Interactions between atrial natriuretic peptide ( ANP ) and bradykinin ( BDK ) on norepinephrine ( NE ) uptake were demonstrated in the adrenal medulla of the rat . ^^^ One hundred nM ANP and 10 nM BDK increased total NE uptake . ^^^ Effective concentrations of ANP and BDK acting simultaneously did not induce additive effects on total NE uptake . ^^^