| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :1.0734865 |
| We conclude that c Met associates with EGFR in tumor cells , and this association facilitates the phosphorylation of c Met in the absence of hepatocyte growth factor . 1.0734865^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| All three cell lines expressed transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , c erb B 2 , and c met genes . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In the second case an amplification of chromosome 7 specific c met sequences was found in the regrown tumour , suggesting that a polysomy 7 was at least partly responsible for the higher copy number of the EGFR sequences . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor ( EGFR ) and the protein products of c erbB 2 and c met proto oncogenes belong to a family of growth factor receptors with tyrosine kinase activity . ^^^ In human colonic carcinomas , the expression of the EGFR and c erbB 2 have been studied at the protein level only , while c met expression has not been reported . ^^^ The results demonstrate that the normal mucosa shows highly variable levels of EGFR and c erbB 2 mRNAs , but expresses consistently low amounts of c met mRNA . ^^^ Overexpression of c met proto oncogene but not epidermal growth factor receptor or c erbB 2 in primary human colorectal carcinomas . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Biopsy specimens of 19 human gliomas ( 10 glioblastomas , 2 anaplastic astrocytomas , 4 astrocytomas , one mixed glioma , one oligodendroglioma and one ependymoma ) were examined for amplification of tumour related genes located on chromosome 7 : the proto oncogene c erb B 1 ( encoding the epidermal growth factor receptor ( EGFR ] , the proto oncogene c met , the platelet derived growth factor A chain gene , and the plasminogen activator inhibitor type 1 gene . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Recent work in several laboratories has shown that elevated expression of certain other specific growth factor genes , including c met and EGFR , correlates with metastatic capability . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| No significant differences in expression of epidermal growth factor receptor ( EGF R ) and c met were found between HCC tumors in mice with PH or laparotomy , suggesting that over expression of EGF R or c met is not an essential component of this phenomenon . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We therefore determined the steady state mRNA expression of five tyrosine kinase receptors , epidermal growth factor receptor ( EGF R ) , c met , nerve growth factor receptor ( NGF R ) , colony stimulating factor receptor ( CSF R ) and c kit , in eleven human melanoma cell lines with different metastatic potentials in nude mice . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| All other growth factors and their receptors examined ( TGF alpha , EGFR , c met and c erbB 2 ) remained constant and were not affected by HGF treatment . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of transforming growth factor alpha ( TGF alpha ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 and c met proto oncogenes in eight newly established cell lines and 29 primary tumors of human non small cell lung carcinoma ( NSCLC ) have been investigated . ^^^ In vitro , the expressions of TGF alpha , c erbB 2 , and c met were consistently high in adenocarcinomas , while EGFR was expressed highest in a squamous cell carcinoma cell line . ^^^ The c met expression was also correlated with those of TGF alpha , EGFR , and c erbB 2 . ^^^ In vivo , The mean mRNA levels of TGF alpha , EGFR , and c met , but not c erbB 2 , were higher in carcinomas than in normal lung tissues ( 2 . 8 , 1 . 7 , and 3 . 0 times , respectively ) ; however , only adenocarcinomas expressed a significantly higher level of c erbB 2 than their corresponding normal tissues ( 2 . 2 times ) . ^^^ In 20 patients whose paired normal and tumor tissue were examined , the percentage of cases with greater than twofold increase in expression in carcinomas than normal were 55 % for both TGF alpha and EGFR , 30 % for c erbB 2 , and 47 % for c met . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We found no detectable transcripts of 9 proto oncogenes ( c sis , c met , c src , c lyn , c fgr , c ros , c pim , Blym and N myc ) , but detected transcripts of 12 other proto oncogenes ( int 2 , erbB , c abl , c raf 1 , c fyn , K ras , H ras , c mos , c myc , c myb , c fos , and c jun ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| All three growth factor / receptor systems , TGFalpha / epidermal growth factor receptor ( EGFR ) , HGF / c met and aFGF / FGF receptors ( flg and bek ) were significantly elevated at early time points when oval cells were proliferating . ^^^ With regard to the receptor expression in the tumors , EGFR was present at varying levels , c met was expressed at higher levels and flg increased significantly , whereas bek remained at low levels . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis also revealed that CD26 / DPP 4 is a more specific marker of differentiated carcinoma than three proto oncogenes previously reported to increase mRNA expression in thyroid carcinomas : c met , c erbB 2 , and EGF R . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| These data suggest that induction of c met mRNA and transactivation of c met may be a sequela of the constitutive expression of TGF alpha and that constitutive activation of the epidermal growth factor receptor pathway leads to phosphorylation and activation of c met . ^^^ These studies provide evidence for a novel mechanism of communication between epidermal growth factor receptor and c met pathways that may partially explain the synergistic effects reported between TGF alpha and HGF . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , the strong expression of growth factor receptors such as the epidermal growth factor receptor ( EGFr ) , p185erbB 2 , p180erbB 3 , and c met suggests that the growth of the basal cells is regulated by autocrine or paracrine factors . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : Southern blot , PCR / SSCP and DNA sequencing techniques were used in 33 gastric carcinomas to detect c met , EGFR , c erbB 2 , AKT 2 , c Ha ras , p 53 , p 16 and nm 23 H1 , for the presence of amplification , deletion , mutation and rearrangement . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Specifically , the epidermal growth factor receptor ( EGFR ) , p185HER2 / Neu and the hepatocyte growth factor receptor ( c Met ) appear to be linked to the process because they preferentially activate c Src in highly metastatic cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Both the EGF R and the c met proto oncogene receptor , to which HGF binds , were immunoprecipitated from H 441 cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| To determine a role for ligand mediated receptor activation in sarcoma progression , the relative expression and function of EGF R , IGF 1 R , and several other molecular determinants implicated in the progression of mesenchymal neoplasms were evaluated in human sarcoma cells established from surgical specimens of primary and metastatic tumors . mRNA blot analyses demonstrated the expression of c Met , p 53 , and MDM 2 specific transcripts . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| These results indicate that the repetitive activation of ERK 2 related to the phosphorylation of c MET and EGFR is required for the renal regeneration in HgCl 2 induced ARF of rat . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We examined amplification of the c met , c erbB 2 , and epidermal growth factor receptor ( EGFR ) gene in the patients with primary gastric cancer , and compared the data with clinical features in order to clarify the relationship between oncogenic abnormality and clinical features . ^^^ Seven of the seventy cancers ( 10 . 0 % ) had c met gene amplification , nine ( 12 . 9 % ) had c erbB 2 gene amplification , and six ( 8 . 6 % ) had EGFR gene amplification , respectively . ^^^ Amplification of the c met , c erbB 2 and epidermal growth factor receptor gene in human gastric cancers : correlation to clinical features . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In order to investigate the relationships of expression and tyrosine phosphorylation of cadherin catenin molecules and expression of growth factor receptor tyrosine kinase with loose cell to cell adhesion , immunohistochemical staining for E cadherin , alpha and beta catenin , phosphorylated tyrosine residues and tyrosine kinase receptors , including c erbB 2 , epidermal growth factor receptor ( EGF R ) , c met and K sam , in 17 undifferentiated and 10 differentiated type human gastric cancers was performed . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Growth factors ( EGF , TGF alpha , HGF ) and growth factor receptors ( EGF R , c met , CCK ) are expressed at levels not found in the normal pancreas . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The objective of the present study was to characterize the expression of two hepatotrophic growth factor / receptor systems [ transforming growth factor alpha / epidermal growth factor receptor ( TGF alpha / EGFR ) and hepatocyte growth factor / c met receptor ( HGF / c met ) ] , both of which are implicated in the development of human liver tumors . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| These receptors included c met proto oncogene product ( c MET ) , epidermal growth factor receptor ( EGFR ) and transforming growth factor beta receptor 2 ( TGFbetaR ) . ^^^ The overexpression of c MET was detected in all cases ( 20 / 20 ) of the tubulo papillary growth type and 78 . 3 % ( 18 / 23 ) of chromophilic cell subtype , resulting in a very significant associations between c MET overexpression and tubulo papillary growth RCCs ( P < 0 . 0001 ) , c MET and chromophilic subtype RCCs ( P < 0 . 0001 ) , and c MET and EGFR ( P < 0 . 0001 ) . ^^^ The overexpression of c MET , EGFR , and TGFbetaR may have roles that are individually significant in the morphogenesis of RCC . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Some studies have suggested that the overexpression of c Met and epidermal growth factor receptor ( EGFR ) are associated with growth advantage , while transforming growth factor beta receptor 2 ( TGF beta R 2 ) is associated with growth disadvantage of human prostatic adenocarcinoma . ^^^ However , it is unclear if the expression of c Met correlates with the expression of EGFR and TGF beta R 2 , and with the proliferative status of human prostatic adenocarcinoma . ^^^ Using immunohistochemical staining with anti c Met ( C 12 ) , anti EGFR ( NCL EGFR ) and anti TGF beta R 2 ( L 21 ) antibodies , we determined the frequency of expression of c MET , EGFR , and TGF beta R 2 respectively in a series of 134 radical prostatectomy specimens . ^^^ Overall , c Met immunostaining was detected in 54 of 134 ( 40 . 3 % ) cases , EGFR in 45 ( 33 . 6 % ) and TGF beta R 2 in 64 ( 48 . 4 % ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Survival analysis was performed for patients with these tumors with variables including c Met positivity , EGFR positivity , and MIB 1 labeling index . ^^^ Positivity of c Met was independent from EGFR positivity and MIB 1 labeling index , and the c Met positive group showed a significant shorter survival ( p < 0 . 05 ) . c Met immunopositivity may be a parameter of biological aggressiveness in high grade astrocytic tumors . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In general , peptide growth factors signaling through cognate receptors with tyrosine kinase intracellular signaling domains such as epidermal growth factor receptor , fibroblast growth factor receptors , hepatocyte growth factor / scatter factor receptor , c met , insulin like growth factor receptor , and platelet derived growth factor receptor , stimulate lung morphogenesis , while the cognate receptors with serine / threonine kinase intracellular signaling domains , such as the transforming growth factor beta receptor family are inhibitory . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Epidermal growth factor receptor , plasminogen , SPARC ( secreted protein , acidic and rich in cysteine , also called osteonectin or BM 40 ) , and collagen 4 decreased , and fibrinogen subunits and c Met expression remained constant 72 hours after PHx when compared to control liver . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In general , peptide growth factors signaling through cognate receptors with tyrosine kinase intracellular signaling domains such as FGFR , EGFR , IGFR , PDGFR and c met stimulate lung morphogenesis . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| It is not active against kinases from other receptor families , such as epidermal growth factor receptor , fibroblast growth factor receptor 1 , c Met , and Tie 2 , or intracellular kinases such as c Src , c Abl , and protein kinase C alpha . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| It induced protein tyrosine phosphor ylation of hepatocyte growth factor ( HGF ) receptor ( c Met ) or epidermal growth factor receptor ( EGFR ) , which increased progressively to a maximum level at 30 min in Panc 1 cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor ( EGFR ) and the hepatocyte growth factor receptor ( c Met ) are two such receptor tyrosine kinases ( RTKs ) that have been causally implicated in colorectal carcinoma ( CRC ) progression and metastasis . ^^^ The coordinated functional expression of epidermal growth factor receptor and c Met in colorectal carcinoma metastasis . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In stratified squamous epithelial cells , these receptors include epidermal growth factor receptor ( EGFR ) that binds both EGF and transforming growth factor alpha ( TGFalpha ) , and c met whose ligand is hepatocyte growth factor / scatter factor ( HGF / SF ) . ^^^ We show that while these cell lines expressed EGFR and c met , stimulation with their respective ligands did not induce proliferation but markedly increased invasion of reconstituted basement membranes . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Changes in the expression of mRNAs of HGF , c met , TGF alpha , and epidermal growth factor receptor ( EGFR ) by treatment with HGF and TGF alpha were observed . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| It is not active against kinases from other receptor families such as EGFR , FGFR 1 , c Met and Tie 2 or intracellular kinases like c Src , c Abl , PKC alpha . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Increases in vascular endothelial growth factor ( VEGF ) receptors Flt 1 and Flk 1 / KDR , angiopoietin receptors Tie 1 , Tie 2 , and platelet derived growth factor receptor beta ( PDGF Rbeta ) , modest increases in epidermal growth factor receptor ( EGF R ) , and no increase in hepatocyte growth factor receptor ( c Met ) or fibroblast growth factor receptors ( FGF R ) were observed in isolated membranes during EC proliferation . ^^^ EGF R was upregulated evenly throughout the sinusoidal membrane , whereas c Met was observed on hepatocyte canaliculae , bile duct epithelium , and large vessel EC . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We report that the epidermal growth factor receptor ( EGFR ) kinase inhibitor PKI 166 blocked both basal and ligand induced tyrosine phosphorylation of the EGFR ( IC ( 50 ) = 60 nM ) , but not of the insulin receptor or c met . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of c met and epidermal growth factor receptor analyzed by RT PCR and immunohistochemistry did not differ between the two groups . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Signaling domains derived from receptors for interleukin 6 ( gp 130 ) , hepatocyte growth factor ( c met ) , epithelial growth factor ( EGF R ) , and thrombopoietin ( mpl ) triggered monkey hepatocytes to enter the cell cycle . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| No correlation was found between epidermal growth factor receptor ( EGFR ) , insulin like growth factor receptor inhibitor ( IGF 1 R ) , gelatinase , p 53 , metalloproteinase 9 ( MMP 9 ) , platelet derived growth factor receptor ( PDGF R ) , vascular endothelial growth factor ( VEGF ) and c met expression and metastatic potential as measured by Northern analysis . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed the presence of high levels of epidermal growth factor receptor and c MET . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Up regulation of transmembrane tyrosine kinase receptors c met , IGFR 1 , IGFR 2 and EGFR family related ligands such as HB EGF , TGFa , amphiregulin and neuregulin as well as c met ligand HGF point to a possible role of this system in metastasis . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In the clinics , EGFR inhibitors and c Kit inhibitors are already being utilized , and c Met inhibitors are in development . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression pattern of phosphorylated ERK1 / 2 in the trophoblasts was compared with that of various growth factor receptors , such as c met , IGF 1R , flt 1 , EGFR , PDGFR , Bek , and flg . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Low levels of hepatocyte growth factor and transforming growth factor alpha mRNAs were found concomitantly in highly differentiated tumors , whereas overexpression of mRNAs for the cognate receptors c met and epidermal growth factor receptor were found in poorly differentiated tumors and primarily in patients with early tumor recurrence . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| These results demonstrate a role of Stat 3 in transducing survival signals downstream of tyrosine kinases such as Src , EGF R , and c Met , as well as cytokines such as IL 6 , in human nonsmall cell lung cancers . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Promising therapeutic targets for cancer metastasis have been identified , including Src , focal adhesion kinase , the integrin receptor , the vascular endothelial growth factor receptor , the epidermal growth factor receptor , Her 2 / neu , c Met , Ras / Rac GTPases , Raf kinase , farnesyl diphosphate synthase ( i . e . , amino bisphosphonate therapeutic target ) and matrix metalloproteases within the context of their implicated functional roles in cancer growth , invasion , angiogenesis and survival at secondary sites . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We will specifically discuss receptors such as epidermal growth factor receptor , c Kit receptor , VEGF receptor , c Met receptor , insulin growth factor receptor , and Eph receptor . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| PTEN and c Met co regulated many genes involved in cell growth regulation such as oncogenes , growth factors , transcription factors , and constituents of the ubiquitin pathway . c Met activation in PTEN null ( but not PTEN reconstituted ) cells led to upregulation of the EGFR agonist TGFalpha and subsequently to EGFR activation . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Sphingosine 1 phosphate transactivates c Met as well as epidermal growth factor receptor ( EGFR ) in human gastric cancer cells . ^^^ We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor ( EGFR ) and c Met in gastric cancer cells , both of which have been proposed as prognostic markers of gastric cancers . ^^^ The pathway of S1P induced c Met transactivation is Gi independent and matrix metalloproteinase independent , which differs from that of EGFR transactivation . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Tgfbr 2 ( fspKO ) mammary fibroblasts transplanted with mammary carcinoma cells promote growth and invasion , which is associated with increased activating phosphorylation of the receptors : erbB 1 , erbB 2 , RON , and c Met . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Amplification and overexpression of c erbB 2 , epidermal growth factor receptor , and c met in biliary tract cancers . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To examine the expression of c Met , c Erb b 2 ( HER2 / neu ) , and epidermal growth factor ( EGFR ) in a cohort of 12 chordomas , based on the current and future availability of targeted molecular inhibitors . ^^^ MAIN OUTCOME MEASURE : The expression of c Met , HER2 / neu , and EGFR . ^^^ RESULTS : Most chordomas displayed strong expression of EGFR and c Met , whereas a variable level of expression of HER2 / neu was seen . ^^^ In addition , we noted a strong correlation between EGFR and c Met expression , especially for primary chordomas ( P = . 006 ) . ^^^ CONCLUSIONS : Chordomas , like many other solid tissue tumors , express HER2 / neu , EGFR , and the hepatocyte growth factor / scatter factor receptor c Met . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry was used in liver biopsy specimens to assess markers of proliferation ( PCNA ) and the expression of mitogens ( TGF alpha , TGF beta ( 1 ) ) or their receptors ( C met and EGFR ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| AIM : To examine whether lysophosphatidic acid ( LPA ) induces phosphorylation of c Met and epidermal growth factor receptor ( EGFR ) , both of which have been proposed as prognostic markers of colorectal cancer , and whether LPA induces cyclooxygenase 2 ( COX 2 ) expression in human colon cancer cells . ^^^ RESULTS : Immunoprecipitation analysis revealed that 10 micromol / L LPA induced tyrosine phosphorylation of c Met and EGFR in LoVo cells within a few minutes . ^^^ We found that c Met tyrosine phosphorylation induced by LPA was not attenuated by pertussis toxin or a matrix metalloproteinase inhibitor , in marked contrast to the results for EGFR . ^^^ Lysophosphatidic acid transactivates both c Met and epidermal growth factor receptor , and induces cyclooxygenase 2 expression in human colon cancer LoVo cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Interestingly , surface accumulation of the chemotactic receptor appears to be selective in VHL mutant cells , since other surface proteins such as epidermal growth factor receptor , platelet derived growth factor receptor , IGFR 1 , and c Met are not affected . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Western blot analyses and co immunoprecipitations were used to investigate the association of proteins involved in epidermal growth factor and hepatocyte growth factor activation and signaling : epidermal growth factor receptor , hepatocyte growth factor receptor ( MET ) , urokinase type plasminogen activator and its receptor , and a member of the signal transducer and activator of transcription family , STAT 3 . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Using rat GEC in culture , we demonstrated that sublytic C5b 9 induced tyrosine phosphorylation of the epidermal growth factor receptor ( EGF R ) , Neu , fibroblast growth factor receptor 2 , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| RESULTS : VK 3 induced phosphorylation of hepatocyte growth factor receptor ( c met ) , epidermal growth factor receptor ( EGFR ) , or external signal regulated kinase ( ERK ) , which increased progressively to a maximum level at 30 minutes , in a dose dependent manner and occurred at growth inhibitory concentrations . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction was performed on each sample with primers for rat epidermal growth factor , epidermal growth factor receptor ( ErbB ) , heparin binding epidermal like growth factor , hepatocyte growth factor , hepatocyte growth factor receptor , keratinocyte growth factor , betacellulin , amphiregulin , and neuregulin alpha . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Although RTKs are a large family , HER 2 , epidermal growth factor receptor ( EGFR ) , Met ( hepatocyte growth factor receptor ) , and others all have shown the ability to predict outcome . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In biochemical assays , SU 10944 exhibits potent inhibitory activity against VEGFR 1 ; weak activity against other related subgroup members , including stem cell factor receptor ( SCFR ) , platelet derived growth factor receptor beta ( PDGFRbeta ) , and fibroblast growth factor receptor 1 ( FGFR 1 ) ; and no detectable activity against other protein tyrosine kinases such as epidermal growth factor receptor ( EGFR ) , Src , and hepatocyte growth factor receptor . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| These findings disclose a cross talk between the COX 2 / PGE ( 2 ) / EP ( 1 ) and EGFR / c Met signaling pathways that coordinately regulate human HCC cell invasion . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of hepatocyte growth factor receptor and epidermal growth factor receptor of human hepatocytes can be maintained in a ( 3D ) collagen sandwich culture system . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Laser microdissection and quantitative reverse transcription polymerase chain reaction ( qRT PCR ) was used to quantify keratinocyte growth factor receptor ( KGFR ) , hepatocyte growth factor receptor ( HGFR ) , epidermal growth factor receptor ( EGFR ) and fibroblast growth factor receptor 1 ( FGFR 1 ) gene expression , and in situ RT PCR localized these increases to specific epithelial cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The TGF alpha receptor EGFr appears primarily to mediate a proliferative signal , whereas mitogenic , motogenic , and morphogenic effects have been attributed to activation of the HGF receptor Met . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| While concentration of PGE 2 as well as expression of Cox 2 , HGF receptor ( c Met R ) , epidermal growth factor receptor ( EGFR ) , and beta catenin are all dramatically increased in colon cancers and implicated in their growth and invasion , the precise role of PGE 2 in the latter process remains unclear . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| PB , EGFR and HGFR mRNA were essentially unchanged over the 13 week dosing period whilst M6PR mRNA was increased 2 to 4 fold . ^^^ PB , EGFR protein levels from immunoblots showed a consistent decrease over the 13 weeks whilst M6PR and HGFR protein levels were essentially unchanged . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Cultured HPDE cells express low levels of epidermal growth factor receptor ( EGFR ) , erbB 2 , transforming growth factor ( TGF ) alpha , Met / hepatocyte growth factor receptor ( HGFR ) , vascular endothelial growth factor ( VEGF ) , and keratinocyte growth factor ( KGF ) . ^^^ The expression levels were similar in primary normal HPDE cells and those expressing transfected E6E7 genes of human papilloma virus 16 , but their immortalization appeared to enhance the expression of EGFR and Met / HGFR . ^^^ In comparison , pancreatic carcinoma cell lines commonly demonstrated overexpression of EGFR , erbB 2 , TGF alpha , Met / HGFR , VEGF , and KGF , but they consistently showed marked down regulation of amphiregulin mRNA expression . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : This study searched for the mRNA expression pattern of six tyrosine and serine / threonine kinase receptors [ hepatocyte growth factor ( HGFR ) , fibroblast growth factor ( FGFR ) , epidermal growth factor ( EGFR ) , insulin like growth factor ( IGF ) 1R , transforming growth factor ( TGF ) betaR 1 , TGF betaR 2 ] together with the five somatostatin receptors in human gastroenteropancreatic neuroendocrine tumours ( gastrinomas , insulinomas , tumours with carcinoid syndrome , functionally inactive neuroendocrine tumours ) using reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : To address this question , we analyzed the extent of EGFR and HGFR expression in gastrinomas from 38 patients with Zollinger Ellison syndrome and correlated it with clinical and tumor characteristics . ^^^ EGFR ( n = 38 ) and HGFR ( n = 22 ) mRNA levels were determined by competitive PCR , and immunohistochemistry was performed on a subset . ^^^ RESULTS : In each of the gastrinomas studied , detectable levels of EGFR and HGFR mRNA were present . ^^^ Low levels of EGFR protein expression were detected in 40 % of gastrinomas and HGFR protein expression in 90 % . ^^^ EGFR mRNA expression varied by 1050 fold and HGFR by 375 fold . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| However , 6ab did not have any inhibitory activity against other kinases such as EGFR , HGFR , InsulinR and others even at 10000 nM . 6ab suppressed the growth of the VEGF stimulated human umbilical vein endothelial cell ( HUVEC ) on a nanomolar level . 6ab showed significant antitumor activity against five human tumor xenografts such as GL 07 ( glioma ) , St 4 ( stomach carcinoma ) , LC 6 ( lung carcinoma ) , DLD 1 ( colon carcinoma ) and A 375 ( melanoma ) in nude mice and also showed complete tumor growth inhibition with the LC 6 xenograft in nude rats following oral administration once a day for 14 days at 5 mg / kg without any body weight loss . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In immunohistochemistry , EGFR , HGFR , FGFR and TNFR 1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h , a nadir after 24 h and another weak increase up to 72 h . ^^^ EGFR , FGFR and TNFR 1 mRNA expression was equal or lower than in resting liver , HGFR expression after I / R was stronger than in the control . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In comparison with normal DNA , tumour DNA of a total of eight patients ( seven with germ cell neoplasm and one with testicular lymphoma ) showed increased dosages of KRAS 2 , PDGFA , EGFR , MET and PDGFB . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| This gene did not hybridize with the met and erbB 1 genes , which are potential oncogenes located on chromosome 7 . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Southern blot analysis of primary NIH3T3 transformant DNAs carrying oncogenes from radiation initiated squamous cell carcinomas indicated that the oncogenes responsible for the transformation of the recipient cells were not Ha ras , Ki ras or N ras genes , nor were they erbB , B lym , met , neu or raf . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The met oncogene , however , which is also located on chromosome # 7 ( 7q31 q 32 ) , was shown not to be overexpressed in a panel of 7 polysomic glioblastoma cell lines overexpressing erbB . ^^^ These findings favor the assumption of differential regulation of the met and erbB oncogenes , e . g . by means of insufficient activity of a trans acting erbB suppressor gene possibly located on a chromosome with a low copy number . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Given the recent recognition that some growth factor receptors can form heterodimers with CD 44 , the present study was undertaken to determine whether the CD 44 and growth factor receptors ( e . g . , EGFR , FGFR , HGFR , VEGFR , TGF betaRI , or TGF betaRII ) can form heterodimers in cancer cells and , if so , to investigate the potential functional consequences of such heterodimerization . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Some of the Shc associated phosphoproteins ( EGFR , PDGFR , erbB 2 , Met , bcr abl , H 4 ret ) bound both the Shc and Grb 2 SH2 domains in vitro ; others ( p 175 ; p 70 p80 ) only the Shc SH 2 domain and yet others ( p 140 ) only the Grb 2 SH3 domains . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Transcripts coding for transcription factors ( RB , P 53 , FOS , MYC , MYB , ERBA , REL ) , growth factors ( FGF 1 , FGF 2 , INT 2 , TGFA , TGFB , PDGF , IGF 1 , IGF 2 ) , interleukins , ( IL 1 , IL 2 , IL 3 , IL 4 , IL 6 , TNF ) , growth factor receptors or cytosolic protein kinases ( RAF , PIM , FES , MET , SRC , ROS , TRK , KIT , CSFR , IGFR , PDGFR , EGFR , NEU ) were quantified in cultured human mammary fibroblasts from normal tissues , benign tumours , carcinomas and post radiation fibrosis lesions by slot blot autoradiography and image analysis . ^^^ The drugs modulated the levels of the anti oncogene transcripts ( RB , P 53 ) and of ERBA , REL , RAF , MET , ROS , TRK , CSFR , EGFR , NEU , FGF 1 , INT 2 , IGF 1 , IL 1 , IL 2 , IL 4 and IL 6 . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The present report summarizes the current molecular biological aspects of several oncogenes ( erbB , ras , myc , raf , fos , jun , bcl , mdm 2 , myb , kit CSF1R , met ) and tumor suppressor genes ( p 53 , rb , mts ) involved in lung cancer development with respect to the pathology of lung tumors , including the importance of these genes as far as the clinical course of the disease is concerned . . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Four of these genes ( EGF R , IGFI R , CSF 1 R , and PDGF R beta ) were expressed in epithelial cells , whereas four ( erbB 2 , erbB 3 , NGF R , and met ) were not . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Here we have evaluated 21 gliomas for amplification of tumor related genes including NMYC , EGFR , TGFalpha , MET , CMYC , SRC , HRAS , NRAS , SEC , ROS 1 , JUN , and WNT 1 . ^^^ The oncogene MET was amplified in a glioblastoma which showed no EGFR gene amplification . ^^^ The finding of MET and EGFR independently amplified in glioma lends further support to a crucial role of chromosome 7 in the development of gliomas . . ^^^ Two independent amplification events on chromosome 7 in glioma : amplification of the epidermal growth factor receptor gene and amplification of the oncogene MET . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Southern blotting demonstrated that the genes for EGFR ( epidermal growth factor receptor ) , PDGFRA ( platelet derived growth factor receptor alpha ) , MET and MYC oncogenes were involved in 7p11 p 12 , 4q11 q 12 , 7q31 and 8q24 . 1 amplifications , respectively . ^^^ These amplifications were found by in situ hybridization on tumor spreads , in dmin or episomes for EGFR , dmin for PDGFRA and MET , and hsr and dmin for MYC genes . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Many genes have been shown to be amplified in more than single cases of gliomas and these include EGFR , CDK 4 , SAS , MDM 2 , GLI , PDGFAR , MYC , N MYC , MYCL 1 , MET , GADD 153 , and KIT . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The CDK 6 gene has been localized to chromosome 7q21 22 , but in the gliomas studied here , it was not coamplified with either the syntenic MET ( 7q31 ) or epidermal growth factor receptor ( 7p11 p 12 ) genes , suggesting that this may be part of a novel amplicon in gliomas . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Several growth factors ( TGF alpha , HGF ) and their receptors ( EGFR , MET , ERBB 2 ) were expressed in the primitive IBS cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Among 346 clones , we identified epidermal growth factor receptor ( EGF R ) , Tie 2 , platelet derived growth factor receptor ( PDGF R ) alpha , PDGF R beta , Flk 1 , Flt 4 , fibroblast growth factor receptor ( FGF R ) 1 , FGF R 3 , FGF R 4 , Met , and RYK / Nbtk 1 . ^^^ EGF R , PDGF R alpha , FGF R 1 , FGF R 3 , Met , and in some cases Tie 2 protein expression was greater in fetal kidneys , as compared with kidneys from 12 week old adult rats ( controls ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Extracted DNA was examined by Southern blot using probes corresponding to the EGFR , CDK 4 , MDM 2 , n MYC , CYCD 1 , PDGFR alpha , MET , c MYC oncogenes . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The transphosphorylation specifically takes place for the receptor subfamily , as it is not observed between Met or Ron and ErbB 1 , ErbB 2 or TrkA . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Preincubation of carcinoma cells with suramin decreased EGFR activation and downregulated Met expression as well as the ligand independent phosphorylation of Met . ^^^ Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : We investigated genomic amplification on chromosomes 7 and 8 by comparative genomic hybridization ( CGH ) and protein expression of relevant oncogenes ( EGFR , HGF , MET , CTSB , MYC ) by immunohistochemistry ( IHC ) in 22 esophageal and 22 gastric cardia carcinomas . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The EGFR JM ( Met ( 644 ) Phe ( 688 ) ) was expressed as a GST fusion protein and immobilised on a sensor chip surface . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| This review discusses the current situation regarding the development of inhibitors with particular reference to the erbB family , the insulin like growth factor receptor , the Met receptor , the receptor for vascular endothelial growth factor and the Kit receptor . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : The expression levels of SF / HGF and TGF alpha as well as their respective receptors , MET and EGFR , are known to correlate with glioma malignancy grade . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Cross communication between the Met receptor tyrosine kinase and the epidermal growth factor receptor ( EGFR ) has been proposed to involve direct association of both receptors and EGFR kinase dependent phosphorylation . ^^^ Whereas specific inhibition of the EGFR kinase activity blocked EGF but not GPCR agonist induced Met receptor transactivation , it was abrogated in the presence of a reducing agent or treatment of cells with a NADPH oxidase inhibitor . ^^^ Our results provide a new molecular explanation for cell surface receptor cross talk involving the Met receptor and thereby link the wide diversity of GPCRs and the EGFR to the oncogenic potential of Met signaling in human carcinoma cells . . ^^^ Reactive oxygen species mediate Met receptor transactivation by G protein coupled receptors and the epidermal growth factor receptor in human carcinoma cells . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : The authors conducted an immunohistochemical analysis of the expression of beta catenin , upstream modulators ( HER 2 / neu , Met , and epidermal growth factor receptor [ EGFR ] ) , downstream target genes ( cyclin D 1 and matrix metalloproteinase 7 [ MMP 7 ] ) , and p 53 on a tissue microarray of 346 lymph node negative breast carcinomas . ^^^ HER 2 / neu and EGFR were observed on the membrane in 21 % and 6 % of tumors , respectively , and Met stained in a membrane / cytoplasm distribution in 28 % of cases . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Met 5 enkephalin induced cardioprotection occurs via transactivation of EGFR and activation of PI3K . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Expression , distribution and activation of the HC receptors ( MET and EGFR ) and the pattern of characteristic cytokeratin ( CK ) filaments were measured by fluorometry , confocal microscopy and Western blotting . ^^^ In AM increased expression of MET and EGFR was associated with receptor translocation into the cytoplasm and induction of atypical CK 19 . ^^^ In DM low expression of MET and EGFR was localized on the cell membrane and CK 19 was reduced . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Systematic copy number analysis of tyrosine kinase genes identified high level amplification of EGFR in three NSCLC specimens , FGFR 1 in two specimens and ERBB 2 and MET in one specimen each . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of 10 proteins ( CAV 1 , CD 44 , EGFR , MET , ETS 1 , GATA 3 , luminal cytokeratin CK 19 , basal cytokeratin CK5 / 6 , CD 10 , and ERM protein moesin ) encoded by luminal vs basal discriminator genes confirmed the subtype classification and the validity of the identified markers . ^^^ |
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| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| In this regard , the recently delineated interplay between COX 2 derived PG signaling and other growth regulatory pathways such as EGFR , Met , iNOS , VEGF and n 3 polyunsaturated fatty acids is expected to provide important therapeutic implications . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| We also report on the existence of likely dominant negative forms for many of the receptor kinases and phosphatases , including some 26 secreted decoys ( seven known and 19 novel : Alk , Csf1r , Egfr , Epha 1 , 3 , 5 , 7 and 10 , Ephb 1 , Flt 1 , Flt 3 , Insr , Insrr , Kdr , Met , Ptk 7 , Ptprc , Ptprd , Ptprg , Ptprl , Ptprn , Ptprn 2 , Ptpro , Ptprr , Ptprs , and Ptprz 1 ) and 13 transmembrane forms ( four known and nine novel : Axl , Bmpr1a , Csf1r , Epha 4 , 5 , 6 and 7 , Ntrk 2 , Ntrk 3 , Pdgfra , Ptprk , Ptprm , Ptpru ) . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Degradation of acutely stimulated receptor tyrosine kinases , epidermal growth factor receptor and Met , is strongly inhibited in UBPY knockdown cells suggesting that UBPY function is essential for growth factor receptor down regulation . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| Beside the previously identified genetic abnormalities ( VHL , MET , EGFR ) , CAIX seems to be a novel molecular marker of RCC . ^^^ |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08581 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|