| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| Interaction of heparin cofactor 2 with neutrophil elastase and cathepsin G . ^^^ We investigated the interaction of the human plasma proteinase inhibitor heparin cofactor 2 ( HC ) with human neutrophil elastase and cathepsin G in order to examine 1 ) proteinase inhibition by HC , 2 ) inactivation of HC , and 3 ) the effect of glycosaminoglycans on inhibition and inactivation . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| We have now studied the specificity of binding and endocytosis by VLDLR and alpha2MR / LRP among a variety of serine proteinase / serpin complexes , including various combinations of the serine proteinases urokinase type and tissue type plasminogen activators , plasmin , thrombin , human leukocyte elastase , cathepsin G , and plasma kallikrein with the serpins PAI 1 , horse leukocyte elastase inhibitor , protein C inhibitor , C 1 inhibitor , alpha 2 antiplasmin , alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , protease nexin 1 , heparin cofactor 2 , and antithrombin 3 . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| Furthermore , neutrophil elastase inactivates anticoagulants including antithrombin 3 , heparin cofactor 2 , and thrombomodulin , suggesting that neutrophil elastase aggravates microcirculatory disturbance after ischemia / reperfusion . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| Heparin cofactor 2 ( HCII ) is plasma glycoprotein and thrombin inhibitor of the serpin type previously shown to inhibit thrombin in the absence of its N terminal 74 amino acids , and to be cleaved by neutrophil elastase ( NE ) at two sites : I 66 F67 and V 439 G440 , the P 6 P5 bond of the reactive center loop . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| In experiments with purified proteases , HCII did not significantly inhibit coagulation factors VIIa , IXa , Xa , XIa , XIIa , kallikrein , activated protein C , plasmin , urokinase , tissue plasminogen activator , leukocyte elastase , the gamma subunit of nerve growth factor , and the epidermal growth factor binding protein . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| When inflammation takes place , at least two other possible existent forms of HCII , the complexed form with thrombin and the cleaved form by leukocyte elastase , are assumed to be present at relatively high concentrations in a local circumstance . ^^^ By HCII in complex with thrombin or cleaved by leukocyte elastase , the affinity of HCII moiety for heparin increases and that for dermatan sulfate decreases . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| Res . 47 , 657 664 , 1987 ) , and that chemotactic activity is produced when HCII is partially proteolyzed with purified leukocyte elastase or cathepsin G ( Hoffman , M . , Pratt , C . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| We have now purified the variant HCII ( designated HCIIOslo ) from the plasma of ne of these individuals . ^^^ |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P05546 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|