| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.59510789 |
| Incubation of recombinant G CSF or a G CSFR form corresponding to its extracellular domain with purified NE resulted in rapid proteolytic cleavage of both proteins . 0.59510789^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Administration of G CSF alone for 3 5 days produced a decrease in L selectin expression in neutrophils ( 25 + / 4 versus 7 + / 1 , mean + / SEM ; mean channel fluorescence , n = 10 ) with no effect on neutrophil elastase activity ( 3 . 1 + / 0 . 3 versus 3 . 4 + / 0 . 6 ; micrograms elastase / million cells ; n = 9 ) . ^^^ Administration of G CSF alone did not cause a decrease in the neutrophil elastase activity but increased plasma elastase / alpha 1 antitrypsin complex levels . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| G CSF stimulated proliferation of the transformants , down regulated Thy 1 and F4 / 80 antigens on the cell surface , and induced expression of neutrophil specific genes such as myeloperoxidase ( MPO ) and leukocyte elastase . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| In transfection assays using the nonhematopoietic cell line , CV 1 , the p 32 isoform activated promoters from the myeloid specific mim 1 , neutrophil elastase , and granulocyte colony stimulating factor ( G CSF ) receptor genes by 2 . 5 , 1 . 8 , and 1 . 6 fold , respectively . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| The Hoxa 9 immortalized progenitor exhibited a promyelocytic transcriptional profile , expressing PU . 1 , AML 1 , c Myb , C / EBP alpha , and C / EBP epsilon as well as their target genes , the receptors for GM CSF , G CSF , and M CSF and the primary granule proteins myeloperoxidase and neutrophil elastase . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| After transplantation , the patient ' s neutrophil elastase ( ELA 2 ) mutation and G CSF R mutation became undetectable by polymerase chain reaction . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Two serine proteases , namely , neutrophil elastase and cathepsin G , were identified , which cleave VCAM 1 and are released by neutrophils accumulating in the BM during the course of immobilization induced by G CSF . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| The transcription factor C / EBPalpha is an important mediator of granulocyte differentiation and regulates the expression of multiple granulocyte specific genes including the granulocyte colony stimulating factor ( G CSF ) receptor , neutrophil elastase , and myeloperoxidase . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| In all these patients we evaluated routine blood tests ( hemoglobin level HGB , white blood cell count WBC , platelet count PLT , white blood cell differential count neutrocyte count NE , lymphocyte count LY , monocyte count MN , eosinophile count EO ) and serum levels of 13 cytokines and soluble cytokine receptors ( IL 6 , IL 8 , IL 10 , TNFalpha , G CSF , M CSF , bFGF , VEGF , IL 1ra , sIL 2R . sIL 6R . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Administration of either G CSF or the myelosuppressive agent cyclophosphamide results in a sharp reduction of VCAM 1 / CD106 expression in the bone marrow that coincides with the accumulation of granulocytic precursors and release of active neutrophil proteases neutrophil elastase and cathepsin G that directly cleave VCAM 1 / CD106 in vitro . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study with anti mouse neutrophil elastase antibody demonstrated strong infiltrations of PMNs into and around the transplanted tumor , treated with c Nd 2 and G CSF . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| To study a possible role of neutrophils in granulocyte colony stimulating factor ( G CSF ) induced hematopoietic mobilization , we assessed the number of circulating CD34+ cells in healthy allogeneic stem cell donors on days 3 , 4 , and 5 of mobilization for comparison with the number of peripheral blood neutrophils and the plasma levels of IL 8 , Flt 3 ligand ( FL ) , matrix metalloproteinase 9 ( MMP 9 ) , and human neutrophil elastase ( HNE ) . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Neutrophil elastase enzymatically antagonizes the in vitro action of G CSF : implications for the regulation of granulopoiesis . ^^^ These results support a role for neutrophil elastase in providing negative feedback to granulopoiesis by direct antagonism of G CSF . . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Patients with CML have high levels of neutrophil elastase , which has recently been shown to antagonize the action of granulocyte colony stimulating factor ( G CSF ) and other growth factors . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| G CSF mobilization correlates with elevated neutrophil elastase ( NE ) , cathepsin G ( CG ) , and MMP 9 levels within marrow and is partially blocked by either anti MMP 9 or the NE inhibitor MeOSuc Ala Ala Pro Val CMK . ^^^ Synergistic PBSC mobilization observed when G CSF and GRObeta / GRObetaT are combined correlates with a synergistic rise in the level of plasma MMP 9 , reduction in marrow NE , CG , and MMP 9 levels , and a coincident increase in peripheral blood PMNs but decrease in marrow PMNs compared to G CSF . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Circulating leukocyte counts , markers of activation on PMN , and circulating levels of G CSF , IL 6 , and PMN elastase were measured . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Most patients respond to treatment with granulocyte colony stimulating factor ( G CSF ) , and the majority harbor mutations in the neutrophil elastase gene . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The onset of synthesis of myeloperoxidase , lysozyme , leukocyte elastase , and proteinase 3 occurred early after differentiation induction with G CSF , while synthesis of cathepsin G , azurocidin , and bactericidal / permeability increasing protein was detected somewhat later . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| All out rowing acutely increased plasma cortisol , neutrophil elastase , flt 3 ligand , hepatocyte growth factor , VEGF , and transforming growth factor beta 1 , and decreased erythropoietin ; K ligand , stromal derived factor 1 , IL 6 , and G CSF were unchanged . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Effects of granulocyte colony stimulating factor ( G CSF ) and neutrophil elastase inhibitor ( ONO 5046 ) on acid induced lung injury in rats . ^^^ We examined the effects of the high dose of granulocyte colony stimulating factor ( G CSF ) , which is capable of increasing peripheral neutrophils , and a specific neutrophil elastase inhibitor ( ONO 5046 ) on acid lung injury in rats . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine ( NE ) signaling controls G CSF induced osteoblast suppression , bone CXCL 12 downregulation , and HSPC mobilization . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| In contrast , overexpression of wild type Gfi 1 abolished G CSF induced up regulation of C / EBPepsilon but had no apparent effect on NE up regulation by G CSF . ^^^ Notably , G CSF dependent proliferation and survival were inhibited upon overexpression of C / EBPepsilon but not NE . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| DESIGN AND METHODS : We studied 14 individuals ( four patients with SCN and ten close relatives ) belonging to the original Kostmann family in northern Sweden for mutations in the ELA 2 and the granulocyte colony stimulating factor ( G CSF ) receptor genes . ^^^ |
|
| Interacting proteins: P09919 and P08246 |
Pubmed |
SVM Score :0.0 |
| We also review the literature elucidating some of the mechanisms and consequences of SCN ( e . g : the neutrophil elastase gene mutations and the risk of progression to myelodysplasia and acute leukemia ) and the role of granulocyte colony stimulating factor . . ^^^ |
|