| Interacting proteins: P61073 and P08246 |
Pubmed |
SVM Score :0.52819787 |
| These primary immunodeficiencies are caused by germline mutations in seven genes : ELA 2 , encoding a neutrophil elastase , and GFI 1 , encoding a regulator of ELA 2 ( mutations associated with severe congenital neutropenia ) ; CXCR 4 , encoding a chemokine receptor ( warts , hypogammaglobulinemia , infections and myelokathexis syndrome ) ; LCRR 8 , encoding a key protein for B cell development ( agammaglobulinemia ) ; IFNGR 1 , encoding the ligand binding chain of the interferon gamma receptor ; STAT 1 , encoding the signal transducer and activator of transcription 1 downstream from interferon gammaR 1 ( Mendelian susceptibility to mycobacterial diseases ) ; and IKBA , encoding IkappaBalpha , the inhibitor alpha of NF kappaB ( anhidrotic ectodermal dysplasia with immunodeficiency ) . 0.52819787^^^ |
|
| Interacting proteins: P61073 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leukocyte elastase negatively regulates Stromal cell derived factor 1 ( SDF 1 ) / CXCR4 binding and functions by amino terminal processing of SDF 1 and CXCR 4 . ^^^ Blockade of SDF 1 and CXCR 4 proteolysis by the specific leukocyte elastase inhibitor , N methoxysuccinyl alanine alanine proline valine chloromethyl ketone , identified elastase as the major enzyme among leukocyte secreted proteinases that accounts for inactivation of both SDF 1 and CXCR 4 . ^^^ Indeed , purified leukocyte elastase generated in either SDF 1 or CXCR 4 a pattern of cleavage indistinguishable from that observed with leukocyte secreted proteinases . ^^^ |
|
| Interacting proteins: P61073 and P08246 |
Pubmed |
SVM Score :0.0 |
| Consistent results were obtained with a set of five genes : in the NE treated animals four genes ( CXCR 4 , VCAM 1 , IL 1R2 , CD 14 ) were found 2 8 fold upregulated as compared to sham treated animals , whereas the gene for CCR 3 was downregulated ( < 0 . 5 fold ) . ^^^ |
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| Interacting proteins: P61073 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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