| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.92519748 |
| Since HLE has been shown to bind to Mac 1 , and ICAM 1 plays a key role during the recruitment and the activation of leukocytes at inflamed sites , we investigated the capacity of HLE to cleave ICAM 1 . 0.92519748^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| High dose CAB 2 significantly blocked monocyte and PMN CD11b upregulation and PMN elastase release . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| A standard immunoperoxidase technique was used to detect expression of ICAM 1 , E selectin , VCAM 1 , and the cell markers CD11a , CD11b , CD11c , von Willebrand factor , CD 3 , CD 68 , and neutrophil elastase ( NP 57 ) . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| An HNE dependent increase in CD11b expression was also observed ; however , HNE did not affect the expression of other neutrophil adhesion molecules ( L selectin ) , superoxide production , or degranulation . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| The expression of CD11b and CD 67 increased in cells treated with HNE or continuously exposed to DMSO , whereas CD 36 was expressed at low levels on both treatments . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| In the pulmonary vein there was a significant increase in neutrophil expressed CD11b ( P < 0 . 001 ) , neutrophil elastase : alpha 1 antitrypsin complexes ( P < 0 . 001 ) , endothelin 1 ( P < 0 . 001 ) and thrombin antithrombin complexes ( P < 0 . 001 ) by the end of bypass compared with pre operative levels . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of plaunotol on neutrophil elastase release , production of O 2 , intracellular calcium concentration and expression of adhesion molecules CD11b and CD 18 in activated neutrophils in vitro . ^^^ |
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| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| METHODS : In a simulated extracorporeal model that activates complement ( C3a and sC5b 9 ) , platelets ( CD62P expression , leukocyte platelet conjugate formation ) , and leukocytes ( increased CD11b expression and neutrophil elastase ) , we examined an anti human C 8 monoclonal antibody that inhibits C5b 9 generation for its effects on cellular activation . ^^^ |
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| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Neutrophil and monocyte CD11b expression levels , determined by flow cytometry ; soluble interleukin ( IL ) 2 receptor ( sIL 2R ) , IL 6 , and IL 8 concentrations , determined by means of Immulite ; and soluble E selectin , determined by ELISA , were higher in patients with NE than in healthy subjects . ^^^ The findings were not specific for NE and did not correlate with serum creatinine levels , but the findings correlated inversely with mean arterial pressure ( sIL 2R and monocyte CD11b expression ) and minimum platelet count ( sIL 2R , IL 6 , neutrophil , and monocyte CD11b expression ) . ^^^ |
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| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| INTERVENTIONS : Effects of ranitidine on neutrophil elastase release , production of O 2 , intracellular calcium concentration and expression of adhesion molecules CD11b and CD 18 were examined in human neutrophils in vitro . ^^^ MEASUREMENTS AND MAIN RESULTS : Ranitidine inhibited the release of neutrophil elastase as well as the production of O 2 , the increase in the concentrations of intracellular calcium , a second messenger of neutrophil activation , and increases in CD11b and CD 18 expression , in activated neutrophils . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Expression of CD11b and HLE on neutrophils , and ICAM 1 on monocytes , were lower in patients who died compared to those who survived ( p < 0 . 05 ) . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Neutrophil CD11b expression increased significantly after exercise only in the claudicants , and was associated with a significant rise in plasma neutrophil elastase . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We found a significantly reduced antibacterial activity of PMN from preterm infants upon stimulation with LPS as indicated by low surface expression of the adhesion molecule CD11b and the reduced secretion of PMN elastase . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| SI induced activation of PMN , which was characterized by increased expression of CD11b , decreased expression of L selectin , and increased F actin content , led to increases in serum IL 6 and PMN elastase level . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| A series of immunohistochemical double staining procedures using the following markers was performed : IL 10 , CD11b , HLA DR , CD 36 , neutrophil elastase , and CD66b . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Clots were analysed immunohistochemically for detection of platelets ( CD41a ) , leucocytes / lymphocytes ( CD11b ) , granulocytes ( CD 16 , lysozyme ) , neutrophilic granulocytes ( neutrophil elastase ) , eosinophilic granulocytes ( NaCN + H ( 2 ) O ( 2 ) ) , macrophages ( CD 68 ) , dendritic cells ( CD209 / DC SIGN ) , B cells ( CD 20 ) and T cells ( CD 4 , CD 8 ) . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| AT supplementation at the higher dose significantly abrogated monocyte and neutrophil CD11b up regulation and neutrophil elastase release . ^^^ CONCLUSION : In addition to anticoagulant and anti PLT effects , pharmacologic AT doses significantly blunted monocyte and neutrophil CD11b up regulation and neutrophil elastase release during sCPB , independent of endothelial effects . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| The number of Mac 1 receptors expressed on polymorphonuclear leukocytes correlated with polymorphonuclear leukocyte elastase complexes ( r = 0 . 93 ) . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Leucocyte adhesion was monitored with radiolabelled neutrophils and scanning electron microscopy ( SEM ) , degranulation by measurement of human neutrophil elastase using an indirect enzyme linked immunosorbent assay and cell surface expression of the integrin receptor Mac 1 , using fluorescent activated cell sorting ( FACS ) . ^^^ |
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| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Human leukocyte elastase is an endogenous ligand for the integrin CR 3 ( CD11b / CD18 , Mac 1 , alpha M beta 2 ) and modulates polymorphonuclear leukocyte adhesion . ^^^ Human leukocyte elastase is an endogenous ligand for the integrin CR 3 ( CD11b / CD18 , Mac 1 , alpha M beta 2 ) and modulates polymorphonuclear leukocyte adhesion . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Expression levels of three markers of terminal myeloid differentiation ( neutrophil elastase , proteinase 3 , and Mac 1 ) were highest in EML cells at the later stages of differentiation . ^^^ |
|
| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| While searching for mechanisms involved in this phenomenon we found that BM myeloid cells bound to fucoidan through the integrin alphaMbeta 2 ( macrophage antigen 1 [ Mac 1 ] ) and L selectin resulting in alphaMbeta 2 independent release of neutrophil elastase , but inhibition of elastase activity did not impair fucoidan induced mobilization . ^^^ |
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| Interacting proteins: P11215 and P08246 |
Pubmed |
SVM Score :0.0 |
| Elastase release in the inflamed tissue was reduced in Mac 1 deficient mice , and a deficiency of Mac 1 or the kinases blocked neutrophil elastase release in vitro . ^^^ |
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