| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| The particular spots were identified as SPARC , vimentin , serine protease , collagen alpha 2 precursor , tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) , and 5 , 10 methlenetetrahdrofolate reductase ( FADH 2 ) . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis of clones that hybridized more intensely with cochlear than with brain cDNA probes revealed some previously characterized genes , including mitochondrial sequences , collagen type 1 alpha 2 ( COL1A2 ) , collagen type 2 alpha 1 ( COL2A1 ) , collagen type 3 alpha 1 ( COL3A1 ) , spermidine / spermine N 1 acetyltransferase ( SAT ) , osteonectin ( SPARC ) , and peripheral myelin protein 22 ( PMP 22 ) . ^^^ Northern blots of cochlear and brain RNAs probed with COL1A2 , COL2A1 , COL3A1 , SAT , SPARC , PMP 22 , and a novel sequence , designated Coch 5B2 , confirm results of the subtractive procedure by showing preferential cochlear expression . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| Specifically , we observed significant overexpression of genes encoding extracellular matrix components ( eg , COL3A1 , COL1A1 , COL1A2 , COL6A1 , COL6A2 , elastin ) and genes involved in extracellular matrix turnover ( TIMP 3 , OSF 2 ) , cell adhesion and antiadhesion ( SPARC , hevin ) , cytokinesis ( PNUTL 2 ) , and cell migration ( tetraspanin 5 ) . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| COL1A2 was the most abundant transcript among both sets of ESTs , followed in order by COL3A1 , SPARC , EEFY1A1 , and TPTI . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| Significant up regulation in Tabby skin was observed for several dermal matrix genes , including Col1a1 , Col1a2 , Col3a1 and SPARC : In contrast , down regulation occurred for the NEMO / NF kappa B pathway , already implicated in skin appendage formation , and even more markedly for a second pathway , JNK / c jun / c fos and their target genes , that has not previously been clearly associated with skin development . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| Genotypes at 14 loci representing eight candidate genes [ type 1 collagen genes ( COL1A1 and COL1A2 ) , osteocalcin , osteonectin , osteopontin , vitamin D receptor ( VDR ) , estrogen receptor ( ER ) , androgen receptor ( AR ) ] were determined . ^^^ Osteonectin , osteopontin and VDR translation initiation site polymorphisms were associated with some individual bone measures , but none of the associations was as consistent as those identified for the COL1A2 and osteocalcin genes . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| Normal fibroblasts incubated with serum from an SSc affected patient or with serum from her unaffected MZ twin sister developed the increased expression of COL1A2 , SPARC , and CTGF typically seen in SSc fibroblasts . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| For gene analysis , conventional and quantitative polymerase chain reactions were used for COL1A2 , COL2A1 , aggrecan , BMP 2 , biglycan , decorin , osteonectin , fibromodulin , fibronectin , matrix metalloproteinase 13 ( MMP 13 ) , and tissue inhibitor of MMP 1 . ^^^ Gene expression analysis showed a significant up regulation of COL1A2 , osteonectin , decorin , fibronectin , tissue inhibitor of MMP 1 , BMP 2 , and MMP 13 in compressed discs . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| RESULTS : SSc fibroblasts showed overexpression of SPARC , COL1A2 , COL3A1 , and CTGF , which is consistent with an activated fibroblast phenotype . ^^^ Upon inhibition of SPARC with siRNA , these activated SSc fibroblasts showed decreased gene expression of COL1A2 , COL3A1 , and CTGF ( 43 % , 54 % , and 58 % , respectively ) . ^^^ |
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| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P08123 and P09486 |
Pubmed |
SVM Score :0.0 |
| NA |
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