Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.59510666
Taken together , our data strongly suggest that HGF induced association of c Src with Met and c Src activation play a critical role in HGF induced cell motility and anchorage independent growth of mammary carcinomas and further support the notion that the presence of paracrine and autocrine HGF loops contributes significantly to the transformed phenotype of carcinoma cells . . 0.59510666^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Oncoproteins c myc , c fos , c jun , L myc , c sis , c ras , c src , c ets 1 , c met were studied immunohistochemically in the material obtained from 25 patients during the operations . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
We found no detectable transcripts of 9 proto oncogenes ( c sis , c met , c src , c lyn , c fgr , c ros , c pim , Blym and N myc ) , but detected transcripts of 12 other proto oncogenes ( int 2 , erbB , c abl , c raf 1 , c fyn , K ras , H ras , c mos , c myc , c myb , c fos , and c jun ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Specifically , the epidermal growth factor receptor ( EGFR ) , p185HER2 / Neu and the hepatocyte growth factor receptor ( c Met ) appear to be linked to the process because they preferentially activate c Src in highly metastatic cells . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In this study , we used mucin and immunoperoxidase stains on formalin fixed , paraffin embedded sections from 12 prostatic adenocarcinomas with SRC components , with antibodies to prostate specific antigen ( PSA ) , cytokeratins , MIB 1 , bcl 2 , c MET , CD44v6 , and CD44v7 ; we performed a comparison study on six bladder and seven gastric carcinomas with SRCs . ^^^ We conclude that prostatic adenocarcinomas with SRC components are typically accompanied by high grade adenocarcinoma ; are variably positive for mucin , with PAS D being the most sensitive stain ; show expression of PSA , cytokeratins , MIB 1 , bcl 2 , c MET , and CD 44 similar to that shown by high grade adenocarcinoma components ; have a low MIB 1 proliferation index ; and are not always distinguishable from SRC components of bladder and stomach carcinomas with any of the above stains , including PSA . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
The mRNA expression of c jun was likely to undergo a negative regulation through a mechanism involving PI3K , while that of c met seemed to be almost independent from various protein kinases ( PI3K , pp 60 ( c src ) , and PKC ) . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
It is not active against kinases from other receptor families , such as epidermal growth factor receptor , fibroblast growth factor receptor 1 , c Met , and Tie 2 , or intracellular kinases such as c Src , c Abl , and protein kinase C alpha . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Additionally , no inhibition of c Met or nonreceptor tyrosine kinases such as Src and Jak 2 has been observed . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
It is not active against kinases from other receptor families such as EGFR , FGFR 1 , c Met and Tie 2 or intracellular kinases like c Src , c Abl , PKC alpha . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
IL 4 enhancement of HGF signaling was partially blocked in 32D / c Met cells treated with inhibitors of MEK 1 or c Src kinases , completely blocked by expression of a catalytically inactive mutant of Janus kinase 3 ( Jak 3 ) , and increased in 32D / c Met cells overexpressing STAT 6 . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Using a model system of in vitro human peripheral blood lymphocytes , the effect of low dose ( 0 . 25 to 1 . 50 Gy ) 250 kVp 10 ray radiation ( 1 Gy . min 1 ) on the expression of several proto oncogenes was examined ( c Haras , c src , c met , c jun , c fos , and c myc ) and beta actin from 0 . 25 to 17 h post radiation . ^^^ A progressive time and dose dependent increase in mRNA levels was observed for c Haras mRNA , while the other proto oncogenes ( c src , c met , c fos , c jun and c myc ) examined were variable during the same time period . beta actin levels were initially decreased but at 17 h post radiation had returned to control levels . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Examples discussed are genes encoding elements of the cadherin / catenin complex , the nonreceptor tyrosine kinase Src , the receptor tyrosine kinases c Met and FGFR , the small GTPase Ras , and the dual phosphatase PTEN . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Using biochemical and immunohistochemical techniques , we have investigated P cadherin , beta catenin , c src and c met protein expression , and phosphorylation of beta catenin in a rat model of tongue cancer induced with 4 nitroquinoline 1 oxide . ^^^ Reaction to the c src product was strongest at the dysplastic stage and , to the c met product , at the cancer stage . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
These results demonstrate a role of Stat 3 in transducing survival signals downstream of tyrosine kinases such as Src , EGF R , and c Met , as well as cytokines such as IL 6 , in human nonsmall cell lung cancers . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
These events are mediated by interaction of cytoplasmic effectors , generally through Src homology 2 ( SH 2 ) domains , with two phosphotyrosine containing sequence motifs in the unique C terminal tail of c Met ( supersite ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In vitro , effects on c Met , Akt , and extracellular signal regulated kinase 1 / 2 expression and phosphorylation , Src expression and activity , and vascular endothelial growth factor expression were determined , as were effects on cell migration and invasion . ^^^ RESULTS : Infection of PC 3 LN4 cells with the Ad c Met expressing ribozyme decreased steady state c Met levels , decreased Src kinase activity , decreased vascular endothelial growth factor expression , and decreased migration and invasion versus the pU 1 ( control ) virus . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Promising therapeutic targets for cancer metastasis have been identified , including Src , focal adhesion kinase , the integrin receptor , the vascular endothelial growth factor receptor , the epidermal growth factor receptor , Her 2 / neu , c Met , Ras / Rac GTPases , Raf kinase , farnesyl diphosphate synthase ( i . e . , amino bisphosphonate therapeutic target ) and matrix metalloproteases within the context of their implicated functional roles in cancer growth , invasion , angiogenesis and survival at secondary sites . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Genetic and pharmaceutical analyses suggest the involvement of c Met and the Src family tyrosine kinases in mediating UV induced Gab 1 phosphorylation as well as JNK activation . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Tetraspanin KAI1 / CD82 suppresses invasion by inhibiting integrin dependent crosstalk with c Met receptor and Src kinases . ^^^ Inhibition of c Met expression or Src kinase function reduced matrigel invasion of PC 3 cells to the same extent as CD 82 expression . ^^^ These data indicate that CD 82 functions to suppress integrin induced invasion by regulating signaling to c Met and Src kinases , and suggests that CD 82 loss may promote metastasis by removing a negative regulator of c Met and Src signaling . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Hepatocyte Growth Factor ( HGF ) and its protooncogene receptor c Met regulate osteoclast function by activating pp 60 ( c Src ) kinase and alpha ( 5 ) beta 3 integrin . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In this study , the c Abl , c Src , and c Met kinases are produced in high yields in Escherichia coli by using a bicistronic vector encoding the PTP1B tyrosine phosphatase . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In biochemical assays , SU 10944 exhibits potent inhibitory activity against VEGFR 1 ; weak activity against other related subgroup members , including stem cell factor receptor ( SCFR ) , platelet derived growth factor receptor beta ( PDGFRbeta ) , and fibroblast growth factor receptor 1 ( FGFR 1 ) ; and no detectable activity against other protein tyrosine kinases such as epidermal growth factor receptor ( EGFR ) , Src , and hepatocyte growth factor receptor . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In osteoclasts , HGF receptor activation is followed by increase in intracellular Ca2+ concentration and by activation of the pp60c Src kinase . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
The HGF receptor tyrosine kinase works through a Src homology ( SH 2 ) docking site that can activate several signalling pathways . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Upon ligand binding , the HGF / SF receptor recruits and activates several cytoplasmic effectors , including phosphatidylinositol 3 kinase ( PI 3 K ) , phospholipase C gamma ( PLC gamma ) , pp60c Src , a tyrosine phosphatase , and a Ras guanine nucleotide exchanger . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
While src and abl tyrosine kinase oncogene products have previously been shown to be inactive in this assay , p65tpr met efficiently induced maturation promoting factor ( MPF ) activation and germinal vesicle breakdown ( GVBD ) together with the associated increase in ribosomal S 6 subunit phosphorylation . tpr met mediated MPF activation and GVBD was dependent on the endogenous c mosxe , while the increase in S 6 protein phosphorylation was not significantly affected by the loss of mos function . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Expression of protooncogenes c myc , N myc , c fos , Ha ras 1 , Ki ras 2 , yes , abl , src , N ras , met and mos was studied in human gastric tumors and in rat gastric mucosal membrane during gastric carcinogenesis induced in rats by means of N methyl N ' nitro N nitroso guanidine ( MNNG ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
The expression of growth factor specific mRNA transcripts and the presence of biologically active growth factors in the conditioned medium and in the cell extracts from mouse NIH 3T3 cells transformed by different oncogenes ( Ki ras , mos , src , fms , fes , met , and trk ) , by a DNA tumor virus ( SV 40 ) , or by a chemical carcinogen ( N nitrosomethylurea ) were studied . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Transformation of rodent fibroblasts by cytoplasmic ( mos , raf ) and membrane associated ( ras , src , met , trk ) , but not nuclear ( myc , fos ) oncogenes results specifically in a very significant elevation of intracellular levels of glycerophosphoinositol ( GPI ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Specific alterations were observed in the inositol phospholipid cycle of ras transformed fibroblasts , but similar changes were also produced by spontaneous transformation or transformation mediated by either membrane associated oncogenes , such as src , met , or trk , or cytoplasmic oncogenes , mos and raf ; the nuclear oncogenes fos and myc did not produce these changes . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
These analyses reveal that the met kinase domain ( located on human chromosome 7 ) possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Here we have evaluated 21 gliomas for amplification of tumor related genes including NMYC , EGFR , TGFalpha , MET , CMYC , SRC , HRAS , NRAS , SEC , ROS 1 , JUN , and WNT 1 . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
DNA probes for the NRAS , HRAS , KRAS 2 , LCK , RAF 1 , MET , MYCL 1 , MYCN , MYB , ERBB 2 , FOS , CSF1R , and SRC protooncogene loci ; the retinoblastoma gene locus ( RB 1 ) ; the tumor virus integration sites INT 2 , PVT 1 , and MLV 12 ; and the locus of the tumor specific antigen T1A were used to screen mouse genomic DNAs from RF / J , CAST / Ei , MOLF / Ei , Mus musculus musculus , M . m . poschiavinus , and M . spretus . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
The structures of the cyclic hexapeptide cyclo ( Gly Tyr Val Pro Met Leu ) ( 1 ) and its phosphotyrosyl ( pTyr ) derivative cyclo [ Gly Tyr ( PO3H2 ) Val Pro Met Leu ] ( 2 ) , designed as constrained models of a sequence that interacts with the src homology 2 ( SH 2 ) region of the p 85 subunit of phosphatidylinositol 3 OH kinase ( PI 3 kinase ) , were studied in methanol / water solutions by 500 MHz nmr spectroscopy . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Met and substrates such as phosphatidylinositol 3 kinase , Src homology and collagen like , pp60c src , focal adhesion kinase p125FAK , and paxillin were associated with tyrosine phosphorylated complexes in a hepatocyte cell line established from the transgenic liver . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Mutation of amino acid residue Lys 219 to Met , by analogy to Src , abolished both kinase activity and transformation capacity . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Progression of familial adenomatous polyposis ( FAP ) colonic cells after transfer of the src or polyoma middle T oncogenes : cooperation between src and HGF / Met in invasion . ^^^ Taken together , the data indicate that : ( 1 ) experimental activation of src and PyMT pathways directly induces tumorigenicity and Met upregulation in a colon adenoma cell line ; ( 2 ) HGF activated Met and src cooperate in inducing invasion ; ( 3 ) in view of the molecular associations between catenins and cadherin or the tumour suppressor gene product APC , the cell adhesion molecule E cadherin may constitute a downstream effector of src and Met . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Oncogenes upstream of Ras cell surface receptors such as ErbB2 / Neu , Met , or Trk ( and their ligands ) , and nonreceptor cytoplasmic protein tyrosine kinases such as Src and Abl not only can act through Ras but also contribute additional signals . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
We mutagenized the signal transducer docking site of Met ( Y1349VHVX3Y1356VNV ) , which has the uncommon property of binding and activating multiple src homology region 2 ( SH 2 ) containing intracellular effectors . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
To study the role of the catalytic domain in 5 Src substrate specificity , we engineered three site directed mutants ( Leu 472 to Tyr or Trp and Thr 429 to Met ) . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Our studies show that activated Met associates with , and phosphorylates , the docking protein Gab 1 , which in turn binds to the src homology 2 ( SH 2 ) domain of the adapter protein Crk and recruits Crk to the Met signaling complex . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
To establish which pathways might be differentially regulated , we have localized the constitutively activated Tpr Met oncoprotein to the membrane using the c src myristoylation signal . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
We found that c Src was constitutively bound to MET proteins in F 4 cells , and that Src kinase activity was elevated . ^^^ The results suggest that c Src participates in the tumorigenic phenotype induced in NIH3T3 cells by MET M1268T by signaling through focal adhesion kinase and paxillin . ^^^ Tumorigenesis mediated by MET mutant M1268T is inhibited by dominant negative Src . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
It was shown previously that platelet activating factor receptors ( PAF Rs ) inhibit invasiveness of colonic and kidney epithelial cells induced by the src and Met oncogenes via a pertussis toxin sensitive mechanism . ^^^ Cellular invasion induced by src , Met , and leptin was abrogated by the AGalphao / i , ct betaARK , and Galphat positive clones , but was induced by coexpression of Gbeta1gamma2 . ^^^ Our data demonstrate the following : 1 ) PAF Rs impair cellular invasion induced by src , Met , and leptin via the activation of Galphao and Galphai 1 to 3 ; 2 ) invasion induced by TFFs is selectively inhibited by PAR 1 receptors and Galphai 3 activation ; and 3 ) Gbetagamma dimers are required as positive effectors of invasion pathways induced by oncogenes and epigenetic factors . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
We hypothesize that increased autocrine HGF Met signaling is a critical downstream function of c Src Stat 3 activation in mammary tumorigenesis . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
In addition , agents targeting other tyrosine kinases implicated in cancer , such as Met , Tie 2 and Src , are in preclinical development . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
GDNF promotes tubulogenesis of GFRalpha 1 expressing MDCK cells by Src mediated phosphorylation of Met receptor tyrosine kinase . ^^^ Met activation is mediated by Src family kinases . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
ICAM 1 promoter activities induced by the overexpression of wild type JAK 1 and PLC gamma 2 were blocked by the PLCgamma 2 mutant or the dominant negative PKCalpha ( Lys > Arg ) , c Src ( Lys > Met ) , or STAT 1 ( Y701M ) mutants , but not by dominant negative STAT 3 ( DN ) mutants . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
Our results indicate a functional role of Met E cadherin interaction in MCF 7 cells through the amplification of the signaling downstream of HGF Met triggering that involved c Src and phosphoinositide 3 kinase activities . . ^^^
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA
Interacting proteins: P08581 and P12931 Pubmed SVM Score :0.0
NA