| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| We determined whether CG and NE could affect PAR 1 expression and function in mononuclear cells . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| EPI hNE 4 was nebulized with Pari LC Star and tested at three concentrations ( 2 . 5 , 5 , and 10 mg / mL ) . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| NE ( nisoxetine ) and dopamine ( DA ) ( GBR 12935 ) reuptake inhibitors on the 5 hydroxytryptophan ( 5 HTP ) induced HTR . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Plasmin , calpain and leukocyte elastase , cathepsin G , and proteinase 3 cleaved at multiple sites and would be expected to disable PAR 1 by cleaving COOH terminal to the activation site . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leukocyte elastase , thrombin , and PAR 1 activating peptide , but not the control peptide , induced apoptosis in human airway and alveolar epithelial cells as assessed by increases in cytoplasmic histone associated DNA fragments and TUNEL staining . ^^^ In concert , these observations provide strong evidence that leukocyte elastase mediates apoptosis of human lung epithelial cells through PAR 1 dependent modulation of the intrinsic apoptotic pathway via alterations in mitochondrial permeability and by modulation of JNK and Akt . . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Because of the importance of thrombin as a ligand for protease activated receptor 1 ( PAR 1 ) , which is involved in inflammation , the inhibition of thrombin activity by natural compounds might enhance the anti inflammatory effects of neutrophil elastase inhibition . . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Evidence that thrombin and cathepsin G act at different receptors was as follows : ( a ) an antibody directed against the thrombin receptor blocked thrombin induced but not cathepsin G induced platelet responses ; ( b ) human fibroblasts responded to thrombin and to a synthetic thrombin receptor peptide ( comprising residues 42 55 of the thrombin receptor ) by exhibiting an elevation in cytosolic Ca2+ concentration but did not respond to cathepsin G ; and ( c ) platelets pretreated with neutrophil elastase failed to respond to thrombin but responded when rechallenged by cathepsin G . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| While confirming that both thrombin and neutrophil elastase proteolyse GPV , we show that neutrophil cathepsin G , thrombin receptor activating peptide ( TRAP ) , and a combination of ADP and epinephrine can each result in a decrease in the platelet surface expression of GPV by a nonproteolytic mechanism : a cytoskeletal mediated redistribution of platelet surface GPV to the surface connected canalicular system ( SCCS ) . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Because a dramatic differential potentiation in HTR frequency is obtained when cocaine is administered prior relative to after L tryptophan injection , the effects of varying doses of cocaine and the selective serotonin ( sertraline ) , dopamine ( DA ) ( GBR 12935 ) , and norepinephrine ( NE ) ( nisoxetine ) uptake blockers were investigated on the d fenfluramine induced behavior in two experimental protocols . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| TR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH 3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . ^^^ Interestingly , coincubation of 35S TR alpha 1 , GH 3 NE , and unlabeled TREp resulted in not only the 35S TR : TREp complex , but in two additional more greatly retarded complexes containing 35S TR alpha 1 and comigrating with those formed by GH 3 extract alone . ^^^ A similar , heat labile activity which altered mobility of the TR : TRE complex was also present in NE from T 3 unresponsive JEG 3 cells . ^^^ At high concentration of NE , all of the TR bound to TREp was more greatly retarded than in the absence of NE . ^^^ Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the carboxyl terminus of the TRs is essential for interaction with nuclear proteins . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Tissue specific sympathetic activity was assessed by the norepinephrine turnover rate ( NE TR ) after 14 and 35 days of treatment . ^^^ Minoxidil increased NE TR in the LV ( after 14 and 35 days ) , in the RV ( after 14 days ) , as well as in the superior mesenteric artery ( after 14 and 35 days ) , but not in the kidney . ^^^ Nisoldipine decreased cardiac NE TR , but did not affect NE TR in the other tissues , suggesting a central effect of nisoldipine . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| TSH , ACTH , and NE declined during the 2nd h of POAH cooling as Tr plateaued ; when POAH cooling was stopped , these hormones fell below basal level as vasodilation and panting restored Tr to normal . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| The calorigenesis occurring in brown adipose tissues ( BAT ) in response to infused norepinephrine [ NE : 4 micrograms / ( kg . min ) ] was estimated from the arteriovenous O 2 difference across the interscapular brown adipose tissue and the rate of blood flow to BAT in physically trained ( TR ) and control ( CT ) rats . ^^^ With NE infusion , the O 2 content of arterial blood was unchanged , but that from Sulzer ' s vein significantly decreased from 12 . 5 to 2 . 5 vol % in TR and from 15 . 7 to 4 . 3 vol % in CT rats . ^^^ The increase in O 2 consumption in BAT with NE was estimated as 1 . 60 ml / min in TR and 0 . 83 ml / min in CT rats . ^^^ The increase in the whole body O 2 consumption with NE was 3 . 19 ml / min in TR and 2 . 29 ml / min in CT rats . ^^^ The contribution of calorigenesis in BAT to the whole body calorigenic response to NE was estimated at 50 % in TR and 36 % in CT rats . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| It was found that nuclear extracts ( NE ) added to rec TR alpha markedly amplified not only DNA binding , which has been well documented , but also T 3 binding ( increased binding site concentration ) , which has not yet been reported . ^^^ This T 3 binding amplifying effect on rec TR alpha occurs at low NE protein concentrations that produce no or minimal endogenous TR with respect to rec TR , while similar concentrations of other proteins ( e . g . ovalbumin or cytosol ) only moderately enhanced T 3 binding . ^^^ A protective effect of NE against a loss of affinity for T 3 under the action of antibodies directed to certain sequences in the TR alpha D domain suggests that nuclear factors help rec TR alpha to acquire and / or stabilize a conformation that allows the high affinity T 3 binding . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| MR imaging demonstrated the NE cyst to be isointense to hyperintense relative to cerebrospinal fluid on long TR sequences and isointense or slightly hyperintense to cerebrospinal fluid on T 1 weighted images . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Planned contrasts ( P < 0 . 05 ) indicated that exercise training increased succinate dehydrogenase activity ( mmol cytochrome C reduced . min 1 . g 1 wet weight ) in soleus muscle for TR compared with WR or C . [ NE ] was higher in the pons medulla and spinal cord for both TR and WR compared with C . [ DHPG ] was higher in the pons medulla for TR compared with C , and [ MHPG ] was higher in the frontal cortex and in the hippocampus for TR compared with C . ^^^ |
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| Interacting proteins: P25116 and P08246 |
Pubmed |
SVM Score :0.0 |
| Nuclear extracts ( NE ) of cultured skin fibroblasts from affected individuals of this family were tested for their interaction with normal TR beta and thyroid hormone response elements by the electrophoretic mobility shift assay . ^^^ NE from the proposita showed a strong additional band compared to NEs from normal individuals and patients with RTH caused by TR beta mutations or deletion . ^^^ Far Western analysis of NE from the affected daughter hybridized with labeled TR beta demonstrated an additional band that was not seen in NEs from a normal control or patients with TR beta gene defects . ^^^ |
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