| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase 9 ( MMP 9 ) , neutrophil elastase ( NE ) , and cathepsin G ( CG ) accumulate in the bone marrow during granulocyte colony stimulating factor ( G CSF ) treatment , where they are thought to degrade key substrates including vascular cell adhesion molecule 1 ( VCAM 1 ) and CXCL 12 . ^^^ G CSF induced a significant decrease in CXCL 12 alpha protein expression in the bone marrow of Ne 10 CG deficient mice , indicating that these proteases are not required to down regulate CXCL 12 expression . ^^^ |
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| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine ( NE ) signaling controls G CSF induced osteoblast suppression , bone CXCL 12 downregulation , and HSPC mobilization . ^^^ |
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| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leukocyte elastase negatively regulates Stromal cell derived factor 1 ( SDF 1 ) / CXCR4 binding and functions by amino terminal processing of SDF 1 and CXCR 4 . ^^^ Blockade of SDF 1 and CXCR 4 proteolysis by the specific leukocyte elastase inhibitor , N methoxysuccinyl alanine alanine proline valine chloromethyl ketone , identified elastase as the major enzyme among leukocyte secreted proteinases that accounts for inactivation of both SDF 1 and CXCR 4 . ^^^ Indeed , purified leukocyte elastase generated in either SDF 1 or CXCR 4 a pattern of cleavage indistinguishable from that observed with leukocyte secreted proteinases . ^^^ |
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| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| The gradual decrease of BM SDF 1 , due mostly to its degradation by neutrophil elastase , correlated with stem cell mobilization . ^^^ |
|
| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P48061 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|