| Interacting proteins: P42338 and P08473 |
Pubmed |
SVM Score :1.0005565 |
| Coimmunoprecipitation experiments show that NEP associates with tyrosine phosphorylated Lyn kinase , which then binds the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in an NEP Lyn PI 3 K protein complex . 1.0005565^^^ |
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| Interacting proteins: P42338 and P08473 |
Pubmed |
SVM Score :0.0 |
| The identity of the p 110 beta was confirmed by Western blot analysis of NEP and p 110 beta immunoprecipitates using monoclonal antibodies specific for NEP and p 110 beta . ^^^ CONCLUSION : These data confirm the association of phosphatidylinositol 3 kinase ( consisting of the p 85 adaptor and p 110 beta subunit ) with NEP . ^^^ Detection of the p 110 beta subunit of phosphatidylinositol 3 kinase complexed with neutral endopeptidase . ^^^ |
|
| Interacting proteins: P42338 and P08473 |
Pubmed |
SVM Score :0.0 |
| We have shown that the effects of NEP are mediated by its ability to catalytically inactivate substrates such as bombesin and endothelin 1 , but also through direct protein protein interaction with other protein such as Lyn kinase [ which associates with the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in NEP Lyn PI 3 K protein complex ] , ezrin / radixin / moesin ( ERM ) proteins , and the PTEN tumor suppressor protein . ^^^ |
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| Interacting proteins: P42338 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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