| Interacting proteins: P08473 and P07948 |
Pubmed |
SVM Score :1.2596832 |
| Coimmunoprecipitation experiments show that NEP associates with tyrosine phosphorylated Lyn kinase , which then binds the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in an NEP Lyn PI 3 K protein complex . 1.2596832^^^ |
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| Interacting proteins: P08473 and P07948 |
Pubmed |
SVM Score :1.0213464 |
| We previously reported that NEP directly associated with tyrosine phosphorylated Lyn kinase , and with the p 85 subunit of the phosphatidylinositol 3 kinase ( PI 3 kinase ) resulting in an NEP Lyn PI 3 kinase protein complex . 1.0213464^^^ |
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| Interacting proteins: P08473 and P07948 |
Pubmed |
SVM Score :0.0 |
| The approximately 56 kD CD10 / NEP associated phosphoprotein was immunoprecipitated with an anti lyn antibody confirming its identity as the lyn src related kinase . ^^^ Taken together , these data indicate that CD10 / NEP is itself phosphorylated by CKII and that CD10 / NEP co associates with additional tyrosine phosphoproteins including lyn . . ^^^ |
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| Interacting proteins: P08473 and P07948 |
Pubmed |
SVM Score :0.0 |
| We have shown that the effects of NEP are mediated by its ability to catalytically inactivate substrates such as bombesin and endothelin 1 , but also through direct protein protein interaction with other protein such as Lyn kinase [ which associates with the p 85 subunit of phosphatidylinositol 3 kinase ( PI 3 K ) resulting in NEP Lyn PI 3 K protein complex ] , ezrin / radixin / moesin ( ERM ) proteins , and the PTEN tumor suppressor protein . ^^^ |
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