| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| All of these results taken together suggest that one of the primary functions of alpha 1 antichymotrypsin is to inactivate leukocyte cathepsin G , while alpha 1 proteinase inhibitor controls the activity of other serine proteinases , particularly leukocyte elastase . . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| In affected skin we applied immunohistochemical methods to examine the topographical organization of neutrophil associated proteinase / proteinase inhibitor systems , i . e . the PMN elastase / alpha 1 proteinase inhibitor and the cathepsin G / alpha 1 antichymotrypsin systems . ^^^ Cathepsin G , PMN elastase and alpha 1 antichymotrypsin were found in association with the polymorphonuclear infiltrating cells , whereas alpha 1 proteinase inhibitor was localized exclusively in the subepidermal oedema . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Studies on the interactions of human pancreatic elastase 2 with human alpha 1 proteinase inhibitor and alpha 1 antichymotrypsin . ^^^ The interactions of human pancreatic elastase 2 with alpha 1 proteinase inhibitor and alpha 1 antichymotrypsin were compared by studies in vitro . ^^^ As the kass . rate constants are of the same order of magnitude , with a slightly lower value for alpha 1 proteinase inhibitor when compared with alpha 1 antichymotrypsin [ ( 5 . 6 + / 1 . 2 ) 10 10 ( 5 ) and ( 8 . 9 + / 1 . 3 ) 10 10 ( 5 ) M 1 . s 1 respectively ] , partition of human pancreatic elastase 2 between both inhibitors in human plasma is mainly dependent on their respective concentrations . ^^^ The patterns obtained are similar when working with normal plasma or with the synthetic mixture , suggesting that , in the conditions used , alpha 1 proteinase inhibitor and alpha 1 antichymotrypsin are the main inhibitors of human pancreatic elastase 2 in the plasma sample . ^^^ The present work suggests that , according to the delay times of inhibition of human pancreatic elastase 2 calculated from the normal plasma concentrations of alpha 1 proteinase inhibitor and alpha 1 antichymotrypsin , a significant role can be assigned to both inhibitors . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Incubation of human serum alpha 1 antichymotrypsin with human pancreatic elastase 2 or porcine pancreatic elastase results in the complete inhibition of each enzyme as determined by spectrophotometric assays . alpha 1 Antichymotrypsin reacts much more rapidly with the human than with the porcine enzyme . ^^^ The inhibitor : enzyme molar ratio , required to obtain full inhibition of enzymatic activity , is equal to 1 . 25 / 1 when alpha 1 antichymotrypsin reacts with human pancreatic elastase 2 while it is markedly higher with porcine pancreatic elastase ( 5 . 5 / 1 ) . ^^^ A contribution of alpha 1 antichymotrypsin to the regulatory balance between plasma inhibitors and human pancreatic elastase 2 in pancreatic diseases is suggested . . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Comparison of the rates of inactivation with those already established for other inhibitors clearly indicate that alpha 1 proteinase inhibitor is the controlling inhibitor for neutrophil elastase and alpha 1 antichymotrypsin for cathepsin G , alpha 2 macroglobulin acting only as a secondary inhibitor . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Conversion of alpha 1 antichymotrypsin into a human neutrophil elastase inhibitor : demonstration of variants with different association rate constants , stoichiometries of inhibition , and complex stabilities . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Neutrophil elastase and cathepsin G were identified using selective chromogenic substrates and by their specific inhibition with alpha 1 proteinase inhibitor and alpha 1 antichymotrypsin , respectively . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| We have now studied the specificity of binding and endocytosis by VLDLR and alpha2MR / LRP among a variety of serine proteinase / serpin complexes , including various combinations of the serine proteinases urokinase type and tissue type plasminogen activators , plasmin , thrombin , human leukocyte elastase , cathepsin G , and plasma kallikrein with the serpins PAI 1 , horse leukocyte elastase inhibitor , protein C inhibitor , C 1 inhibitor , alpha 2 antiplasmin , alpha 1 proteinase inhibitor , alpha 1 antichymotrypsin , protease nexin 1 , heparin cofactor 2 , and antithrombin 3 . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| We utilized a reactive loop switching strategy to determine the extent to which the inhibitory activity of alpha 1 protease inhibitor ( PI ) against human neutrophil elastase ( HNE ) could be transferred to alpha 1 antichymotrypsin ( ACT ) , a serpin that does not inhibit HNE . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Wild type mice given NE inhibitors ( alpha 1 proteinase inhibitor and Me O Suc Ala Ala Pro Val CH ( 2 ) Cl ) , but not mice given cathepsin G / chymase inhibitors ( alpha 1 antichymotrypsin or Z Gly Leu Phe CH ( 2 ) Cl ) , were resistant to the pathogenic activity of anti BP 180 antibodies . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Using ion exchange chromatography and gel filtration , elastase 2 , the main elastolytic component of protofradin ( preparation of proteases of Act . fradiae 119 ) , was purified to an electrophoretically homogeneous state . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| These results suggest that GRP , NT and DN 1417 act at the hypothalamic catecholamine nerve terminals and stimulate the release of DA and NE in the rat . . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Both human neutrophil elastase ( HNE ) and free chymotrypsin ( Chtr ) proteolyze Chtr within the complex that Chtr forms with antichymotrypsin ( ACT ) . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| Acta 1481 , 75 87 ] , ( b ) the effect of added NaCl in dramatically increasing the rate of ACT inhibition of PSA correlates with salt induced changes in PSA conformation , and ( c ) the PSA * ACT * complex is subject to proteolysis by human neutrophil elastase . ^^^ |
|
| Interacting proteins: P01011 and P08246 |
Pubmed |
SVM Score :0.0 |
| We studied the immunoreactivity to six CgA epitopes and SV 2 in ten typical ( TC ) and ten atypical ( ACT ) carcinoids , five large cell NE carcinomas ( LCNEC ) and five small cell carcinomas ( SCLC ) , also comparing the results with clinicopathological characteristics of tumors . ^^^ |
|