| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| We found that in cells expressing the endogenous proteins , Plexin B 1 ( the Sema 4D Receptor ) and Met ( the Scatter Factor 1 / Hepatocyte Growth Factor Receptor ) associate in a complex . ^^^ In addition , binding of Sema 4D to Plexin B 1 stimulates the tyrosine kinase activity of Met , resulting in tyrosine phosphorylation of both receptors . ^^^ |
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| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| Recent data indicate that the signalling activity of the Met receptor for hepatocyte growth factor is affected by association with cell specific surface molecules , namely the alpha6beta4 integrin , Plexin B 1 and CD 44 . ^^^ |
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| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| A physical and functional association between Met and Plexin B 1 , the prototype of class B Plexin subfamily , has been previously demonstrated . ^^^ Here , we show that both Met and Ron receptors can interact with each of the three members of class B Plexins , even in the absence of their ligands and that Plexin B 1 ligand , Sema 4D , can induce activation of Met and Ron receptors , promoting an invasive response . ^^^ These data extend the crosstalk previously described between Met and Plexin B 1 to the entire families of Scatter Factor Receptors and class B Plexins and show that interaction with multiple upstream activators can finely tune the invasive growth process both in physiological conditions and in tumor growth and metastatization . . ^^^ |
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| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| Whereas c Met , with which plexin B 1 can interact , is known to be a potent promoter of angiogenesis , the effects of semaphorin mediated plexin activation in endothelial cells are still poorly understood . ^^^ |
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| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| Sema4D induces angiogenesis through Met recruitment by Plexin B 1 . ^^^ Moreover , we prove that biologic effects elicited by Plexin B 1 require coupling and activation of the Met tyrosine kinase . ^^^ |
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| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43157 and P08581 |
Pubmed |
SVM Score :0.0 |
| NA |
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