| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| The influence of neutral endopeptidase ( NEP ) inhibition with ( S ) thiorphan on the hormonal , renal , and blood pressure lowering effects of an infusion of atrial ( ANP ) , brain ( BNP ) , and C type natriuretic peptide ( CNP ) was evaluated in hypertensive transgenic rats ( TGR ) harboring an additional mouse renin gene ( TGR ( m ( Ren 2 ) 27 ) ) . ^^^ Co administration of ANP , BNP , or CNP with the NEP inhibitor ( S ) thiorphan potentiated the plasma ANP , BNP , and cGMP . ^^^ These results indicate that inhibition of neutral endopeptidase by ( S ) thiorphan potentiates the hemodynamic and renal effects of natriuretic peptides ANP and BNP , and to some extent those of CNP , in hypertensive TGR and normotensive SDR . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| UK 73967 , an active form of UK 79300 , or phosphoramidon partly reversed the atherosclerotic impairment of relaxation of the isolated thoracic aortic rings from Cholesterol rabbits in response to exogenous additions of C type natriuretic peptide ( CNP ) and substance P , which are NEP substrates known to exist endogenously in the vascular endothelium . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| The depressor and renal responses to C type natriuretic peptide ( CNP ) were determined in conscious cynomolgus monkeys treated with vehicle or inhibitors of neutral endopeptidase EC 3 . 4 . 24 . 11 ( NEP ) and angiotensin converting enzyme ( ACE ) . ^^^ These data are consistent with the protection of CNP from degradation by renal NEP . ^^^ The potentiation of the depressor , cyclic GMP , and natriuretic responses to CNP in nonhuman primates by SQ 28603 suggested that NEP is an important mechanism for in vivo inactivation of natriuretic peptides , including CNP . . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| Recent in vitro studies have reported that CNP is the most susceptible of all natriuretic peptides to enzymatic degradation by neutral endopeptidase 24 . 11 ( NEP ) . ^^^ The present study was undertaken to define the role of NEP in total and regional CNP metabolism and the modulatory actions of NEP inhibition on the biological actions of CNP . ^^^ CNP ( 10 ng 10 kg ( 1 ) 10 min ( 1 ) ) followed by candoxatrilat ( 240 microg 10 kg ( 1 ) bolus and 8 microg 10 kg ( 1 ) 10 min ( 1 ) ) , a potent and selective NEP inhibitor , was administered intravenously to a group of anesthetized mongrel dogs ( group 1 ) to permit calculation of total metabolic clearance rate ( MCR ) ; results were compared with those in a group receiving vehicle infusion followed by candoxatrilat ( group 2 ; both groups , n=7 ) . ^^^ NEP inhibition increased circulating CNP achieved by exogenous infusion and reduced total MCR in group 1 . ^^^ Urinary CNP excretion did not change with CNP infusion but markedly increased after NEP inhibition . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| In addition to clearance by the NPR C receptor , CNP is subject to degradation by the ectoenzyme neutral endopeptidase 24 . 11 ( NEP ) , which is widely distributed in the kidney , lung , heart , and endothelial cells . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated the effects of CNP against leukotriene ( LT ) D 4 induced airway microvascular leakage and bronchoconstriction and how these effects were potentiated by thiorphan , a potent neutral endopeptidase 3 . 4 . 24 . 11 ( NEP ) inhibitor . 2 . ^^^ These inhibitory effects were enhanced by pretreatment with 20 mg / kg thiorphan , suggesting the important role of NEP in the pulmonary metabolism of CNP . 4 . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| Simultaneous inhibition of NEP and ACE increases natriuretic and vasodilatory peptides ( including atrial natriuretic peptide [ ANP ] , brain natriuretic peptide [ BNP ] of myocardial cell origin , and C type natriuretic peptide [ CNP ] of endothelial cell origin ) and increases the half life of other vasodilator peptides including bradykinin and adrenomedullin . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| Animal studies have demonstrated that CNP causes endothelium independent vasodilation , which is limited by neutral endopeptidase ( NEP ) activity . ^^^ Therefore , we investigated the vasodilator actions of CNP in human forearm resistance vessels before and after inhibition of nitric oxide ( NO ) and then prostacyclin production and after inhibition of Ca ( 2+ ) dependent potassium channel activation and NEP activity . ^^^ Vasodilation to all doses of CNP was significantly increased when activity of NEP was blocked with thiorphan ( 30 nmol / min ) , which suggests that NEP activity limits vasodilation of CNP . ^^^ Inhibition of local NEP activity increases CNP bioavailability . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| Inhibition of NEP increases levels of atrial natriuretic peptide ( ANP ) , brain natriuretic peptide ( BNP ) of myocardial cell origin , and C type natriuretic peptide ( CNP ) of endothelial cell origin as well as bradykinin and adrenomedullin . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| C type natriuretic peptide ( CNP ) , a local regulator of vascular tone and cell proliferation , is eliminated from the circulation via NPR C receptors and neutral endopeptidase enzyme ( NEP , EC . 3 . 4 . 24 . 11 ) . ^^^ The increased contractility of coronary arteries in different cardiovascular diseases made us study the possible enhancement of vasodilator capacity of exogenously added CNP with concomitant NEP inhibition on porcine coronary arteries in vitro . ^^^ The combined NEP / endothelin converting enzyme inhibitor ( NEP / ECE inhibitor ) , phosphoramidon ( 10 microM ) or the specific inhibitor of the NEP , thiorphan ( 10 microM ) resulted in an enhanced magnitude of CNP induced relaxation without significant change in the EC 50 both on endothelium intact and endothelium deprived preparations . ^^^ |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23582 and P08473 |
Pubmed |
SVM Score :0.0 |
| NA |
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