Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q99683 and P08069	Pubmed	SVM Score :0.0
The cytoplasmic domain of the IGF IR was used to screen a human fetal brain library and two isoforms of the 14 3 3 family were identified . 14 3 3 proteins are a highly conserved family of proteins which have recently been shown to interact with other components of the mitogenic and apoptotic signaling pathways , including Raf , BAD , Bcr / Bcr Abl , middle T antigen , Ksr , PKC , PI 3 kinase , ASK 1 kinase , and cdc25C phosphatase . ^^^
Interacting proteins: Q99683 and P08069	Pubmed	SVM Score :0.0
Type 1 insulin like growth factor receptor ( IGF IR ) signaling inhibits apoptosis signal regulating kinase 1 ( ASK 1 ) . ^^^ The results presented here indicate that ASK 1 forms a complex with the IGF IR and becomes phosphorylated on tyrosine residue ( s ) in a manner dependent on IGF IR activity . ^^^ IGF IR signaling inhibited ASK 1 irrespective of TNFalpha induced ASK 1 activation and resulted in decreased ASK 1 dependent JNK 1 stimulation . ^^^ Signaling through IGF IR rescued cells from ASK 1 induced apoptotic cell death in a manner independent of PI3K activity . ^^^ These results indicate that IGF IR signaling suppresses the ASK 1 mediated stimulation of JNK / p38 and the induction of programmed cell death . ^^^