STC 1 did not inhibit HGF induced c met receptor phosphorylation , but did block HGF induced focal adhesion kinase activation . ^^^ HGF effects are mediated through a specific tyrosine kinase , c met , and aberrant HGF and c met expression are frequently observed in a variety of tumors . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These data suggest that interfering with c Met signaling to Rho GTPases represents a major mechanism by which EphA kinase activation inhibits HGF induced MDCK branching morphogenesis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Real time reverse transcriptase polymerase chain reaction showed that the expression of the c met / HGF receptor gene in SMG increased and peaked between E 14 and E16 . 5 , concomitant with epithelial branching , and high levels of HGF mRNA were detected in the surrounding mesenchyme at E 14 E15 . 5 . ^^^ Although strong expression of the HGF and c met transcripts was observed in the tongue muscles , this expression was limited at E13 . 5 E14 . 5 . ^^^ The branching morphogenesis of SMG was also inhibited by the addition of either antisense HGF or c met oligodeoxynucleotides to the cultures . ^^^ Moreover , the expression of both HGF and c Met in the SMG of explant 2 was higher than in the SMG of explant 1 . ^^^ These findings provide the first demonstration that the branching morphogenesis of SMG is regulated by interactions with the surrounding mesenchyme derived HGF and c met expression in SMG , which occur concomitant with epithelial branching . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : HGF receptor in MDA ( + / + ) cells and HGF in MRC 5 ( + / + ) cells were successfully removed with respective ribozymes as shown by reverse transcription PCR and Western blotting , respectively . ^^^ This study examined if inhibition of HGF / SF receptor expression by cancer cells and HGF / SF expression by stromal fibroblasts affects the growth of mammary cancer . ^^^ EXPERIMENTAL DESIGN : Transgenes encoding ribozymes to specifically target human HGF / SF receptor ( pLXSN MET ) or HGF / SF ( pLXSN HGF ) were constructed using a pLXSN retroviral vector . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to evaluate the effect of HGF on the mRNA levels of molecules involved in the extracellular matrix turnover and of the c met receptor in isolated human glomeruli . ^^^ TGF beta and TIMP 1 gene expression was markedly reduced by HGF treatment , whereas the expression of MMP 9 and c met did not change . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To further characterize the role of hepatocyte growth factor scatter factor ( HGF SF ) and its receptor ( c Met ) in osteosarcoma ( OS ) , human OS cell lines with low ( SAOS 2 ) and high ( SAOS LM 2 ) metastatic potential , and cell lines derived from spontaneous canine OS were studied . ^^^ All cell lines were evaluated for c Met and HGF SF expression and receptor activation using Northern , RT PCR , and Western blot analyses , respectively . ^^^ Western analysis showed c Met protein expression and HGF stimulated ( human ) or constitutive ( canine ) receptor autophosphorylation . ^^^ These data support the involvement of c Met and HGF SF in the growth and progression of human and canine OS , and may offer new targets for the development of therapeutic strategies for OS . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Infection depends on activation of the HGF receptor , MET , by secreted HGF . ^^^ HGF / MET signaling induces rearrangements of the host cell actin cytoskeleton that are required for the early development of the parasites within hepatocytes . ^^^ Our findings identify HGF and MET as potential targets for new approaches to malaria prevention . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The activities of HGF are mediated through the signalling pathway of its receptor , c Met . ^^^ During tooth development , HGF is expressed in the dental papilla and c Met is expressed in the inner enamel epithelium . ^^^ The expression of HGF and c Met indicates that HGF is involved in morphogenesis of the tooth by mediating epithelial mesenchymal interactions . ^^^ Both HGF and c Met are expressed in the developing tongue , and the signalling pathway of the latter is shown to be essential for myogenesis . ^^^ Dysregulation of c Met signalling is observed in carcinogenesis , but HGF also has cytotoxic activity to certain tumour cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the expression of these growth factors and their receptors ; fetal liver kinase 1 ( Flk 1 ) for VEGF and c Met for HGF , to acertain whether VEGF and HGF play a role in the neovascularization of transplanted islets . ^^^ Serial slices were immunostained for VEGF , HGF , Flk 1 , or c Met , respectively . ^^^ RESULTS : Islets in the normal pancreas were positively stained for VEGF , HGF , and c Met ; however , Flk 1 was only stained at the periphery of the islets . ^^^ In the transplanted islets , staining for VEGF , HGF , and c Met was positive , but Flk 1 was not stained . ^^^ Moreover , staining for HGF and c Met became stronger in the transplanted islets with time . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Myogenic precursor cell migration is dependent on limb bud mesenchymal expression of hepatocyte growth factor / scatter factor ( Hgf ) , which encodes a secreted ligand that signals to dermomyotome through the membrane receptor tyrosine kinase Met . ^^^ Our studies suggest that RA signaling provides proximodistal information for limb buds that counterbalances Bmp signaling , which in turn helps mediate proximodistal and anteroposterior patterning of Hgf expression to correctly direct migration of Met expressing myogenic precursor cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / SF and its receptor Met are present in the developing and adult mammalian brain and control neuritogenesis of sympathetic and sensory neurons . ^^^ We report that the striatal progenitor ST14A cells express the Met receptor , which is activated after binding with HGF / SF . ^^^ The interaction between Met and HGF / SF triggers a signaling cascade that leads to increased levels of c Jun , c Fos , and Egr 1 proteins , in agreement with data reported on the signaling events evoked by HGF in other cellular types . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These mice display ( 1 ) abundant expression of the respective transgenes in the kidney ; ( 2 ) similar PTH type 1 receptor and HGF receptor ( c met ) expression levels in the proximal tubule compared with control littermates ; and ( 3 ) normal renal morphology , function , and tubule cell proliferation under basal conditions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined HGF , the HGF receptor ( c Met ) , HGFA , matriptase , and the activation inhibitors ( HAI 1 and HAI 2 ) , tissues from patients with breast cancer . ^^^ HGF , c Met , HGFA , matriptase 1 , HAI 1 , and HAI 2 expression was quantified using real time quantitative PCR . ^^^ RESULTS : The breast cancer specimens expressed a significantly higher level of HGF , c Met , HGFA , HAI 1 , and HAI 2 , but not matriptase , compared with the normal background tissues . ^^^ CONCLUSIONS : This study shows that there are aberrant levels of HGF , c Met , HGFA , HAI 1 , and HAI 2 expressed in breast cancer tissues compared with background breast tissue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Granulosa cells and thecal tissues in small ( < 4 mm ) , medium ( 4 5 mm ) or large ( > 5 mm ) individual follicles were collected for detection of mRNA expression of HGF , Ang 1 and Ang 2 in granulosa cells , and HGF receptor ( HGF R ) and Tie 2 in the theca cells by semi quantitative RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Using U87human astrocytoma cells , which express TGFbeta receptors ( TbetaRs ) , we show ( 1 ) mRNA expression of Smads ( 2 , 3 , 4 ) , bone morphogenetic protein ( BMP ) and activin A receptors ; ( 2 ) TGFbeta 1 inhibits and HGF induces proliferation ; ( 3 ) TGFbeta 1 and activin A equipotently inhibit HGF secretion more than BMP 2 , but none alters c Met expression . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Consistent with this downregulation , phosphorylation of HGF receptor , c Met , which is frequently overexpressed in SCCHN , was also attenuated in HSulf 1 clonal 012SCC cell lines . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| For the first time , the authors establish diminished HGF signaling , via its high affinity receptor c Met , in the absence of CD 44 in vivo . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Lastly , we demonstrate that HGF , the endogenous ligand of Met , substitutes for InlB in promoting intracellular invasion , suggesting that no special properties are required of InlB in invasion besides its hormone like mimicry of HGF . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Interestingly , stimulation of the Met receptor by either GPCR agonists , EGF or its cognate ligand HGF , resulted in release of Met associated beta catenin and in its Met dependent translocation into the nucleus , as analyzed by small interfering RNA mediated knockdown of the Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed that the receptor for HGF ( c Met ) was highly expressed on the surface of SAEC and its downstream signal transduction pathway was functional . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The proliferation of LECs in a capsular bag culture was significantly inhibited by treatment with the neutralizing antibody for HGF receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF expression in these specimens associated with c Met receptor mediated signal molecules was examined by reverse transcription polymerase chain reaction ( RT PCR ) , Western blot or immunohistochemical study . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that , compared to IOSE 29 , IOSE Ov 29 and IOSE Ov29 / T4 exhibited higher levels of the HGF receptor Met and an increasing duration of ERK1 / 2 activation with malignant progression , in conjunction with other neoplastic properties . ^^^ HGF activated Met signaling in all lines but elicited different responses : HGF induced cell dispersion ( scattering ) and collagen gel invasion in IOSE Ov 29 and IOSE Ov29 / T4 but did not alter the growth pattern of IOSE 29 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of HGF and its receptor c Met in renal cell carcinoma ] . ^^^ OBJECTIVE : To study the clinical significance of expression of hepatic growth factor ( HGF ) and its receptor c Met in renal cell cancer ( RCC ) . ^^^ The expression of HGF and c Met mRNA was detected using Northern blot . ^^^ RESULTS : Twenty one out of 26 patients with RCC had positive gene expression of HGF and c Met with the positive rate of 80 . 8 % . ^^^ According to the tumor TNM staging , the more advanced the cancer had a stronger expression of HGF and c Met , the expression of c Met was higher than that of HGF in the RCC . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The inactivation of HGF genes or that of its receptor , c met , in mice causes hypoplasia of skeletal muscle organs , such as the tongue . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In the hippocampus of juvenile rats , we found that the HGF receptor c Met was expressed in neurons . ^^^ Considering that the expression of both HGF and c Met are known to be induced by ischemic stimuli , this modulation would provide a novel understanding of a neuronal regulatory systems shared with pathogenic ischemic states . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Fibrosis and infarct size of the ventricular wall was significantly reduced in the HGF treated hearts . 5 Bromo 2 ' deoxy uridine ( BrdU ) and Ki 67 positive cardiomyocytes were observed in the border area of the HGF treated infarcted hearts . c Met and c kit positive cardiomyocytes were observed in the border area and epicardium . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This study investigates the expression of thrombospondin 1 in papillary carcinoma of the thyroid and the role of Met HGF interaction in TSP 1 regulation . ^^^ The high level expression of Met protein , the high affinity receptor for HGF , in most cases of papillary carcinoma of the thyroid is consistent with the possibility that HGF Met interaction plays a crucial role in regulating the expression of TSP 1 in this tumour type . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also evaluated the distribution of HGF and its cellular receptor c Met in the carotid fork obtained from 2 patients with moyamoya disease and 2 control patients . ^^^ Both HGF and c Met were widely distributed in the media and thickened intima of the carotid fork in patients with moyamoya disease but not in control patients . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation analysis revealed that LPA induced transient tyrosine phosphorylation of c Met in LPA 2 expressing cells , which suggests that the transactivation of c Met by LPA causes a cooperative migratory response with HGF to these cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These findings not only identify a novel mode of interaction between the signals activated by HGF receptor tyrosine kinase and TGF beta receptor serine / threonine kinases but also illustrate the feasibility of confining Smad activity as an effective strategy for blocking renal fibrosis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| When ECs and / or stromal cells were incubated with anti HGF or anti HGF receptor ( HGFR ) antibody before HGF , the effects of HGF were blocked . ^^^ These findings indicate that ECs express the HGFR at their basolateral surfaces and that HGFR mediates the effects of HGF on TER and TNFalpha . ^^^ Neutralization of stromal cell secretions with antibodies for HGF and HGFR demonstrate that stromal derived HGF is the mediator of EC TER . ^^^ In contrast , neither anti HGF antibody nor HGFR antibody had any effect on stromal cell induced decreases in TNFalpha secretion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , the simultaneous addition of Ngal and HGF leads to direct association of the two proteins , and results in a partial inhibition of HGF mediated activation of c Met and the downstream MAPK and phosphatidylinositol 3 kinase signaling pathways . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Met ( the HGF receptor ) , actin , and total AnxI were increased in pseudopodial lysates on immunoblots . ^^^ Met ( the HGF receptor ) , actin , and total AnxI were increased in pseudopodial lysates on immunoblots . ^^^ Increased constituents of the pseudopodial proteome in glioma cells , identified in this study as actin , HGF , Met , and isoforms of AnxI , AnxII , and several glycolytic enzymes , represent therapeutic targets to consider for suppression of tumor invasion . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We studied HGF and the membrane bound receptor , c met locally in patients who suffered from chronic leg ulcers ( > or =1 year ) caused by venous insufficiency . ^^^ METHODS : Skin biopsies from the edge of the ulcers were taken from patients ( n=13 ) and studied by immunohistochemical staining for detection of HGF and c met . ^^^ CONCLUSION : We conclude that in chronic skin ulcers decreased biological activity of endogenous HGF and overexpression of c met is seen which might explain fibrosis and delayed recovery . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| When MRC 5 human lung fibroblasts were treated with transforming growth factor beta 1 , the cells underwent phenotypic change similar to myofibroblasts and this was associated with up regulation of c Met / HGF receptor expression . ^^^ In bleomycin treated mice , c Met expression was found on interstitial myofibroblasts and HGF increased apoptosis in culture of myofibroblasts isolated from bleomycin treated murine lungs . ^^^ In conclusion , we identified HGF as a key ligand to elicit myofibroblast apoptosis and ECM degradation , whereas activation of the HGF / c Met system in fibrotic lungs may be considered a target to attenuate progression of chronic lung disorders . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Scleroderma fibroblasts overexpressed c met protein , the receptor for HGF . ^^^ Our study indicated that HGF may reduce type 1 collagen accumulation only in scleroderma fibroblasts by enhancing collagenolysis activity , probably because of the overexpression of c met because of autocrine TGF beta signaling . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Involvement of HGF / SF Met signaling in prostate adenocarcinoma cells : evidence for alternative mechanisms leading to a metastatic phenotype in Pr 14c . ^^^ BACKGROUND : Hepatocyte growth factor / scatter factor ( HGF / SF ) facilitates intercellular communication between the epithelial carcinoma and its surrounding stromal tissue during metastatic invasion through interaction with its proto oncogenic receptor , Met , found on carcinoma cells . ^^^ This study utilizes the C31 / Tag transgenic mouse prostate cancer cell line model in an attempt to characterize the interaction between HGF / SF and Met on the metastatic potential of prostate cancer . ^^^ Motility studies of the metastatic cells following HGF / SF treatment reveal a potentially faulty signaling pathway downstream of Met activation in the metastatic prostate cells . ^^^ CONCLUSIONS : Our studies suggest that proliferation , invasion , and cell morphological characteristics may be induced independently from the HGF / SF Met pathway in C31 / Tag metastatic prostate cancer cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| When activated HGF binds its cognate receptor Met , cellular signals lead to cell growth , differentiation , and migration , activities which promote tissue regeneration in liver , kidney and skin . ^^^ Intervention in the conversion of HGF to its active form has the potential to provide therapeutic benefit where HGF / Met activity is associated with tumorigenesis . ^^^ To help identify ways to moderate HGF / Met effects , we have determined the molecular structure of the protease domain of HGFA . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| TGF beta treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF c Met pathway . ^^^ Our studies show that TGF beta 1 2 3 as well as IFN beta induce HGF secretion by microglia and that antibodies to the HGF receptor c Met abrogate OPC chemotaxis induced by TGF beta 2 treated microglia . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF / MET signalling protects Plasmodium infected host cells from apoptosis . ^^^ The signalling initiated by HGF through its receptor MET has multifunctional effects on various cell types . ^^^ Our results reveal a major role for apoptosis protection of host cells by HGF / MET signalling on the host susceptibility to infection . ^^^ Inhibition of HGF / MET signalling induces a specific increase in apoptosis of infected cells leading to a great reduction on infection . ^^^ Since HGF / MET signalling is capable of protecting cells from apoptosis by using both PI 3 kinase / Akt and , to a lesser extent , MAPK pathways , we determined the impact of these pathways on Plasmodium sporozoite infection . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We examined the effects of a high concentration of glucose and then focused on following four critical points : 1 ) the production of HGF from HPMCs exposed to a high concentration of glucose , 2 ) the expression of c Met on HPMCs , 3 ) the viability of those cells , and 4 ) matrix metalloproteinase 2 ( MMP 2 ) and tissue inhibitors of metalloproteinase 2 ( TIMP 2 ) . ^^^ The following significant changes are described herein : high glucose solution and TGF beta 1 1 ) decreased HGF production from HPMCs and 2 ) up regulated expression of c Met on HPMCs , and addition of HGF 3 ) restored viability of HPMCs damaged by glucose , 4 ) suppressed TGF beta 1 production by HGF , and 5 ) induced up regulation of MMP 2 and decreased TIMP 2 production by HPMCs . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Upon stimulation with HGF , the expression of E cadherin is downregulated in wild type MET transfected cells , whereas cells expressing mutated MET show low E cadherin levels independent of stimulation with ligand . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In quiescent HSCs , c Met receptor expression was undetected whereas c Met receptor expression was detected in activated HSCs and liver myofibroblasts expressing alpha smooth muscle actin ( alpha SMA ) , suggesting that activated HSCs and portal myofibroblasts are targets of HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Mouse anti human HGF monoclonal antibodies and recombinant human HGF receptor ( c Met ) / Fc chimera were immobilised in flow cells of a CM 5 biosensor chip . ^^^ RESULTS : We found that infectious gastroenteritis produced a higher signal response compared to controls , due to binding of HGF to monoclonal anti HGF antibody as well as binding of HGF to c Met receptor ( p < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Expression of mRNA for HGF and its receptor , c Met in macrophages and stromal cells in response to ovarian steroid was investigated by RT PCR . ^^^ The mRNA expressions of HGF and its receptor , c Met , were also detected in macrophages and stroma in response to estrogen , suggesting an autocrine regulation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| This hepsin processed HGF induced c Met receptor tyrosine phosphorylation in SKOV 3 ovarian cancer cells , indicating that the hepsin cleaved HGF is biologically active . ^^^ Together , our findings suggest that the HGF precursor is a potential in vivo substrate for hepsin in tumours , where hepsin expression is dysregulated and may influence tumorigenesis through inappropriate activation and / or regulation of HGF receptor ( c Met ) functions . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The c Met ribozyme inhibited IGF 1 and HGF mediated migration and invasion , indicating that c Met is essential for these processes . uPA and uPAR inhibition blocked IGF 1 and HGF mediated migration and invasion , suggesting that uPAR is downstream of IGF / IGF IR and HGF / c Met in the signaling pathways that mediate cell migration and invasion . ^^^ CONCLUSIONS : IGF 1 and HGF cooperate to induce migration and invasion of CRC cells , and c Met and uPA / uPAR are required for IGF 1 mediated migration and invasion . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Treatment of tumor cells with fibroblast conditioned medium leads to increased tumor cell proliferation and motility , which are blocked by addition of pharmacologic inhibitors of TGF alpha signaling or neutralizing antibodies to macrophage stimulating protein ( MSP ) , HGF , or c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| NYGM cells concomitantly expressed MET receptor tyrosine kinase ( a product of c met protooncogene ) and its ligand HGF / SF ( hepatocyte growth factor / scatter factor ) , as well as HGF activator and HGF activator inhibitors . ^^^ The cells might be useful for the study of pericellular regulation of HGF / SF MET signaling and HGF activation of GBM cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The present study evaluated the effect of HGF on the extracellular matrix turnover and on c met receptor in human glomeruli . ^^^ The expression of c met was up regulated by HGF treatment . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We then examined the epithelial localization of the HGF receptor c met and identified it on the surface epithelia , where apoptosis was observed , but did not find it in the proliferative zone . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In mice after renal I / R , plasma HGF levels increased , along with c Met / HGF receptor phosphorylation in the vascular endothelium . ^^^ However , this c Met activation was transient , associated with a decrease in endogenous HGF level , and followed by neutrophil infiltration and renal dysfunction . ^^^ Suppression of endothelial c Met phosphorylation by anti HGF IgG led to rapid progressions of neutrophil extravasation , tubular apoptosis , and renal dysfunction . ^^^ Inversely , enhancement of the c Met activation by exogenous HGF blocked endothelial / tubular apoptotic injuries and acute renal failure . ^^^ Thus , we conclude that 1 ) the HGF / c Met system of endothelial cells confers an initial barrier to block neutrophil infiltration , and 2 ) transient and insufficient HGF production allows manifestation of postischemic renal failure . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| As activating mutations in the MET proto oncogene ( the HGF receptor ) cause familial RCC , we investigated whether HAI 2 / SPINT2 might act as a RCC tumor suppressor gene . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| These results suggest that HAI 1 regulates the HGF Met axis on prostate epithelial cells and influences HGF mediated tumor invasion and metastasis . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Immunoreactive TGF beta 1 , connective tissue growth factor , HGF receptor , c Met , and fibronectin all increased in remnant ( 2 . 85 + / 0 . 51 , 3 . 83 + / 0 . 55 , 2 . 56 + / 0 . 31 , and 2 . 80 + / 0 . 39 fold sham respectively , n = 4 8 , p < 0 . 05 ) , and SC 58236 blunted the increases ( to 1 . 45 + / 0 . 34 , 1 . 85 + / 0 . 13 , 1 . 75 + / 0 . 30 , and 1 . 60 + / 0 . 32 fold sham ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of HGF and its receptor c Met in the stroma was investigated by RT PCR . ^^^ The localization of HGF and c Met in isolated stromal cells and in intact tissue was examined by immunohistochemistry . ^^^ This effect was paralleled by increased expression of HGF and c Met mRNA , as demonstrated by RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In addition , the relationship between intravitreous HGF levels and the presence of epiretinal membranes ( ERM ) , as well as the expression of c Met in ERM were also investigated . ^^^ HGF and VEGF were determined by ELISA and c Met expression by immunohistochemistry . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We previously showed that the Kaposi Sarcoma line KS IMM express a functional Met tyrosine kinase receptor , which , upon HGF stimulation , activates motogenic , proliferative , and invasive responses . ^^^ In this study , we investigated the signalling pathways activated by HGF , as well as by Met monoclonal antibodies ( Mabs ) , acting as full or partial agonists . ^^^ Since Gab 1 , JNK and PI 3 kinase are activated with same intensity and kinetics by HGF and by the two agonist antibodies , it is concluded that level and duration of MAPK activation by Met receptor are crucial for the induction of a full HGF dependent mitogenic and invasive program in KS cells . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| In this context , we show that short term exposure of mesenchymal stem cells ( MSCs ) to HGF can induce the activation of its cognate Met receptor and the downstream effectors ERK1 / 2 , p38MAPK , and PI3K / Akt , while long term exposure to HGF resulted in cytoskeletal rearrangement , cell migration , and marked inhibition of proliferation through the arrest in the G 1 S checkpoint . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| STUDY DESIGN : Using specimens from 30 hepatocellular carcinoma patients operated on in our department from 2002 to 2003 , we evaluated expression levels of HGF , c Met , ERK , and cyclin D 1 by Western blot . ^^^ In patients with overexpression of HGF and c Met , the expression level of ERK was significantly higher , but cyclin D 1 expression was not . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| CD 151 has been found to function as a molecular linker in the formation of complexes between c Met / hepatocyte growth factor ( HGF ) receptor and integrin alpha3 / alpha6 . ^^^ These results suggest that CD 151 forms a structural and functional complex with c Met and integrin alpha3 / alpha6 , and exerts its oncogenic functions through excessive activation of the HGF / c Met signalling pathway . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Liver injury and its regeneration , the conversion of proHGF to mature HGF , and the activation of its signal through HGF receptor ( c Met ) were analyzed . ^^^ RESULTS : rhHGF activator improved the recovery of liver function after resection in cirrhotic liver as compared with the control group . rhHGF activator also enhanced the proliferating cell nuclear antigen labeling index and liver regeneration rate . rhHGF activator converted the proHGF to mature HGF , showing the maximal effect at 10 min after injection , which was followed by tyrosine phosphorylation of insulin receptor substrate ( IRS ) 1 , and the association of IRS 1 with c Met and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Callus samples from tibial fractures in mice were harvested for immunohistochemical analysis of HGF and phosphorylated c Met , for in situ hybridization of BMPRs , and for real time RT PCR analysis for the expression of HGF , c Met , and BMPRs . ^^^ RESULTS : Positive immunostaining of HGF and phosphorylated c Met was detected around the fracture site at 1 day after the fracture was made . mRNA expression of BMPRs was increased 1 day after fracture and localized in mesenchymal cells at the fracture site . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We first confirmed that dendritic cells ( DCs ) expressed the receptor for HGF , c met , which was not expressed in T cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF receptor c met , fibroblast growth factor ( FGF ) 3 , its receptor FGFR 3 , tissue inhibitor of metalloproteinase ( TIMP ) 4 , laminin alpha 4 chain , and thymosin beta ( 4 ) genes were downregulated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We also identified an amplicon at 11p13 that resulted in amplification and overexpression of CD 44 , a gene involved in MET autophosphorylation upon HGF stimulation . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| HGF presented locally to cultured muscle cells by latex beads induced new AChR clusters and dispersed AChR hot spots , and HGF beads also clustered phosphotyrosine , activated c Met , and proteins of dystrophin complex ; clustering of AChRs and associated proteins by HGF beads required actin polymerization . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Using in vivo and in vitro models to further examine the interaction between c MET and COX 2 , we found that HGF stimulated the growth of SC M 1 cells in a dose dependent manner . ^^^ These results suggest that COX 2 specific inhibitors may play some role on the therapy of gastric cancer patients with high serum HGF level and overexpression of c Met in tumor . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : Tumor tissues from 50 patients with gastric carcinoma were evaluated for the expression of HGF , its receptor c Met , and E cadherin . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS : Previously isolated HuCCA 1 cells were re characterized by immunofluorescent staining and reverse transcriptase polymerase chain reaction assay for the expression of cytokeratin 19 , HGF and c Met mRNA . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Levels of CINC 1 and its mRNA , tyrosine phosphorylation of HGF receptor ( c Met ) , the activation of transcription factor , nuclear factor kappaB ( NF kappaB ) , and activities of DNA synthesis were measured . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The interaction of HGF with c met , a receptor tyrosine kinase expressed by many cells , is important in cell growth , migration , and formation of endothelial and epithelial tubes . ^^^ Stimulation of c met requires two chain , disulfide linked HGF . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| A recombinant single chain IL 7 / HGFbeta hybrid cytokine induces juxtacrine interactions of the IL 7 and HGF ( c Met ) receptors and stimulates the proliferation of CFU S 12 , CLPs , and pre pro B cells . ^^^ Antibody blocking , receptor phosphorylation , and confocal microscopy demonstrated that scIL 7 / HGFbeta signals though both the IL 7 and HGF ( c Met ) receptors , which form IL 7R / c Met complexes on the surface of CLPs and pre pro B cells . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHOD : Hernial sacs collected from 20 children ( 15 males , 4 females , 1 XY female ) undergoing inguinal hernia repair were immunohistochemically stained for HGF receptor ( c met ) . ^^^ We localized the HGF receptor in the PV and tested whether CGRP was responsible for HGF release . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Since LPA can transactivate HGF receptor ( c Met ) as well as EGF receptor , LPA may promote the progression of gastric cancer in diffuse type with high expression of c Met . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| However , the intracellular pathways controlling neuronal migration triggered by the HGF receptor Met have not been elucidated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Consistent with this finding , the HGF receptor ( c Met ) is only localized on corneal blood vessels but is absent on lymphatic vessels in a mouse corneal assay . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The hepatic expression and kinase activity of HGF receptor , c Met , were unchanged among WT mice and NK 2 transgenic mice after PH . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the c Met / hepatocyte growth factor receptor ( HGF R ) proto oncogene and abnormal generation of intracellular oxygen species ( reactive oxygen species ( ROS ) ) have been linked , by independent lines of evidence , to cell transformation and to malignant growth . ^^^ By comparing two subpopulations of the B 16 mouse melanoma ( B 16 F0 and B 16 F10 ) endowed with different lung metastasis capacities ( low and high , respectively ) we found that both the expression / phosphorylation of c Met and the steady state levels of ROS positively correlated with metastatic growth . shRNA mediated downregulation of c Met in F 10 cells led to a parallel decrease in the generation of oxygen species and in metastatic capacity , suggesting that oxidants may mediate the pro metastatic activity of the HGF receptor . c Met activation by a ligand elicits the formation of oxidant species through the oxidase coupled small GTPase Rac 1 , a relevant downstream target of the HGF R . ^^^ Moreover , cell treatment with the catalytic ROS scavengers EUK 134 and EUK 189 attenuates Met signaling to ERKs and inhibits the anchorage independent growth of F 10 cells , consistent with a critical role for oxygen species in HGF signaling and in aggressive cell behavior . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| When c Met tyrosine phosphorylation was abolished by anti HGF IgG , mucosal cell proliferation became faint , leading to delayed recovery from mucotitis , and vice versa in cases of HGF supplementation . ^^^ Our findings indicate that : ( 1 ) HGF / c Met signal on mucosa is needed to restore gastric injuries ; and ( 2 ) the loss of local HGF leads to manifestation of gastric lesions . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Consistent expression of HGF and c met in the perinatal lung . ^^^ OBJECTIVES : We studied the protein expression of HGF and its receptor c met during the perinatal period in the human lung . ^^^ METHODS : Immunohistochemistry for HGF and c met was performed on lung tissues from autopsies of 4 fetuses , 5 preterm infants , 5 term infants , and 4 infants with bronchopulmonary dysplasia . ^^^ CONCLUSIONS : The consistent expression of HGF and c met during the perinatal period supports a physiological role for HGF in human lung development . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| The transcription factor Ets 1 and the HGF receptor c Met were up regulated in P 1 ( 0 . 5 ) cells and in HUVEC cultured in P 1 ( 0 . 5 ) CM . ^^^ HGF production , Ets 1 and c Met up regulation , and iNOS expression can be part of the molecular mechanisms that enhance the angiogenic activity of the MDR positive hepatocellular carcinoma cell line . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Up regulations of hepatocytes growth factor ( HGF ) , its receptor ( c Met ) , and urokinase type plasminogen activator ( uPA ) are correlated with the development and metastasis of cancers . ^^^ In order to investigate roles of HGF / c Met signaling in tumor progression and metastasis in stomach cancers , we determined effects of a specific MEK 1 inhibitor ( PD 098059 ) and a p 38 kinase inhibitor ( SB 203580 ) on HGF mediated cell proliferation and uPA expression in stomach cancer cell lines ( NUGC 3 and MKN 28 ) . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| To examine the role of TGF beta 1 in the process of compensatory renal growth , renal tissue HGF , TGF beta 1 , TGF beta 1 mRNA , and c met protein were measured . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate canine histiocytic sarcoma cell lines and tumor samples for dysregulation of the Kit / stem cell factor ( SCF ) , Flt3 / Flt3 ligand ( Flt3L ) , and Met / hepatocyte growth factor ( HGF ) receptor tyrosine kinase signaling pathways , as these are known to contribute to the differentiation and survival of normal dendritic cells as well as malignant transformation of dendritic cells in mouse models . ^^^ PROCEDURE : Histiocytic sarcoma cell lines were evaluated for expression of Kit / SCF , Flt3 / Flt3L , and Met / HGF by use of reverse transcriptase PCR procedures . ^^^ CONCLUSIONS AND CLINICAL RELEVANCE : These data suggest that dysregulation of Kit / SCF , Flt3 / Flt3L , and Met / HGF signaling pathways is unlikely to occur in histiocytic sarcomas of dogs and that inhibitors of the Kit , Flt 3 , and Met pathways are unlikely to provide clinical benefit to dogs with histiocytic sarcomas . . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Binding of HGF from conditioned medium to its receptor , c Met , was compared with recombinant HGF by SPR . ^^^ Similar to recombinant HGF , HGF from conditioned medium had a high affinity for dextran sulfate and albumin , and the same epitopes were engaged by the interaction of HGF with the c Met receptor . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Proliferative activity ( proliferating cell nuclear antigen ( PCNA ) protein expression ) , hepatic growth factor ( HGF ) receptor ( c Met ) , stem cell factor receptor ( c kit ) , Notch 2 and Hes 1 expression were also evaluated . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| Conversely , rhG CSF had no effect on the pre PHx mRNA levels or the PHx induced upregulation of mRNA levels of TNF alpha , IL 1beta , IL 6 , TGF beta , IL 10 , HGF , and c Met determined by real time RT PCR . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Immunofluorescent analysis demonstrated that canine primary lymphatic endothelial cells ( cLECs ) were positive for lymphatic specific markers ( vascular endothelial growth factor receptor 3 , LYVE 1 , podoplanin , and Prox 1 ) and the HGF receptor c Met . ^^^ In human LECs , c Met also was expressed , and treatment with HGF increased cell growth and migration in a dose dependent manner . ^^^ |
|
| Interacting proteins: P14210 and P08581 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that beta catenin forms a complex with c Met ( HGF receptor ) that undergoes dissociation because of beta catenin tyrosine phosphorylation on stimulation by HGF . ^^^ |
|